RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HF08_LEIBR

TriTrypDb:

LbrM.26.1550 , LBRM2903_260021000

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HF08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF08

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	121	125	PF00082	0.314
CLV_PCSK_SKI1_1	169	173	PF00082	0.314
DEG_Nend_UBRbox_2	1	3	PF02207	0.664
DOC_CKS1_1	69	74	PF01111	0.498
DOC_CYCLIN_RxL_1	118	125	PF00134	0.514
DOC_MAPK_gen_1	142	151	PF00069	0.514
DOC_WW_Pin1_4	181	186	PF00397	0.618
DOC_WW_Pin1_4	68	73	PF00397	0.498
LIG_14-3-3_CanoR_1	121	130	PF00244	0.525
LIG_BRCT_BRCA1_1	217	221	PF00533	0.445
LIG_FHA_1	202	208	PF00498	0.615
LIG_FHA_2	151	157	PF00498	0.546
LIG_LIR_Nem_3	125	130	PF02991	0.543
LIG_LIR_Nem_3	78	82	PF02991	0.565
LIG_PAM2_1	6	18	PF00658	0.658
LIG_PCNA_yPIPBox_3	56	70	PF02747	0.513
LIG_SH2_CRK	168	172	PF00017	0.514
LIG_SH2_CRK	79	83	PF00017	0.564
LIG_SH2_SRC	77	80	PF00017	0.481
LIG_SH3_3	11	17	PF00018	0.661
LIG_SH3_3	200	206	PF00018	0.654
LIG_SH3_3	91	97	PF00018	0.523
LIG_TRAF2_1	153	156	PF00917	0.514
MOD_CK1_1	140	146	PF00069	0.487
MOD_CK1_1	201	207	PF00069	0.624
MOD_CK2_1	150	156	PF00069	0.514
MOD_CK2_1	191	197	PF00069	0.616
MOD_GlcNHglycan	124	127	PF01048	0.348
MOD_GlcNHglycan	193	196	PF01048	0.625
MOD_GlcNHglycan	44	47	PF01048	0.605
MOD_GlcNHglycan	48	51	PF01048	0.755
MOD_GlcNHglycan	8	11	PF01048	0.680
MOD_GSK3_1	156	163	PF00069	0.493
MOD_GSK3_1	181	188	PF00069	0.622
MOD_GSK3_1	31	38	PF00069	0.699
MOD_GSK3_1	42	49	PF00069	0.589
MOD_LATS_1	29	35	PF00433	0.680
MOD_N-GLC_1	140	145	PF02516	0.314
MOD_N-GLC_1	185	190	PF02516	0.575
MOD_N-GLC_1	6	11	PF02516	0.647
MOD_N-GLC_1	62	67	PF02516	0.650
MOD_NEK2_1	85	90	PF00069	0.549
MOD_NEK2_1	99	104	PF00069	0.603
MOD_NEK2_2	160	165	PF00069	0.514
MOD_PIKK_1	18	24	PF00454	0.647
MOD_PIKK_1	212	218	PF00454	0.668
MOD_PIKK_1	35	41	PF00454	0.788
MOD_PKB_1	167	175	PF00069	0.514
MOD_ProDKin_1	181	187	PF00069	0.624
MOD_ProDKin_1	68	74	PF00069	0.500
TRG_ENDOCYTIC_2	127	130	PF00928	0.548
TRG_ENDOCYTIC_2	168	171	PF00928	0.489
TRG_ENDOCYTIC_2	79	82	PF00928	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I044	Leptomonas seymouri	68%	96%
A0A3Q8IC83	Leishmania donovani	87%	100%
A4I287	Leishmania infantum	86%	100%
E9AYD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q6X2	Leishmania major	32%	100%
Q4Q941	Leishmania major	87%	99%