AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HF07_LEIBR

TriTrypDb:

LbrM.26.1540 , LBRM2903_260020900

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HF07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF07

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	301	303	PF00082	0.207
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.207
CLV_PCSK_SKI1_1	14	18	PF00082	0.555
CLV_PCSK_SKI1_1	324	328	PF00082	0.402
CLV_PCSK_SKI1_1	389	393	PF00082	0.495
DOC_ANK_TNKS_1	135	142	PF00023	0.432
DOC_CKS1_1	9	14	PF01111	0.521
DOC_CYCLIN_RxL_1	66	77	PF00134	0.322
DOC_CYCLIN_yClb5_NLxxxL_5	256	265	PF00134	0.189
DOC_MAPK_gen_1	22	29	PF00069	0.447
DOC_MAPK_MEF2A_6	195	202	PF00069	0.357
DOC_MAPK_MEF2A_6	22	29	PF00069	0.247
DOC_PP2B_LxvP_1	200	203	PF13499	0.386
DOC_PP2B_LxvP_1	293	296	PF13499	0.416
DOC_PP4_FxxP_1	378	381	PF00568	0.309
DOC_USP7_MATH_1	119	123	PF00917	0.459
DOC_USP7_MATH_1	178	182	PF00917	0.317
DOC_USP7_MATH_1	187	191	PF00917	0.203
DOC_USP7_MATH_1	41	45	PF00917	0.401
DOC_USP7_UBL2_3	389	393	PF12436	0.266
DOC_WW_Pin1_4	176	181	PF00397	0.395
DOC_WW_Pin1_4	342	347	PF00397	0.337
DOC_WW_Pin1_4	8	13	PF00397	0.504
DOC_WW_Pin1_4	83	88	PF00397	0.278
LIG_14-3-3_CanoR_1	156	162	PF00244	0.370
LIG_14-3-3_CanoR_1	254	263	PF00244	0.444
LIG_14-3-3_CanoR_1	272	278	PF00244	0.438
LIG_Actin_WH2_2	221	239	PF00022	0.398
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_Clathr_ClatBox_1	197	201	PF01394	0.381
LIG_EVH1_2	25	29	PF00568	0.332
LIG_FHA_1	148	154	PF00498	0.368
LIG_FHA_1	209	215	PF00498	0.375
LIG_FHA_1	256	262	PF00498	0.344
LIG_FHA_1	332	338	PF00498	0.398
LIG_FHA_1	382	388	PF00498	0.376
LIG_FHA_1	89	95	PF00498	0.290
LIG_GBD_Chelix_1	97	105	PF00786	0.386
LIG_LIR_Gen_1	44	53	PF02991	0.376
LIG_LIR_Gen_1	70	80	PF02991	0.189
LIG_LIR_Nem_3	146	152	PF02991	0.360
LIG_LIR_Nem_3	70	76	PF02991	0.189
LIG_MYND_3	281	285	PF01753	0.309
LIG_OCRL_FandH_1	28	40	PF00620	0.219
LIG_PCNA_TLS_4	151	158	PF02747	0.189
LIG_PTB_Apo_2	347	354	PF02174	0.189
LIG_PTB_Phospho_1	347	353	PF10480	0.189
LIG_SH2_STAP1	360	364	PF00017	0.436
LIG_SH2_STAT5	104	107	PF00017	0.371
LIG_SH2_STAT5	152	155	PF00017	0.386
LIG_SH2_STAT5	157	160	PF00017	0.386
LIG_SH2_STAT5	377	380	PF00017	0.450
LIG_SH3_2	267	272	PF14604	0.411
LIG_SH3_3	129	135	PF00018	0.319
LIG_SH3_3	264	270	PF00018	0.405
LIG_SH3_3	6	12	PF00018	0.478
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.415
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.426
LIG_SUMO_SIM_par_1	196	201	PF11976	0.338
LIG_SUMO_SIM_par_1	217	223	PF11976	0.386
LIG_SUMO_SIM_par_1	74	79	PF11976	0.189
LIG_TRAF2_1	238	241	PF00917	0.344
