Zinc finger protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Zinc finger protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF27_LEIBR

TriTrypDb:

LbrM.26.1740 , LBRM2903_230029800

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.490
CLV_NRD_NRD_1	226	228	PF00675	0.587
CLV_NRD_NRD_1	374	376	PF00675	0.570
CLV_NRD_NRD_1	409	411	PF00675	0.593
CLV_NRD_NRD_1	414	416	PF00675	0.637
CLV_NRD_NRD_1	46	48	PF00675	0.385
CLV_NRD_NRD_1	517	519	PF00675	0.553
CLV_NRD_NRD_1	74	76	PF00675	0.216
CLV_PCSK_FUR_1	159	163	PF00082	0.510
CLV_PCSK_FUR_1	223	227	PF00082	0.560
CLV_PCSK_KEX2_1	158	160	PF00082	0.490
CLV_PCSK_KEX2_1	161	163	PF00082	0.495
CLV_PCSK_KEX2_1	225	227	PF00082	0.583
CLV_PCSK_KEX2_1	316	318	PF00082	0.652
CLV_PCSK_KEX2_1	374	376	PF00082	0.584
CLV_PCSK_KEX2_1	408	410	PF00082	0.599
CLV_PCSK_KEX2_1	414	416	PF00082	0.645
CLV_PCSK_KEX2_1	422	424	PF00082	0.620
CLV_PCSK_KEX2_1	46	48	PF00082	0.385
CLV_PCSK_KEX2_1	517	519	PF00082	0.608
CLV_PCSK_KEX2_1	74	76	PF00082	0.216
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.383
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.592
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.545
CLV_PCSK_PC7_1	154	160	PF00082	0.510
CLV_PCSK_PC7_1	410	416	PF00082	0.624
CLV_PCSK_PC7_1	42	48	PF00082	0.367
CLV_PCSK_SKI1_1	17	21	PF00082	0.397
CLV_PCSK_SKI1_1	30	34	PF00082	0.405
CLV_PCSK_SKI1_1	417	421	PF00082	0.556
CLV_PCSK_SKI1_1	47	51	PF00082	0.309
DEG_APCC_DBOX_1	250	258	PF00400	0.577
DEG_SCF_FBW7_2	84	90	PF00400	0.455
DEG_SPOP_SBC_1	479	483	PF00917	0.714
DOC_CKS1_1	499	504	PF01111	0.605
DOC_CKS1_1	84	89	PF01111	0.450
DOC_CYCLIN_RxL_1	42	53	PF00134	0.361
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.539
DOC_MAPK_gen_1	223	233	PF00069	0.634
DOC_MAPK_gen_1	561	568	PF00069	0.449
DOC_MAPK_MEF2A_6	226	235	PF00069	0.624
DOC_PP2B_LxvP_1	109	112	PF13499	0.535
DOC_PP4_FxxP_1	172	175	PF00568	0.508
DOC_PP4_FxxP_1	530	533	PF00568	0.473
DOC_USP7_MATH_1	249	253	PF00917	0.728
DOC_USP7_MATH_1	260	264	PF00917	0.599
DOC_USP7_MATH_1	325	329	PF00917	0.602
DOC_USP7_MATH_1	343	347	PF00917	0.658
DOC_USP7_MATH_1	349	353	PF00917	0.583
DOC_USP7_MATH_1	4	8	PF00917	0.513
DOC_USP7_MATH_1	472	476	PF00917	0.615
DOC_USP7_MATH_1	479	483	PF00917	0.743
DOC_USP7_MATH_1	495	499	PF00917	0.490
DOC_USP7_MATH_1	579	583	PF00917	0.509
DOC_WW_Pin1_4	104	109	PF00397	0.529
DOC_WW_Pin1_4	267	272	PF00397	0.632
DOC_WW_Pin1_4	285	290	PF00397	0.777
DOC_WW_Pin1_4	301	306	PF00397	0.688
DOC_WW_Pin1_4	315	320	PF00397	0.829
DOC_WW_Pin1_4	323	328	PF00397	0.805
DOC_WW_Pin1_4	335	340	PF00397	0.565
DOC_WW_Pin1_4	394	399	PF00397	0.534
DOC_WW_Pin1_4	435	440	PF00397	0.567
DOC_WW_Pin1_4	470	475	PF00397	0.686
DOC_WW_Pin1_4	498	503	PF00397	0.612
DOC_WW_Pin1_4	83	88	PF00397	0.438
LIG_14-3-3_CanoR_1	17	22	PF00244	0.392
LIG_14-3-3_CanoR_1	232	236	PF00244	0.566
LIG_14-3-3_CanoR_1	307	313	PF00244	0.588
