Phosphatidate cytidylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CDP-DAG synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4HF17_LEIBR

TriTrypDb:

LbrM.26.1640 , LBRM2903_260022100

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A4HF17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF17

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0016024	CDP-diacylglycerol biosynthetic process	6	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046341	CDP-diacylglycerol metabolic process	6	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006655	phosphatidylglycerol biosynthetic process	6	1
GO:0046471	phosphatidylglycerol metabolic process	6	1
GO:0046488	phosphatidylinositol metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004605	phosphatidate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070567	cytidylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.739
CLV_MEL_PAP_1	84	90	PF00089	0.528
CLV_NRD_NRD_1	111	113	PF00675	0.242
CLV_NRD_NRD_1	177	179	PF00675	0.253
CLV_NRD_NRD_1	239	241	PF00675	0.333
CLV_PCSK_KEX2_1	353	355	PF00082	0.242
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.242
CLV_PCSK_SKI1_1	241	245	PF00082	0.329
CLV_PCSK_SKI1_1	320	324	PF00082	0.534
CLV_PCSK_SKI1_1	353	357	PF00082	0.242
CLV_PCSK_SKI1_1	407	411	PF00082	0.407
CLV_PCSK_SKI1_1	67	71	PF00082	0.280
CLV_PCSK_SKI1_1	8	12	PF00082	0.446
DEG_APCC_DBOX_1	239	247	PF00400	0.442
DEG_APCC_DBOX_1	7	15	PF00400	0.703
DEG_APCC_DBOX_1	86	94	PF00400	0.441
DEG_SPOP_SBC_1	46	50	PF00917	0.581
DOC_CYCLIN_RxL_1	236	247	PF00134	0.453
DOC_MAPK_DCC_7	112	122	PF00069	0.482
DOC_MAPK_gen_1	112	122	PF00069	0.453
DOC_MAPK_gen_1	240	246	PF00069	0.535
DOC_MAPK_gen_1	3	12	PF00069	0.682
DOC_MAPK_MEF2A_6	113	122	PF00069	0.476
DOC_MAPK_MEF2A_6	5	14	PF00069	0.702
DOC_MAPK_MEF2A_6	87	94	PF00069	0.415
DOC_MAPK_NFAT4_5	87	95	PF00069	0.415
DOC_MAPK_RevD_3	166	179	PF00069	0.301
DOC_PP2B_LxvP_1	340	343	PF13499	0.294
DOC_PP4_FxxP_1	217	220	PF00568	0.294
DOC_USP7_MATH_1	24	28	PF00917	0.681
DOC_USP7_MATH_1	47	51	PF00917	0.740
DOC_USP7_MATH_1	53	57	PF00917	0.718
DOC_USP7_UBL2_3	353	357	PF12436	0.442
DOC_WW_Pin1_4	19	24	PF00397	0.666
DOC_WW_Pin1_4	244	249	PF00397	0.442
DOC_WW_Pin1_4	322	327	PF00397	0.326
LIG_14-3-3_CanoR_1	417	421	PF00244	0.569
LIG_Actin_WH2_2	163	180	PF00022	0.294
LIG_APCC_ABBA_1	98	103	PF00400	0.264
LIG_APCC_ABBAyCdc20_2	390	396	PF00400	0.573
LIG_BRCT_BRCA1_1	118	122	PF00533	0.528
LIG_BRCT_BRCA1_1	130	134	PF00533	0.234
LIG_BRCT_BRCA1_1	265	269	PF00533	0.379
LIG_BRCT_BRCA1_2	118	124	PF00533	0.528
LIG_Clathr_ClatBox_1	93	97	PF01394	0.441
LIG_deltaCOP1_diTrp_1	228	234	PF00928	0.294
