TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TLC domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HF37_LEIBR

TriTrypDb:

LbrM.26.1850 , LBRM2903_260023200

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HF37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF37

Function

Biological processes
Term	Name	Level	Count
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0055088	lipid homeostasis	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.174
CLV_PCSK_KEX2_1	178	180	PF00082	0.308
CLV_PCSK_KEX2_1	190	192	PF00082	0.201
CLV_PCSK_KEX2_1	271	273	PF00082	0.350
CLV_PCSK_KEX2_1	283	285	PF00082	0.434
CLV_PCSK_KEX2_1	301	303	PF00082	0.483
CLV_PCSK_KEX2_1	47	49	PF00082	0.361
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.253
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.401
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.500
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.522
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.353
CLV_PCSK_SKI1_1	190	194	PF00082	0.174
CLV_PCSK_SKI1_1	47	51	PF00082	0.406
DEG_MDM2_SWIB_1	118	125	PF02201	0.298
DOC_MAPK_RevD_3	165	179	PF00069	0.452
DOC_USP7_UBL2_3	295	299	PF12436	0.729
DOC_WW_Pin1_4	236	241	PF00397	0.217
DOC_WW_Pin1_4	9	14	PF00397	0.377
LIG_14-3-3_CanoR_1	103	112	PF00244	0.400
LIG_14-3-3_CanoR_1	178	185	PF00244	0.527
LIG_14-3-3_CanoR_1	191	195	PF00244	0.369
LIG_APCC_ABBA_1	141	146	PF00400	0.525
LIG_BRCT_BRCA1_1	106	110	PF00533	0.427
LIG_FHA_1	237	243	PF00498	0.302
LIG_FHA_2	191	197	PF00498	0.487
LIG_LIR_Apic_2	8	13	PF02991	0.284
LIG_LIR_Gen_1	137	144	PF02991	0.497
LIG_LIR_Gen_1	180	188	PF02991	0.497
LIG_LIR_Gen_1	90	101	PF02991	0.290
LIG_LIR_Nem_3	137	141	PF02991	0.497
LIG_LIR_Nem_3	145	151	PF02991	0.431
LIG_LIR_Nem_3	180	185	PF02991	0.497
LIG_LIR_Nem_3	196	202	PF02991	0.419
LIG_LIR_Nem_3	217	223	PF02991	0.215
LIG_LIR_Nem_3	90	96	PF02991	0.250
LIG_MLH1_MIPbox_1	106	110	PF16413	0.400
LIG_Pex14_2	118	122	PF04695	0.344
LIG_Pex14_2	77	81	PF04695	0.329
LIG_SH2_CRK	203	207	PF00017	0.472
LIG_SH2_CRK	220	224	PF00017	0.174
LIG_SH2_CRK	93	97	PF00017	0.260
LIG_SH2_GRB2like	119	122	PF00017	0.460
LIG_SH2_NCK_1	93	97	PF00017	0.287
LIG_SH2_PTP2	138	141	PF00017	0.400
LIG_SH2_STAP1	7	11	PF00017	0.304
LIG_SH2_STAT5	109	112	PF00017	0.267
LIG_SH2_STAT5	119	122	PF00017	0.421
LIG_SH2_STAT5	138	141	PF00017	0.405
LIG_SH2_STAT5	152	155	PF00017	0.460
LIG_SH2_STAT5	197	200	PF00017	0.390
LIG_SH2_STAT5	203	206	PF00017	0.235
LIG_SH2_STAT5	213	216	PF00017	0.375
LIG_SH2_STAT5	238	241	PF00017	0.217
LIG_SH2_STAT5	263	266	PF00017	0.304
LIG_SH2_STAT5	33	36	PF00017	0.443
LIG_TYR_ITIM	261	266	PF00017	0.374
LIG_UBA3_1	184	190	PF00899	0.425
LIG_WRC_WIRS_1	131	136	PF05994	0.444
MOD_CDK_SPK_2	236	241	PF00069	0.217
MOD_CDK_SPxxK_3	9	16	PF00069	0.386
MOD_CK1_1	180	186	PF00069	0.527
MOD_CK1_1	236	242	PF00069	0.284
MOD_CK2_1	190	196	PF00069	0.476
MOD_Cter_Amidation	299	302	PF01082	0.415
MOD_GlcNHglycan	106	109	PF01048	0.422
MOD_GlcNHglycan	235	238	PF01048	0.498
MOD_GlcNHglycan	275	278	PF01048	0.359
MOD_GlcNHglycan	287	290	PF01048	0.507
MOD_GlcNHglycan	4	7	PF01048	0.613
MOD_GlcNHglycan	72	75	PF01048	0.308
MOD_GSK3_1	130	137	PF00069	0.464
MOD_GSK3_1	180	187	PF00069	0.506
MOD_GSK3_1	2	9	PF00069	0.430
MOD_GSK3_1	221	228	PF00069	0.294
MOD_N-GLC_2	66	68	PF02516	0.457
MOD_NEK2_1	134	139	PF00069	0.487
MOD_NEK2_1	144	149	PF00069	0.440
MOD_NEK2_1	163	168	PF00069	0.464
MOD_NEK2_1	70	75	PF00069	0.282
MOD_NEK2_1	76	81	PF00069	0.340
MOD_NEK2_1	92	97	PF00069	0.325
MOD_PIKK_1	177	183	PF00454	0.460
MOD_PK_1	60	66	PF00069	0.431
MOD_PKA_1	190	196	PF00069	0.374
MOD_PKA_1	283	289	PF00069	0.556
MOD_PKA_1	47	53	PF00069	0.590
MOD_PKA_2	102	108	PF00069	0.258
MOD_PKA_2	177	183	PF00069	0.471
MOD_PKA_2	190	196	PF00069	0.525
MOD_PKA_2	283	289	PF00069	0.648
MOD_PKA_2	47	53	PF00069	0.590
MOD_Plk_4	130	136	PF00069	0.461
MOD_Plk_4	163	169	PF00069	0.494
MOD_Plk_4	201	207	PF00069	0.454
MOD_Plk_4	209	215	PF00069	0.279
MOD_Plk_4	253	259	PF00069	0.375
MOD_Plk_4	6	12	PF00069	0.340
MOD_Plk_4	60	66	PF00069	0.453
MOD_ProDKin_1	236	242	PF00069	0.217
MOD_ProDKin_1	9	15	PF00069	0.379
TRG_ENDOCYTIC_2	138	141	PF00928	0.525
TRG_ENDOCYTIC_2	203	206	PF00928	0.387
TRG_ENDOCYTIC_2	220	223	PF00928	0.173
TRG_ENDOCYTIC_2	263	266	PF00928	0.282
TRG_ENDOCYTIC_2	33	36	PF00928	0.327
TRG_ENDOCYTIC_2	93	96	PF00928	0.250
TRG_ENDOCYTIC_2	98	101	PF00928	0.268
TRG_ER_diLys_1	299	304	PF00400	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH5	Leptomonas seymouri	63%	100%
A0A0S4IR24	Bodo saltans	32%	98%
A0A1X0P7L3	Trypanosomatidae	39%	100%
A0A3S7X033	Leishmania donovani	77%	100%
A0A422NQS0	Trypanosoma rangeli	39%	100%
C9ZX92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AYH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q900	Leishmania major	77%	100%
V5DB81	Trypanosoma cruzi	38%	100%