Putative thimet oligopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thimet oligopeptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HF12_LEIBR

TriTrypDb:

LbrM.26.1590 , LBRM2903_260021500

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF12

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004222	metalloendopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.420
CLV_NRD_NRD_1	73	75	PF00675	0.400
CLV_PCSK_KEX2_1	185	187	PF00082	0.306
CLV_PCSK_KEX2_1	420	422	PF00082	0.325
CLV_PCSK_KEX2_1	73	75	PF00082	0.399
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.306
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.325
CLV_PCSK_SKI1_1	165	169	PF00082	0.316
CLV_PCSK_SKI1_1	206	210	PF00082	0.306
CLV_PCSK_SKI1_1	266	270	PF00082	0.438
CLV_PCSK_SKI1_1	287	291	PF00082	0.306
CLV_PCSK_SKI1_1	382	386	PF00082	0.438
CLV_PCSK_SKI1_1	410	414	PF00082	0.325
CLV_PCSK_SKI1_1	451	455	PF00082	0.292
CLV_PCSK_SKI1_1	466	470	PF00082	0.362
DEG_APCC_DBOX_1	185	193	PF00400	0.306
DEG_APCC_DBOX_1	471	479	PF00400	0.306
DOC_CYCLIN_RxL_1	263	273	PF00134	0.434
DOC_CYCLIN_RxL_1	284	291	PF00134	0.306
DOC_CYCLIN_RxL_1	472	484	PF00134	0.385
DOC_MAPK_gen_1	185	193	PF00069	0.385
DOC_MAPK_gen_1	265	271	PF00069	0.342
DOC_MAPK_gen_1	420	426	PF00069	0.325
DOC_MAPK_gen_1	73	79	PF00069	0.401
DOC_MAPK_MEF2A_6	185	193	PF00069	0.382
DOC_PP1_RVXF_1	474	481	PF00149	0.306
DOC_PP4_FxxP_1	488	491	PF00568	0.325
DOC_USP7_MATH_1	242	246	PF00917	0.438
DOC_USP7_MATH_1	401	405	PF00917	0.438
DOC_USP7_UBL2_3	224	228	PF12436	0.430
DOC_USP7_UBL2_3	462	466	PF12436	0.398
DOC_WW_Pin1_4	2	7	PF00397	0.456
DOC_WW_Pin1_4	207	212	PF00397	0.314
DOC_WW_Pin1_4	244	249	PF00397	0.438
DOC_WW_Pin1_4	362	367	PF00397	0.306
LIG_14-3-3_CanoR_1	33	42	PF00244	0.520
LIG_14-3-3_CanoR_1	410	415	PF00244	0.350
LIG_APCC_ABBA_1	385	390	PF00400	0.325
LIG_BIR_II_1	1	5	PF00653	0.320
LIG_BRCT_BRCA1_1	544	548	PF00533	0.322
LIG_deltaCOP1_diTrp_1	432	436	PF00928	0.306
LIG_EH1_1	399	407	PF00400	0.325
LIG_EH1_1	569	577	PF00400	0.225
LIG_eIF4E_1	331	337	PF01652	0.438
LIG_FHA_1	157	163	PF00498	0.346
LIG_FHA_1	21	27	PF00498	0.426
LIG_FHA_1	211	217	PF00498	0.234
LIG_FHA_1	313	319	PF00498	0.305
LIG_FHA_1	480	486	PF00498	0.358
LIG_FHA_1	500	506	PF00498	0.311
LIG_FHA_1	587	593	PF00498	0.286
LIG_FHA_2	521	527	PF00498	0.325
LIG_IRF3_LxIS_1	198	204	PF10401	0.438
LIG_LIR_Gen_1	146	151	PF02991	0.497
LIG_LIR_Gen_1	197	203	PF02991	0.369
LIG_LIR_Gen_1	291	301	PF02991	0.320
LIG_LIR_Gen_1	392	402	PF02991	0.309
LIG_LIR_Gen_1	422	431	PF02991	0.326
LIG_LIR_Gen_1	81	90	PF02991	0.477
LIG_LIR_LC3C_4	315	320	PF02991	0.225
LIG_LIR_Nem_3	143	147	PF02991	0.404
LIG_LIR_Nem_3	197	201	PF02991	0.348
LIG_LIR_Nem_3	291	296	PF02991	0.383
LIG_LIR_Nem_3	298	304	PF02991	0.438
LIG_LIR_Nem_3	392	398	PF02991	0.309
LIG_LIR_Nem_3	422	426	PF02991	0.326
LIG_LIR_Nem_3	503	509	PF02991	0.386
LIG_LIR_Nem_3	526	532	PF02991	0.306
LIG_LIR_Nem_3	551	556	PF02991	0.306
