Proline dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Proline dehydrogenase, mitochondrial

Species:

Leishmania braziliensis

UniProt:

A4HF16_LEIBR

TriTrypDb:

LbrM.26.1630 , LBRM2903_260022000

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HF16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF16

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006520	amino acid metabolic process	3	12
GO:0006560	proline metabolic process	6	12
GO:0006562	proline catabolic process	5	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009063	amino acid catabolic process	4	12
GO:0009064	glutamine family amino acid metabolic process	5	12
GO:0009065	glutamine family amino acid catabolic process	6	12
GO:0009987	cellular process	1	12
GO:0016054	organic acid catabolic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046395	carboxylic acid catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12
GO:1901605	alpha-amino acid metabolic process	4	12
GO:1901606	alpha-amino acid catabolic process	5	12
GO:0006536	glutamate metabolic process	6	1
GO:0010133	proline catabolic process to glutamate	6	1
GO:0043648	dicarboxylic acid metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004657	proline dehydrogenase activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	12
GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	4	12
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	1
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.511
CLV_C14_Caspase3-7	543	547	PF00656	0.574
CLV_MEL_PAP_1	204	210	PF00089	0.275
CLV_MEL_PAP_1	488	494	PF00089	0.311
CLV_NRD_NRD_1	2	4	PF00675	0.585
CLV_NRD_NRD_1	241	243	PF00675	0.483
CLV_NRD_NRD_1	280	282	PF00675	0.486
CLV_NRD_NRD_1	533	535	PF00675	0.214
CLV_NRD_NRD_1	558	560	PF00675	0.367
CLV_PCSK_KEX2_1	2	4	PF00082	0.585
CLV_PCSK_KEX2_1	449	451	PF00082	0.244
CLV_PCSK_KEX2_1	484	486	PF00082	0.181
CLV_PCSK_KEX2_1	533	535	PF00082	0.214
CLV_PCSK_KEX2_1	557	559	PF00082	0.364
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.265
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.168
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.493
CLV_PCSK_SKI1_1	221	225	PF00082	0.437
CLV_PCSK_SKI1_1	29	33	PF00082	0.475
CLV_PCSK_SKI1_1	292	296	PF00082	0.191
CLV_PCSK_SKI1_1	449	453	PF00082	0.270
CLV_PCSK_SKI1_1	554	558	PF00082	0.397
DEG_Nend_UBRbox_1	1	4	PF02207	0.642
DOC_CYCLIN_yClb5_NLxxxL_5	501	508	PF00134	0.511
DOC_MAPK_gen_1	242	248	PF00069	0.484
DOC_MAPK_gen_1	461	467	PF00069	0.511
DOC_MAPK_MEF2A_6	501	508	PF00069	0.522
DOC_MAPK_MEF2A_6	52	59	PF00069	0.400
DOC_PP1_RVXF_1	489	495	PF00149	0.511
DOC_PP2B_LxvP_1	31	34	PF13499	0.269
DOC_PP2B_LxvP_1	504	507	PF13499	0.420
DOC_USP7_MATH_1	18	22	PF00917	0.671
DOC_USP7_MATH_1	206	210	PF00917	0.286
DOC_USP7_MATH_1	316	320	PF00917	0.538
DOC_USP7_MATH_1	66	70	PF00917	0.498
DOC_USP7_UBL2_3	323	327	PF12436	0.511
DOC_USP7_UBL2_3	553	557	PF12436	0.378
DOC_USP7_UBL2_3	74	78	PF12436	0.408
DOC_WW_Pin1_4	181	186	PF00397	0.500
