Deoxyhypusine hydroxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyhypusine hydroxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HF36_LEIBR

TriTrypDb:

LbrM.26.1840 , LBRM2903_260023100

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF36

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	3	11
GO:0009058	biosynthetic process	2	11
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018205	peptidyl-lysine modification	6	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0051604	protein maturation	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0008283	cell population proliferation	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004497	monooxygenase activity	3	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	11
GO:0019135	deoxyhypusine monooxygenase activity	3	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0005506	iron ion binding	6	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.363
CLV_C14_Caspase3-7	55	59	PF00656	0.389
CLV_NRD_NRD_1	12	14	PF00675	0.489
CLV_NRD_NRD_1	141	143	PF00675	0.460
CLV_NRD_NRD_1	201	203	PF00675	0.362
CLV_PCSK_KEX2_1	201	203	PF00082	0.362
CLV_PCSK_SKI1_1	143	147	PF00082	0.533
DEG_APCC_KENBOX_2	36	40	PF00400	0.407
DEG_COP1_1	73	82	PF00400	0.504
DEG_SPOP_SBC_1	2	6	PF00917	0.444
DOC_MAPK_MEF2A_6	299	308	PF00069	0.310
DOC_MAPK_MEF2A_6	42	51	PF00069	0.467
DOC_USP7_MATH_1	105	109	PF00917	0.249
DOC_USP7_MATH_1	145	149	PF00917	0.421
DOC_USP7_MATH_1	170	174	PF00917	0.450
DOC_USP7_MATH_1	25	29	PF00917	0.399
DOC_USP7_MATH_1	70	74	PF00917	0.487
DOC_USP7_UBL2_3	14	18	PF12436	0.530
DOC_WW_Pin1_4	162	167	PF00397	0.446
DOC_WW_Pin1_4	228	233	PF00397	0.430
LIG_14-3-3_CanoR_1	210	218	PF00244	0.487
LIG_14-3-3_CanoR_1	84	90	PF00244	0.504
LIG_Actin_WH2_2	26	44	PF00022	0.502
LIG_Actin_WH2_2	72	89	PF00022	0.421
LIG_BRCT_BRCA1_1	164	168	PF00533	0.445
LIG_BRCT_BRCA1_1	230	234	PF00533	0.351
LIG_FHA_1	130	136	PF00498	0.488
LIG_FHA_1	281	287	PF00498	0.413
LIG_FHA_1	46	52	PF00498	0.404
LIG_FHA_1	55	61	PF00498	0.318
LIG_FHA_2	121	127	PF00498	0.587
LIG_FHA_2	180	186	PF00498	0.442
LIG_FHA_2	290	296	PF00498	0.413
LIG_FHA_2	93	99	PF00498	0.272
LIG_LIR_Gen_1	15	22	PF02991	0.483
LIG_LIR_Gen_1	158	167	PF02991	0.509
LIG_LIR_Gen_1	313	319	PF02991	0.351
LIG_LIR_Gen_1	88	99	PF02991	0.386
LIG_LIR_Nem_3	15	19	PF02991	0.432
LIG_LIR_Nem_3	158	162	PF02991	0.537
LIG_LIR_Nem_3	165	171	PF02991	0.538
LIG_LIR_Nem_3	197	203	PF02991	0.347
LIG_LIR_Nem_3	313	318	PF02991	0.348
LIG_LIR_Nem_3	88	94	PF02991	0.406
LIG_MYND_3	284	288	PF01753	0.351
LIG_MYND_3	79	83	PF01753	0.491
LIG_SH2_CRK	16	20	PF00017	0.400
LIG_SH2_CRK	91	95	PF00017	0.358
LIG_SH2_NCK_1	91	95	PF00017	0.358
LIG_SH2_STAP1	16	20	PF00017	0.411
LIG_SH3_2	125	130	PF14604	0.458
LIG_SH3_3	122	128	PF00018	0.479
LIG_SH3_3	148	154	PF00018	0.481
LIG_SH3_3	19	25	PF00018	0.404
LIG_SUMO_SIM_par_1	300	307	PF11976	0.310
LIG_SUMO_SIM_par_1	47	52	PF11976	0.489
LIG_TRAF2_1	182	185	PF00917	0.504
LIG_TRAF2_1	8	11	PF00917	0.504
LIG_TYR_ITIM	89	94	PF00017	0.281
LIG_UBA3_1	254	259	PF00899	0.379
MOD_CDK_SPxxK_3	228	235	PF00069	0.189
MOD_CK1_1	119	125	PF00069	0.526
MOD_CK1_1	194	200	PF00069	0.461
MOD_CK1_1	289	295	PF00069	0.441
MOD_CK2_1	120	126	PF00069	0.590
MOD_CK2_1	152	158	PF00069	0.588
MOD_CK2_1	171	177	PF00069	0.648
MOD_CK2_1	179	185	PF00069	0.288
MOD_CK2_1	289	295	PF00069	0.413
MOD_CK2_1	5	11	PF00069	0.512
MOD_CK2_1	70	76	PF00069	0.461
MOD_CK2_1	92	98	PF00069	0.350
MOD_GlcNHglycan	147	150	PF01048	0.430
MOD_GlcNHglycan	154	157	PF01048	0.548
MOD_GlcNHglycan	168	171	PF01048	0.367
MOD_GlcNHglycan	192	196	PF01048	0.446
MOD_GlcNHglycan	72	75	PF01048	0.401