LIG_LIR_Nem_3	81	87	PF02991	0.426
LIG_PCNA_yPIPBox_3	585	594	PF02747	0.427
LIG_PDZ_Class_2	602	607	PF00595	0.308
LIG_Pex14_1	544	548	PF04695	0.306
LIG_Pex14_2	297	301	PF04695	0.306
LIG_Pex14_2	394	398	PF04695	0.306
LIG_Pex14_2	488	492	PF04695	0.306
LIG_Pex14_2	525	529	PF04695	0.328
LIG_PTB_Apo_2	166	173	PF02174	0.385
LIG_PTB_Phospho_1	166	172	PF10480	0.385
LIG_Rb_pABgroove_1	284	292	PF01858	0.306
LIG_SH2_CRK	147	151	PF00017	0.284
LIG_SH2_CRK	255	259	PF00017	0.438
LIG_SH2_CRK	36	40	PF00017	0.453
LIG_SH2_GRB2like	52	55	PF00017	0.392
LIG_SH2_GRB2like	571	574	PF00017	0.249
LIG_SH2_NCK_1	255	259	PF00017	0.387
LIG_SH2_PTP2	331	334	PF00017	0.438
LIG_SH2_SRC	52	55	PF00017	0.367
LIG_SH2_STAP1	483	487	PF00017	0.306
LIG_SH2_STAT3	483	486	PF00017	0.382
LIG_SH2_STAT5	113	116	PF00017	0.537
LIG_SH2_STAT5	202	205	PF00017	0.389
LIG_SH2_STAT5	279	282	PF00017	0.306
LIG_SH2_STAT5	331	334	PF00017	0.438
LIG_SH2_STAT5	555	558	PF00017	0.361
LIG_SH2_STAT5	571	574	PF00017	0.296
LIG_SH3_3	348	354	PF00018	0.344
LIG_SH3_3	421	427	PF00018	0.306
LIG_SUMO_SIM_par_1	17	23	PF11976	0.425
LIG_SUMO_SIM_par_1	313	322	PF11976	0.381
LIG_SUMO_SIM_par_1	353	359	PF11976	0.385
LIG_TRAF2_1	80	83	PF00917	0.504
LIG_TYR_ITIM	329	334	PF00017	0.438
LIG_UBA3_1	260	266	PF00899	0.350
LIG_UBA3_1	440	449	PF00899	0.306
LIG_WRC_WIRS_1	195	200	PF05994	0.385
LIG_WRC_WIRS_1	21	26	PF05994	0.412
LIG_WRC_WIRS_1	293	298	PF05994	0.382
LIG_WRC_WIRS_1	391	396	PF05994	0.306
LIG_WRC_WIRS_1	411	416	PF05994	0.325
MOD_CDC14_SPxK_1	5	8	PF00782	0.498
MOD_CDK_SPxK_1	2	8	PF00069	0.496
MOD_CK1_1	125	131	PF00069	0.573
MOD_CK1_1	443	449	PF00069	0.346
MOD_CK1_1	96	102	PF00069	0.477
MOD_CK2_1	269	275	PF00069	0.309
MOD_CK2_1	520	526	PF00069	0.325
MOD_GlcNHglycan	127	130	PF01048	0.526
MOD_GlcNHglycan	307	310	PF01048	0.482
MOD_GlcNHglycan	324	327	PF01048	0.422
MOD_GlcNHglycan	36	39	PF01048	0.501
MOD_GlcNHglycan	469	472	PF01048	0.341
MOD_GlcNHglycan	526	529	PF01048	0.414
MOD_GSK3_1	103	110	PF00069	0.457
MOD_GSK3_1	240	247	PF00069	0.306
MOD_GSK3_1	310	317	PF00069	0.442
MOD_GSK3_1	406	413	PF00069	0.311
MOD_GSK3_1	443	450	PF00069	0.360
MOD_GSK3_1	467	474	PF00069	0.364
MOD_GSK3_1	520	527	PF00069	0.438
MOD_N-GLC_1	103	108	PF02516	0.421
MOD_N-GLC_1	269	274	PF02516	0.306
MOD_N-GLC_1	305	310	PF02516	0.355
MOD_N-GLC_1	322	327	PF02516	0.258
MOD_N-GLC_1	500	505	PF02516	0.355
MOD_N-GLC_2	15	17	PF02516	0.341
MOD_NEK2_1	282	287	PF00069	0.332
MOD_NEK2_1	297	302	PF00069	0.306
MOD_NEK2_1	406	411	PF00069	0.320
MOD_NEK2_1	414	419	PF00069	0.318
MOD_NEK2_1	500	505	PF00069	0.355
MOD_NEK2_2	136	141	PF00069	0.463
MOD_NEK2_2	471	476	PF00069	0.325
MOD_PIKK_1	425	431	PF00454	0.306
MOD_PIKK_1	491	497	PF00454	0.496
MOD_PIKK_1	500	506	PF00454	0.423
MOD_PIKK_1	578	584	PF00454	0.434
MOD_PKA_2	471	477	PF00069	0.365
MOD_PKB_1	408	416	PF00069	0.350
MOD_Plk_1	136	142	PF00069	0.460
MOD_Plk_1	282	288	PF00069	0.315
MOD_Plk_1	297	303	PF00069	0.306
MOD_Plk_1	500	506	PF00069	0.350
MOD_Plk_1	59	65	PF00069	0.359
