Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF29_LEIBR

TriTrypDb:

LbrM.26.1770 , LBRM2903_230029500

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.511
CLV_C14_Caspase3-7	328	332	PF00656	0.503
CLV_C14_Caspase3-7	504	508	PF00656	0.506
CLV_C14_Caspase3-7	726	730	PF00656	0.434
CLV_NRD_NRD_1	132	134	PF00675	0.524
CLV_NRD_NRD_1	223	225	PF00675	0.607
CLV_NRD_NRD_1	3	5	PF00675	0.608
CLV_NRD_NRD_1	309	311	PF00675	0.562
CLV_NRD_NRD_1	491	493	PF00675	0.541
CLV_NRD_NRD_1	494	496	PF00675	0.541
CLV_NRD_NRD_1	558	560	PF00675	0.608
CLV_NRD_NRD_1	675	677	PF00675	0.415
CLV_NRD_NRD_1	703	705	PF00675	0.552
CLV_PCSK_KEX2_1	132	134	PF00082	0.524
CLV_PCSK_KEX2_1	222	224	PF00082	0.604
CLV_PCSK_KEX2_1	490	492	PF00082	0.539
CLV_PCSK_KEX2_1	558	560	PF00082	0.664
CLV_PCSK_KEX2_1	675	677	PF00082	0.415
CLV_PCSK_KEX2_1	703	705	PF00082	0.552
CLV_PCSK_PC7_1	128	134	PF00082	0.522
CLV_PCSK_SKI1_1	101	105	PF00082	0.676
CLV_PCSK_SKI1_1	208	212	PF00082	0.508
CLV_PCSK_SKI1_1	310	314	PF00082	0.555
CLV_PCSK_SKI1_1	321	325	PF00082	0.581
CLV_PCSK_SKI1_1	402	406	PF00082	0.589
CLV_PCSK_SKI1_1	650	654	PF00082	0.525
CLV_PCSK_SKI1_1	703	707	PF00082	0.476
CLV_PCSK_SKI1_1	8	12	PF00082	0.662
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DEG_SCF_FBW7_2	737	744	PF00400	0.627
DEG_SPOP_SBC_1	459	463	PF00917	0.506
DOC_CKS1_1	159	164	PF01111	0.517
DOC_CKS1_1	577	582	PF01111	0.541
DOC_CYCLIN_yCln2_LP_2	685	691	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	709	715	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.531
DOC_MAPK_gen_1	490	502	PF00069	0.534
DOC_MAPK_MEF2A_6	193	202	PF00069	0.503
DOC_MAPK_MEF2A_6	292	301	PF00069	0.503
DOC_MAPK_MEF2A_6	538	545	PF00069	0.504
DOC_PP1_RVXF_1	206	212	PF00149	0.507
DOC_PP2B_LxvP_1	324	327	PF13499	0.583
DOC_PP2B_PxIxI_1	658	664	PF00149	0.646
DOC_PP4_FxxP_1	159	162	PF00568	0.516
DOC_USP7_MATH_1	146	150	PF00917	0.552
DOC_USP7_MATH_1	163	167	PF00917	0.652
DOC_USP7_MATH_1	325	329	PF00917	0.658
DOC_USP7_MATH_1	351	355	PF00917	0.548
DOC_USP7_MATH_1	359	363	PF00917	0.632
DOC_USP7_MATH_1	397	401	PF00917	0.672
DOC_USP7_MATH_1	453	457	PF00917	0.663
DOC_USP7_MATH_1	514	518	PF00917	0.546
DOC_USP7_MATH_1	620	624	PF00917	0.618
DOC_USP7_MATH_1	628	632	PF00917	0.681
DOC_USP7_MATH_1	747	751	PF00917	0.582
DOC_WW_Pin1_4	131	136	PF00397	0.550
