Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HF04_LEIBR

TriTrypDb:

LbrM.26.1510 , LBRM2903_260020300

Length:

653

Annotations

LeishMANIAdb annotations

PhoD domain containing alkaline phosphatase. Based on distant Eukaryotic orthologs, an N-terminal signal peptide is likely.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 9
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HF04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.580
CLV_C14_Caspase3-7	558	562	PF00656	0.343
CLV_NRD_NRD_1	193	195	PF00675	0.539
CLV_NRD_NRD_1	23	25	PF00675	0.504
CLV_NRD_NRD_1	265	267	PF00675	0.556
CLV_NRD_NRD_1	276	278	PF00675	0.545
CLV_NRD_NRD_1	394	396	PF00675	0.602
CLV_NRD_NRD_1	418	420	PF00675	0.600
CLV_NRD_NRD_1	430	432	PF00675	0.603
CLV_NRD_NRD_1	591	593	PF00675	0.662
CLV_PCSK_KEX2_1	193	195	PF00082	0.539
CLV_PCSK_KEX2_1	265	267	PF00082	0.556
CLV_PCSK_KEX2_1	394	396	PF00082	0.644
CLV_PCSK_KEX2_1	418	420	PF00082	0.600
CLV_PCSK_KEX2_1	430	432	PF00082	0.603
CLV_PCSK_KEX2_1	475	477	PF00082	0.624
CLV_PCSK_KEX2_1	590	592	PF00082	0.619
CLV_PCSK_KEX2_1	62	64	PF00082	0.734
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.623
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.619
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.573
CLV_PCSK_SKI1_1	146	150	PF00082	0.603
CLV_PCSK_SKI1_1	209	213	PF00082	0.738
CLV_PCSK_SKI1_1	365	369	PF00082	0.508
CLV_PCSK_SKI1_1	377	381	PF00082	0.484
CLV_PCSK_SKI1_1	476	480	PF00082	0.661
DEG_APCC_DBOX_1	193	201	PF00400	0.382
DEG_APCC_DBOX_1	23	31	PF00400	0.419
DEG_APCC_DBOX_1	362	370	PF00400	0.302
DEG_APCC_DBOX_1	430	438	PF00400	0.357
DOC_CYCLIN_RxL_1	473	484	PF00134	0.352
DOC_MAPK_gen_1	363	370	PF00069	0.312
DOC_MAPK_gen_1	430	437	PF00069	0.362
DOC_MAPK_gen_1	519	526	PF00069	0.338
DOC_MAPK_MEF2A_6	108	117	PF00069	0.305
DOC_MAPK_MEF2A_6	363	370	PF00069	0.318
DOC_MAPK_MEF2A_6	519	526	PF00069	0.308
DOC_MAPK_MEF2A_6	531	539	PF00069	0.382
DOC_MAPK_MEF2A_6	613	622	PF00069	0.363
DOC_MAPK_NFAT4_5	363	371	PF00069	0.320
DOC_USP7_MATH_1	135	139	PF00917	0.350
DOC_USP7_MATH_1	182	186	PF00917	0.351
DOC_USP7_MATH_1	361	365	PF00917	0.301
DOC_USP7_MATH_1	509	513	PF00917	0.408
DOC_USP7_MATH_1	550	554	PF00917	0.551
DOC_USP7_UBL2_3	560	564	PF12436	0.347
DOC_USP7_UBL2_3	58	62	PF12436	0.407
DOC_WW_Pin1_4	213	218	PF00397	0.483
DOC_WW_Pin1_4	229	234	PF00397	0.387
DOC_WW_Pin1_4	321	326	PF00397	0.444
DOC_WW_Pin1_4	338	343	PF00397	0.350
DOC_WW_Pin1_4	579	584	PF00397	0.394
LIG_14-3-3_CanoR_1	24	34	PF00244	0.543
LIG_14-3-3_CanoR_1	250	256	PF00244	0.434
LIG_14-3-3_CanoR_1	312	318	PF00244	0.312
LIG_14-3-3_CanoR_1	418	422	PF00244	0.396
LIG_14-3-3_CanoR_1	482	487	PF00244	0.431
LIG_14-3-3_CanoR_1	521	527	PF00244	0.369
LIG_14-3-3_CanoR_1	63	72	PF00244	0.435
LIG_14-3-3_CanoR_1	79	87	PF00244	0.418
LIG_Actin_WH2_2	164	182	PF00022	0.238
LIG_BIR_III_4	210	214	PF00653	0.413
LIG_BIR_III_4	327	331	PF00653	0.357
LIG_BRCT_BRCA1_1	31	35	PF00533	0.309
LIG_CaM_NSCaTE_8	87	94	PF13499	0.308
LIG_Clathr_ClatBox_1	536	540	PF01394	0.394
LIG_CtBP_PxDLS_1	256	260	PF00389	0.376
