Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF21_LEIBR

TriTrypDb:

LbrM.26.1680 , LBRM2903_260022500

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HF21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.243
CLV_C14_Caspase3-7	345	349	PF00656	0.338
CLV_NRD_NRD_1	145	147	PF00675	0.390
CLV_NRD_NRD_1	548	550	PF00675	0.431
CLV_NRD_NRD_1	58	60	PF00675	0.528
CLV_PCSK_FUR_1	143	147	PF00082	0.401
CLV_PCSK_KEX2_1	145	147	PF00082	0.390
CLV_PCSK_KEX2_1	373	375	PF00082	0.408
CLV_PCSK_KEX2_1	392	394	PF00082	0.350
CLV_PCSK_KEX2_1	548	550	PF00082	0.396
CLV_PCSK_KEX2_1	58	60	PF00082	0.639
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.442
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.350
CLV_PCSK_SKI1_1	136	140	PF00082	0.347
CLV_PCSK_SKI1_1	18	22	PF00082	0.566
CLV_PCSK_SKI1_1	228	232	PF00082	0.298
CLV_PCSK_SKI1_1	291	295	PF00082	0.405
CLV_PCSK_SKI1_1	354	358	PF00082	0.475
CLV_PCSK_SKI1_1	367	371	PF00082	0.517
CLV_PCSK_SKI1_1	46	50	PF00082	0.533
CLV_PCSK_SKI1_1	541	545	PF00082	0.473
CLV_PCSK_SKI1_1	576	580	PF00082	0.512
CLV_PCSK_SKI1_1	589	593	PF00082	0.390
DEG_APCC_DBOX_1	45	53	PF00400	0.578
DEG_Nend_UBRbox_3	1	3	PF02207	0.591
DEG_SPOP_SBC_1	104	108	PF00917	0.372
DOC_CYCLIN_RxL_1	13	23	PF00134	0.546
DOC_MAPK_DCC_7	505	514	PF00069	0.459
DOC_MAPK_gen_1	175	184	PF00069	0.482
DOC_MAPK_gen_1	18	26	PF00069	0.607
DOC_MAPK_gen_1	289	298	PF00069	0.383
DOC_MAPK_gen_1	372	381	PF00069	0.355
DOC_MAPK_MEF2A_6	289	298	PF00069	0.293
DOC_MAPK_MEF2A_6	505	514	PF00069	0.413
DOC_MAPK_MEF2A_6	551	560	PF00069	0.590
DOC_MAPK_NFAT4_5	291	299	PF00069	0.283
DOC_PP1_RVXF_1	143	150	PF00149	0.402
DOC_PP1_RVXF_1	521	528	PF00149	0.457
DOC_USP7_MATH_1	256	260	PF00917	0.401
DOC_USP7_MATH_1	387	391	PF00917	0.344
DOC_USP7_MATH_1	401	405	PF00917	0.385
DOC_USP7_MATH_1	487	491	PF00917	0.401
DOC_USP7_MATH_1	533	537	PF00917	0.438
DOC_USP7_MATH_1	597	601	PF00917	0.526
DOC_USP7_UBL2_3	471	475	PF12436	0.615
DOC_WW_Pin1_4	69	74	PF00397	0.588
LIG_14-3-3_CanoR_1	175	180	PF00244	0.467
LIG_14-3-3_CanoR_1	195	204	PF00244	0.214
LIG_14-3-3_CanoR_1	232	238	PF00244	0.360
LIG_14-3-3_CanoR_1	239	244	PF00244	0.371
LIG_14-3-3_CanoR_1	29	36	PF00244	0.463
LIG_14-3-3_CanoR_1	317	325	PF00244	0.407
LIG_14-3-3_CanoR_1	367	376	PF00244	0.393
LIG_14-3-3_CanoR_1	489	494	PF00244	0.367
LIG_14-3-3_CanoR_1	541	547	PF00244	0.551
LIG_14-3-3_CanoR_1	589	596	PF00244	0.463
LIG_BRCT_BRCA1_1	302	306	PF00533	0.403
LIG_BRCT_BRCA1_1	312	316	PF00533	0.379