DOC_WW_Pin1_4	158	163	PF00397	0.806
DOC_WW_Pin1_4	225	230	PF00397	0.691
DOC_WW_Pin1_4	377	382	PF00397	0.682
DOC_WW_Pin1_4	56	61	PF00397	0.738
DOC_WW_Pin1_4	576	581	PF00397	0.634
DOC_WW_Pin1_4	631	636	PF00397	0.599
DOC_WW_Pin1_4	652	657	PF00397	0.520
DOC_WW_Pin1_4	728	733	PF00397	0.644
DOC_WW_Pin1_4	737	742	PF00397	0.608
DOC_WW_Pin1_4	88	93	PF00397	0.649
LIG_14-3-3_CanoR_1	172	177	PF00244	0.560
LIG_14-3-3_CanoR_1	223	229	PF00244	0.667
LIG_14-3-3_CanoR_1	249	256	PF00244	0.735
LIG_14-3-3_CanoR_1	4	8	PF00244	0.644
LIG_14-3-3_CanoR_1	495	501	PF00244	0.606
LIG_14-3-3_CanoR_1	515	520	PF00244	0.493
LIG_14-3-3_CanoR_1	650	655	PF00244	0.524
LIG_APCC_ABBAyCdc20_2	101	107	PF00400	0.674
LIG_deltaCOP1_diTrp_1	766	776	PF00928	0.562
LIG_FHA_1	151	157	PF00498	0.610
LIG_FHA_1	251	257	PF00498	0.536
LIG_FHA_1	369	375	PF00498	0.560
LIG_FHA_1	463	469	PF00498	0.651
LIG_FHA_1	572	578	PF00498	0.525
LIG_FHA_1	679	685	PF00498	0.455
LIG_FHA_1	693	699	PF00498	0.448
LIG_FHA_1	716	722	PF00498	0.502
LIG_FHA_2	260	266	PF00498	0.555
LIG_FHA_2	336	342	PF00498	0.665
LIG_FHA_2	469	475	PF00498	0.509
LIG_FHA_2	48	54	PF00498	0.566
LIG_FHA_2	534	540	PF00498	0.564
LIG_FHA_2	653	659	PF00498	0.601
LIG_FHA_2	761	767	PF00498	0.533
LIG_Integrin_isoDGR_2	206	208	PF01839	0.515
LIG_LIR_Apic_2	158	162	PF02991	0.518
LIG_LIR_Gen_1	212	220	PF02991	0.445
LIG_LIR_Gen_1	25	36	PF02991	0.542
LIG_LIR_LC3C_4	540	545	PF02991	0.561
LIG_LIR_Nem_3	212	216	PF02991	0.520
LIG_LIR_Nem_3	25	31	PF02991	0.536
LIG_LIR_Nem_3	598	603	PF02991	0.597
LIG_LIR_Nem_3	695	699	PF02991	0.618
LIG_PDZ_Class_2	777	782	PF00595	0.445
LIG_Pex14_1	776	780	PF04695	0.439
LIG_SH2_CRK	279	283	PF00017	0.609
LIG_SH2_GRB2like	317	320	PF00017	0.642
LIG_SH2_STAP1	701	705	PF00017	0.461
LIG_SH2_STAT5	317	320	PF00017	0.569
LIG_SH3_3	142	148	PF00018	0.561
LIG_SH3_3	165	171	PF00018	0.717
LIG_SH3_3	275	281	PF00018	0.450
LIG_SH3_3	330	336	PF00018	0.605
LIG_SH3_3	339	345	PF00018	0.576
LIG_SH3_3	52	58	PF00018	0.768
LIG_SH3_3	574	580	PF00018	0.527
LIG_SH3_3	653	659	PF00018	0.538
LIG_SH3_3	688	694	PF00018	0.496
LIG_SUMO_SIM_anti_2	681	687	PF11976	0.484
LIG_SUMO_SIM_par_1	196	201	PF11976	0.569
LIG_SUMO_SIM_par_1	650	655	PF11976	0.524
LIG_TRAF2_1	634	637	PF00917	0.657
LIG_TRAF2_2	229	234	PF00917	0.527
LIG_TRFH_1	35	39	PF08558	0.555
