MIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF20_LEIBR

TriTrypDb:

LbrM.26.1670 , LBRM2903_260022400

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HF20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.539
CLV_C14_Caspase3-7	39	43	PF00656	0.510
CLV_NRD_NRD_1	184	186	PF00675	0.449
CLV_NRD_NRD_1	64	66	PF00675	0.474
CLV_NRD_NRD_1	71	73	PF00675	0.503
CLV_PCSK_KEX2_1	118	120	PF00082	0.448
CLV_PCSK_KEX2_1	184	186	PF00082	0.370
CLV_PCSK_KEX2_1	57	59	PF00082	0.495
CLV_PCSK_KEX2_1	64	66	PF00082	0.422
CLV_PCSK_KEX2_1	71	73	PF00082	0.416
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.458
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.560
CLV_PCSK_SKI1_1	115	119	PF00082	0.430
CLV_PCSK_SKI1_1	205	209	PF00082	0.667
CLV_PCSK_SKI1_1	220	224	PF00082	0.595
DEG_Nend_UBRbox_2	1	3	PF02207	0.637
DOC_CKS1_1	126	131	PF01111	0.461
DOC_PP1_RVXF_1	107	113	PF00149	0.390
DOC_PP4_FxxP_1	126	129	PF00568	0.407
DOC_USP7_MATH_1	159	163	PF00917	0.489
DOC_USP7_MATH_1	166	170	PF00917	0.487
DOC_USP7_MATH_1	210	214	PF00917	0.594
DOC_USP7_MATH_1	316	320	PF00917	0.438
DOC_USP7_UBL2_3	208	212	PF12436	0.699
DOC_WW_Pin1_4	102	107	PF00397	0.507
DOC_WW_Pin1_4	125	130	PF00397	0.451
DOC_WW_Pin1_4	261	266	PF00397	0.467
LIG_14-3-3_CanoR_1	194	198	PF00244	0.523
LIG_14-3-3_CanoR_1	72	82	PF00244	0.444
LIG_Actin_WH2_2	103	120	PF00022	0.491
LIG_Actin_WH2_2	180	196	PF00022	0.514
LIG_BRCT_BRCA1_1	107	111	PF00533	0.450
LIG_BRCT_BRCA1_1	145	149	PF00533	0.555
LIG_Clathr_ClatBox_1	314	318	PF01394	0.592
LIG_deltaCOP1_diTrp_1	250	256	PF00928	0.455
LIG_EH1_1	293	301	PF00400	0.454
LIG_FHA_1	126	132	PF00498	0.462
LIG_FHA_1	155	161	PF00498	0.532
LIG_FHA_1	295	301	PF00498	0.461
LIG_FHA_1	58	64	PF00498	0.497
LIG_FHA_2	17	23	PF00498	0.462
LIG_FHA_2	170	176	PF00498	0.537
LIG_FHA_2	37	43	PF00498	0.199
LIG_LIR_Apic_2	98	103	PF02991	0.493
LIG_LIR_Gen_1	105	114	PF02991	0.490
LIG_LIR_Nem_3	105	110	PF02991	0.207
LIG_LIR_Nem_3	213	218	PF02991	0.682
LIG_LIR_Nem_3	250	255	PF02991	0.428
LIG_LIR_Nem_3	80	86	PF02991	0.529
LIG_LIR_Nem_3	87	93	PF02991	0.508
LIG_NRBOX	112	118	PF00104	0.385
LIG_PCNA_yPIPBox_3	302	315	PF02747	0.545
LIG_Pex14_1	252	256	PF04695	0.378
LIG_Pex14_2	107	111	PF04695	0.395
LIG_Pex14_2	86	90	PF04695	0.598
LIG_SH2_CRK	100	104	PF00017	0.547
LIG_SH2_CRK	285	289	PF00017	0.388
LIG_SH2_PTP2	279	282	PF00017	0.266
LIG_SH2_STAP1	156	160	PF00017	0.470
LIG_SH2_STAP1	232	236	PF00017	0.500
LIG_SH2_STAT3	255	258	PF00017	0.442
LIG_SH2_STAT5	132	135	PF00017	0.420
LIG_SH2_STAT5	156	159	PF00017	0.432
LIG_SH2_STAT5	255	258	PF00017	0.514
