WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF13_LEIBR

TriTrypDb:

LbrM.26.1600 , LBRM2903_260021600

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.571
CLV_C14_Caspase3-7	236	240	PF00656	0.345
CLV_C14_Caspase3-7	564	568	PF00656	0.535
CLV_C14_Caspase3-7	7	11	PF00656	0.603
CLV_NRD_NRD_1	143	145	PF00675	0.492
CLV_NRD_NRD_1	395	397	PF00675	0.321
CLV_NRD_NRD_1	488	490	PF00675	0.496
CLV_NRD_NRD_1	56	58	PF00675	0.545
CLV_NRD_NRD_1	76	78	PF00675	0.449
CLV_NRD_NRD_1	93	95	PF00675	0.554
CLV_PCSK_FUR_1	91	95	PF00082	0.574
CLV_PCSK_KEX2_1	167	169	PF00082	0.606
CLV_PCSK_KEX2_1	395	397	PF00082	0.370
CLV_PCSK_KEX2_1	488	490	PF00082	0.496
CLV_PCSK_KEX2_1	76	78	PF00082	0.501
CLV_PCSK_KEX2_1	91	93	PF00082	0.559
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.612
CLV_PCSK_PC7_1	87	93	PF00082	0.580
CLV_PCSK_SKI1_1	128	132	PF00082	0.429
CLV_PCSK_SKI1_1	382	386	PF00082	0.339
CLV_PCSK_SKI1_1	446	450	PF00082	0.510
CLV_PCSK_SKI1_1	554	558	PF00082	0.465
DEG_Nend_UBRbox_2	1	3	PF02207	0.655
DEG_SPOP_SBC_1	251	255	PF00917	0.550
DEG_SPOP_SBC_1	366	370	PF00917	0.487
DOC_AGCK_PIF_1	569	574	PF00069	0.419
DOC_ANK_TNKS_1	80	87	PF00023	0.490
DOC_CDC14_PxL_1	463	471	PF14671	0.308
DOC_CKS1_1	162	167	PF01111	0.500
DOC_CYCLIN_RxL_1	341	352	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	342	348	PF00134	0.420
DOC_MAPK_gen_1	57	65	PF00069	0.566
DOC_MAPK_MEF2A_6	120	127	PF00069	0.463
DOC_MAPK_MEF2A_6	57	65	PF00069	0.550
DOC_MAPK_RevD_3	63	77	PF00069	0.430
DOC_PP1_RVXF_1	444	450	PF00149	0.401
DOC_PP1_RVXF_1	552	558	PF00149	0.395
DOC_PP2B_LxvP_1	213	216	PF13499	0.478
DOC_PP2B_PxIxI_1	155	161	PF00149	0.490
DOC_PP4_FxxP_1	46	49	PF00568	0.633
DOC_USP7_MATH_1	121	125	PF00917	0.453
DOC_USP7_MATH_1	259	263	PF00917	0.465
DOC_USP7_MATH_1	366	370	PF00917	0.689
DOC_USP7_MATH_1	380	384	PF00917	0.427
DOC_USP7_MATH_1	523	527	PF00917	0.403
DOC_USP7_MATH_1	556	560	PF00917	0.433
DOC_WW_Pin1_4	115	120	PF00397	0.496
DOC_WW_Pin1_4	161	166	PF00397	0.599
DOC_WW_Pin1_4	211	216	PF00397	0.602
DOC_WW_Pin1_4	283	288	PF00397	0.374
DOC_WW_Pin1_4	34	39	PF00397	0.547
DOC_WW_Pin1_4	449	454	PF00397	0.493
DOC_WW_Pin1_4	547	552	PF00397	0.488
DOC_WW_Pin1_4	572	577	PF00397	0.431
LIG_14-3-3_CanoR_1	120	126	PF00244	0.506
LIG_14-3-3_CanoR_1	168	173	PF00244	0.741
LIG_14-3-3_CanoR_1	183	187	PF00244	0.447
LIG_14-3-3_CanoR_1	189	195	PF00244	0.490
LIG_14-3-3_CanoR_1	256	263	PF00244	0.425
LIG_14-3-3_CanoR_1	318	324	PF00244	0.472
LIG_14-3-3_CanoR_1	33	38	PF00244	0.671
LIG_14-3-3_CanoR_1	398	403	PF00244	0.476
LIG_APCC_ABBA_1	135	140	PF00400	0.598
LIG_BIR_III_4	290	294	PF00653	0.462
LIG_Clathr_ClatBox_1	531	535	PF01394	0.413
