Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HF15_LEIBR

TriTrypDb:

LbrM.26.1620 , LBRM2903_260021900

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF15

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.697
CLV_C14_Caspase3-7	424	428	PF00656	0.528
CLV_NRD_NRD_1	310	312	PF00675	0.444
CLV_NRD_NRD_1	43	45	PF00675	0.644
CLV_NRD_NRD_1	489	491	PF00675	0.753
CLV_NRD_NRD_1	503	505	PF00675	0.630
CLV_NRD_NRD_1	525	527	PF00675	0.760
CLV_NRD_NRD_1	594	596	PF00675	0.547
CLV_NRD_NRD_1	75	77	PF00675	0.637
CLV_PCSK_FUR_1	486	490	PF00082	0.833
CLV_PCSK_KEX2_1	215	217	PF00082	0.555
CLV_PCSK_KEX2_1	488	490	PF00082	0.747
CLV_PCSK_KEX2_1	502	504	PF00082	0.648
CLV_PCSK_KEX2_1	524	526	PF00082	0.784
CLV_PCSK_KEX2_1	535	537	PF00082	0.646
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.555
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.590
CLV_PCSK_PC7_1	498	504	PF00082	0.594
CLV_PCSK_PC7_1	521	527	PF00082	0.704
CLV_PCSK_SKI1_1	193	197	PF00082	0.608
CLV_PCSK_SKI1_1	216	220	PF00082	0.666
CLV_PCSK_SKI1_1	311	315	PF00082	0.574
CLV_PCSK_SKI1_1	423	427	PF00082	0.383
CLV_PCSK_SKI1_1	459	463	PF00082	0.501
CLV_Separin_Metazoa	190	194	PF03568	0.556
DEG_APCC_DBOX_1	289	297	PF00400	0.431
DEG_Kelch_Keap1_1	567	572	PF01344	0.568
DEG_Nend_UBRbox_2	1	3	PF02207	0.599
DEG_SCF_FBW7_1	93	99	PF00400	0.598
DEG_SPOP_SBC_1	544	548	PF00917	0.649
DEG_SPOP_SBC_1	621	625	PF00917	0.605
DOC_CDC14_PxL_1	616	624	PF14671	0.548
DOC_CKS1_1	93	98	PF01111	0.594
DOC_CYCLIN_RxL_1	187	200	PF00134	0.604
DOC_CYCLIN_RxL_1	213	222	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.662
DOC_MAPK_gen_1	137	146	PF00069	0.574
DOC_MAPK_gen_1	442	450	PF00069	0.584
DOC_MAPK_gen_1	535	541	PF00069	0.544
DOC_MAPK_MEF2A_6	322	330	PF00069	0.552
DOC_MAPK_MEF2A_6	368	376	PF00069	0.325
DOC_MAPK_RevD_3	63	77	PF00069	0.611
DOC_PP1_RVXF_1	191	198	PF00149	0.604
DOC_PP4_FxxP_1	250	253	PF00568	0.453
DOC_USP7_MATH_1	107	111	PF00917	0.653
DOC_USP7_MATH_1	170	174	PF00917	0.550
DOC_USP7_MATH_1	267	271	PF00917	0.633
DOC_USP7_MATH_1	334	338	PF00917	0.476
DOC_USP7_MATH_1	392	396	PF00917	0.551
DOC_USP7_MATH_1	52	56	PF00917	0.662
DOC_USP7_MATH_1	580	584	PF00917	0.731
DOC_USP7_MATH_1	94	98	PF00917	0.622
DOC_WW_Pin1_4	265	270	PF00397	0.681
DOC_WW_Pin1_4	34	39	PF00397	0.683
DOC_WW_Pin1_4	449	454	PF00397	0.533
DOC_WW_Pin1_4	469	474	PF00397	0.468
DOC_WW_Pin1_4	493	498	PF00397	0.646
DOC_WW_Pin1_4	92	97	PF00397	0.570
LIG_14-3-3_CanoR_1	109	115	PF00244	0.719
LIG_14-3-3_CanoR_1	137	147	PF00244	0.459
LIG_14-3-3_CanoR_1	193	198	PF00244	0.467
LIG_14-3-3_CanoR_1	333	339	PF00244	0.420
LIG_14-3-3_CanoR_1	393	399	PF00244	0.393
LIG_14-3-3_CanoR_1	44	53	PF00244	0.599
LIG_Actin_WH2_2	295	313	PF00022	0.495
LIG_BRCT_BRCA1_1	230	234	PF00533	0.666
LIG_deltaCOP1_diTrp_1	664	673	PF00928	0.411
LIG_EH1_1	182	190	PF00400	0.593
LIG_EH1_1	235	243	PF00400	0.496
LIG_FHA_1	115	121	PF00498	0.474
LIG_FHA_1	152	158	PF00498	0.609
LIG_FHA_1	184	190	PF00498	0.355