LIG_BRCT_BRCA1_1	41	45	PF00533	0.598
LIG_CtBP_PxDLS_1	456	460	PF00389	0.424
LIG_FHA_1	142	148	PF00498	0.252
LIG_FHA_1	20	26	PF00498	0.500
LIG_FHA_1	535	541	PF00498	0.500
LIG_FHA_1	577	583	PF00498	0.447
LIG_FHA_1	70	76	PF00498	0.541
LIG_FHA_2	122	128	PF00498	0.470
LIG_FHA_2	329	335	PF00498	0.448
LIG_FHA_2	407	413	PF00498	0.442
LIG_GBD_Chelix_1	161	169	PF00786	0.349
LIG_HP1_1	510	514	PF01393	0.374
LIG_IRF3_LxIS_1	260	266	PF10401	0.362
LIG_LIR_Gen_1	176	185	PF02991	0.395
LIG_LIR_Gen_1	203	212	PF02991	0.308
LIG_LIR_Gen_1	245	255	PF02991	0.447
LIG_LIR_Gen_1	295	306	PF02991	0.385
LIG_LIR_Gen_1	478	488	PF02991	0.536
LIG_LIR_Gen_1	521	532	PF02991	0.410
LIG_LIR_LC3C_4	115	118	PF02991	0.452
LIG_LIR_Nem_3	15	20	PF02991	0.418
LIG_LIR_Nem_3	176	182	PF02991	0.483
LIG_LIR_Nem_3	193	197	PF02991	0.309
LIG_LIR_Nem_3	203	207	PF02991	0.399
LIG_LIR_Nem_3	245	250	PF02991	0.472
LIG_LIR_Nem_3	295	301	PF02991	0.381
LIG_LIR_Nem_3	303	309	PF02991	0.308
LIG_LIR_Nem_3	338	343	PF02991	0.253
LIG_LIR_Nem_3	388	394	PF02991	0.501
LIG_LIR_Nem_3	478	484	PF02991	0.553
LIG_LIR_Nem_3	521	527	PF02991	0.381
LIG_LIR_Nem_3	569	575	PF02991	0.551
LIG_NRBOX	134	140	PF00104	0.467
LIG_SH2_CRK	132	136	PF00017	0.424
LIG_SH2_CRK	204	208	PF00017	0.455
LIG_SH2_SRC	495	498	PF00017	0.397
LIG_SH2_STAP1	204	208	PF00017	0.386
LIG_SH2_STAT5	226	229	PF00017	0.385
LIG_SH2_STAT5	495	498	PF00017	0.397
LIG_SH3_3	395	401	PF00018	0.350
LIG_SH3_3	421	427	PF00018	0.291
LIG_SH3_3	44	50	PF00018	0.573
LIG_SH3_3	504	510	PF00018	0.465
LIG_SH3_3	57	63	PF00018	0.641
LIG_SH3_3	70	76	PF00018	0.566
LIG_SUMO_SIM_anti_2	257	262	PF11976	0.357
LIG_SUMO_SIM_par_1	510	516	PF11976	0.333
LIG_WRC_WIRS_1	347	352	PF05994	0.211
MOD_CK1_1	173	179	PF00069	0.574
MOD_CK1_1	193	199	PF00069	0.328
MOD_CK1_1	355	361	PF00069	0.392
MOD_CK1_1	528	534	PF00069	0.377
MOD_CK2_1	175	181	PF00069	0.390
MOD_CK2_1	328	334	PF00069	0.460
MOD_CK2_1	446	452	PF00069	0.438
MOD_CK2_1	528	534	PF00069	0.407
MOD_CK2_1	564	570	PF00069	0.514
MOD_GlcNHglycan	228	231	PF01048	0.498
MOD_GlcNHglycan	41	44	PF01048	0.503
MOD_GlcNHglycan	448	451	PF01048	0.482
MOD_GlcNHglycan	491	494	PF01048	0.466
MOD_GlcNHglycan	500	504	PF01048	0.396
MOD_GlcNHglycan	566	569	PF01048	0.467
MOD_GlcNHglycan	66	69	PF01048	0.516
MOD_GSK3_1	173	180	PF00069	0.472
MOD_GSK3_1	196	203	PF00069	0.355
MOD_GSK3_1	234	241	PF00069	0.487
MOD_GSK3_1	348	355	PF00069	0.459
MOD_GSK3_1	402	409	PF00069	0.473
MOD_GSK3_1	433	440	PF00069	0.213
