Conserved oligomeric Golgi complex subunit 7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HF03_LEIBR

TriTrypDb:

LbrM.26.1500 , LBRM2903_260020200

Length:

999

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	7
GO:0016020	membrane	2	7
GO:0017119	Golgi transport complex	3	7
GO:0031090	organelle membrane	3	7
GO:0032991	protein-containing complex	1	7
GO:0098588	bounding membrane of organelle	4	7
GO:0099023	vesicle tethering complex	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HF03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF03

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006886	intracellular protein transport	4	7
GO:0008104	protein localization	4	7
GO:0009987	cellular process	1	7
GO:0015031	protein transport	4	7
GO:0033036	macromolecule localization	2	7
GO:0045184	establishment of protein localization	3	7
GO:0046907	intracellular transport	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	7
GO:0070727	cellular macromolecule localization	3	7
GO:0071702	organic substance transport	4	7
GO:0071705	nitrogen compound transport	4	7
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	570	574	PF00656	0.402
CLV_NRD_NRD_1	118	120	PF00675	0.614
CLV_NRD_NRD_1	203	205	PF00675	0.427
CLV_NRD_NRD_1	419	421	PF00675	0.472
CLV_NRD_NRD_1	661	663	PF00675	0.331
CLV_NRD_NRD_1	698	700	PF00675	0.511
CLV_NRD_NRD_1	743	745	PF00675	0.347
CLV_PCSK_KEX2_1	166	168	PF00082	0.385
CLV_PCSK_KEX2_1	215	217	PF00082	0.503
CLV_PCSK_KEX2_1	352	354	PF00082	0.357
CLV_PCSK_KEX2_1	419	421	PF00082	0.472
CLV_PCSK_KEX2_1	661	663	PF00082	0.331
CLV_PCSK_KEX2_1	697	699	PF00082	0.507
CLV_PCSK_KEX2_1	70	72	PF00082	0.491
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.385
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.437
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.388
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.471
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.491
CLV_PCSK_SKI1_1	167	171	PF00082	0.453
CLV_PCSK_SKI1_1	290	294	PF00082	0.506
CLV_PCSK_SKI1_1	336	340	PF00082	0.405
CLV_PCSK_SKI1_1	580	584	PF00082	0.391
CLV_PCSK_SKI1_1	628	632	PF00082	0.501
CLV_PCSK_SKI1_1	673	677	PF00082	0.353
CLV_PCSK_SKI1_1	756	760	PF00082	0.491
CLV_PCSK_SKI1_1	764	768	PF00082	0.468
CLV_Separin_Metazoa	393	397	PF03568	0.410
DEG_APCC_DBOX_1	285	293	PF00400	0.420
DEG_APCC_DBOX_1	763	771	PF00400	0.478
DEG_APCC_KENBOX_2	224	228	PF00400	0.321
DEG_SCF_FBW7_1	18	25	PF00400	0.535
DEG_SPOP_SBC_1	22	26	PF00917	0.534
DEG_SPOP_SBC_1	6	10	PF00917	0.503
DOC_CYCLIN_RxL_1	117	126	PF00134	0.588
DOC_CYCLIN_RxL_1	196	207	PF00134	0.372
DOC_CYCLIN_RxL_1	406	416	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	505	511	PF00134	0.294
DOC_MAPK_DCC_7	890	898	PF00069	0.319
DOC_MAPK_gen_1	157	165	PF00069	0.458
DOC_MAPK_gen_1	890	898	PF00069	0.461
DOC_MAPK_HePTP_8	501	513	PF00069	0.296
DOC_MAPK_MEF2A_6	504	513	PF00069	0.300
DOC_MAPK_MEF2A_6	890	898	PF00069	0.400
DOC_PP1_RVXF_1	407	414	PF00149	0.422
DOC_PP2B_LxvP_1	14	17	PF13499	0.530
DOC_PP2B_LxvP_1	33	36	PF13499	0.664
DOC_PP2B_LxvP_1	903	906	PF13499	0.486
DOC_USP7_MATH_1	100	104	PF00917	0.662
DOC_USP7_MATH_1	107	111	PF00917	0.564
DOC_USP7_MATH_1	118	122	PF00917	0.450
DOC_USP7_MATH_1	191	195	PF00917	0.433
DOC_USP7_MATH_1	206	210	PF00917	0.601
DOC_USP7_MATH_1	259	263	PF00917	0.602
DOC_USP7_MATH_1	372	376	PF00917	0.431
DOC_USP7_MATH_1	381	385	PF00917	0.505
DOC_USP7_MATH_1	405	409	PF00917	0.437