DOC_WW_Pin1_4	302	307	PF00397	0.433
DOC_WW_Pin1_4	428	433	PF00397	0.409
DOC_WW_Pin1_4	5	10	PF00397	0.455
LIG_14-3-3_CanoR_1	19	25	PF00244	0.575
LIG_14-3-3_CanoR_1	207	215	PF00244	0.276
LIG_14-3-3_CanoR_1	332	336	PF00244	0.431
LIG_14-3-3_CanoR_1	421	429	PF00244	0.523
LIG_14-3-3_CanoR_1	43	49	PF00244	0.372
LIG_14-3-3_CanoR_1	491	495	PF00244	0.511
LIG_14-3-3_CanoR_1	58	63	PF00244	0.412
LIG_Clathr_ClatBox_1	228	232	PF01394	0.252
LIG_Clathr_ClatBox_1	299	303	PF01394	0.511
LIG_EH1_1	48	56	PF00400	0.378
LIG_eIF4E_1	49	55	PF01652	0.374
LIG_FHA_1	273	279	PF00498	0.500
LIG_FHA_1	294	300	PF00498	0.463
LIG_FHA_1	428	434	PF00498	0.511
LIG_FHA_1	45	51	PF00498	0.473
LIG_FHA_1	477	483	PF00498	0.476
LIG_FHA_1	503	509	PF00498	0.409
LIG_FHA_1	65	71	PF00498	0.402
LIG_FHA_2	222	228	PF00498	0.537
LIG_FHA_2	267	273	PF00498	0.377
LIG_FHA_2	337	343	PF00498	0.390
LIG_FHA_2	385	391	PF00498	0.433
LIG_FHA_2	434	440	PF00498	0.410
LIG_FHA_2	541	547	PF00498	0.521
LIG_LIR_Gen_1	249	257	PF02991	0.410
LIG_LIR_Gen_1	268	278	PF02991	0.265
LIG_LIR_Gen_1	85	94	PF02991	0.382
LIG_LIR_Nem_3	249	253	PF02991	0.405
LIG_LIR_Nem_3	268	274	PF02991	0.463
LIG_LIR_Nem_3	324	329	PF02991	0.390
LIG_LIR_Nem_3	352	358	PF02991	0.420
LIG_LIR_Nem_3	381	385	PF02991	0.419
LIG_LIR_Nem_3	431	437	PF02991	0.448
LIG_LIR_Nem_3	46	51	PF02991	0.367
LIG_LIR_Nem_3	493	497	PF02991	0.511
LIG_LIR_Nem_3	85	89	PF02991	0.350
LIG_LIR_Nem_3	93	98	PF02991	0.329
LIG_Pex14_1	219	223	PF04695	0.302
LIG_Pex14_2	494	498	PF04695	0.511
LIG_Pex14_2	94	98	PF04695	0.397
LIG_SH2_CRK	250	254	PF00017	0.395
LIG_SH2_CRK	429	433	PF00017	0.409
LIG_SH2_CRK	516	520	PF00017	0.423
LIG_SH2_CRK	521	525	PF00017	0.395
LIG_SH2_CRK	86	90	PF00017	0.340
LIG_SH2_NCK_1	260	264	PF00017	0.298
LIG_SH2_NCK_1	444	448	PF00017	0.476
LIG_SH2_STAP1	125	129	PF00017	0.360
LIG_SH2_STAP1	86	90	PF00017	0.414
LIG_SH2_STAT3	416	419	PF00017	0.420
LIG_SH2_STAT5	288	291	PF00017	0.340
LIG_SH2_STAT5	385	388	PF00017	0.437
LIG_SH2_STAT5	416	419	PF00017	0.544
LIG_SH2_STAT5	429	432	PF00017	0.454
LIG_SH2_STAT5	49	52	PF00017	0.439
LIG_SH2_STAT5	518	521	PF00017	0.409
LIG_SH2_STAT5	530	533	PF00017	0.409
LIG_SH2_STAT5	97	100	PF00017	0.384
LIG_SH3_1	3	9	PF00018	0.632
LIG_SH3_1	517	523	PF00018	0.409
LIG_SH3_2	520	525	PF14604	0.409
LIG_SH3_3	149	155	PF00018	0.427
LIG_SH3_3	3	9	PF00018	0.598
LIG_SH3_3	517	523	PF00018	0.409
LIG_SUMO_SIM_anti_2	473	479	PF11976	0.511
LIG_SUMO_SIM_anti_2	69	74	PF11976	0.291
LIG_SUMO_SIM_par_1	298	303	PF11976	0.438
LIG_TRAF2_1	224	227	PF00917	0.400
LIG_TRAF2_1	436	439	PF00917	0.420
LIG_TRFH_1	5	9	PF08558	0.405
LIG_TYR_ITIM	248	253	PF00017	0.407
LIG_TYR_ITIM	519	524	PF00017	0.409
LIG_TYR_ITIM	84	89	PF00017	0.342
LIG_WRC_WIRS_1	452	457	PF05994	0.463
MOD_CDK_SPK_2	181	186	PF00069	0.432
MOD_CK1_1	147	153	PF00069	0.395
MOD_CK1_1	181	187	PF00069	0.521
MOD_CK1_1	490	496	PF00069	0.509
MOD_CK1_1	540	546	PF00069	0.573
MOD_CK1_1	82	88	PF00069	0.498
MOD_CK2_1	221	227	PF00069	0.536
MOD_CK2_1	266	272	PF00069	0.349