LIG_FHA_1	191	197	PF00498	0.220
LIG_FHA_1	285	291	PF00498	0.323
LIG_FHA_1	319	325	PF00498	0.322
LIG_FHA_1	34	40	PF00498	0.714
LIG_GBD_Chelix_1	420	428	PF00786	0.411
LIG_LIR_Gen_1	131	137	PF02991	0.335
LIG_LIR_Gen_1	147	155	PF02991	0.326
LIG_LIR_Gen_1	190	198	PF02991	0.310
LIG_LIR_Gen_1	228	238	PF02991	0.379
LIG_LIR_Gen_1	336	344	PF02991	0.379
LIG_LIR_Gen_1	385	394	PF02991	0.443
LIG_LIR_Gen_1	68	78	PF02991	0.310
LIG_LIR_Nem_3	131	137	PF02991	0.335
LIG_LIR_Nem_3	147	151	PF02991	0.258
LIG_LIR_Nem_3	152	158	PF02991	0.251
LIG_LIR_Nem_3	228	233	PF02991	0.351
LIG_LIR_Nem_3	266	272	PF02991	0.338
LIG_LIR_Nem_3	336	340	PF02991	0.379
LIG_LIR_Nem_3	360	364	PF02991	0.442
LIG_LIR_Nem_3	385	389	PF02991	0.438
LIG_LIR_Nem_3	391	397	PF02991	0.508
LIG_LIR_Nem_3	68	73	PF02991	0.319
LIG_LIR_Nem_3	99	104	PF02991	0.315
LIG_MAD2	8	16	PF02301	0.694
LIG_PCNA_yPIPBox_3	226	240	PF02747	0.415
LIG_PCNA_yPIPBox_3	415	425	PF02747	0.580
LIG_PDZ_Class_2	425	430	PF00595	0.636
LIG_Pex14_1	230	234	PF04695	0.294
LIG_Pex14_1	265	269	PF04695	0.296
LIG_Pex14_2	234	238	PF04695	0.442
LIG_Pex14_2	255	259	PF04695	0.294
LIG_Pex14_2	261	265	PF04695	0.294
LIG_Pex14_2	272	276	PF04695	0.294
LIG_Pex14_2	344	348	PF04695	0.294
LIG_PTB_Apo_2	294	301	PF02174	0.328
LIG_SH2_CRK	155	159	PF00017	0.347
LIG_SH2_CRK	184	188	PF00017	0.466
LIG_SH2_CRK	386	390	PF00017	0.556
LIG_SH2_PTP2	132	135	PF00017	0.402
LIG_SH2_PTP2	76	79	PF00017	0.329
LIG_SH2_STAT3	182	185	PF00017	0.442
LIG_SH2_STAT3	275	278	PF00017	0.196
LIG_SH2_STAT5	126	129	PF00017	0.399
LIG_SH2_STAT5	132	135	PF00017	0.415
LIG_SH2_STAT5	232	235	PF00017	0.379
LIG_SH2_STAT5	275	278	PF00017	0.230
LIG_SH2_STAT5	280	283	PF00017	0.258
LIG_SH2_STAT5	386	389	PF00017	0.441
LIG_SH2_STAT5	392	395	PF00017	0.477
LIG_SH2_STAT5	76	79	PF00017	0.298
LIG_SH3_3	302	308	PF00018	0.259
LIG_SH3_3	394	400	PF00018	0.578
LIG_SH3_3	7	13	PF00018	0.628
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.571
LIG_SUMO_SIM_par_1	192	199	PF11976	0.324
LIG_SUMO_SIM_par_1	242	247	PF11976	0.452
LIG_SUMO_SIM_par_1	94	99	PF11976	0.266
LIG_TRFH_1	155	159	PF08558	0.347
LIG_TYR_ITAM	58	79	PF00017	0.366
LIG_TYR_ITIM	130	135	PF00017	0.409
LIG_TYR_ITIM	59	64	PF00017	0.642
LIG_UBA3_1	172	179	PF00899	0.394
LIG_UBA3_1	243	250	PF00899	0.449
LIG_WRC_WIRS_1	264	269	PF05994	0.415
LIG_WRC_WIRS_1	319	324	PF05994	0.309
LIG_WRC_WIRS_1	334	339	PF05994	0.221
MOD_CDC14_SPxK_1	247	250	PF00782	0.442
MOD_CDK_SPK_2	244	249	PF00069	0.442
MOD_CDK_SPxK_1	244	250	PF00069	0.442
MOD_CDK_SPxxK_3	322	329	PF00069	0.328
MOD_CMANNOS	265	268	PF00535	0.310
MOD_Cter_Amidation	238	241	PF01082	0.347
MOD_GlcNHglycan	314	317	PF01048	0.528
