Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase subunit NuA4, putative

Species:

Leishmania braziliensis

UniProt:

A4HF24_LEIBR

TriTrypDb:

LbrM.26.1710 , LBRM2903_230030100

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000123	histone acetyltransferase complex	4	7
GO:0031248	protein acetyltransferase complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0140535	intracellular protein-containing complex	2	7
GO:1902493	acetyltransferase complex	4	7
GO:1902494	catalytic complex	2	7
GO:1990234	transferase complex	3	7
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF24

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	7
GO:0006473	protein acetylation	6	7
GO:0006475	internal protein amino acid acetylation	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0016570	histone modification	5	7
GO:0016573	histone acetylation	6	7
GO:0018193	peptidyl-amino acid modification	5	7
GO:0018205	peptidyl-lysine modification	6	7
GO:0018393	internal peptidyl-lysine acetylation	8	7
GO:0018394	peptidyl-lysine acetylation	7	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0043543	protein acylation	5	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.479
CLV_NRD_NRD_1	253	255	PF00675	0.530
CLV_NRD_NRD_1	294	296	PF00675	0.629
CLV_NRD_NRD_1	3	5	PF00675	0.637
CLV_NRD_NRD_1	323	325	PF00675	0.656
CLV_NRD_NRD_1	40	42	PF00675	0.348
CLV_NRD_NRD_1	81	83	PF00675	0.538
CLV_PCSK_FUR_1	319	323	PF00082	0.632
CLV_PCSK_KEX2_1	253	255	PF00082	0.624
CLV_PCSK_KEX2_1	294	296	PF00082	0.625
CLV_PCSK_KEX2_1	3	5	PF00082	0.637
CLV_PCSK_KEX2_1	319	321	PF00082	0.659
CLV_PCSK_KEX2_1	322	324	PF00082	0.654
CLV_PCSK_KEX2_1	40	42	PF00082	0.348
CLV_PCSK_KEX2_1	81	83	PF00082	0.538
CLV_PCSK_PC7_1	319	325	PF00082	0.713
DEG_SCF_FBW7_1	92	98	PF00400	0.592
DEG_SPOP_SBC_1	117	121	PF00917	0.503
DEG_SPOP_SBC_1	240	244	PF00917	0.666
DEG_SPOP_SBC_1	97	101	PF00917	0.592
DOC_CKS1_1	92	97	PF01111	0.593
DOC_MAPK_MEF2A_6	46	55	PF00069	0.566
DOC_PP1_RVXF_1	203	209	PF00149	0.531
DOC_PP4_FxxP_1	208	211	PF00568	0.514
DOC_PP4_FxxP_1	25	28	PF00568	0.576
DOC_USP7_MATH_1	165	169	PF00917	0.628
DOC_USP7_MATH_1	183	187	PF00917	0.457
DOC_USP7_MATH_1	97	101	PF00917	0.569
DOC_WW_Pin1_4	122	127	PF00397	0.652
DOC_WW_Pin1_4	167	172	PF00397	0.722
DOC_WW_Pin1_4	207	212	PF00397	0.516
DOC_WW_Pin1_4	24	29	PF00397	0.481
DOC_WW_Pin1_4	91	96	PF00397	0.592
LIG_14-3-3_CanoR_1	141	149	PF00244	0.697
LIG_14-3-3_CanoR_1	214	221	PF00244	0.705
LIG_14-3-3_CanoR_1	238	245	PF00244	0.574
LIG_14-3-3_CterR_2	322	327	PF00244	0.631
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BRCT_BRCA1_1	143	147	PF00533	0.651
LIG_BRCT_BRCA1_1	280	284	PF00533	0.546
LIG_BRCT_BRCA1_2	280	286	PF00533	0.545
LIG_FHA_1	21	27	PF00498	0.441
LIG_FHA_1	58	64	PF00498	0.489
LIG_LIR_Apic_2	23	28	PF02991	0.417
LIG_LIR_Nem_3	72	77	PF02991	0.479
LIG_RPA_C_Fungi	36	48	PF08784	0.235
LIG_SH2_CRK	140	144	PF00017	0.568
LIG_SH3_3	120	126	PF00018	0.592
LIG_SH3_3	177	183	PF00018	0.646
LIG_SH3_3	89	95	PF00018	0.588
LIG_SUMO_SIM_par_1	88	94	PF11976	0.594
MOD_CDK_SPxxK_3	207	214	PF00069	0.510
MOD_CK1_1	156	162	PF00069	0.646
MOD_CK1_1	170	176	PF00069	0.595
MOD_CK1_1	194	200	PF00069	0.592
MOD_CK1_1	217	223	PF00069	0.518
MOD_CK1_1	241	247	PF00069	0.669
MOD_CK1_1	99	105	PF00069	0.556
MOD_CK2_1	207	213	PF00069	0.514
MOD_CK2_1	222	228	PF00069	0.530
MOD_GlcNHglycan	10	13	PF01048	0.599
MOD_GlcNHglycan	120	123	PF01048	0.704
MOD_GlcNHglycan	158	161	PF01048	0.596
MOD_GlcNHglycan	185	188	PF01048	0.545
MOD_GlcNHglycan	197	200	PF01048	0.500
MOD_GlcNHglycan	216	219	PF01048	0.504
MOD_GlcNHglycan	265	268	PF01048	0.735
MOD_GlcNHglycan	313	316	PF01048	0.616
MOD_GSK3_1	118	125	PF00069	0.710
MOD_GSK3_1	165	172	PF00069	0.682
MOD_GSK3_1	191	198	PF00069	0.541
MOD_GSK3_1	20	27	PF00069	0.444
MOD_GSK3_1	230	237	PF00069	0.558
MOD_GSK3_1	239	246	PF00069	0.596
MOD_GSK3_1	307	314	PF00069	0.578
MOD_GSK3_1	65	72	PF00069	0.322
MOD_GSK3_1	91	98	PF00069	0.600
MOD_N-GLC_1	156	161	PF02516	0.654
MOD_NEK2_1	127	132	PF00069	0.527
MOD_NEK2_1	164	169	PF00069	0.524
MOD_NEK2_1	234	239	PF00069	0.593
MOD_NEK2_1	96	101	PF00069	0.556
MOD_PK_1	40	46	PF00069	0.403
MOD_PKA_1	40	46	PF00069	0.413
MOD_PKA_2	40	46	PF00069	0.413
MOD_Plk_1	20	26	PF00069	0.454
MOD_Plk_1	307	313	PF00069	0.533
MOD_Plk_4	20	26	PF00069	0.454
MOD_Plk_4	69	75	PF00069	0.332
MOD_ProDKin_1	122	128	PF00069	0.655
MOD_ProDKin_1	167	173	PF00069	0.723
MOD_ProDKin_1	207	213	PF00069	0.514
MOD_ProDKin_1	24	30	PF00069	0.474
MOD_ProDKin_1	91	97	PF00069	0.591
TRG_DiLeu_BaEn_2	20	26	PF01217	0.622
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.518
TRG_ENDOCYTIC_2	140	143	PF00928	0.574
TRG_ER_diArg_1	293	295	PF00400	0.562
TRG_ER_diArg_1	319	322	PF00400	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C1	Leptomonas seymouri	52%	100%
A0A3S7WZY7	Leishmania donovani	75%	99%
E9ACT4	Leishmania major	76%	100%
E9AHB5	Leishmania infantum	75%	99%
E9AYF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%