LIG_14-3-3_CanoR_1	545	554	PF00244	0.389
LIG_14-3-3_CanoR_1	565	574	PF00244	0.424
LIG_14-3-3_CanoR_1	66	73	PF00244	0.421
LIG_Actin_WH2_2	241	257	PF00022	0.530
LIG_APCC_ABBA_1	552	557	PF00400	0.528
LIG_APCC_ABBAyCdc20_2	168	174	PF00400	0.508
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_BRCT_BRCA1_1	272	276	PF00533	0.554
LIG_CSL_BTD_1	395	398	PF09270	0.556
LIG_eIF4E_1	45	51	PF01652	0.355
LIG_FHA_1	131	137	PF00498	0.563
LIG_FHA_1	18	24	PF00498	0.524
LIG_FHA_1	36	42	PF00498	0.358
LIG_FHA_1	499	505	PF00498	0.602
LIG_FHA_1	554	560	PF00498	0.410
LIG_FHA_1	92	98	PF00498	0.723
LIG_FHA_2	141	147	PF00498	0.506
LIG_FHA_2	236	242	PF00498	0.513
LIG_FHA_2	377	383	PF00498	0.680
LIG_FHA_2	395	401	PF00498	0.525
LIG_LIR_Apic_2	169	175	PF02991	0.510
LIG_LIR_Apic_2	528	533	PF02991	0.369
LIG_LIR_Gen_1	487	495	PF02991	0.531
LIG_LIR_Nem_3	487	493	PF02991	0.536
LIG_LIR_Nem_3	537	541	PF02991	0.450
LIG_RPA_C_Fungi	403	415	PF08784	0.568
LIG_SH2_CRK	490	494	PF00017	0.655
LIG_SH2_STAP1	93	97	PF00017	0.515
LIG_SH2_STAT3	183	186	PF00017	0.574
LIG_SH2_STAT3	62	65	PF00017	0.236
LIG_SH2_STAT5	164	167	PF00017	0.478
LIG_SH2_STAT5	244	247	PF00017	0.517
LIG_SH2_STAT5	492	495	PF00017	0.579
LIG_SH2_STAT5	534	537	PF00017	0.515
LIG_SH2_STAT5	538	541	PF00017	0.467
LIG_SH2_STAT5	62	65	PF00017	0.229
LIG_SH2_STAT5	93	96	PF00017	0.515
LIG_SH3_2	302	307	PF14604	0.687
LIG_SH3_3	121	127	PF00018	0.802
LIG_SH3_3	133	139	PF00018	0.473
LIG_SH3_3	296	302	PF00018	0.703
LIG_SH3_3	440	446	PF00018	0.613
LIG_SUMO_SIM_par_1	215	221	PF11976	0.558
LIG_TRAF2_1	204	207	PF00917	0.539
LIG_WRC_WIRS_1	538	543	PF05994	0.378
MOD_CDC14_SPxK_1	288	291	PF00782	0.669
MOD_CDC14_SPxK_1	304	307	PF00782	0.700
MOD_CDC14_SPxK_1	438	441	PF00782	0.579
MOD_CDK_SPK_2	335	340	PF00069	0.560
MOD_CDK_SPxK_1	285	291	PF00069	0.659
MOD_CDK_SPxK_1	301	307	PF00069	0.528
MOD_CDK_SPxK_1	435	441	PF00069	0.572
MOD_CK1_1	152	158	PF00069	0.380
MOD_CK1_1	216	222	PF00069	0.561
MOD_CK1_1	263	269	PF00069	0.629
MOD_CK1_1	270	276	PF00069	0.815
MOD_CK1_1	277	283	PF00069	0.630
MOD_CK1_1	285	291	PF00069	0.635
MOD_CK1_1	326	332	PF00069	0.647
MOD_CK1_1	338	344	PF00069	0.632
MOD_CK1_1	36	42	PF00069	0.399
MOD_CK1_1	368	374	PF00069	0.633
MOD_CK1_1	376	382	PF00069	0.775
MOD_CK1_1	482	488	PF00069	0.743
MOD_CK1_1	498	504	PF00069	0.463
MOD_CK1_1	582	588	PF00069	0.525
MOD_CK2_1	201	207	PF00069	0.576
MOD_CK2_1	235	241	PF00069	0.485
MOD_CK2_1	376	382	PF00069	0.703
MOD_CK2_1	8	14	PF00069	0.495
MOD_GlcNHglycan	250	254	PF01048	0.616
MOD_GlcNHglycan	264	268	PF01048	0.594
MOD_GlcNHglycan	272	275	PF01048	0.616
MOD_GlcNHglycan	343	346	PF01048	0.694
MOD_GlcNHglycan	370	373	PF01048	0.740
MOD_GlcNHglycan	38	41	PF01048	0.389
MOD_GlcNHglycan	410	413	PF01048	0.611
MOD_GlcNHglycan	450	453	PF01048	0.558
MOD_GlcNHglycan	474	477	PF01048	0.608
MOD_GlcNHglycan	523	526	PF01048	0.479
MOD_GlcNHglycan	527	530	PF01048	0.392
MOD_GlcNHglycan	9	13	PF01048	0.495