MOD_CK2_1	316	322	PF00069	0.416
MOD_CK2_1	336	342	PF00069	0.317
MOD_CK2_1	384	390	PF00069	0.433
MOD_CK2_1	432	438	PF00069	0.411
MOD_Cter_Amidation	531	534	PF01082	0.209
MOD_GlcNHglycan	141	144	PF01048	0.626
MOD_GlcNHglycan	208	211	PF01048	0.286
MOD_GlcNHglycan	318	321	PF01048	0.263
MOD_GSK3_1	211	218	PF00069	0.360
MOD_GSK3_1	331	338	PF00069	0.442
MOD_GSK3_1	363	370	PF00069	0.546
MOD_GSK3_1	428	435	PF00069	0.444
MOD_GSK3_1	537	544	PF00069	0.457
MOD_GSK3_1	64	71	PF00069	0.305
MOD_N-GLC_1	502	507	PF02516	0.251
MOD_N-GLC_1	537	542	PF02516	0.233
MOD_N-GLC_1	546	551	PF02516	0.393
MOD_N-GLC_2	441	443	PF02516	0.276
MOD_NEK2_1	107	112	PF00069	0.362
MOD_NEK2_1	178	183	PF00069	0.365
MOD_NEK2_1	211	216	PF00069	0.431
MOD_NEK2_1	266	271	PF00069	0.433
MOD_NEK2_1	335	340	PF00069	0.463
MOD_NEK2_1	367	372	PF00069	0.463
MOD_NEK2_1	466	471	PF00069	0.409
MOD_NEK2_2	351	356	PF00069	0.420
MOD_PIKK_1	266	272	PF00454	0.355
MOD_PK_1	58	64	PF00069	0.534
MOD_PKA_2	107	113	PF00069	0.492
MOD_PKA_2	18	24	PF00069	0.710
MOD_PKA_2	206	212	PF00069	0.274
MOD_PKA_2	331	337	PF00069	0.432
MOD_PKA_2	420	426	PF00069	0.433
MOD_PKA_2	44	50	PF00069	0.245
MOD_PKA_2	490	496	PF00069	0.450
MOD_Plk_1	144	150	PF00069	0.363
MOD_Plk_1	351	357	PF00069	0.409
MOD_Plk_1	37	43	PF00069	0.389
MOD_Plk_1	502	508	PF00069	0.441
MOD_Plk_1	537	543	PF00069	0.419
MOD_Plk_1	546	552	PF00069	0.365
MOD_Plk_4	147	153	PF00069	0.385
MOD_Plk_4	173	179	PF00069	0.444
MOD_Plk_4	331	337	PF00069	0.405
MOD_Plk_4	351	357	PF00069	0.402
MOD_Plk_4	44	50	PF00069	0.281
MOD_Plk_4	478	484	PF00069	0.511
MOD_Plk_4	537	543	PF00069	0.432
MOD_Plk_4	546	552	PF00069	0.385
MOD_Plk_4	68	74	PF00069	0.409
MOD_Plk_4	90	96	PF00069	0.370
MOD_ProDKin_1	181	187	PF00069	0.509
MOD_ProDKin_1	302	308	PF00069	0.433
MOD_ProDKin_1	428	434	PF00069	0.409
MOD_ProDKin_1	5	11	PF00069	0.454
MOD_SUMO_for_1	229	232	PF00179	0.469
MOD_SUMO_for_1	552	555	PF00179	0.288
TRG_DiLeu_BaEn_4	226	232	PF01217	0.415
TRG_ENDOCYTIC_2	250	253	PF00928	0.395
TRG_ENDOCYTIC_2	291	294	PF00928	0.415
TRG_ENDOCYTIC_2	516	519	PF00928	0.423
TRG_ENDOCYTIC_2	521	524	PF00928	0.395
TRG_ENDOCYTIC_2	86	89	PF00928	0.348
TRG_ENDOCYTIC_2	95	98	PF00928	0.312
TRG_ER_diArg_1	1	3	PF00400	0.595
TRG_ER_diArg_1	398	401	PF00400	0.524
TRG_ER_diArg_1	42	45	PF00400	0.473
TRG_NLS_MonoExtN_4	554	561	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.220

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUG0	Leptomonas seymouri	77%	99%
A0A0S4JS18	Bodo saltans	39%	99%
A0A1X0NS42	Trypanosomatidae	57%	100%
A0A3Q8IFX0	Leishmania donovani	93%	100%
A0A3R7N3G7	Trypanosoma rangeli	54%	100%
A4I294	Leishmania infantum	92%	100%
C9ZRP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AYE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O43272	Homo sapiens	30%	94%
O45228	Caenorhabditis elegans	29%	91%
Q04499	Drosophila melanogaster	30%	83%
Q148G5	Bos taurus	28%	95%
Q4Q933	Leishmania major	92%	100%
Q9WU79	Mus musculus	30%	94%
V5B5Q5	Trypanosoma cruzi	56%	99%