LIG_FHA_1	265	271	PF00498	0.423
LIG_FHA_1	333	339	PF00498	0.438
LIG_FHA_1	431	437	PF00498	0.382
LIG_FHA_1	500	506	PF00498	0.526
LIG_FHA_1	527	533	PF00498	0.490
LIG_FHA_1	538	544	PF00498	0.416
LIG_FHA_2	124	130	PF00498	0.532
LIG_FHA_2	264	270	PF00498	0.445
LIG_LIR_Apic_2	171	175	PF02991	0.630
LIG_LIR_Apic_2	43	49	PF02991	0.625
LIG_LIR_Apic_2	461	467	PF02991	0.285
LIG_LIR_Gen_1	178	187	PF02991	0.547
LIG_LIR_Gen_1	206	216	PF02991	0.481
LIG_LIR_Gen_1	40	49	PF02991	0.486
LIG_LIR_Gen_1	67	75	PF02991	0.553
LIG_LIR_Nem_3	132	138	PF02991	0.571
LIG_LIR_Nem_3	193	199	PF02991	0.562
LIG_LIR_Nem_3	206	211	PF02991	0.471
LIG_LIR_Nem_3	383	388	PF02991	0.479
LIG_LIR_Nem_3	567	572	PF02991	0.389
LIG_LIR_Nem_3	60	65	PF02991	0.567
LIG_LIR_Nem_3	67	72	PF02991	0.483
LIG_LYPXL_yS_3	196	199	PF13949	0.399
LIG_PDZ_Class_2	581	586	PF00595	0.454
LIG_Pex14_1	323	327	PF04695	0.523
LIG_Pex14_2	186	190	PF04695	0.566
LIG_Pex14_2	385	389	PF04695	0.492
LIG_REV1ctd_RIR_1	133	143	PF16727	0.603
LIG_SH2_CRK	464	468	PF00017	0.453
LIG_SH2_CRK	471	475	PF00017	0.393
LIG_SH2_GRB2like	247	250	PF00017	0.432
LIG_SH2_NCK_1	289	293	PF00017	0.460
LIG_SH2_NCK_1	464	468	PF00017	0.306
LIG_SH2_PTP2	62	65	PF00017	0.604
LIG_SH2_PTP2	69	72	PF00017	0.502
LIG_SH2_SRC	296	299	PF00017	0.592
LIG_SH2_SRC	69	72	PF00017	0.571
LIG_SH2_STAP1	225	229	PF00017	0.420
LIG_SH2_STAP1	247	251	PF00017	0.501
LIG_SH2_STAP1	578	582	PF00017	0.551
LIG_SH2_STAT5	244	247	PF00017	0.455
LIG_SH2_STAT5	280	283	PF00017	0.375
LIG_SH2_STAT5	321	324	PF00017	0.411
LIG_SH2_STAT5	572	575	PF00017	0.410
LIG_SH2_STAT5	578	581	PF00017	0.411
LIG_SH2_STAT5	62	65	PF00017	0.585
LIG_SH2_STAT5	69	72	PF00017	0.464
LIG_SH3_1	159	165	PF00018	0.489
LIG_SH3_2	162	167	PF14604	0.488
LIG_SH3_3	150	156	PF00018	0.627
LIG_SH3_3	159	165	PF00018	0.548
LIG_SH3_3	360	366	PF00018	0.624
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.515
LIG_SUMO_SIM_par_1	121	126	PF11976	0.472
LIG_SUMO_SIM_par_1	266	272	PF11976	0.421
LIG_SUMO_SIM_par_1	305	310	PF11976	0.424
LIG_SUMO_SIM_par_1	520	526	PF11976	0.402
LIG_TYR_ITIM	469	474	PF00017	0.431
LIG_WRC_WIRS_1	399	404	PF05994	0.457
LIG_WRC_WIRS_1	571	576	PF05994	0.418
MOD_CDK_SPK_2	115	120	PF00069	0.496
MOD_CDK_SPK_2	449	454	PF00069	0.493
MOD_CDK_SPxK_1	161	167	PF00069	0.488
MOD_CDK_SPxxK_3	161	168	PF00069	0.502
MOD_CDK_SPxxK_3	547	554	PF00069	0.477
MOD_CK1_1	340	346	PF00069	0.413
MOD_CK1_1	368	374	PF00069	0.564
MOD_CK1_1	37	43	PF00069	0.572
MOD_CK1_1	4	10	PF00069	0.564
MOD_CK1_1	458	464	PF00069	0.483
MOD_CK1_1	525	531	PF00069	0.423
MOD_CK1_1	550	556	PF00069	0.433
MOD_CK2_1	123	129	PF00069	0.434
MOD_CK2_1	6	12	PF00069	0.462
