EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HF14_LEIBR

TriTrypDb:

LbrM.26.1610 , LBRM2903_260021700

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF14

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.495
CLV_C14_Caspase3-7	202	206	PF00656	0.514
CLV_NRD_NRD_1	284	286	PF00675	0.419
CLV_NRD_NRD_1	301	303	PF00675	0.300
CLV_NRD_NRD_1	356	358	PF00675	0.296
CLV_NRD_NRD_1	441	443	PF00675	0.251
CLV_PCSK_KEX2_1	119	121	PF00082	0.478
CLV_PCSK_KEX2_1	284	286	PF00082	0.429
CLV_PCSK_KEX2_1	356	358	PF00082	0.269
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.478
CLV_PCSK_SKI1_1	119	123	PF00082	0.428
CLV_PCSK_SKI1_1	356	360	PF00082	0.313
CLV_PCSK_SKI1_1	366	370	PF00082	0.339
DEG_APCC_DBOX_1	365	373	PF00400	0.441
DEG_MDM2_SWIB_1	313	321	PF02201	0.415
DEG_SPOP_SBC_1	520	524	PF00917	0.248
DOC_AGCK_PIF_2	3	8	PF00069	0.530
DOC_CKS1_1	463	468	PF01111	0.449
DOC_MAPK_MEF2A_6	375	383	PF00069	0.344
DOC_PP1_RVXF_1	441	448	PF00149	0.446
DOC_USP7_MATH_1	194	198	PF00917	0.622
DOC_USP7_MATH_1	210	214	PF00917	0.588
DOC_USP7_MATH_1	384	388	PF00917	0.351
DOC_USP7_MATH_1	431	435	PF00917	0.480
DOC_WW_Pin1_4	253	258	PF00397	0.357
DOC_WW_Pin1_4	296	301	PF00397	0.407
DOC_WW_Pin1_4	373	378	PF00397	0.348
DOC_WW_Pin1_4	462	467	PF00397	0.447
LIG_14-3-3_CanoR_1	148	154	PF00244	0.536
LIG_14-3-3_CanoR_1	356	365	PF00244	0.428
LIG_14-3-3_CanoR_1	456	462	PF00244	0.484
LIG_14-3-3_CanoR_1	48	58	PF00244	0.537
LIG_14-3-3_CanoR_1	517	521	PF00244	0.361
LIG_14-3-3_CanoR_1	89	99	PF00244	0.492
LIG_14-3-3_CterR_2	542	546	PF00244	0.396
LIG_BIR_III_4	209	213	PF00653	0.457
LIG_BRCT_BRCA1_1	294	298	PF00533	0.269
LIG_CaM_IQ_9	59	74	PF13499	0.492
LIG_deltaCOP1_diTrp_1	470	479	PF00928	0.412
LIG_FHA_1	137	143	PF00498	0.563
LIG_FHA_1	318	324	PF00498	0.432
LIG_FHA_1	374	380	PF00498	0.515
LIG_FHA_1	473	479	PF00498	0.316
LIG_FHA_1	520	526	PF00498	0.491
LIG_FHA_2	154	160	PF00498	0.551
LIG_FHA_2	200	206	PF00498	0.545
LIG_FHA_2	386	392	PF00498	0.353
LIG_FHA_2	416	422	PF00498	0.440
LIG_FHA_2	436	442	PF00498	0.388
LIG_FHA_2	63	69	PF00498	0.494
LIG_FHA_2	92	98	PF00498	0.617
LIG_LIR_Gen_1	168	176	PF02991	0.542
LIG_LIR_Gen_1	450	458	PF02991	0.375
LIG_LIR_Gen_1	97	107	PF02991	0.525
LIG_LIR_Nem_3	168	174	PF02991	0.538
LIG_LIR_Nem_3	450	455	PF02991	0.422
LIG_LIR_Nem_3	535	540	PF02991	0.399
LIG_LIR_Nem_3	97	102	PF02991	0.577
LIG_Pex14_1	425	429	PF04695	0.461
LIG_Pex14_2	313	317	PF04695	0.386
LIG_PTB_Apo_2	137	144	PF02174	0.538
LIG_PTB_Apo_2	2	9	PF02174	0.463
LIG_PTB_Phospho_1	2	8	PF10480	0.460
LIG_Rb_LxCxE_1	432	454	PF01857	0.430
LIG_SH2_CRK	537	541	PF00017	0.432
LIG_SH2_CRK	99	103	PF00017	0.550
LIG_SH2_SRC	6	9	PF00017	0.539
LIG_SH2_STAP1	521	525	PF00017	0.330
LIG_SH2_STAP1	6	10	PF00017	0.608
LIG_SH2_STAT5	117	120	PF00017	0.443
LIG_SH2_STAT5	165	168	PF00017	0.497
LIG_SH2_STAT5	404	407	PF00017	0.377
LIG_SH2_STAT5	521	524	PF00017	0.333
LIG_SH3_2	370	375	PF14604	0.339
LIG_SH3_3	102	108	PF00018	0.447
LIG_SH3_3	367	373	PF00018	0.439
LIG_SH3_3	460	466	PF00018	0.571
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.412
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.635
LIG_SUMO_SIM_par_1	379	385	PF11976	0.432
LIG_TRAF2_1	480	483	PF00917	0.283
LIG_UBA3_1	58	67	PF00899	0.559
LIG_WRC_WIRS_1	171	176	PF05994	0.502
MOD_CDC14_SPxK_1	299	302	PF00782	0.426
MOD_CDK_SPK_2	462	467	PF00069	0.364