LIG_TYR_ITIM	103	108	PF00017	0.590
LIG_WRC_WIRS_1	156	161	PF05994	0.524
LIG_WRC_WIRS_1	236	241	PF05994	0.519
MOD_CDK_SPK_2	225	230	PF00069	0.529
MOD_CDK_SPxxK_3	631	638	PF00069	0.558
MOD_CK1_1	120	126	PF00069	0.592
MOD_CK1_1	151	157	PF00069	0.754
MOD_CK1_1	158	164	PF00069	0.749
MOD_CK1_1	175	181	PF00069	0.517
MOD_CK1_1	189	195	PF00069	0.469
MOD_CK1_1	251	257	PF00069	0.761
MOD_CK1_1	353	359	PF00069	0.586
MOD_CK1_1	369	375	PF00069	0.546
MOD_CK1_1	377	383	PF00069	0.629
MOD_CK1_1	417	423	PF00069	0.579
MOD_CK1_1	464	470	PF00069	0.728
MOD_CK1_1	6	12	PF00069	0.508
MOD_CK1_1	63	69	PF00069	0.723
MOD_CK1_1	631	637	PF00069	0.617
MOD_CK1_1	723	729	PF00069	0.596
MOD_CK2_1	255	261	PF00069	0.593
MOD_CK2_1	335	341	PF00069	0.509
MOD_CK2_1	468	474	PF00069	0.511
MOD_CK2_1	533	539	PF00069	0.608
MOD_CK2_1	579	585	PF00069	0.681
MOD_CK2_1	631	637	PF00069	0.706
MOD_CK2_1	70	76	PF00069	0.645
MOD_CK2_1	760	766	PF00069	0.542
MOD_CMANNOS	291	294	PF00535	0.615
MOD_GlcNHglycan	165	168	PF01048	0.766
MOD_GlcNHglycan	174	177	PF01048	0.609
MOD_GlcNHglycan	327	330	PF01048	0.723
MOD_GlcNHglycan	352	356	PF01048	0.653
MOD_GlcNHglycan	399	402	PF01048	0.660
MOD_GlcNHglycan	445	448	PF01048	0.762
MOD_GlcNHglycan	468	471	PF01048	0.790
MOD_GlcNHglycan	485	488	PF01048	0.712
MOD_GlcNHglycan	713	716	PF01048	0.495
MOD_GlcNHglycan	72	75	PF01048	0.556
MOD_GlcNHglycan	770	773	PF01048	0.419
MOD_GlcNHglycan	95	98	PF01048	0.599
MOD_GSK3_1	117	124	PF00069	0.611
MOD_GSK3_1	146	153	PF00069	0.804
MOD_GSK3_1	245	252	PF00069	0.692
MOD_GSK3_1	255	262	PF00069	0.625
MOD_GSK3_1	265	272	PF00069	0.550
MOD_GSK3_1	353	360	PF00069	0.624
MOD_GSK3_1	369	376	PF00069	0.668
MOD_GSK3_1	377	384	PF00069	0.684
MOD_GSK3_1	454	461	PF00069	0.627
MOD_GSK3_1	462	469	PF00069	0.794
MOD_GSK3_1	56	63	PF00069	0.738
MOD_GSK3_1	571	578	PF00069	0.627
MOD_GSK3_1	627	634	PF00069	0.726
MOD_GSK3_1	711	718	PF00069	0.552
MOD_GSK3_1	733	740	PF00069	0.635
MOD_GSK3_1	755	762	PF00069	0.538
MOD_GSK3_1	764	771	PF00069	0.581
MOD_LATS_1	674	680	PF00433	0.403
MOD_N-GLC_1	249	254	PF02516	0.531
MOD_N-GLC_1	417	422	PF02516	0.574
MOD_N-GLC_1	481	486	PF02516	0.738
MOD_N-GLC_2	751	753	PF02516	0.484
MOD_NEK2_1	121	126	PF00069	0.659
MOD_NEK2_1	152	157	PF00069	0.545
MOD_NEK2_1	211	216	PF00069	0.430
MOD_NEK2_1	3	8	PF00069	0.514
MOD_NEK2_1	436	441	PF00069	0.688
