Glutaredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaredoxin, putative

Species:

Leishmania braziliensis

UniProt:

A4HF09_LEIBR

TriTrypDb:

LbrM.26.1560 , LBRM2903_260021100

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 21
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0020023	kinetoplast	2	1

Expansion

Sequence features

A4HF09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF09

Function

Biological processes
Term	Name	Level	Count
GO:0001516	prostaglandin biosynthetic process	8	4
GO:0006082	organic acid metabolic process	3	4
GO:0006629	lipid metabolic process	3	4
GO:0006631	fatty acid metabolic process	4	4
GO:0006633	fatty acid biosynthetic process	5	4
GO:0006636	unsaturated fatty acid biosynthetic process	6	4
GO:0006690	icosanoid metabolic process	6	4
GO:0006692	prostanoid metabolic process	6	4
GO:0006693	prostaglandin metabolic process	7	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0016053	organic acid biosynthetic process	4	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0032787	monocarboxylic acid metabolic process	6	4
GO:0033559	unsaturated fatty acid metabolic process	5	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0044281	small molecule metabolic process	2	4
GO:0044283	small molecule biosynthetic process	3	4
GO:0046394	carboxylic acid biosynthetic process	5	4
GO:0046456	icosanoid biosynthetic process	6	4
GO:0046457	prostanoid biosynthetic process	7	4
GO:0071704	organic substance metabolic process	2	4
GO:0072330	monocarboxylic acid biosynthetic process	6	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0015035	protein-disulfide reductase activity	3	18
GO:0015036	disulfide oxidoreductase activity	4	18
GO:0016491	oxidoreductase activity	2	18
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	18
GO:0097573	obsolete glutathione oxidoreductase activity	4	18
GO:0140096	catalytic activity, acting on a protein	2	18
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	5
GO:0016740	transferase activity	2	13
GO:0016853	isomerase activity	2	11
GO:0016860	intramolecular oxidoreductase activity	3	11
GO:0019153	protein-disulfide reductase (glutathione) activity	4	5
GO:0050220	prostaglandin-E synthase activity	4	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0036134	12-hydroxyheptadecatrienoic acid synthase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.325
CLV_C14_Caspase3-7	279	283	PF00656	0.666
CLV_NRD_NRD_1	153	155	PF00675	0.620
CLV_NRD_NRD_1	168	170	PF00675	0.697
CLV_NRD_NRD_1	308	310	PF00675	0.378
CLV_NRD_NRD_1	335	337	PF00675	0.419
CLV_PCSK_KEX2_1	153	155	PF00082	0.612
CLV_PCSK_KEX2_1	335	337	PF00082	0.381
CLV_PCSK_SKI1_1	111	115	PF00082	0.518
CLV_PCSK_SKI1_1	309	313	PF00082	0.376
