LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved (fragment)
Species:
Leishmania braziliensis
UniProt:
A4HF22_LEIBR
TriTrypDb:
LbrM.26.1690 , LBRM2903_260022600 *
Length:
166

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF22
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF22

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 16 18 PF00675 0.559
CLV_NRD_NRD_1 30 32 PF00675 0.394
CLV_NRD_NRD_1 42 44 PF00675 0.473
CLV_NRD_NRD_1 51 53 PF00675 0.501
CLV_NRD_NRD_1 68 70 PF00675 0.337
CLV_PCSK_KEX2_1 16 18 PF00082 0.559
CLV_PCSK_KEX2_1 30 32 PF00082 0.394
CLV_PCSK_KEX2_1 42 44 PF00082 0.473
CLV_PCSK_KEX2_1 68 70 PF00082 0.676
CLV_PCSK_PC7_1 64 70 PF00082 0.681
CLV_PCSK_SKI1_1 119 123 PF00082 0.345
CLV_PCSK_SKI1_1 24 28 PF00082 0.576
DEG_Nend_UBRbox_3 1 3 PF02207 0.525
DEG_SCF_FBW7_1 155 162 PF00400 0.515
DOC_CKS1_1 156 161 PF01111 0.518
DOC_MAPK_gen_1 42 50 PF00069 0.436
DOC_MAPK_MEF2A_6 96 104 PF00069 0.470
DOC_USP7_MATH_1 159 163 PF00917 0.725
DOC_WW_Pin1_4 155 160 PF00397 0.649
LIG_14-3-3_CanoR_1 30 35 PF00244 0.391
LIG_14-3-3_CanoR_1 68 75 PF00244 0.526
LIG_FHA_1 118 124 PF00498 0.586
LIG_FHA_1 87 93 PF00498 0.475
LIG_FHA_1 97 103 PF00498 0.236
LIG_FHA_2 8 14 PF00498 0.471
LIG_MYND_1 131 135 PF01753 0.532
LIG_REV1ctd_RIR_1 38 47 PF16727 0.464
LIG_RPA_C_Fungi 40 52 PF08784 0.561
LIG_SH2_NCK_1 55 59 PF00017 0.651
LIG_SH3_1 149 155 PF00018 0.613
LIG_SH3_3 145 151 PF00018 0.720
LIG_SH3_3 153 159 PF00018 0.654
LIG_SUMO_SIM_par_1 119 124 PF11976 0.511
MOD_CK2_1 7 13 PF00069 0.486
MOD_GlcNHglycan 70 73 PF01048 0.621
MOD_GlcNHglycan 75 78 PF01048 0.504
MOD_GSK3_1 155 162 PF00069 0.742
MOD_GSK3_1 20 27 PF00069 0.420
MOD_NEK2_1 41 46 PF00069 0.352
MOD_PK_1 30 36 PF00069 0.352
MOD_PKA_1 30 36 PF00069 0.352
MOD_PKA_1 68 74 PF00069 0.628
MOD_PKA_2 29 35 PF00069 0.468
MOD_PKA_2 41 47 PF00069 0.392
MOD_PKA_2 68 74 PF00069 0.559
MOD_Plk_1 7 13 PF00069 0.449
MOD_Plk_4 117 123 PF00069 0.473
MOD_Plk_4 30 36 PF00069 0.431
MOD_ProDKin_1 155 161 PF00069 0.652
TRG_ER_diArg_1 41 43 PF00400 0.377

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I008 Leptomonas seymouri 40% 88%
A0A3S7WZY2 Leishmania donovani 80% 85%
E9AYE6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS