ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Engulfment and cell motility domain-containing protein

Species:

Leishmania braziliensis

UniProt:

A4HF30_LEIBR

TriTrypDb:

LbrM.26.1780 , LBRM2903_230029400

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	8
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HF30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.410
CLV_NRD_NRD_1	48	50	PF00675	0.609
CLV_PCSK_KEX2_1	229	231	PF00082	0.410
CLV_PCSK_KEX2_1	48	50	PF00082	0.609
CLV_PCSK_SKI1_1	164	168	PF00082	0.387
DEG_APCC_DBOX_1	47	55	PF00400	0.391
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.541
DOC_MAPK_gen_1	48	54	PF00069	0.393
DOC_PP1_RVXF_1	4	10	PF00149	0.477
DOC_PP2B_LxvP_1	29	32	PF13499	0.530
DOC_USP7_MATH_1	185	189	PF00917	0.279
DOC_USP7_MATH_1	292	296	PF00917	0.197
DOC_USP7_MATH_1	80	84	PF00917	0.543
DOC_WW_Pin1_4	61	66	PF00397	0.587
LIG_14-3-3_CanoR_1	30	36	PF00244	0.679
LIG_Actin_WH2_2	128	144	PF00022	0.347
LIG_Actin_WH2_2	201	218	PF00022	0.282
LIG_BRCT_BRCA1_1	128	132	PF00533	0.355
LIG_BRCT_BRCA1_1	299	303	PF00533	0.467
LIG_FHA_1	16	22	PF00498	0.522
LIG_FHA_1	190	196	PF00498	0.340
LIG_FHA_1	62	68	PF00498	0.504
LIG_FHA_2	14	20	PF00498	0.680
LIG_FHA_2	166	172	PF00498	0.288
LIG_FHA_2	91	97	PF00498	0.322
LIG_LIR_Gen_1	119	125	PF02991	0.229
LIG_LIR_Gen_1	129	138	PF02991	0.157
LIG_LIR_Gen_1	209	219	PF02991	0.297
LIG_LIR_Gen_1	70	79	PF02991	0.484
LIG_LIR_Nem_3	119	123	PF02991	0.342
LIG_LIR_Nem_3	129	135	PF02991	0.272
LIG_LIR_Nem_3	180	184	PF02991	0.304
LIG_LIR_Nem_3	209	215	PF02991	0.311
LIG_LIR_Nem_3	289	293	PF02991	0.279
LIG_LIR_Nem_3	70	74	PF02991	0.493
LIG_MLH1_MIPbox_1	299	303	PF16413	0.397
LIG_PDZ_Class_1	310	315	PF00595	0.327
LIG_Pex14_2	276	280	PF04695	0.330
LIG_Pex14_2	303	307	PF04695	0.382
LIG_PTB_Apo_2	157	164	PF02174	0.258
LIG_Rb_pABgroove_1	206	214	PF01858	0.201
LIG_REV1ctd_RIR_1	300	310	PF16727	0.433
LIG_SH2_CRK	120	124	PF00017	0.410
LIG_SH2_CRK	212	216	PF00017	0.318
LIG_SH2_SRC	43	46	PF00017	0.580
LIG_SH2_STAP1	299	303	PF00017	0.299
LIG_SH2_STAP1	71	75	PF00017	0.298
LIG_SH2_STAT5	182	185	PF00017	0.279
LIG_SH2_STAT5	38	41	PF00017	0.629
LIG_SH2_STAT5	43	46	PF00017	0.640
LIG_SUMO_SIM_par_1	182	188	PF11976	0.297
LIG_WRC_WIRS_1	299	304	PF05994	0.324
MOD_CK1_1	116	122	PF00069	0.311
MOD_CK1_1	14	20	PF00069	0.572
MOD_CK1_1	254	260	PF00069	0.326
MOD_CK1_1	61	67	PF00069	0.656
MOD_CK2_1	13	19	PF00069	0.626
MOD_CK2_1	165	171	PF00069	0.288
MOD_GlcNHglycan	11	14	PF01048	0.759
MOD_GlcNHglycan	115	118	PF01048	0.327
MOD_GlcNHglycan	243	246	PF01048	0.273
MOD_GlcNHglycan	259	262	PF01048	0.294
MOD_GlcNHglycan	294	297	PF01048	0.515
MOD_GlcNHglycan	45	48	PF01048	0.508
MOD_GSK3_1	185	192	PF00069	0.279
MOD_GSK3_1	21	28	PF00069	0.615
MOD_GSK3_1	236	243	PF00069	0.261
MOD_GSK3_1	251	258	PF00069	0.362
MOD_GSK3_1	297	304	PF00069	0.367
MOD_GSK3_1	39	46	PF00069	0.568
MOD_GSK3_1	9	16	PF00069	0.644
MOD_N-GLC_1	98	103	PF02516	0.421
MOD_NEK2_1	240	245	PF00069	0.406
MOD_NEK2_1	251	256	PF00069	0.449
MOD_NEK2_1	302	307	PF00069	0.472
MOD_NEK2_1	60	65	PF00069	0.402
MOD_NEK2_1	9	14	PF00069	0.600
MOD_NEK2_2	80	85	PF00069	0.432
MOD_PIKK_1	190	196	PF00454	0.357
MOD_PKA_2	241	247	PF00069	0.241
MOD_PKA_2	90	96	PF00069	0.235
MOD_Plk_1	308	314	PF00069	0.463
MOD_Plk_1	69	75	PF00069	0.509
MOD_Plk_1	80	86	PF00069	0.489
MOD_Plk_1	98	104	PF00069	0.410
MOD_Plk_2-3	165	171	PF00069	0.197
MOD_Plk_4	177	183	PF00069	0.322
MOD_Plk_4	298	304	PF00069	0.307
MOD_Plk_4	31	37	PF00069	0.626
MOD_Plk_4	39	45	PF00069	0.543
MOD_Plk_4	69	75	PF00069	0.299
MOD_ProDKin_1	61	67	PF00069	0.578
MOD_SUMO_rev_2	171	180	PF00179	0.381
TRG_ENDOCYTIC_2	120	123	PF00928	0.410
TRG_ENDOCYTIC_2	212	215	PF00928	0.328
TRG_ENDOCYTIC_2	299	302	PF00928	0.337
TRG_ENDOCYTIC_2	71	74	PF00928	0.397
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILP2	Leptomonas seymouri	66%	78%
A0A1X0P7Q3	Trypanosomatidae	42%	70%
A0A3Q8IDR4	Leishmania donovani	81%	75%
A0A422NQV3	Trypanosoma rangeli	45%	84%
A4I273	Leishmania infantum	80%	75%
C9ZXA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	85%
E9AYG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	75%
Q4Q907	Leishmania major	82%	100%
V5BAK6	Trypanosoma cruzi	45%	66%