MOD_Plk_4	122	128	PF00069	0.552
MOD_Plk_4	264	270	PF00069	0.438
MOD_Plk_4	292	298	PF00069	0.521
MOD_Plk_4	314	320	PF00069	0.308
MOD_Plk_4	347	353	PF00069	0.372
MOD_Plk_4	390	396	PF00069	0.405
MOD_Plk_4	401	407	PF00069	0.328
MOD_Plk_4	59	65	PF00069	0.359
MOD_Plk_4	96	102	PF00069	0.551
MOD_ProDKin_1	2	8	PF00069	0.461
MOD_ProDKin_1	207	213	PF00069	0.314
MOD_ProDKin_1	244	250	PF00069	0.438
MOD_ProDKin_1	362	368	PF00069	0.306
MOD_SUMO_rev_2	106	110	PF00179	0.478
MOD_SUMO_rev_2	308	318	PF00179	0.480
MOD_SUMO_rev_2	335	344	PF00179	0.229
MOD_SUMO_rev_2	558	567	PF00179	0.438
TRG_ENDOCYTIC_2	113	116	PF00928	0.537
TRG_ENDOCYTIC_2	147	150	PF00928	0.376
TRG_ENDOCYTIC_2	195	198	PF00928	0.398
TRG_ENDOCYTIC_2	279	282	PF00928	0.346
TRG_ENDOCYTIC_2	293	296	PF00928	0.346
TRG_ENDOCYTIC_2	331	334	PF00928	0.419
TRG_ENDOCYTIC_2	36	39	PF00928	0.413
TRG_ENDOCYTIC_2	540	543	PF00928	0.306
TRG_ER_diArg_1	408	411	PF00400	0.350
TRG_ER_diArg_1	556	559	PF00400	0.408
TRG_ER_diArg_1	72	74	PF00400	0.409
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.225
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N6	Leptomonas seymouri	23%	90%
A0A0N1HT30	Leptomonas seymouri	26%	90%
A0A0N1PBM8	Leptomonas seymouri	83%	89%
A0A0N1PDB7	Leptomonas seymouri	26%	90%
A0A0S4JRG5	Bodo saltans	59%	89%
A0A0S4JWM4	Bodo saltans	25%	92%
A0A1X0NTS0	Trypanosomatidae	64%	89%
A0A1X0P0Z5	Trypanosomatidae	23%	88%
A0A3Q8IKU0	Leishmania donovani	25%	90%
A0A3S5H518	Leishmania donovani	26%	90%
A0A3S7WZY5	Leishmania donovani	91%	89%
A0A422MUB5	Trypanosoma rangeli	62%	89%
A0A422P572	Trypanosoma rangeli	23%	89%
A1CTP5	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	76%
A1DMR2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	76%
A2QWM4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	76%
A2VDQ5	Bos taurus	34%	86%
A3LUT4	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	23%	75%
A4HFS7	Leishmania braziliensis	27%	100%
A4HFS8	Leishmania braziliensis	27%	100%
A4HG35	Leishmania braziliensis	26%	90%
A4HG37	Leishmania braziliensis	28%	100%
A4HPW2	Leishmania braziliensis	24%	90%
A4HRR9	Leishmania infantum	25%	90%
A4I291	Leishmania infantum	91%	89%
A4IDM4	Leishmania infantum	25%	90%
A4RF25	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	75%
A5DI46	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	77%
A5E4V6	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	22%	75%
A6H611	Mus musculus	25%	85%
A6SHZ5	Botryotinia fuckeliana (strain B05.10)	25%	80%
A6ZZI7	Saccharomyces cerevisiae (strain YJM789)	27%	79%
A7E7L8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	26%	77%
A7TSL2	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	27%	77%
A8N2T3	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	24%	78%
A8QB25	Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)	26%	75%
B0CRC2	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	25%	79%
B0Y7Q2	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	23%	76%