CLV_PCSK_SKI1_1	56	60	PF00082	0.554
CLV_PCSK_SKI1_1	6	10	PF00082	0.288
CLV_PCSK_SKI1_1	82	86	PF00082	0.701
DEG_Nend_UBRbox_1	1	4	PF02207	0.602
DOC_CDC14_PxL_1	155	163	PF14671	0.308
DOC_CKS1_1	243	248	PF01111	0.325
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.271
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.356
DOC_MAPK_MEF2A_6	154	163	PF00069	0.287
DOC_MAPK_RevD_3	140	154	PF00069	0.432
DOC_PP1_RVXF_1	109	115	PF00149	0.308
DOC_USP7_MATH_1	105	109	PF00917	0.427
DOC_USP7_MATH_1	35	39	PF00917	0.481
DOC_USP7_MATH_1	8	12	PF00917	0.355
DOC_WW_Pin1_4	242	247	PF00397	0.311
DOC_WW_Pin1_4	344	349	PF00397	0.498
DOC_WW_Pin1_4	93	98	PF00397	0.478
LIG_14-3-3_CanoR_1	101	110	PF00244	0.396
LIG_Actin_WH2_2	45	61	PF00022	0.421
LIG_deltaCOP1_diTrp_1	216	222	PF00928	0.362
LIG_FHA_1	10	16	PF00498	0.318
LIG_FHA_1	357	363	PF00498	0.521
LIG_FHA_1	39	45	PF00498	0.508
LIG_FHA_1	390	396	PF00498	0.626
LIG_FHA_2	86	92	PF00498	0.353
LIG_LIR_Apic_2	240	246	PF02991	0.303
LIG_LIR_Gen_1	134	145	PF02991	0.281
LIG_LIR_Gen_1	240	249	PF02991	0.335
LIG_LIR_Gen_1	48	55	PF02991	0.331
LIG_LIR_Gen_1	76	84	PF02991	0.475
LIG_LIR_Nem_3	134	140	PF02991	0.289
LIG_LIR_Nem_3	236	241	PF02991	0.303
LIG_LIR_Nem_3	247	252	PF02991	0.296
LIG_LIR_Nem_3	315	321	PF02991	0.475
LIG_LIR_Nem_3	48	52	PF02991	0.351
LIG_LIR_Nem_3	76	81	PF02991	0.514
LIG_PCNA_PIPBox_1	326	335	PF02747	0.414
LIG_PCNA_yPIPBox_3	326	340	PF02747	0.428
LIG_PDZ_Class_2	392	397	PF00595	0.634
LIG_PTB_Apo_2	228	235	PF02174	0.379
LIG_PTB_Apo_2	248	255	PF02174	0.214
LIG_PTB_Phospho_1	248	254	PF10480	0.230
LIG_SH2_CRK	115	119	PF00017	0.256
LIG_SH2_CRK	241	245	PF00017	0.313
LIG_SH2_CRK	78	82	PF00017	0.371
LIG_SH2_GRB2like	249	252	PF00017	0.333
LIG_SH2_GRB2like	78	81	PF00017	0.361
LIG_SH2_NCK_1	137	141	PF00017	0.269
LIG_SH2_PTP2	243	246	PF00017	0.315
LIG_SH2_SRC	137	140	PF00017	0.319
LIG_SH2_STAP1	202	206	PF00017	0.399
LIG_SH2_STAT5	103	106	PF00017	0.464
LIG_SH2_STAT5	122	125	PF00017	0.238
LIG_SH2_STAT5	162	165	PF00017	0.370
LIG_SH2_STAT5	185	188	PF00017	0.328
LIG_SH2_STAT5	24	27	PF00017	0.436
LIG_SH2_STAT5	241	244	PF00017	0.306
LIG_SH2_STAT5	78	81	PF00017	0.361
LIG_SH3_3	203	209	PF00018	0.232
LIG_TRAF2_1	136	139	PF00917	0.326
LIG_TRAF2_1	320	323	PF00917	0.596
LIG_TRAF2_1	383	386	PF00917	0.466
LIG_TRFH_1	155	159	PF08558	0.299
LIG_TYR_ITIM	113	118	PF00017	0.301
LIG_TYR_ITIM	130	135	PF00017	0.242
LIG_WRC_WIRS_1	329	334	PF05994	0.538
MOD_CK1_1	11	17	PF00069	0.463
MOD_CK1_1	171	177	PF00069	0.545
MOD_CK1_1	194	200	PF00069	0.329
MOD_CK1_1	263	269	PF00069	0.392
MOD_CK1_1	285	291	PF00069	0.690
MOD_CK1_1	305	311	PF00069	0.625
MOD_CK1_1	38	44	PF00069	0.485
MOD_CK1_1	89	95	PF00069	0.545
MOD_CK2_1	37	43	PF00069	0.385
MOD_CK2_1	85	91	PF00069	0.520
MOD_GlcNHglycan	188	191	PF01048	0.545
