Methylated-DNA--protein-cysteine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylated-DNA-[protein]-cysteine S-methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HF26_LEIBR

TriTrypDb:

LbrM.26.1730 , LBRM2903_230029900

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF26

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0032259	methylation	2	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	6	10
GO:0008168	methyltransferase activity	4	10
GO:0008172	S-methyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.641
CLV_PCSK_KEX2_1	9	11	PF00082	0.637
CLV_PCSK_SKI1_1	110	114	PF00082	0.542
CLV_PCSK_SKI1_1	13	17	PF00082	0.564
CLV_PCSK_SKI1_1	23	27	PF00082	0.595
CLV_PCSK_SKI1_1	30	34	PF00082	0.429
DEG_SPOP_SBC_1	168	172	PF00917	0.315
DEG_SPOP_SBC_1	235	239	PF00917	0.525
DOC_CKS1_1	60	65	PF01111	0.369
DOC_CYCLIN_RxL_1	199	209	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.472
DOC_MAPK_gen_1	107	116	PF00069	0.422
DOC_MAPK_gen_1	19	28	PF00069	0.458
DOC_MAPK_MEF2A_6	158	165	PF00069	0.412
DOC_PP2B_LxvP_1	204	207	PF13499	0.472
DOC_PP2B_LxvP_1	26	29	PF13499	0.458
DOC_PP4_FxxP_1	143	146	PF00568	0.325
DOC_PP4_FxxP_1	33	36	PF00568	0.474
DOC_SPAK_OSR1_1	250	254	PF12202	0.488
DOC_USP7_MATH_1	11	15	PF00917	0.436
DOC_USP7_MATH_1	131	135	PF00917	0.480
DOC_USP7_MATH_1	46	50	PF00917	0.646
DOC_USP7_UBL2_3	19	23	PF12436	0.600
DOC_WW_Pin1_4	59	64	PF00397	0.364
LIG_14-3-3_CanoR_1	10	16	PF00244	0.525
LIG_14-3-3_CanoR_1	234	242	PF00244	0.525
LIG_APCC_ABBA_1	67	72	PF00400	0.430
LIG_BIR_III_4	72	76	PF00653	0.467
LIG_FHA_1	111	117	PF00498	0.469
LIG_FHA_1	237	243	PF00498	0.525
LIG_FHA_2	178	184	PF00498	0.451
LIG_LIR_Apic_2	141	146	PF02991	0.376
LIG_LIR_Apic_2	31	36	PF02991	0.468
LIG_LIR_Nem_3	190	196	PF02991	0.416
LIG_NRBOX	155	161	PF00104	0.419
LIG_SH2_CRK	193	197	PF00017	0.459
LIG_SH2_GRB2like	142	145	PF00017	0.428
LIG_SH2_SRC	70	73	PF00017	0.448
LIG_SH2_STAT5	142	145	PF00017	0.367
LIG_SH2_STAT5	70	73	PF00017	0.315
LIG_SH3_3	163	169	PF00018	0.291
LIG_SH3_3	225	231	PF00018	0.484
LIG_SH3_3	57	63	PF00018	0.465
LIG_SUMO_SIM_anti_2	133	141	PF11976	0.278
LIG_TYR_ITIM	191	196	PF00017	0.393
MOD_CK1_1	187	193	PF00069	0.407
MOD_CK1_1	238	244	PF00069	0.341
MOD_GlcNHglycan	122	125	PF01048	0.552
MOD_GlcNHglycan	127	130	PF01048	0.499
MOD_GlcNHglycan	133	136	PF01048	0.328
MOD_GlcNHglycan	186	189	PF01048	0.306
MOD_GlcNHglycan	208	211	PF01048	0.402
MOD_GlcNHglycan	30	33	PF01048	0.612
MOD_GlcNHglycan	43	46	PF01048	0.678
MOD_GSK3_1	177	184	PF00069	0.371
MOD_GSK3_1	234	241	PF00069	0.309
MOD_GSK3_1	24	31	PF00069	0.637
MOD_GSK3_1	275	282	PF00069	0.635
MOD_GSK3_1	9	16	PF00069	0.642
MOD_N-GLC_1	110	115	PF02516	0.411
MOD_NEK2_1	181	186	PF00069	0.407
MOD_NEK2_1	236	241	PF00069	0.393
MOD_NEK2_1	39	44	PF00069	0.620
MOD_NEK2_1	47	52	PF00069	0.615
MOD_NEK2_2	177	182	PF00069	0.199
MOD_PKA_1	19	25	PF00069	0.566
MOD_PKA_1	9	15	PF00069	0.668
MOD_PKA_2	125	131	PF00069	0.390
MOD_PKA_2	181	187	PF00069	0.401
MOD_PKA_2	9	15	PF00069	0.646
MOD_Plk_1	110	116	PF00069	0.284
MOD_Plk_4	169	175	PF00069	0.278
MOD_ProDKin_1	59	65	PF00069	0.355
TRG_DiLeu_BaEn_1	155	160	PF01217	0.458
TRG_DiLeu_LyEn_5	155	160	PF01217	0.406
TRG_ENDOCYTIC_2	193	196	PF00928	0.276
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Q0	Leptomonas seymouri	59%	100%
A0A1X0P7S0	Trypanosomatidae	33%	100%
A0A3Q8IFY3	Leishmania donovani	82%	100%
A0A3R7ML39	Trypanosoma rangeli	33%	100%
A4I2B3	Leishmania infantum	80%	100%
E9AYG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q912	Leishmania major	80%	99%
V5AV65	Trypanosoma cruzi	32%	100%