MOD_GlcNHglycan	98	101	PF01048	0.544
MOD_GSK3_1	125	132	PF00069	0.698
MOD_GSK3_1	227	234	PF00069	0.775
MOD_GSK3_1	263	270	PF00069	0.560
MOD_GSK3_1	274	281	PF00069	0.637
MOD_GSK3_1	285	292	PF00069	0.699
MOD_GSK3_1	30	37	PF00069	0.396
MOD_GSK3_1	307	314	PF00069	0.738
MOD_GSK3_1	323	330	PF00069	0.654
MOD_GSK3_1	344	351	PF00069	0.810
MOD_GSK3_1	366	373	PF00069	0.694
MOD_GSK3_1	377	384	PF00069	0.562
MOD_GSK3_1	4	11	PF00069	0.509
MOD_GSK3_1	478	485	PF00069	0.629
MOD_GSK3_1	521	528	PF00069	0.490
MOD_GSK3_1	536	543	PF00069	0.555
MOD_LATS_1	406	412	PF00433	0.652
MOD_LATS_1	64	70	PF00433	0.236
MOD_N-GLC_1	152	157	PF02516	0.376
MOD_N-GLC_1	227	232	PF02516	0.512
MOD_N-GLC_1	34	39	PF02516	0.406
MOD_NEK2_1	129	134	PF00069	0.547
MOD_NEK2_1	149	154	PF00069	0.588
MOD_NEK2_1	182	187	PF00069	0.574
MOD_NEK2_1	276	281	PF00069	0.701
MOD_NEK2_1	366	371	PF00069	0.654
MOD_PIKK_1	182	188	PF00454	0.575
MOD_PIKK_1	493	499	PF00454	0.646
MOD_PIKK_1	540	546	PF00454	0.478
MOD_PK_1	227	233	PF00069	0.595
MOD_PKA_1	408	414	PF00069	0.586
MOD_PKA_2	192	198	PF00069	0.544
MOD_PKA_2	231	237	PF00069	0.564
MOD_PKA_2	290	296	PF00069	0.723
MOD_PKA_2	373	379	PF00069	0.566
MOD_PKA_2	408	414	PF00069	0.586
MOD_PKA_2	455	461	PF00069	0.544
MOD_PKA_2	579	585	PF00069	0.513
MOD_PKA_2	65	71	PF00069	0.236
MOD_PKA_2	91	97	PF00069	0.507
MOD_PKB_1	191	199	PF00069	0.651
MOD_PKB_1	225	233	PF00069	0.558
MOD_Plk_1	227	233	PF00069	0.510
MOD_Plk_1	536	542	PF00069	0.524
MOD_Plk_1	8	14	PF00069	0.495
MOD_Plk_2-3	201	207	PF00069	0.537
MOD_Plk_4	213	219	PF00069	0.514
MOD_Plk_4	457	463	PF00069	0.524
MOD_Plk_4	495	501	PF00069	0.565
MOD_Plk_4	507	513	PF00069	0.526
MOD_ProDKin_1	104	110	PF00069	0.526
MOD_ProDKin_1	267	273	PF00069	0.635
MOD_ProDKin_1	285	291	PF00069	0.780
MOD_ProDKin_1	301	307	PF00069	0.692
MOD_ProDKin_1	315	321	PF00069	0.831
MOD_ProDKin_1	323	329	PF00069	0.808
MOD_ProDKin_1	335	341	PF00069	0.562
MOD_ProDKin_1	394	400	PF00069	0.530
MOD_ProDKin_1	435	441	PF00069	0.572
MOD_ProDKin_1	470	476	PF00069	0.686
MOD_ProDKin_1	498	504	PF00069	0.608
MOD_ProDKin_1	83	89	PF00069	0.442
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.651
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.609
TRG_ENDOCYTIC_2	164	167	PF00928	0.478
TRG_ENDOCYTIC_2	490	493	PF00928	0.643
TRG_ENDOCYTIC_2	538	541	PF00928	0.505
TRG_ER_diArg_1	157	159	PF00400	0.437
TRG_ER_diArg_1	191	194	PF00400	0.634
TRG_ER_diArg_1	223	226	PF00400	0.586
TRG_ER_diArg_1	408	410	PF00400	0.647
TRG_ER_diArg_1	45	47	PF00400	0.373
TRG_ER_diArg_1	516	518	PF00400	0.600
TRG_ER_diArg_1	563	566	PF00400	0.593
TRG_ER_diArg_1	73	75	PF00400	0.229
TRG_NLS_Bipartite_1	408	426	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B6	Leptomonas seymouri	38%	100%
A0A3Q8ID10	Leishmania donovani	65%	100%
A4I2B4	Leishmania infantum	65%	100%
E9AYG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q911	Leishmania major	65%	100%