MOD_CDK_SPxK_1	296	302	PF00069	0.413
MOD_CDK_SPxxK_3	253	260	PF00069	0.267
MOD_CDK_SPxxK_3	296	303	PF00069	0.419
MOD_CK1_1	197	203	PF00069	0.668
MOD_CK1_1	245	251	PF00069	0.553
MOD_CK1_1	340	346	PF00069	0.432
MOD_CK1_1	519	525	PF00069	0.288
MOD_CK2_1	164	170	PF00069	0.654
MOD_CK2_1	323	329	PF00069	0.267
MOD_CK2_1	415	421	PF00069	0.440
MOD_CK2_1	435	441	PF00069	0.388
MOD_CK2_1	465	471	PF00069	0.452
MOD_GlcNHglycan	179	182	PF01048	0.649
MOD_GlcNHglycan	214	217	PF01048	0.456
MOD_GlcNHglycan	347	350	PF01048	0.296
MOD_GlcNHglycan	467	470	PF01048	0.440
MOD_GlcNHglycan	51	54	PF01048	0.642
MOD_GlcNHglycan	72	75	PF01048	0.669
MOD_GSK3_1	120	127	PF00069	0.545
MOD_GSK3_1	132	139	PF00069	0.518
MOD_GSK3_1	149	156	PF00069	0.621
MOD_GSK3_1	166	173	PF00069	0.595
MOD_GSK3_1	194	201	PF00069	0.666
MOD_GSK3_1	212	219	PF00069	0.568
MOD_GSK3_1	238	245	PF00069	0.397
MOD_GSK3_1	292	299	PF00069	0.397
MOD_GSK3_1	313	320	PF00069	0.310
MOD_GSK3_1	415	422	PF00069	0.455
MOD_GSK3_1	431	438	PF00069	0.428
MOD_GSK3_1	447	454	PF00069	0.585
MOD_GSK3_1	515	522	PF00069	0.337
MOD_N-GLC_2	242	244	PF02516	0.392
MOD_NEK2_1	136	141	PF00069	0.550
MOD_NEK2_1	323	328	PF00069	0.328
MOD_NEK2_1	345	350	PF00069	0.461
MOD_NEK2_1	435	440	PF00069	0.456
MOD_NEK2_1	473	478	PF00069	0.268
MOD_NEK2_1	507	512	PF00069	0.406
MOD_NEK2_1	516	521	PF00069	0.265
MOD_NEK2_1	62	67	PF00069	0.592
MOD_NEK2_1	91	96	PF00069	0.462
MOD_NEK2_2	521	526	PF00069	0.340
MOD_PIKK_1	124	130	PF00454	0.450
MOD_PIKK_1	192	198	PF00454	0.555
MOD_PIKK_1	242	248	PF00454	0.359
MOD_PIKK_1	340	346	PF00454	0.387
MOD_PIKK_1	382	388	PF00454	0.395
MOD_PIKK_1	478	484	PF00454	0.263
MOD_PIKK_1	97	103	PF00454	0.478
MOD_PK_1	120	126	PF00069	0.572
MOD_PK_1	267	273	PF00069	0.287
MOD_PK_1	34	40	PF00069	0.484
MOD_PKA_1	356	362	PF00069	0.320
MOD_PKA_2	147	153	PF00069	0.628
MOD_PKA_2	356	362	PF00069	0.305
MOD_PKA_2	42	48	PF00069	0.492
MOD_PKA_2	516	522	PF00069	0.270
MOD_PKB_1	87	95	PF00069	0.499
MOD_Plk_1	317	323	PF00069	0.357
MOD_Plk_1	431	437	PF00069	0.437
MOD_Plk_1	450	456	PF00069	0.341
MOD_Plk_1	507	513	PF00069	0.423
MOD_Plk_2-3	18	24	PF00069	0.479
MOD_Plk_2-3	54	60	PF00069	0.439
MOD_Plk_4	138	144	PF00069	0.476
MOD_Plk_4	149	155	PF00069	0.464
MOD_Plk_4	170	176	PF00069	0.569
MOD_Plk_4	292	298	PF00069	0.314
MOD_Plk_4	419	425	PF00069	0.421
MOD_Plk_4	431	437	PF00069	0.497
MOD_Plk_4	457	463	PF00069	0.446
MOD_Plk_4	507	513	PF00069	0.430
MOD_Plk_4	516	522	PF00069	0.313
MOD_Plk_4	527	533	PF00069	0.371
MOD_Plk_4	54	60	PF00069	0.518
MOD_ProDKin_1	253	259	PF00069	0.360
MOD_ProDKin_1	296	302	PF00069	0.413
MOD_ProDKin_1	373	379	PF00069	0.340
MOD_ProDKin_1	462	468	PF00069	0.446
MOD_SUMO_rev_2	188	195	PF00179	0.636
MOD_SUMO_rev_2	256	261	PF00179	0.278
MOD_SUMO_rev_2	295	305	PF00179	0.361
TRG_DiLeu_BaEn_1	282	287	PF01217	0.436
TRG_DiLeu_BaEn_1	483	488	PF01217	0.349
TRG_DiLeu_BaEn_1	54	59	PF01217	0.436
TRG_DiLeu_BaEn_2	169	175	PF01217	0.439
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.283
TRG_ENDOCYTIC_2	537	540	PF00928	0.438
TRG_ENDOCYTIC_2	99	102	PF00928	0.498
TRG_ER_diArg_1	283	285	PF00400	0.393
TRG_ER_diArg_1	355	357	PF00400	0.395
TRG_ER_diArg_1	541	544	PF00400	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G5	Leptomonas seymouri	57%	91%
A0A0S4JNE6	Bodo saltans	32%	85%
A0A1X0NSH5	Trypanosomatidae	35%	100%
Q4Q935	Leishmania major	73%	100%