Sedlin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Sedlin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF34_LEIBR

TriTrypDb:

LbrM.26.1820 , LBRM2903_260022900

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	163	167	PF00082	0.590
CLV_PCSK_SKI1_1	30	34	PF00082	0.540
DEG_SPOP_SBC_1	102	106	PF00917	0.522
DEG_SPOP_SBC_1	80	84	PF00917	0.529
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.602
DOC_PP1_RVXF_1	213	219	PF00149	0.420
DOC_PP1_RVXF_1	51	57	PF00149	0.450
DOC_PP4_FxxP_1	203	206	PF00568	0.526
DOC_USP7_MATH_1	112	116	PF00917	0.606
DOC_USP7_MATH_1	261	265	PF00917	0.722
DOC_USP7_MATH_1	72	76	PF00917	0.714
DOC_USP7_MATH_1	80	84	PF00917	0.713
DOC_WW_Pin1_4	137	142	PF00397	0.632
DOC_WW_Pin1_4	16	21	PF00397	0.475
DOC_WW_Pin1_4	202	207	PF00397	0.531
DOC_WW_Pin1_4	25	30	PF00397	0.457
DOC_WW_Pin1_4	32	37	PF00397	0.429
LIG_14-3-3_CanoR_1	156	161	PF00244	0.467
LIG_14-3-3_CanoR_1	24	29	PF00244	0.473
LIG_14-3-3_CanoR_1	298	308	PF00244	0.576
LIG_14-3-3_CanoR_1	89	97	PF00244	0.625
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_BIR_III_4	15	19	PF00653	0.350
LIG_BRCT_BRCA1_1	158	162	PF00533	0.405
LIG_BRCT_BRCA1_1	296	300	PF00533	0.510
LIG_deltaCOP1_diTrp_1	274	277	PF00928	0.680
LIG_EH_1	200	204	PF12763	0.498
LIG_FHA_1	122	128	PF00498	0.487
LIG_FHA_1	133	139	PF00498	0.577
LIG_FHA_1	168	174	PF00498	0.463
LIG_FHA_1	17	23	PF00498	0.482
LIG_FHA_1	291	297	PF00498	0.618
LIG_FHA_1	3	9	PF00498	0.467
LIG_FHA_1	49	55	PF00498	0.518
LIG_FHA_1	83	89	PF00498	0.631
LIG_FHA_2	102	108	PF00498	0.723
LIG_FHA_2	300	306	PF00498	0.524
LIG_LIR_Apic_2	25	29	PF02991	0.449
LIG_LIR_Apic_2	274	280	PF02991	0.719
LIG_LIR_Gen_1	263	273	PF02991	0.684
LIG_LIR_Nem_3	159	165	PF02991	0.367
LIG_LIR_Nem_3	263	268	PF02991	0.495
LIG_NRBOX	147	153	PF00104	0.497
LIG_PCNA_yPIPBox_3	298	308	PF02747	0.576
LIG_SH2_CRK	26	30	PF00017	0.580
LIG_SH2_NCK_1	192	196	PF00017	0.422
LIG_SH2_PTP2	45	48	PF00017	0.536
LIG_SH2_STAT5	26	29	PF00017	0.568
LIG_SH2_STAT5	45	48	PF00017	0.493
LIG_SH3_3	33	39	PF00018	0.602
LIG_SUMO_SIM_par_1	169	174	PF11976	0.501
LIG_SUMO_SIM_par_1	19	25	PF11976	0.451
LIG_SUMO_SIM_par_1	291	297	PF11976	0.645
LIG_WRC_WIRS_1	308	313	PF05994	0.598
MOD_CAAXbox	318	321	PF01239	0.679
MOD_CDK_SPK_2	25	30	PF00069	0.503
MOD_CK1_1	115	121	PF00069	0.689
MOD_CK1_1	126	132	PF00069	0.590
MOD_CK1_1	140	146	PF00069	0.503
MOD_CK1_1	2	8	PF00069	0.534
MOD_CK1_1	264	270	PF00069	0.744
MOD_CK1_1	309	315	PF00069	0.617
MOD_CK1_1	82	88	PF00069	0.543
MOD_CK1_1	95	101	PF00069	0.697
MOD_CK2_1	101	107	PF00069	0.754
MOD_CK2_1	299	305	PF00069	0.526
MOD_GlcNHglycan	128	131	PF01048	0.545
MOD_GlcNHglycan	195	198	PF01048	0.440
MOD_GlcNHglycan	222	225	PF01048	0.688
MOD_GlcNHglycan	283	286	PF01048	0.685
MOD_GlcNHglycan	99	102	PF01048	0.702
MOD_GSK3_1	111	118	PF00069	0.604
MOD_GSK3_1	119	126	PF00069	0.532
MOD_GSK3_1	128	135	PF00069	0.491
MOD_GSK3_1	163	170	PF00069	0.429
MOD_GSK3_1	260	267	PF00069	0.761
MOD_GSK3_1	286	293	PF00069	0.590
MOD_GSK3_1	307	314	PF00069	0.575
MOD_GSK3_1	88	95	PF00069	0.651
MOD_GSK3_1	97	104	PF00069	0.695
MOD_NEK2_1	119	124	PF00069	0.634
MOD_NEK2_1	151	156	PF00069	0.480
MOD_NEK2_1	171	176	PF00069	0.510
MOD_NEK2_1	22	27	PF00069	0.481
MOD_NEK2_1	273	278	PF00069	0.761
MOD_NEK2_1	294	299	PF00069	0.530
MOD_NEK2_1	307	312	PF00069	0.485
MOD_NEK2_2	48	53	PF00069	0.428
MOD_PIKK_1	232	238	PF00454	0.782
MOD_PIKK_1	299	305	PF00454	0.593
MOD_PKA_2	88	94	PF00069	0.705
MOD_Plk_1	248	254	PF00069	0.588
MOD_Plk_1	273	279	PF00069	0.730
MOD_Plk_1	48	54	PF00069	0.420
MOD_Plk_1	92	98	PF00069	0.762
MOD_Plk_4	123	129	PF00069	0.571
MOD_Plk_4	167	173	PF00069	0.545
MOD_Plk_4	92	98	PF00069	0.744
MOD_ProDKin_1	137	143	PF00069	0.622
MOD_ProDKin_1	16	22	PF00069	0.469
MOD_ProDKin_1	202	208	PF00069	0.531
MOD_ProDKin_1	25	31	PF00069	0.465
MOD_ProDKin_1	32	38	PF00069	0.427
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.678
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.397
TRG_DiLeu_LyEn_5	17	22	PF01217	0.559
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P7	Leptomonas seymouri	57%	95%
A0A1X0P7Q6	Trypanosomatidae	35%	100%
A0A3Q8ICA3	Leishmania donovani	77%	100%
A4I2B8	Leishmania infantum	77%	100%
C9ZX95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AYG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q903	Leishmania major	75%	98%
V5AV59	Trypanosoma cruzi	37%	100%