MOD_GlcNHglycan	196	199	PF01048	0.552
MOD_GlcNHglycan	211	214	PF01048	0.594
MOD_GlcNHglycan	258	261	PF01048	0.334
MOD_GlcNHglycan	284	287	PF01048	0.452
MOD_GlcNHglycan	293	296	PF01048	0.482
MOD_GlcNHglycan	43	47	PF01048	0.536
MOD_GSK3_1	101	108	PF00069	0.344
MOD_GSK3_1	223	230	PF00069	0.292
MOD_GSK3_1	256	263	PF00069	0.386
MOD_GSK3_1	285	292	PF00069	0.675
MOD_GSK3_1	34	41	PF00069	0.483
MOD_GSK3_1	387	394	PF00069	0.667
MOD_GSK3_1	82	89	PF00069	0.525
MOD_LATS_1	365	371	PF00433	0.555
MOD_N-GLC_1	171	176	PF02516	0.682
MOD_N-GLC_1	230	235	PF02516	0.505
MOD_NEK2_1	227	232	PF00069	0.290
MOD_NEK2_1	312	317	PF00069	0.570
MOD_PIKK_1	191	197	PF00454	0.321
MOD_PIKK_1	285	291	PF00454	0.717
MOD_PIKK_1	83	89	PF00454	0.511
MOD_PK_1	367	373	PF00069	0.551
MOD_PKA_2	168	174	PF00069	0.518
MOD_PKA_2	26	32	PF00069	0.419
MOD_PKA_2	76	82	PF00069	0.445
MOD_Plk_1	230	236	PF00069	0.288
MOD_Plk_4	239	245	PF00069	0.333
MOD_Plk_4	260	266	PF00069	0.386
MOD_Plk_4	328	334	PF00069	0.535
MOD_Plk_4	367	373	PF00069	0.583
MOD_Plk_4	391	397	PF00069	0.548
MOD_ProDKin_1	242	248	PF00069	0.313
MOD_ProDKin_1	344	350	PF00069	0.493
MOD_ProDKin_1	93	99	PF00069	0.478
MOD_SUMO_for_1	124	127	PF00179	0.271
MOD_SUMO_rev_2	106	113	PF00179	0.395
TRG_DiLeu_BaEn_2	327	333	PF01217	0.510
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.290
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.492
TRG_ENDOCYTIC_2	115	118	PF00928	0.257
TRG_ENDOCYTIC_2	132	135	PF00928	0.279
TRG_ENDOCYTIC_2	137	140	PF00928	0.277
TRG_ENDOCYTIC_2	241	244	PF00928	0.304
TRG_ENDOCYTIC_2	249	252	PF00928	0.334
TRG_ENDOCYTIC_2	78	81	PF00928	0.491
TRG_ER_diArg_1	153	155	PF00400	0.420
TRG_ER_diArg_1	270	273	PF00400	0.478
TRG_ER_diArg_1	335	337	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.217
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.219
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS46	Leptomonas seymouri	26%	100%
A0A0N1ILY8	Leptomonas seymouri	60%	100%
A0A0S4IXT4	Bodo saltans	23%	100%
A0A0S4JV60	Bodo saltans	32%	100%
A0A1X0NND6	Trypanosomatidae	28%	100%
A0A1X0NTT0	Trypanosomatidae	39%	100%
A0A3S7WT83	Leishmania donovani	27%	100%
A0A3S7WZV5	Leishmania donovani	84%	100%
A0A422MZ79	Trypanosoma rangeli	41%	100%
A0A422N3R5	Trypanosoma rangeli	26%	100%
A4H7W8	Leishmania braziliensis	28%	100%
A4HW95	Leishmania infantum	27%	100%
A4I288	Leishmania infantum	84%	100%
C9ZRQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
C9ZSR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9APZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AYD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q940	Leishmania major	83%	100%
Q4QFI5	Leishmania major	27%	100%
V5AYZ4	Trypanosoma cruzi	40%	100%
V5DC17	Trypanosoma cruzi	26%	100%