MOD_GlcNHglycan	349	352	PF01048	0.294
MOD_GlcNHglycan	51	54	PF01048	0.538
MOD_GSK3_1	24	31	PF00069	0.663
MOD_GSK3_1	244	251	PF00069	0.448
MOD_GSK3_1	259	266	PF00069	0.294
MOD_GSK3_1	318	325	PF00069	0.282
MOD_GSK3_1	41	48	PF00069	0.740
MOD_GSK3_1	49	56	PF00069	0.676
MOD_N-GLC_1	19	24	PF02516	0.535
MOD_N-GLC_1	65	70	PF02516	0.310
MOD_NEK2_1	128	133	PF00069	0.180
MOD_NEK2_1	144	149	PF00069	0.283
MOD_NEK2_1	173	178	PF00069	0.291
MOD_NEK2_1	189	194	PF00069	0.342
MOD_NEK2_1	196	201	PF00069	0.291
MOD_NEK2_1	259	264	PF00069	0.310
MOD_NEK2_1	318	323	PF00069	0.309
MOD_NEK2_1	347	352	PF00069	0.280
MOD_NEK2_1	424	429	PF00069	0.541
MOD_PIKK_1	196	202	PF00454	0.298
MOD_PIKK_1	289	295	PF00454	0.194
MOD_PIKK_1	419	425	PF00454	0.525
MOD_PKA_2	416	422	PF00069	0.542
MOD_Plk_1	25	31	PF00069	0.757
MOD_Plk_1	65	71	PF00069	0.310
MOD_Plk_1	96	102	PF00069	0.339
MOD_Plk_4	116	122	PF00069	0.453
MOD_Plk_4	128	134	PF00069	0.250
MOD_Plk_4	190	196	PF00069	0.200
MOD_Plk_4	271	277	PF00069	0.264
MOD_Plk_4	318	324	PF00069	0.317
MOD_Plk_4	336	342	PF00069	0.111
MOD_Plk_4	416	422	PF00069	0.605
MOD_ProDKin_1	19	25	PF00069	0.667
MOD_ProDKin_1	244	250	PF00069	0.442
MOD_ProDKin_1	322	328	PF00069	0.326
MOD_SUMO_rev_2	50	59	PF00179	0.713
TRG_DiLeu_BaEn_1	7	12	PF01217	0.572
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.730
TRG_ENDOCYTIC_2	126	129	PF00928	0.407
TRG_ENDOCYTIC_2	132	135	PF00928	0.415
TRG_ENDOCYTIC_2	155	158	PF00928	0.258
TRG_ENDOCYTIC_2	184	187	PF00928	0.453
TRG_ENDOCYTIC_2	386	389	PF00928	0.465
TRG_ENDOCYTIC_2	61	64	PF00928	0.542
TRG_ENDOCYTIC_2	76	79	PF00928	0.237

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P387	Leptomonas seymouri	82%	100%
A0A0S4JNH9	Bodo saltans	49%	100%
A0A1X0NS18	Trypanosomatidae	59%	100%
A0A3S7WZX3	Leishmania donovani	88%	100%
A0A422N205	Trypanosoma rangeli	55%	100%
A0JNC1	Bos taurus	34%	97%
A4I295	Leishmania infantum	88%	100%
C9ZRP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AYE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O04928	Arabidopsis thaliana	37%	100%
O04940	Solanum tuberosum	40%	100%
O35052	Rattus norvegicus	38%	93%
O49639	Arabidopsis thaliana	37%	100%
O95674	Homo sapiens	35%	97%
P38221	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	94%
P53439	Caenorhabditis elegans	35%	92%
P56079	Drosophila melanogaster	34%	96%
P98191	Mus musculus	38%	93%
Q1PE48	Arabidopsis thaliana	37%	91%
Q4Q932	Leishmania major	88%	100%
Q55D90	Dictyostelium discoideum	39%	90%
Q91XU8	Rattus norvegicus	34%	97%
Q92903	Homo sapiens	35%	93%
Q99L43	Mus musculus	35%	97%
Q9P381	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	98%
V5D1I7	Trypanosoma cruzi	56%	100%