Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 2

Species:

Leishmania braziliensis

UniProt:

A4HF31_LEIBR

TriTrypDb:

LbrM.26.1790 , LBRM2903_230029300

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HF31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF31

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.597
CLV_MEL_PAP_1	73	79	PF00089	0.635
CLV_NRD_NRD_1	155	157	PF00675	0.668
CLV_NRD_NRD_1	207	209	PF00675	0.594
CLV_PCSK_KEX2_1	141	143	PF00082	0.626
CLV_PCSK_KEX2_1	190	192	PF00082	0.699
CLV_PCSK_KEX2_1	209	211	PF00082	0.452
CLV_PCSK_KEX2_1	323	325	PF00082	0.818
CLV_PCSK_KEX2_1	365	367	PF00082	0.420
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.626
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.691
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.442
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.818
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.420
CLV_PCSK_SKI1_1	157	161	PF00082	0.661
CLV_PCSK_SKI1_1	182	186	PF00082	0.582
CLV_PCSK_SKI1_1	243	247	PF00082	0.469
CLV_PCSK_SKI1_1	25	29	PF00082	0.717
CLV_PCSK_SKI1_1	39	43	PF00082	0.611
DEG_APCC_DBOX_1	209	217	PF00400	0.380
DOC_ANK_TNKS_1	275	282	PF00023	0.396
DOC_CYCLIN_RxL_1	238	249	PF00134	0.280
DOC_MAPK_DCC_7	63	73	PF00069	0.411
DOC_MAPK_gen_1	153	162	PF00069	0.392
DOC_MAPK_gen_1	323	330	PF00069	0.440
DOC_MAPK_MEF2A_6	65	73	PF00069	0.412
DOC_MAPK_RevD_3	349	365	PF00069	0.513
DOC_PP2B_LxvP_1	328	331	PF13499	0.436
DOC_PP2B_LxvP_1	91	94	PF13499	0.451
DOC_PP2B_PxIxI_1	68	74	PF00149	0.404
DOC_PP4_FxxP_1	56	59	PF00568	0.393
DOC_USP7_MATH_1	125	129	PF00917	0.449
DOC_USP7_MATH_1	272	276	PF00917	0.431
DOC_USP7_MATH_1	288	292	PF00917	0.540
DOC_USP7_MATH_1	332	336	PF00917	0.517
DOC_USP7_UBL2_3	21	25	PF12436	0.626
DOC_WW_Pin1_4	51	56	PF00397	0.406
LIG_Actin_WH2_2	177	192	PF00022	0.428
LIG_Actin_WH2_2	233	249	PF00022	0.277
LIG_FHA_1	183	189	PF00498	0.382
LIG_FHA_1	198	204	PF00498	0.387
LIG_FHA_1	246	252	PF00498	0.330
LIG_FHA_1	295	301	PF00498	0.473
LIG_FHA_1	315	321	PF00498	0.374
LIG_FHA_1	353	359	PF00498	0.441
LIG_GBD_Chelix_1	180	188	PF00786	0.651
LIG_LIR_Apic_2	54	59	PF02991	0.393
LIG_LIR_Gen_1	118	126	PF02991	0.322
LIG_LIR_Gen_1	218	227	PF02991	0.387
LIG_LIR_Gen_1	265	274	PF02991	0.417
LIG_LIR_Gen_1	339	349	PF02991	0.419
LIG_LIR_Nem_3	118	122	PF02991	0.316
LIG_LIR_Nem_3	138	143	PF02991	0.444
LIG_LIR_Nem_3	212	217	PF02991	0.393
LIG_LIR_Nem_3	218	223	PF02991	0.358
LIG_LIR_Nem_3	265	271	PF02991	0.416
LIG_LIR_Nem_3	339	344	PF02991	0.584
LIG_NRP_CendR_1	364	367	PF00754	0.387
LIG_Pex14_2	115	119	PF04695	0.362
LIG_Pex14_2	220	224	PF04695	0.376
LIG_Rb_pABgroove_1	211	219	PF01858	0.376
LIG_SH2_CRK	143	147	PF00017	0.361
LIG_SH2_NCK_1	143	147	PF00017	0.385
LIG_SH2_STAP1	117	121	PF00017	0.437
LIG_SH2_STAP1	176	180	PF00017	0.433
LIG_SH2_STAP1	217	221	PF00017	0.444
LIG_SH2_STAT5	147	150	PF00017	0.361
LIG_SUMO_SIM_anti_2	357	362	PF11976	0.513
LIG_SUMO_SIM_par_1	258	265	PF11976	0.517
LIG_SUMO_SIM_par_1	345	350	PF11976	0.261
LIG_TYR_ITIM	145	150	PF00017	0.366
MOD_CK1_1	239	245	PF00069	0.460
MOD_CK1_1	340	346	PF00069	0.277
MOD_CK2_1	199	205	PF00069	0.462
MOD_Cter_Amidation	321	324	PF01082	0.632
MOD_GlcNHglycan	127	130	PF01048	0.542
MOD_GlcNHglycan	285	288	PF01048	0.723
MOD_GlcNHglycan	320	323	PF01048	0.701
MOD_GlcNHglycan	334	337	PF01048	0.743
MOD_GlcNHglycan	5	10	PF01048	0.653
MOD_GlcNHglycan	79	82	PF01048	0.700
MOD_GSK3_1	232	239	PF00069	0.415
MOD_GSK3_1	314	321	PF00069	0.468
MOD_GSK3_1	332	339	PF00069	0.549
MOD_GSK3_1	352	359	PF00069	0.183
MOD_GSK3_1	5	12	PF00069	0.636
MOD_LATS_1	23	29	PF00433	0.605
MOD_NEK2_1	197	202	PF00069	0.478
MOD_NEK2_1	245	250	PF00069	0.303
MOD_NEK2_1	347	352	PF00069	0.514
MOD_NEK2_1	49	54	PF00069	0.441
MOD_NEK2_1	77	82	PF00069	0.487
MOD_NEK2_2	219	224	PF00069	0.374
MOD_PIKK_1	34	40	PF00454	0.573
MOD_PKA_1	25	31	PF00069	0.591
MOD_Plk_1	272	278	PF00069	0.524
MOD_Plk_2-3	199	205	PF00069	0.462
MOD_Plk_4	199	205	PF00069	0.390
MOD_Plk_4	219	225	PF00069	0.218
MOD_ProDKin_1	51	57	PF00069	0.400
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.261
TRG_ENDOCYTIC_2	147	150	PF00928	0.377
TRG_ENDOCYTIC_2	217	220	PF00928	0.417
TRG_ER_diArg_1	207	210	PF00400	0.396
TRG_ER_diArg_1	99	102	PF00400	0.412
TRG_ER_diLys_1	364	367	PF00400	0.768
TRG_NES_CRM1_1	111	124	PF08389	0.444
TRG_NES_CRM1_1	193	205	PF08389	0.456
TRG_NES_CRM1_1	269	280	PF08389	0.529
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.774

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDW3	Leishmania donovani	88%	67%
A4I274	Leishmania infantum	88%	67%
E9AYG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	67%
Q4Q906	Leishmania major	88%	67%
V5BJP4	Trypanosoma cruzi	59%	100%