LIG_SH2_STAT5	279	282	PF00017	0.358
LIG_SH2_STAT5	34	37	PF00017	0.387
LIG_SH3_1	100	106	PF00018	0.576
LIG_SH3_3	100	106	PF00018	0.522
LIG_SH3_3	262	268	PF00018	0.559
LIG_SH3_3	88	94	PF00018	0.541
LIG_SH3_5	96	100	PF00018	0.607
LIG_Sin3_3	11	18	PF02671	0.427
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.519
LIG_TRAF2_1	226	229	PF00917	0.615
LIG_TRAF2_1	242	245	PF00917	0.474
LIG_TYR_ITIM	277	282	PF00017	0.358
LIG_UBA3_1	113	118	PF00899	0.404
LIG_ULM_U2AF65_1	71	76	PF00076	0.584
LIG_WRC_WIRS_1	83	88	PF05994	0.640
MOD_CDK_SPxxK_3	102	109	PF00069	0.520
MOD_CK1_1	105	111	PF00069	0.460
MOD_CK1_1	143	149	PF00069	0.489
MOD_CK1_1	169	175	PF00069	0.606
MOD_CK1_1	73	79	PF00069	0.576
MOD_CK2_1	159	165	PF00069	0.453
MOD_CK2_1	316	322	PF00069	0.445
MOD_GlcNHglycan	142	145	PF01048	0.527
MOD_GlcNHglycan	157	160	PF01048	0.489
MOD_GlcNHglycan	161	164	PF01048	0.502
MOD_GlcNHglycan	22	26	PF01048	0.440
MOD_GlcNHglycan	285	288	PF01048	0.423
MOD_GlcNHglycan	322	325	PF01048	0.711
MOD_GSK3_1	127	134	PF00069	0.511
MOD_GSK3_1	155	162	PF00069	0.494
MOD_GSK3_1	192	199	PF00069	0.506
MOD_GSK3_1	210	217	PF00069	0.434
MOD_GSK3_1	316	323	PF00069	0.554
MOD_GSK3_1	73	80	PF00069	0.522
MOD_N-GLC_1	140	145	PF02516	0.324
MOD_NEK2_1	117	122	PF00069	0.372
MOD_NEK2_1	52	57	PF00069	0.540
MOD_NEK2_1	70	75	PF00069	0.270
MOD_NEK2_2	166	171	PF00069	0.518
MOD_PKA_1	57	63	PF00069	0.500
MOD_PKA_2	193	199	PF00069	0.526
MOD_PKA_2	57	63	PF00069	0.500
MOD_PKA_2	70	76	PF00069	0.510
MOD_Plk_1	1	7	PF00069	0.541
MOD_Plk_1	294	300	PF00069	0.481
MOD_Plk_1	77	83	PF00069	0.573
MOD_Plk_4	127	133	PF00069	0.523
MOD_Plk_4	210	216	PF00069	0.689
MOD_Plk_4	294	300	PF00069	0.386
MOD_Plk_4	78	84	PF00069	0.623
MOD_ProDKin_1	102	108	PF00069	0.502
MOD_ProDKin_1	125	131	PF00069	0.452
MOD_ProDKin_1	261	267	PF00069	0.462
MOD_SUMO_rev_2	200	210	PF00179	0.635
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.382
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.500
TRG_ENDOCYTIC_2	279	282	PF00928	0.424
TRG_ENDOCYTIC_2	285	288	PF00928	0.413
TRG_ER_diArg_1	183	185	PF00400	0.420
TRG_ER_diArg_1	63	65	PF00400	0.439
TRG_ER_diArg_1	70	72	PF00400	0.438
TRG_NES_CRM1_1	283	295	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAG5	Leptomonas seymouri	76%	99%
A0A0S4JUF0	Bodo saltans	35%	99%
A0A1X0NS29	Trypanosomatidae	44%	100%
A0A3R7KFL2	Trypanosoma rangeli	43%	100%
A0A3S7WZW5	Leishmania donovani	89%	100%
A4I299	Leishmania infantum	89%	100%
E9AYE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q929	Leishmania major	89%	100%
V5AKX8	Trypanosoma cruzi	45%	99%