DUF4460 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4460), putative

Species:

Leishmania braziliensis

UniProt:

A4HF33_LEIBR

TriTrypDb:

LbrM.26.1810 , LBRM2903_260022800

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.454
CLV_C14_Caspase3-7	240	244	PF00656	0.518
CLV_NRD_NRD_1	171	173	PF00675	0.368
CLV_NRD_NRD_1	193	195	PF00675	0.521
CLV_NRD_NRD_1	201	203	PF00675	0.514
CLV_NRD_NRD_1	409	411	PF00675	0.324
CLV_NRD_NRD_1	423	425	PF00675	0.389
CLV_NRD_NRD_1	502	504	PF00675	0.542
CLV_NRD_NRD_1	542	544	PF00675	0.522
CLV_NRD_NRD_1	574	576	PF00675	0.773
CLV_NRD_NRD_1	64	66	PF00675	0.370
CLV_NRD_NRD_1	694	696	PF00675	0.560
CLV_PCSK_KEX2_1	171	173	PF00082	0.382
CLV_PCSK_KEX2_1	193	195	PF00082	0.514
CLV_PCSK_KEX2_1	200	202	PF00082	0.509
CLV_PCSK_KEX2_1	502	504	PF00082	0.472
CLV_PCSK_KEX2_1	542	544	PF00082	0.517
CLV_PCSK_KEX2_1	574	576	PF00082	0.773
CLV_PCSK_KEX2_1	64	66	PF00082	0.395
CLV_PCSK_KEX2_1	694	696	PF00082	0.560
CLV_PCSK_PC7_1	167	173	PF00082	0.359
CLV_PCSK_SKI1_1	167	171	PF00082	0.340
CLV_PCSK_SKI1_1	194	198	PF00082	0.619
CLV_PCSK_SKI1_1	216	220	PF00082	0.400
CLV_PCSK_SKI1_1	3	7	PF00082	0.277
CLV_PCSK_SKI1_1	370	374	PF00082	0.362
CLV_PCSK_SKI1_1	43	47	PF00082	0.303
CLV_PCSK_SKI1_1	431	435	PF00082	0.385
CLV_PCSK_SKI1_1	471	475	PF00082	0.335
CLV_PCSK_SKI1_1	486	490	PF00082	0.345
CLV_PCSK_SKI1_1	532	536	PF00082	0.576
CLV_PCSK_SKI1_1	679	683	PF00082	0.476
CLV_PCSK_SKI1_1	722	726	PF00082	0.614
DEG_APCC_DBOX_1	265	273	PF00400	0.389
DEG_APCC_DBOX_1	409	417	PF00400	0.386
DEG_Nend_Nbox_1	1	3	PF02207	0.366
DEG_SCF_TRCP1_1	120	126	PF00400	0.512
DOC_CDC14_PxL_1	232	240	PF14671	0.452
DOC_CYCLIN_RxL_1	340	349	PF00134	0.252
DOC_CYCLIN_RxL_1	673	684	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	298	304	PF00134	0.376
DOC_MAPK_MEF2A_6	392	401	PF00069	0.480
DOC_PP1_RVXF_1	464	470	PF00149	0.340
DOC_PP2B_LxvP_1	298	301	PF13499	0.361
DOC_PP2B_LxvP_1	505	508	PF13499	0.428
DOC_PP4_FxxP_1	142	145	PF00568	0.410
DOC_USP7_MATH_1	123	127	PF00917	0.701
DOC_USP7_MATH_1	150	154	PF00917	0.570
DOC_USP7_MATH_1	54	58	PF00917	0.337
DOC_USP7_MATH_1	83	87	PF00917	0.729
DOC_USP7_MATH_1	88	92	PF00917	0.732
DOC_USP7_UBL2_3	212	216	PF12436	0.616
DOC_USP7_UBL2_3	528	532	PF12436	0.563
DOC_WW_Pin1_4	251	256	PF00397	0.374
DOC_WW_Pin1_4	49	54	PF00397	0.308
DOC_WW_Pin1_4	490	495	PF00397	0.431
DOC_WW_Pin1_4	598	603	PF00397	0.537
LIG_14-3-3_CanoR_1	201	207	PF00244	0.652
LIG_14-3-3_CanoR_1	266	270	PF00244	0.514
LIG_14-3-3_CanoR_1	324	334	PF00244	0.339
LIG_14-3-3_CanoR_1	537	544	PF00244	0.592
LIG_14-3-3_CanoR_1	598	602	PF00244	0.568
LIG_14-3-3_CanoR_1	622	630	PF00244	0.577
LIG_APCC_ABBA_1	11	16	PF00400	0.274
LIG_BRCT_BRCA1_1	56	60	PF00533	0.343
LIG_BRCT_BRCA1_1	692	696	PF00533	0.560
