AT-rich interactive domain-containing protein 1B

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF28_LEIBR

TriTrypDb:

LbrM.26.1750 , LBRM2903_230029700

Length:

2404

Annotations

LeishMANIAdb annotations

Almost completely disordered, unique Lieshmaniid protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

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Expansion

Sequence features

A4HF28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	1
GO:0003713	transcription coactivator activity	3	1
GO:0140110	transcription regulator activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1101	1105	PF00656	0.416
CLV_C14_Caspase3-7	1242	1246	PF00656	0.618
CLV_C14_Caspase3-7	1989	1993	PF00656	0.569
CLV_C14_Caspase3-7	2028	2032	PF00656	0.538
CLV_C14_Caspase3-7	877	881	PF00656	0.434
CLV_C14_Caspase3-7	994	998	PF00656	0.486
CLV_NRD_NRD_1	1028	1030	PF00675	0.619
CLV_NRD_NRD_1	1060	1062	PF00675	0.561
CLV_NRD_NRD_1	1148	1150	PF00675	0.612
CLV_NRD_NRD_1	1151	1153	PF00675	0.599

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IPB5	Leishmania donovani	70%	100%
A4I2B5	Leishmania infantum	70%	99%
E9AYG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q910	Leishmania major	70%	99%

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