MOD_GSK3_1	1	8	PF00069	0.650
MOD_GSK3_1	116	123	PF00069	0.579
MOD_GSK3_1	158	165	PF00069	0.473
MOD_GSK3_1	166	173	PF00069	0.516
MOD_GSK3_1	190	197	PF00069	0.397
MOD_GSK3_1	310	317	PF00069	0.438
MOD_NEK2_1	190	195	PF00069	0.397
MOD_NEK2_2	205	210	PF00069	0.318
MOD_PIKK_1	247	253	PF00454	0.329
MOD_PKA_2	129	135	PF00069	0.365
MOD_PKA_2	298	304	PF00069	0.310
MOD_Plk_1	226	232	PF00069	0.380
MOD_Plk_2-3	120	126	PF00069	0.454
MOD_Plk_2-3	158	164	PF00069	0.543
MOD_Plk_2-3	172	178	PF00069	0.394
MOD_Plk_4	45	51	PF00069	0.392
MOD_Plk_4	56	62	PF00069	0.348
MOD_ProDKin_1	162	168	PF00069	0.448
MOD_ProDKin_1	228	234	PF00069	0.430
MOD_SUMO_for_1	258	261	PF00179	0.329
MOD_SUMO_rev_2	141	148	PF00179	0.306
TRG_DiLeu_BaEn_3	261	267	PF01217	0.379
TRG_ENDOCYTIC_2	16	19	PF00928	0.386
TRG_ENDOCYTIC_2	203	206	PF00928	0.315
TRG_ENDOCYTIC_2	91	94	PF00928	0.364
TRG_ER_diArg_1	196	199	PF00400	0.424
TRG_ER_diArg_1	200	202	PF00400	0.360
TRG_NES_CRM1_1	101	116	PF08389	0.324
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I695	Leptomonas seymouri	80%	99%
A0A0S4J984	Bodo saltans	47%	100%
A0A1X0P8G1	Trypanosomatidae	60%	96%
A0A3R7KQN3	Trypanosoma rangeli	68%	100%
A0A3S7X004	Leishmania donovani	93%	100%
A1CED0	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	42%	99%
A1DFW7	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	44%	99%
A2QXL3	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	43%	98%
A4I2C0	Leishmania infantum	93%	100%
A5JZ19	Plasmodium vivax (strain Salvador I)	34%	95%
C9ZX93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
D9IFD5	Leishmania donovani	93%	100%
E9AYH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P0CN10	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	38%	91%
P0CN11	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	38%	91%
P47120	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
Q0UHL8	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	41%	100%
Q0VC53	Bos taurus	42%	100%
Q17949	Caenorhabditis elegans	42%	100%
Q1E9L2	Coccidioides immitis (strain RS)	39%	99%
Q297S2	Drosophila pseudoobscura pseudoobscura	43%	100%
Q2H0C0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	44%	96%
Q2QLW3	Oryza sativa subsp. japonica	42%	100%
Q2QXB3	Oryza sativa subsp. japonica	41%	100%
Q2UMQ8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	42%	97%
Q4HZ35	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	40%	98%
Q4PHU4	Ustilago maydis (strain 521 / FGSC 9021)	37%	92%
Q4Q901	Leishmania major	92%	100%
Q4WHG5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	44%	99%
Q556G4	Dictyostelium discoideum	40%	100%
Q59Z14	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	100%
Q5AW32	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	40%	98%
Q5PPJ4	Rattus norvegicus	41%	100%
Q5ZIP3	Gallus gallus	43%	100%
Q66KT3	Xenopus laevis	41%	100%
Q6BKA6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	43%	100%
Q6CHJ7	Yarrowia lipolytica (strain CLIB 122 / E 150)	43%	100%
Q6CV81	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	38%	100%
Q6FUV3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	39%	100%
Q752Z8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	40%	100%
Q7S891	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q7ZUX6	Danio rerio	42%	100%
Q8SV71	Encephalitozoon cuniculi (strain GB-M1)	41%	100%
Q94JW0	Arabidopsis thaliana	41%	100%
Q96WP5	Lentinula edodes	42%	100%
Q99LN9	Mus musculus	41%	100%
Q9BU89	Homo sapiens	44%	100%
Q9P6K9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
Q9V9U4	Drosophila melanogaster	42%	100%
V5BF70	Trypanosoma cruzi	66%	100%