LIG_deltaCOP1_diTrp_1	110	118	PF00928	0.658
LIG_deltaCOP1_diTrp_1	484	490	PF00928	0.403
LIG_FHA_1	133	139	PF00498	0.471
LIG_FHA_1	178	184	PF00498	0.404
LIG_FHA_1	262	268	PF00498	0.391
LIG_FHA_1	293	299	PF00498	0.354
LIG_FHA_1	380	386	PF00498	0.363
LIG_FHA_1	487	493	PF00498	0.343
LIG_FHA_1	654	660	PF00498	0.578
LIG_FHA_1	663	669	PF00498	0.568
LIG_FHA_2	215	221	PF00498	0.539
LIG_FHA_2	235	241	PF00498	0.238
LIG_FHA_2	330	336	PF00498	0.438
LIG_FHA_2	607	613	PF00498	0.634
LIG_LIR_Apic_2	140	145	PF02991	0.393
LIG_LIR_Apic_2	643	649	PF02991	0.560
LIG_LIR_Gen_1	275	284	PF02991	0.398
LIG_LIR_Gen_1	303	312	PF02991	0.472
LIG_LIR_Gen_1	487	496	PF02991	0.405
LIG_LIR_Gen_1	697	705	PF02991	0.536
LIG_LIR_Nem_3	484	488	PF02991	0.380
LIG_LIR_Nem_3	514	519	PF02991	0.314
LIG_LIR_Nem_3	57	63	PF02991	0.368
LIG_MYND_3	235	239	PF01753	0.449
LIG_NRBOX	165	171	PF00104	0.335
LIG_NRBOX	34	40	PF00104	0.274
LIG_Pex14_1	41	45	PF04695	0.274
LIG_Pex14_1	642	646	PF04695	0.514
LIG_REV1ctd_RIR_1	7	14	PF16727	0.274
LIG_SH2_SRC	646	649	PF00017	0.549
LIG_SH2_STAP1	463	467	PF00017	0.349
LIG_SH2_STAT3	650	653	PF00017	0.577
LIG_SH2_STAT5	519	522	PF00017	0.378
LIG_SH2_STAT5	650	653	PF00017	0.596
LIG_SH3_3	578	584	PF00018	0.658
LIG_SH3_3	617	623	PF00018	0.554
LIG_SUMO_SIM_par_1	278	286	PF11976	0.369
LIG_SUMO_SIM_par_1	395	400	PF11976	0.407
LIG_SUMO_SIM_par_1	616	621	PF11976	0.587
LIG_TRAF2_1	237	240	PF00917	0.432
LIG_TRAF2_1	545	548	PF00917	0.567
LIG_TRFH_1	490	494	PF08558	0.340
LIG_WRC_WIRS_1	309	314	PF05994	0.343
MOD_CK1_1	113	119	PF00069	0.690
MOD_CK1_1	126	132	PF00069	0.629
MOD_CK1_1	234	240	PF00069	0.481
MOD_CK1_1	402	408	PF00069	0.463
MOD_CK1_1	96	102	PF00069	0.536
MOD_CK2_1	137	143	PF00069	0.402
MOD_CK2_1	181	187	PF00069	0.407
MOD_CK2_1	234	240	PF00069	0.386
MOD_CK2_1	265	271	PF00069	0.506
MOD_CK2_1	329	335	PF00069	0.409
MOD_CK2_1	352	358	PF00069	0.411
MOD_CK2_1	523	529	PF00069	0.554
MOD_CK2_1	542	548	PF00069	0.568
MOD_CK2_1	606	612	PF00069	0.633
MOD_CK2_1	629	635	PF00069	0.533
MOD_GlcNHglycan	119	123	PF01048	0.742
MOD_GlcNHglycan	125	128	PF01048	0.694
MOD_GlcNHglycan	212	215	PF01048	0.680
MOD_GlcNHglycan	258	261	PF01048	0.341
MOD_GlcNHglycan	525	528	PF01048	0.486
MOD_GlcNHglycan	538	541	PF01048	0.417
MOD_GlcNHglycan	70	75	PF01048	0.623
MOD_GlcNHglycan	81	84	PF01048	0.645
MOD_GlcNHglycan	85	88	PF01048	0.641
MOD_GlcNHglycan	90	93	PF01048	0.721
MOD_GSK3_1	126	133	PF00069	0.549
MOD_GSK3_1	175	182	PF00069	0.431
MOD_GSK3_1	210	217	PF00069	0.551
MOD_GSK3_1	220	227	PF00069	0.329
MOD_GSK3_1	230	237	PF00069	0.271
MOD_GSK3_1	261	268	PF00069	0.462
MOD_GSK3_1	292	299	PF00069	0.434
MOD_GSK3_1	325	332	PF00069	0.364
MOD_GSK3_1	399	406	PF00069	0.407
MOD_GSK3_1	486	493	PF00069	0.415