MOD_NEK2_1	481	486	PF00069	0.752
MOD_NEK2_1	595	600	PF00069	0.538
MOD_NEK2_1	602	607	PF00069	0.492
MOD_NEK2_1	62	67	PF00069	0.644
MOD_NEK2_1	70	75	PF00069	0.576
MOD_NEK2_1	720	725	PF00069	0.529
MOD_NEK2_1	760	765	PF00069	0.537
MOD_PIKK_1	11	17	PF00454	0.653
MOD_PIKK_1	642	648	PF00454	0.537
MOD_PK_1	676	682	PF00069	0.379
MOD_PKA_1	223	229	PF00069	0.532
MOD_PKA_2	223	229	PF00069	0.606
MOD_PKA_2	248	254	PF00069	0.752
MOD_PKA_2	3	9	PF00069	0.516
MOD_PKA_2	374	380	PF00069	0.577
MOD_PKA_2	514	520	PF00069	0.496
MOD_PKB_1	222	230	PF00069	0.520
MOD_Plk_1	106	112	PF00069	0.633
MOD_Plk_1	211	217	PF00069	0.427
MOD_Plk_1	417	423	PF00069	0.579
MOD_Plk_1	584	590	PF00069	0.553
MOD_Plk_1	715	721	PF00069	0.478
MOD_Plk_1	765	771	PF00069	0.443
MOD_Plk_2-3	501	507	PF00069	0.513
MOD_Plk_2-3	636	642	PF00069	0.544
MOD_Plk_4	235	241	PF00069	0.683
MOD_Plk_4	369	375	PF00069	0.606
MOD_Plk_4	584	590	PF00069	0.594
MOD_Plk_4	765	771	PF00069	0.596
MOD_ProDKin_1	131	137	PF00069	0.553
MOD_ProDKin_1	158	164	PF00069	0.807
MOD_ProDKin_1	225	231	PF00069	0.692
MOD_ProDKin_1	377	383	PF00069	0.682
MOD_ProDKin_1	56	62	PF00069	0.738
MOD_ProDKin_1	576	582	PF00069	0.636
MOD_ProDKin_1	631	637	PF00069	0.600
MOD_ProDKin_1	652	658	PF00069	0.519
MOD_ProDKin_1	728	734	PF00069	0.650
MOD_ProDKin_1	737	743	PF00069	0.609
MOD_ProDKin_1	88	94	PF00069	0.646
MOD_SUMO_rev_2	636	645	PF00179	0.543
TRG_DiLeu_BaEn_1	539	544	PF01217	0.497
TRG_DiLeu_BaEn_1	716	721	PF01217	0.579
TRG_DiLeu_BaEn_2	234	240	PF01217	0.522
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.504
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.501
TRG_ENDOCYTIC_2	105	108	PF00928	0.586
TRG_ENDOCYTIC_2	279	282	PF00928	0.606
TRG_ENDOCYTIC_2	317	320	PF00928	0.569
TRG_ENDOCYTIC_2	523	526	PF00928	0.642
TRG_ER_diArg_1	222	224	PF00400	0.594
TRG_ER_diArg_1	305	308	PF00400	0.544
TRG_ER_diArg_1	490	492	PF00400	0.539
TRG_ER_diArg_1	557	559	PF00400	0.634
TRG_ER_diArg_1	675	677	PF00400	0.415
TRG_ER_diArg_1	703	705	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	402	407	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFF4	Leptomonas seymouri	42%	82%
A0A3Q8IDY5	Leishmania donovani	65%	79%
A4I2B7	Leishmania infantum	65%	79%
E9AYG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	79%
Q4Q908	Leishmania major	64%	100%