C9ZRP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	82%
D0A4B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	90%
E9AC74	Leishmania major	25%	100%
E9ACE8	Leishmania major	26%	100%
E9AJN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	90%
E9ATM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	90%
E9AYD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	89%
F4HTQ1	Arabidopsis thaliana	28%	85%
F4KDA5	Arabidopsis thaliana	26%	86%
P0CQ18	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	80%
P0CQ19	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	80%
P0CQ20	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	74%
P0CQ21	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	74%
P24155	Rattus norvegicus	35%	88%
P24171	Escherichia coli (strain K12)	27%	89%
P25375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	85%
P27236	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	89%
P27237	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	29%	89%
P27298	Escherichia coli (strain K12)	30%	89%
P35999	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	79%
P37932	Schizophyllum commune	23%	78%
P42675	Oryctolagus cuniculus	33%	86%
P42676	Rattus norvegicus	34%	86%
P44573	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	89%
P47788	Sus scrofa	35%	88%
P52888	Homo sapiens	34%	88%
Q01992	Rattus norvegicus	25%	85%
Q02038	Sus scrofa	33%	86%
Q0CI79	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	76%
Q0TXL7	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	24%	77%
Q10415	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	80%
Q1E8M9	Coccidioides immitis (strain RS)	24%	76%
Q1JPJ8	Bos taurus	35%	88%
Q2HFL8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	25%	78%
Q2UN31	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	22%	76%
Q4PBS8	Ustilago maydis (strain 521 / FGSC 9021)	24%	68%
Q4Q0W9	Leishmania major	24%	100%
Q4Q937	Leishmania major	90%	100%
Q4WMU9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	76%
Q54DD2	Dictyostelium discoideum	30%	90%
Q59RK9	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	78%
Q5R9V6	Pongo abelii	32%	86%
Q5RF14	Pongo abelii	25%	85%
Q6BJ61	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	76%
Q6CHD6	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	78%
Q6CVF7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	78%
Q6FW88	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	80%
Q6VMB4	Leucoagaricus gongylophorus	25%	80%
Q6Y5M5	Pleurotus djamor	25%	77%
Q6Y5M6	Coprinellus disseminatus	26%	79%
Q6Y5M7	Coprinopsis scobicola	25%	79%
Q753X4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	78%
Q7SDD5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	75%
Q8C1A5	Mus musculus	35%	88%
Q91YP2	Mus musculus	34%	86%
Q949P2	Arabidopsis thaliana	27%	87%
Q94AM1	Arabidopsis thaliana	27%	77%
Q99797	Homo sapiens	26%	85%
Q9BYT8	Homo sapiens	33%	86%
V5B526	Trypanosoma cruzi	22%	89%