MOD_GSK3_1	495	502	PF00069	0.453
MOD_GSK3_1	576	583	PF00069	0.568
MOD_GSK3_1	64	71	PF00069	0.549
MOD_N-GLC_1	170	175	PF02516	0.420
MOD_N-GLC_1	263	268	PF02516	0.415
MOD_N-GLC_1	437	442	PF02516	0.301
MOD_N-GLC_1	471	476	PF02516	0.556
MOD_N-GLC_1	525	530	PF02516	0.453
MOD_NEK2_1	103	108	PF00069	0.486
MOD_NEK2_1	139	144	PF00069	0.439
MOD_NEK2_1	238	243	PF00069	0.449
MOD_NEK2_1	263	268	PF00069	0.364
MOD_NEK2_1	279	284	PF00069	0.329
MOD_NEK2_1	294	299	PF00069	0.364
MOD_NEK2_1	300	305	PF00069	0.379
MOD_NEK2_1	346	351	PF00069	0.405
MOD_NEK2_1	36	41	PF00069	0.573
MOD_NEK2_1	406	411	PF00069	0.389
MOD_NEK2_1	432	437	PF00069	0.271
MOD_NEK2_1	462	467	PF00069	0.402
MOD_NEK2_1	499	504	PF00069	0.379
MOD_NEK2_1	527	532	PF00069	0.336
MOD_NEK2_1	563	568	PF00069	0.324
MOD_NEK2_2	387	392	PF00069	0.368
MOD_NEK2_2	518	523	PF00069	0.466
MOD_OFUCOSY	102	109	PF10250	0.375
MOD_PIKK_1	581	587	PF00454	0.522
MOD_PK_1	170	176	PF00069	0.350
MOD_PKA_2	231	237	PF00069	0.379
MOD_PKA_2	238	244	PF00069	0.405
MOD_PKA_2	28	34	PF00069	0.443
MOD_PKB_1	175	183	PF00069	0.400
MOD_PKB_1	539	547	PF00069	0.468
MOD_PKB_1	86	94	PF00069	0.508
MOD_Plk_1	170	176	PF00069	0.415
MOD_Plk_1	294	300	PF00069	0.434
MOD_Plk_1	335	341	PF00069	0.539
MOD_Plk_1	528	534	PF00069	0.478
MOD_Plk_1	592	598	PF00069	0.628
MOD_Plk_4	256	262	PF00069	0.369
MOD_Plk_4	402	408	PF00069	0.369
MOD_Plk_4	542	548	PF00069	0.415
MOD_ProDKin_1	69	75	PF00069	0.578
MOD_SUMO_for_1	12	15	PF00179	0.472
TRG_DiLeu_BaEn_1	164	169	PF01217	0.466
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.366
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.427
TRG_ENDOCYTIC_2	132	135	PF00928	0.358
TRG_ENDOCYTIC_2	204	207	PF00928	0.432
TRG_ENDOCYTIC_2	344	347	PF00928	0.462
TRG_ER_diArg_1	143	146	PF00400	0.545
TRG_ER_diArg_1	174	177	PF00400	0.433
TRG_ER_diArg_1	288	291	PF00400	0.434
TRG_ER_diArg_1	539	542	PF00400	0.441
TRG_ER_diArg_1	547	549	PF00400	0.402
TRG_ER_diArg_1	57	59	PF00400	0.618
TRG_ER_diArg_1	86	89	PF00400	0.512
TRG_NES_CRM1_1	15	30	PF08389	0.364
TRG_Pf-PMV_PEXEL_1	589	593	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P389	Leptomonas seymouri	66%	100%
A0A1X0NSQ4	Trypanosomatidae	31%	100%
A0A3Q8IPA0	Leishmania donovani	92%	100%
A0A422N1Z7	Trypanosoma rangeli	34%	100%
A4I2A0	Leishmania infantum	92%	88%
C9ZRP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	93%
E9AYE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q928	Leishmania major	91%	100%
V5B197	Trypanosoma cruzi	32%	100%