MOD_GSK3_1	49	56	PF00069	0.314
MOD_GSK3_1	622	629	PF00069	0.600
MOD_GSK3_1	662	669	PF00069	0.540
MOD_GSK3_1	75	82	PF00069	0.638
MOD_GSK3_1	83	90	PF00069	0.604
MOD_N-GLC_1	379	384	PF02516	0.378
MOD_N-GLC_2	459	461	PF02516	0.452
MOD_NEK2_1	118	123	PF00069	0.790
MOD_NEK2_1	137	142	PF00069	0.264
MOD_NEK2_1	228	233	PF00069	0.452
MOD_NEK2_1	249	254	PF00069	0.444
MOD_NEK2_1	256	261	PF00069	0.428
MOD_NEK2_1	326	331	PF00069	0.344
MOD_NEK2_1	433	438	PF00069	0.344
MOD_NEK2_1	536	541	PF00069	0.425
MOD_NEK2_1	662	667	PF00069	0.518
MOD_NEK2_1	685	690	PF00069	0.585
MOD_NEK2_1	79	84	PF00069	0.490
MOD_NEK2_2	261	266	PF00069	0.356
MOD_PIKK_1	130	136	PF00454	0.592
MOD_PKA_1	542	548	PF00069	0.581
MOD_PKA_2	265	271	PF00069	0.509
MOD_PKA_2	427	433	PF00069	0.318
MOD_PKA_2	536	542	PF00069	0.593
MOD_PKA_2	597	603	PF00069	0.549
MOD_PKA_2	666	672	PF00069	0.651
MOD_PKA_2	88	94	PF00069	0.773
MOD_PKB_1	200	208	PF00069	0.479
MOD_Plk_1	302	308	PF00069	0.510
MOD_Plk_1	379	385	PF00069	0.351
MOD_Plk_1	399	405	PF00069	0.490
MOD_Plk_1	434	440	PF00069	0.345
MOD_Plk_1	459	465	PF00069	0.383
MOD_Plk_1	486	492	PF00069	0.328
MOD_Plk_1	93	99	PF00069	0.619
MOD_Plk_2-3	616	622	PF00069	0.569
MOD_Plk_4	113	119	PF00069	0.727
MOD_Plk_4	214	220	PF00069	0.418
MOD_Plk_4	434	440	PF00069	0.345
MOD_Plk_4	96	102	PF00069	0.718
MOD_ProDKin_1	251	257	PF00069	0.368
MOD_ProDKin_1	49	55	PF00069	0.308
MOD_ProDKin_1	490	496	PF00069	0.438
MOD_ProDKin_1	598	604	PF00069	0.537
MOD_SUMO_for_1	640	643	PF00179	0.524
MOD_SUMO_rev_2	606	615	PF00179	0.605
TRG_DiLeu_BaEn_1	333	338	PF01217	0.472
TRG_DiLeu_BaEn_1	487	492	PF01217	0.465
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.501
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.467
TRG_ENDOCYTIC_2	63	66	PF00928	0.417
TRG_ENDOCYTIC_2	698	701	PF00928	0.535
TRG_ER_diArg_1	170	172	PF00400	0.380
TRG_ER_diArg_1	199	202	PF00400	0.557
TRG_ER_diArg_1	541	543	PF00400	0.555
TRG_ER_diArg_1	63	65	PF00400	0.417
TRG_ER_diArg_1	694	696	PF00400	0.551
TRG_NES_CRM1_1	335	349	PF08389	0.334
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	343	348	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	575	579	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	594	599	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	679	683	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB5	Leptomonas seymouri	76%	100%
A0A0S4IT81	Bodo saltans	49%	100%
A0A1X0P7G1	Trypanosomatidae	58%	100%
A0A3R7MTD0	Trypanosoma rangeli	58%	100%
A0A3S7WZZ9	Leishmania donovani	87%	99%
A4I272	Leishmania infantum	87%	99%
C9ZX97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AYG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q904	Leishmania major	86%	100%
V5DB85	Trypanosoma cruzi	57%	100%