LIG_FHA_1	220	226	PF00498	0.643
LIG_FHA_1	346	352	PF00498	0.459
LIG_FHA_1	600	606	PF00498	0.655
LIG_FHA_1	623	629	PF00498	0.416
LIG_FHA_1	93	99	PF00498	0.598
LIG_FHA_2	110	116	PF00498	0.762
LIG_FHA_2	197	203	PF00498	0.562
LIG_FHA_2	299	305	PF00498	0.487
LIG_FHA_2	392	398	PF00498	0.442
LIG_FHA_2	52	58	PF00498	0.422
LIG_GBD_Chelix_1	184	192	PF00786	0.333
LIG_GSK3_LRP6_1	469	474	PF00069	0.545
LIG_LIR_Apic_2	249	253	PF02991	0.462
LIG_LIR_Gen_1	199	208	PF02991	0.588
LIG_LIR_Gen_1	303	314	PF02991	0.575
LIG_LIR_Gen_1	452	462	PF02991	0.623
LIG_LIR_Gen_1	652	661	PF02991	0.375
LIG_LIR_Nem_3	196	201	PF02991	0.563
LIG_LIR_Nem_3	303	309	PF02991	0.545
LIG_LIR_Nem_3	452	458	PF02991	0.614
LIG_LIR_Nem_3	636	640	PF02991	0.480
LIG_LIR_Nem_3	652	656	PF02991	0.525
LIG_NRBOX	187	193	PF00104	0.336
LIG_NRBOX	295	301	PF00104	0.570
LIG_NRBOX	64	70	PF00104	0.620
LIG_SH2_CRK	162	166	PF00017	0.608
LIG_SH2_CRK	306	310	PF00017	0.569
LIG_SH2_CRK	455	459	PF00017	0.626
LIG_SH2_STAP1	306	310	PF00017	0.569
LIG_SH2_STAP1	653	657	PF00017	0.495
LIG_SH2_STAT5	257	260	PF00017	0.451
LIG_SH2_STAT5	433	436	PF00017	0.496
LIG_SH2_STAT5	607	610	PF00017	0.482
LIG_SH2_STAT5	627	630	PF00017	0.237
LIG_SH2_STAT5	637	640	PF00017	0.482
LIG_SH3_3	320	326	PF00018	0.453
LIG_SH3_3	333	339	PF00018	0.420
LIG_SH3_3	467	473	PF00018	0.743
LIG_Sin3_3	537	544	PF02671	0.517
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.651
LIG_SUMO_SIM_anti_2	152	159	PF11976	0.606
LIG_SUMO_SIM_anti_2	560	570	PF11976	0.584
LIG_SUMO_SIM_par_1	127	133	PF11976	0.632
LIG_SUMO_SIM_par_1	292	298	PF11976	0.412
LIG_SUMO_SIM_par_1	372	378	PF11976	0.437
LIG_TRAF2_1	200	203	PF00917	0.682
LIG_TRAF2_1	550	553	PF00917	0.528
LIG_TYR_ITIM	638	643	PF00017	0.606
LIG_UBA3_1	418	423	PF00899	0.366
LIG_WW_3	598	602	PF00397	0.485
MOD_CDK_SPK_2	493	498	PF00069	0.575
MOD_CK1_1	110	116	PF00069	0.567
MOD_CK1_1	121	127	PF00069	0.559
MOD_CK1_1	133	139	PF00069	0.645
MOD_CK1_1	221	227	PF00069	0.650
MOD_CK1_1	228	234	PF00069	0.572
MOD_CK1_1	270	276	PF00069	0.744
MOD_CK1_1	298	304	PF00069	0.343
MOD_CK1_1	409	415	PF00069	0.491
MOD_CK1_1	451	457	PF00069	0.605
MOD_CK1_1	496	502	PF00069	0.602
MOD_CK1_1	566	572	PF00069	0.744
MOD_CK1_1	574	580	PF00069	0.695
MOD_CK1_1	92	98	PF00069	0.614
MOD_CK2_1	109	115	PF00069	0.683
MOD_CK2_1	150	156	PF00069	0.622
MOD_CK2_1	196	202	PF00069	0.646
MOD_CK2_1	28	34	PF00069	0.675
MOD_CK2_1	391	397	PF00069	0.506
MOD_CK2_1	51	57	PF00069	0.428
MOD_CK2_1	566	572	PF00069	0.819
MOD_CK2_1	94	100	PF00069	0.685
MOD_GlcNHglycan	132	135	PF01048	0.629
MOD_GlcNHglycan	172	175	PF01048	0.640
MOD_GlcNHglycan	176	179	PF01048	0.585
MOD_GlcNHglycan	230	233	PF01048	0.563
MOD_GlcNHglycan	358	361	PF01048	0.424
MOD_GlcNHglycan	394	397	PF01048	0.517
MOD_GlcNHglycan	427	430	PF01048	0.570
MOD_GlcNHglycan	46	49	PF01048	0.625
MOD_GlcNHglycan	569	572	PF01048	0.566
MOD_GlcNHglycan	584	587	PF01048	0.467
MOD_GlcNHglycan	617	620	PF01048	0.501
MOD_GlcNHglycan	646	649	PF01048	0.465
MOD_GlcNHglycan	79	82	PF01048	0.589