LIG_deltaCOP1_diTrp_1	304	314	PF00928	0.284
LIG_FHA_1	109	115	PF00498	0.329
LIG_FHA_1	242	248	PF00498	0.341
LIG_FHA_1	405	411	PF00498	0.471
LIG_FHA_1	441	447	PF00498	0.391
LIG_FHA_1	454	460	PF00498	0.511
LIG_FHA_1	490	496	PF00498	0.378
LIG_FHA_1	518	524	PF00498	0.373
LIG_FHA_1	63	69	PF00498	0.440
LIG_FHA_2	278	284	PF00498	0.447
LIG_FHA_2	314	320	PF00498	0.240
LIG_FHA_2	399	405	PF00498	0.543
LIG_FHA_2	407	413	PF00498	0.584
LIG_FHA_2	443	449	PF00498	0.420
LIG_FHA_2	482	488	PF00498	0.367
LIG_GBD_Chelix_1	451	459	PF00786	0.604
LIG_LIR_Apic_2	316	320	PF02991	0.325
LIG_LIR_Gen_1	304	315	PF02991	0.340
LIG_LIR_Gen_1	341	347	PF02991	0.361
LIG_LIR_Gen_1	376	385	PF02991	0.399
LIG_LIR_Gen_1	567	577	PF02991	0.487
LIG_LIR_Nem_3	142	148	PF02991	0.361
LIG_LIR_Nem_3	222	226	PF02991	0.336
LIG_LIR_Nem_3	304	310	PF02991	0.298
LIG_LIR_Nem_3	311	317	PF02991	0.316
LIG_LIR_Nem_3	341	346	PF02991	0.320
LIG_LIR_Nem_3	354	359	PF02991	0.316
LIG_LIR_Nem_3	376	381	PF02991	0.393
LIG_LIR_Nem_3	487	493	PF02991	0.339
LIG_LIR_Nem_3	567	572	PF02991	0.467
LIG_LIR_Nem_3	585	589	PF02991	0.292
LIG_LYPXL_yS_3	586	589	PF13949	0.385
LIG_NRBOX	365	371	PF00104	0.318
LIG_PTB_Apo_2	116	123	PF02174	0.350
LIG_PTB_Apo_2	148	155	PF02174	0.288
LIG_PTB_Phospho_1	116	122	PF10480	0.350
LIG_PTB_Phospho_1	148	154	PF10480	0.285
LIG_SH2_CRK	145	149	PF00017	0.386
LIG_SH2_CRK	569	573	PF00017	0.302
LIG_SH2_CRK	580	584	PF00017	0.309
LIG_SH2_NCK_1	122	126	PF00017	0.340
LIG_SH2_NCK_1	580	584	PF00017	0.371
LIG_SH2_SRC	122	125	PF00017	0.297
LIG_SH2_SRC	317	320	PF00017	0.245
LIG_SH2_STAT3	633	636	PF00017	0.434
LIG_SH2_STAT5	196	199	PF00017	0.366
LIG_SH2_STAT5	317	320	PF00017	0.388
LIG_SH3_1	15	21	PF00018	0.582
LIG_SH3_3	131	137	PF00018	0.377
LIG_SH3_3	15	21	PF00018	0.660
LIG_SH3_3	319	325	PF00018	0.270
LIG_SH3_3	569	575	PF00018	0.358
LIG_SH3_4	58	65	PF00018	0.375
LIG_Sin3_3	616	623	PF02671	0.287
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.360
LIG_SUMO_SIM_par_1	2	7	PF11976	0.576
LIG_SUMO_SIM_par_1	204	210	PF11976	0.454
LIG_SUMO_SIM_par_1	243	248	PF11976	0.321
LIG_SUMO_SIM_par_1	432	440	PF11976	0.370
LIG_SUMO_SIM_par_1	522	528	PF11976	0.292
LIG_SUMO_SIM_par_1	535	540	PF11976	0.364
LIG_TRAF2_1	512	515	PF00917	0.447
LIG_TRAF2_1	553	556	PF00917	0.538
LIG_TRAF2_1	642	645	PF00917	0.535
LIG_TYR_ITIM	632	637	PF00017	0.518
LIG_UBA3_1	366	372	PF00899	0.352
LIG_WRC_WIRS_1	220	225	PF05994	0.386
MOD_CK1_1	241	247	PF00069	0.385
MOD_CK1_1	29	35	PF00069	0.283
MOD_CK1_1	429	435	PF00069	0.511
MOD_CK1_1	440	446	PF00069	0.423
MOD_CK1_1	481	487	PF00069	0.350
MOD_CK1_1	507	513	PF00069	0.642
MOD_CK2_1	313	319	PF00069	0.259
MOD_CK2_1	393	399	PF00069	0.429
MOD_CK2_1	442	448	PF00069	0.466
MOD_CK2_1	459	465	PF00069	0.628
MOD_CK2_1	481	487	PF00069	0.552
MOD_CK2_1	509	515	PF00069	0.655
MOD_CK2_1	550	556	PF00069	0.689
MOD_Cter_Amidation	275	278	PF01082	0.419
MOD_Cter_Amidation	60	63	PF01082	0.480
MOD_GlcNHglycan	381	384	PF01048	0.299
MOD_GlcNHglycan	439	442	PF01048	0.412
MOD_GlcNHglycan	470	473	PF01048	0.458
MOD_GlcNHglycan	506	509	PF01048	0.572