LIG_UBA3_1	218	226	PF00899	0.432
LIG_WRC_WIRS_1	158	163	PF05994	0.189
LIG_WRC_WIRS_1	42	47	PF05994	0.309
MOD_CDC14_SPxK_1	179	182	PF00782	0.189
MOD_CDK_SPxK_1	176	182	PF00069	0.347
MOD_CDK_SPxK_1	8	14	PF00069	0.512
MOD_CK1_1	114	120	PF00069	0.309
MOD_CK1_1	122	128	PF00069	0.246
MOD_CK1_1	143	149	PF00069	0.379
MOD_CK1_1	208	214	PF00069	0.408
MOD_CK1_1	287	293	PF00069	0.405
MOD_CK1_1	331	337	PF00069	0.356
MOD_CK1_1	86	92	PF00069	0.345
MOD_CK2_1	187	193	PF00069	0.189
MOD_CK2_1	235	241	PF00069	0.329
MOD_GlcNHglycan	116	119	PF01048	0.381
MOD_GlcNHglycan	121	124	PF01048	0.390
MOD_GlcNHglycan	185	188	PF01048	0.499
MOD_GlcNHglycan	237	240	PF01048	0.326
MOD_GlcNHglycan	289	292	PF01048	0.400
MOD_GlcNHglycan	38	41	PF01048	0.402
MOD_GSK3_1	143	150	PF00069	0.376
MOD_GSK3_1	178	185	PF00069	0.368
MOD_GSK3_1	208	215	PF00069	0.313
MOD_GSK3_1	231	238	PF00069	0.355
MOD_GSK3_1	60	67	PF00069	0.317
MOD_N-GLC_1	182	187	PF02516	0.320
MOD_NEK2_1	170	175	PF00069	0.327
MOD_NEK2_1	256	261	PF00069	0.327
MOD_NEK2_1	284	289	PF00069	0.373
MOD_NEK2_1	36	41	PF00069	0.338
MOD_PK_1	365	371	PF00069	0.457
MOD_PKA_2	114	120	PF00069	0.309
MOD_Plk_1	284	290	PF00069	0.398
MOD_Plk_1	99	105	PF00069	0.371
MOD_Plk_4	295	301	PF00069	0.412
MOD_Plk_4	336	342	PF00069	0.285
MOD_Plk_4	41	47	PF00069	0.394
MOD_ProDKin_1	176	182	PF00069	0.378
MOD_ProDKin_1	342	348	PF00069	0.337
MOD_ProDKin_1	8	14	PF00069	0.512
MOD_ProDKin_1	83	89	PF00069	0.278
MOD_SUMO_for_1	162	165	PF00179	0.189
MOD_SUMO_rev_2	190	197	PF00179	0.195
TRG_DiLeu_BaEn_1	193	198	PF01217	0.179
TRG_DiLeu_BaEn_1	383	388	PF01217	0.350
TRG_ENDOCYTIC_2	353	356	PF00928	0.389
TRG_ER_diArg_1	134	137	PF00400	0.327
TRG_ER_diArg_1	251	254	PF00400	0.361
TRG_ER_diArg_1	322	325	PF00400	0.259
TRG_NES_CRM1_1	220	231	PF08389	0.345
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.189

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8L5	Leptomonas seymouri	25%	99%
A0A0N1I6V6	Leptomonas seymouri	56%	100%
A0A0S4J886	Bodo saltans	22%	96%
A0A1X0NNK2	Trypanosomatidae	25%	100%
A0A1X0NS30	Trypanosomatidae	34%	100%
A0A3Q8I9M0	Leishmania donovani	25%	99%
A0A3Q8IDU3	Leishmania donovani	79%	99%
A0A3R7LZE9	Trypanosoma rangeli	25%	100%
A4H7A0	Leishmania braziliensis	25%	100%
A4HVP2	Leishmania infantum	25%	99%
A4I286	Leishmania infantum	79%	99%
C9ZRQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A6K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9APD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	99%
E9AYD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4Q942	Leishmania major	81%	100%
Q4QG40	Leishmania major	25%	94%
V5ARR6	Trypanosoma cruzi	25%	93%