MOD_GSK3_1	109	116	PF00069	0.635
MOD_GSK3_1	133	140	PF00069	0.427
MOD_GSK3_1	170	177	PF00069	0.575
MOD_GSK3_1	193	200	PF00069	0.511
MOD_GSK3_1	214	221	PF00069	0.655
MOD_GSK3_1	252	259	PF00069	0.374
MOD_GSK3_1	30	37	PF00069	0.696
MOD_GSK3_1	421	428	PF00069	0.626
MOD_GSK3_1	44	51	PF00069	0.407
MOD_GSK3_1	563	570	PF00069	0.737
MOD_GSK3_1	607	614	PF00069	0.476
MOD_GSK3_1	92	99	PF00069	0.678
MOD_LATS_1	75	81	PF00433	0.423
MOD_N-GLC_1	110	115	PF02516	0.612
MOD_N-GLC_1	118	123	PF02516	0.669
MOD_N-GLC_1	270	275	PF02516	0.517
MOD_N-GLC_1	409	414	PF02516	0.342
MOD_N-GLC_1	442	447	PF02516	0.469
MOD_N-GLC_1	493	498	PF02516	0.681
MOD_N-GLC_1	574	579	PF02516	0.580
MOD_NEK2_1	101	106	PF00069	0.750
MOD_NEK2_1	204	209	PF00069	0.713
MOD_NEK2_1	218	223	PF00069	0.472
MOD_NEK2_1	28	33	PF00069	0.666
MOD_NEK2_1	284	289	PF00069	0.533
MOD_NEK2_1	295	300	PF00069	0.391
MOD_NEK2_1	345	350	PF00069	0.558
MOD_NEK2_1	383	388	PF00069	0.494
MOD_NEK2_1	4	9	PF00069	0.657
MOD_NEK2_1	421	426	PF00069	0.396
MOD_NEK2_1	448	453	PF00069	0.502
MOD_NEK2_1	46	51	PF00069	0.335
MOD_NEK2_1	611	616	PF00069	0.479
MOD_NEK2_1	622	627	PF00069	0.436
MOD_PIKK_1	121	127	PF00454	0.586
MOD_PIKK_1	57	63	PF00454	0.640
MOD_PKA_1	44	50	PF00069	0.632
MOD_PKA_1	525	531	PF00069	0.665
MOD_PKA_2	392	398	PF00069	0.595
MOD_PKA_2	525	531	PF00069	0.586
MOD_PKA_2	542	548	PF00069	0.562
MOD_PKB_1	515	523	PF00069	0.791
MOD_Plk_1	110	116	PF00069	0.661
MOD_Plk_1	118	124	PF00069	0.668
MOD_Plk_1	151	157	PF00069	0.514
MOD_Plk_1	377	383	PF00069	0.537
MOD_Plk_1	589	595	PF00069	0.571
MOD_Plk_4	118	124	PF00069	0.447
MOD_Plk_4	193	199	PF00069	0.513
MOD_Plk_4	253	259	PF00069	0.559
MOD_Plk_4	284	290	PF00069	0.461
MOD_Plk_4	295	301	PF00069	0.361
MOD_Plk_4	326	332	PF00069	0.439
MOD_Plk_4	340	346	PF00069	0.503
MOD_Plk_4	4	10	PF00069	0.664
MOD_Plk_4	421	427	PF00069	0.623
MOD_Plk_4	611	617	PF00069	0.481
MOD_ProDKin_1	265	271	PF00069	0.695
MOD_ProDKin_1	34	40	PF00069	0.686
MOD_ProDKin_1	449	455	PF00069	0.528
MOD_ProDKin_1	469	475	PF00069	0.474
MOD_ProDKin_1	493	499	PF00069	0.647
MOD_ProDKin_1	92	98	PF00069	0.570
MOD_SUMO_for_1	662	665	PF00179	0.509
TRG_DiLeu_BaEn_1	341	346	PF01217	0.329
TRG_DiLeu_BaEn_2	117	123	PF01217	0.607
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.541
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.598
TRG_ENDOCYTIC_2	162	165	PF00928	0.509
TRG_ENDOCYTIC_2	201	204	PF00928	0.590
TRG_ENDOCYTIC_2	248	251	PF00928	0.573
TRG_ENDOCYTIC_2	306	309	PF00928	0.582
TRG_ENDOCYTIC_2	455	458	PF00928	0.617
TRG_ENDOCYTIC_2	640	643	PF00928	0.616
TRG_ENDOCYTIC_2	653	656	PF00928	0.415
TRG_ER_diArg_1	485	488	PF00400	0.809
TRG_ER_diArg_1	502	504	PF00400	0.696
TRG_ER_diArg_1	523	526	PF00400	0.771
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I134	Leptomonas seymouri	42%	100%
A0A3S7WZX2	Leishmania donovani	75%	100%
A4I293	Leishmania infantum	76%	100%
E9AYD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q934	Leishmania major	77%	100%