MOD_GSK3_1	104	111	PF00069	0.492
MOD_GSK3_1	182	189	PF00069	0.521
MOD_GSK3_1	209	216	PF00069	0.504
MOD_GSK3_1	25	32	PF00069	0.473
MOD_GSK3_1	334	341	PF00069	0.334
MOD_GSK3_1	394	401	PF00069	0.572
MOD_GSK3_1	404	411	PF00069	0.644
MOD_GSK3_1	436	443	PF00069	0.375
MOD_GSK3_1	478	485	PF00069	0.552
MOD_GSK3_1	53	60	PF00069	0.604
MOD_GSK3_1	535	542	PF00069	0.370
MOD_GSK3_1	78	85	PF00069	0.516
MOD_GSK3_1	87	94	PF00069	0.403
MOD_LATS_1	275	281	PF00433	0.406
MOD_N-GLC_1	104	109	PF02516	0.497
MOD_N-GLC_1	645	650	PF02516	0.485
MOD_NEK2_1	238	243	PF00069	0.440
MOD_NEK2_1	310	315	PF00069	0.431
MOD_NEK2_1	393	398	PF00069	0.528
MOD_NEK2_1	4	9	PF00069	0.595
MOD_NEK2_1	410	415	PF00069	0.640
MOD_NEK2_1	43	48	PF00069	0.274
MOD_NEK2_1	442	447	PF00069	0.438
MOD_NEK2_1	459	464	PF00069	0.564
MOD_NEK2_1	478	483	PF00069	0.458
MOD_NEK2_1	517	522	PF00069	0.421
MOD_NEK2_1	539	544	PF00069	0.288
MOD_PIKK_1	248	254	PF00454	0.501
MOD_PKA_1	277	283	PF00069	0.388
MOD_PKA_1	394	400	PF00069	0.481
MOD_PKA_1	62	68	PF00069	0.379
MOD_PKA_2	135	141	PF00069	0.411
MOD_PKA_2	393	399	PF00069	0.517
MOD_PKA_2	417	423	PF00069	0.485
MOD_PKA_2	429	435	PF00069	0.449
MOD_PKA_2	481	487	PF00069	0.550
MOD_PKA_2	62	68	PF00069	0.511
MOD_PKA_2	78	84	PF00069	0.549
MOD_Plk_1	278	284	PF00069	0.377
MOD_Plk_1	310	316	PF00069	0.496
MOD_Plk_1	539	545	PF00069	0.460
MOD_Plk_1	82	88	PF00069	0.455
MOD_Plk_4	29	35	PF00069	0.401
MOD_Plk_4	313	319	PF00069	0.370
MOD_Plk_4	334	340	PF00069	0.295
MOD_Plk_4	410	416	PF00069	0.545
MOD_Plk_4	43	49	PF00069	0.364
MOD_Plk_4	82	88	PF00069	0.405
MOD_ProDKin_1	213	219	PF00069	0.600
MOD_ProDKin_1	229	235	PF00069	0.471
MOD_ProDKin_1	321	327	PF00069	0.550
MOD_ProDKin_1	338	344	PF00069	0.427
MOD_ProDKin_1	579	585	PF00069	0.489
MOD_SUMO_rev_2	138	148	PF00179	0.495
MOD_SUMO_rev_2	462	471	PF00179	0.504
MOD_SUMO_rev_2	552	562	PF00179	0.433
TRG_DiLeu_BaEn_2	375	381	PF01217	0.425
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.437
TRG_ENDOCYTIC_2	122	125	PF00928	0.393
TRG_ENDOCYTIC_2	145	148	PF00928	0.414
TRG_ENDOCYTIC_2	154	157	PF00928	0.376
TRG_ENDOCYTIC_2	569	572	PF00928	0.362
TRG_ENDOCYTIC_2	586	589	PF00928	0.663
TRG_ENDOCYTIC_2	634	637	PF00928	0.541
TRG_ER_diArg_1	192	194	PF00400	0.428
TRG_ER_diArg_1	264	266	PF00400	0.467
TRG_ER_diArg_1	363	366	PF00400	0.413
TRG_ER_diArg_1	393	395	PF00400	0.535
TRG_ER_diArg_1	519	522	PF00400	0.449
TRG_ER_diArg_1	591	593	PF00400	0.581
TRG_ER_diLys_1	649	653	PF00400	0.537
TRG_NLS_MonoExtC_3	589	595	PF00514	0.450
TRG_NLS_MonoExtN_4	587	594	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M6	Leptomonas seymouri	58%	100%
A0A0S4JKY7	Bodo saltans	27%	100%
A0A1X0P7Z9	Trypanosomatidae	25%	100%
A0A3S5H7G3	Leishmania donovani	77%	100%
A0A3S7WV71	Leishmania donovani	24%	79%
A4H9L0	Leishmania braziliensis	25%	79%
A4HXX7	Leishmania infantum	24%	79%
A4I283	Leishmania infantum	77%	100%
C9ZZS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AYC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q945	Leishmania major	77%	100%
Q4QDT9	Leishmania major	24%	84%
V5B6M4	Trypanosoma cruzi	26%	100%