MOD_GlcNHglycan	235	238	PF01048	0.339
MOD_GlcNHglycan	509	512	PF01048	0.471
MOD_GSK3_1	1	8	PF00069	0.614
MOD_GSK3_1	250	257	PF00069	0.523
MOD_GSK3_1	259	266	PF00069	0.348
MOD_GSK3_1	33	40	PF00069	0.641
MOD_GSK3_1	368	375	PF00069	0.636
MOD_GSK3_1	398	405	PF00069	0.458
MOD_GSK3_1	455	462	PF00069	0.434
MOD_GSK3_1	496	503	PF00069	0.501
MOD_GSK3_1	507	514	PF00069	0.514
MOD_GSK3_1	522	529	PF00069	0.308
MOD_GSK3_1	543	550	PF00069	0.500
MOD_GSK3_1	572	579	PF00069	0.405
MOD_N-GLC_1	349	354	PF02516	0.318
MOD_N-GLC_1	430	435	PF02516	0.362
MOD_N-GLC_2	300	302	PF02516	0.334
MOD_NEK2_1	1	6	PF00069	0.685
MOD_NEK2_1	176	181	PF00069	0.600
MOD_NEK2_1	307	312	PF00069	0.397
MOD_NEK2_1	319	324	PF00069	0.450
MOD_NEK2_1	367	372	PF00069	0.472
MOD_NEK2_1	416	421	PF00069	0.506
MOD_NEK2_1	500	505	PF00069	0.510
MOD_NEK2_1	522	527	PF00069	0.401
MOD_NEK2_1	542	547	PF00069	0.315
MOD_NEK2_2	380	385	PF00069	0.396
MOD_PIKK_1	537	543	PF00454	0.486
MOD_PIKK_1	576	582	PF00454	0.444
MOD_PK_1	337	343	PF00069	0.463
MOD_PK_1	57	63	PF00069	0.487
MOD_PKA_1	57	63	PF00069	0.487
MOD_PKA_2	104	110	PF00069	0.530
MOD_PKA_2	182	188	PF00069	0.474
MOD_PKA_2	255	261	PF00069	0.426
MOD_PKA_2	32	38	PF00069	0.722
MOD_PKB_1	396	404	PF00069	0.593
MOD_Plk_1	372	378	PF00069	0.454
MOD_Plk_1	405	411	PF00069	0.371
MOD_Plk_1	458	464	PF00069	0.409
MOD_Plk_2-3	50	56	PF00069	0.619
MOD_Plk_4	182	188	PF00069	0.445
MOD_Plk_4	337	343	PF00069	0.550
MOD_Plk_4	398	404	PF00069	0.335
MOD_Plk_4	459	465	PF00069	0.384
MOD_Plk_4	496	502	PF00069	0.477
MOD_Plk_4	57	63	PF00069	0.550
MOD_ProDKin_1	115	121	PF00069	0.496
MOD_ProDKin_1	161	167	PF00069	0.599
MOD_ProDKin_1	211	217	PF00069	0.592
MOD_ProDKin_1	283	289	PF00069	0.382
MOD_ProDKin_1	34	40	PF00069	0.545
MOD_ProDKin_1	449	455	PF00069	0.482
MOD_ProDKin_1	547	553	PF00069	0.479
MOD_ProDKin_1	572	578	PF00069	0.430
MOD_SUMO_for_1	336	339	PF00179	0.468
TRG_AP2beta_CARGO_1	132	142	PF09066	0.459
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.481
TRG_ENDOCYTIC_2	196	199	PF00928	0.399
TRG_ENDOCYTIC_2	225	228	PF00928	0.284
TRG_ENDOCYTIC_2	41	44	PF00928	0.481
TRG_ENDOCYTIC_2	471	474	PF00928	0.407
TRG_ENDOCYTIC_2	62	65	PF00928	0.581
TRG_ENDOCYTIC_2	69	72	PF00928	0.507
TRG_ER_diArg_1	141	144	PF00400	0.469
TRG_ER_diArg_1	394	396	PF00400	0.562
TRG_ER_diArg_1	487	489	PF00400	0.500
TRG_ER_diArg_1	90	93	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II93	Leptomonas seymouri	43%	100%
A0A3S7WZW7	Leishmania donovani	80%	100%
A4I292	Leishmania infantum	80%	100%
C9ZRP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AYD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q936	Leishmania major	80%	100%