DOC_USP7_MATH_1	42	46	PF00917	0.660
DOC_USP7_MATH_1	454	458	PF00917	0.598
DOC_USP7_MATH_1	465	469	PF00917	0.644
DOC_USP7_MATH_1	543	547	PF00917	0.464
DOC_USP7_MATH_1	680	684	PF00917	0.533
DOC_USP7_MATH_1	707	711	PF00917	0.479
DOC_USP7_MATH_1	750	754	PF00917	0.417
DOC_USP7_MATH_1	786	790	PF00917	0.585
DOC_USP7_MATH_1	811	815	PF00917	0.468
DOC_USP7_MATH_1	913	917	PF00917	0.552
DOC_USP7_MATH_1	991	995	PF00917	0.521
DOC_WW_Pin1_4	18	23	PF00397	0.642
DOC_WW_Pin1_4	266	271	PF00397	0.608
DOC_WW_Pin1_4	426	431	PF00397	0.570
DOC_WW_Pin1_4	455	460	PF00397	0.676
DOC_WW_Pin1_4	545	550	PF00397	0.516
DOC_WW_Pin1_4	555	560	PF00397	0.657
DOC_WW_Pin1_4	564	569	PF00397	0.587
DOC_WW_Pin1_4	606	611	PF00397	0.307
DOC_WW_Pin1_4	96	101	PF00397	0.583
DOC_WW_Pin1_4	965	970	PF00397	0.371
LIG_14-3-3_CanoR_1	119	123	PF00244	0.455
LIG_14-3-3_CanoR_1	135	143	PF00244	0.469
LIG_14-3-3_CanoR_1	157	165	PF00244	0.458
LIG_14-3-3_CanoR_1	167	175	PF00244	0.452
LIG_14-3-3_CanoR_1	204	211	PF00244	0.507
LIG_14-3-3_CanoR_1	336	342	PF00244	0.404
LIG_14-3-3_CanoR_1	419	423	PF00244	0.490
LIG_14-3-3_CanoR_1	490	498	PF00244	0.316
LIG_14-3-3_CanoR_1	50	55	PF00244	0.511
LIG_14-3-3_CanoR_1	661	671	PF00244	0.385
LIG_14-3-3_CanoR_1	723	731	PF00244	0.407
LIG_14-3-3_CanoR_1	764	773	PF00244	0.336
LIG_14-3-3_CanoR_1	919	926	PF00244	0.591
LIG_Actin_WH2_2	274	292	PF00022	0.506
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BIR_III_3	1	5	PF00653	0.528
LIG_BIR_III_4	297	301	PF00653	0.380
LIG_BRCT_BRCA1_1	540	544	PF00533	0.360
LIG_FHA_1	107	113	PF00498	0.607
LIG_FHA_1	160	166	PF00498	0.461
LIG_FHA_1	174	180	PF00498	0.450
LIG_FHA_1	22	28	PF00498	0.591
LIG_FHA_1	426	432	PF00498	0.502
LIG_FHA_1	490	496	PF00498	0.328
LIG_FHA_1	516	522	PF00498	0.484
LIG_FHA_1	639	645	PF00498	0.468
LIG_FHA_1	715	721	PF00498	0.572
LIG_FHA_1	761	767	PF00498	0.410
LIG_FHA_1	927	933	PF00498	0.428
LIG_FHA_1	934	940	PF00498	0.445
LIG_FHA_2	143	149	PF00498	0.515
LIG_FHA_2	159	165	PF00498	0.442
LIG_FHA_2	283	289	PF00498	0.483
LIG_FHA_2	291	297	PF00498	0.482
LIG_FHA_2	419	425	PF00498	0.501
LIG_FHA_2	522	528	PF00498	0.410
LIG_FHA_2	568	574	PF00498	0.496
LIG_FHA_2	629	635	PF00498	0.600
LIG_FHA_2	7	13	PF00498	0.524
LIG_FHA_2	717	723	PF00498	0.525
LIG_FHA_2	766	772	PF00498	0.334
LIG_FHA_2	928	934	PF00498	0.521
LIG_FHA_2	935	941	PF00498	0.387
LIG_FHA_2	983	989	PF00498	0.494
LIG_GBD_Chelix_1	323	331	PF00786	0.462
LIG_LIR_Gen_1	771	777	PF02991	0.420
LIG_LIR_Nem_3	308	313	PF02991	0.486
LIG_LIR_Nem_3	737	743	PF02991	0.401
LIG_LIR_Nem_3	771	776	PF02991	0.412
LIG_MAD2	892	900	PF02301	0.461
LIG_NRBOX	127	133	PF00104	0.544
LIG_PCNA_yPIPBox_3	70	81	PF02747	0.474
LIG_PCNA_yPIPBox_3	701	715	PF02747	0.446
LIG_Pex14_2	590	594	PF04695	0.370
LIG_PTB_Apo_2	227	234	PF02174	0.394
LIG_PTB_Phospho_1	227	233	PF10480	0.394
LIG_Rb_LxCxE_1	174	196	PF01857	0.379
LIG_SH2_CRK	773	777	PF00017	0.424
LIG_SH2_SRC	313	316	PF00017	0.473
LIG_SH2_STAP1	603	607	PF00017	0.381
LIG_SH2_STAP1	928	932	PF00017	0.415
LIG_SH2_STAT3	303	306	PF00017	0.422
LIG_SH2_STAT3	354	357	PF00017	0.386
LIG_SH2_STAT5	197	200	PF00017	0.454
LIG_SH2_STAT5	217	220	PF00017	0.308
LIG_SH2_STAT5	233	236	PF00017	0.359
LIG_SH2_STAT5	313	316	PF00017	0.408
LIG_SH2_STAT5	773	776	PF00017	0.618
LIG_SH2_STAT5	806	809	PF00017	0.590
LIG_SH2_STAT5	928	931	PF00017	0.399
LIG_SH2_STAT5	941	944	PF00017	0.426
LIG_SH3_3	153	159	PF00018	0.482
LIG_SH3_3	182	188	PF00018	0.446
LIG_SH3_3	25	31	PF00018	0.706
LIG_SH3_3	604	610	PF00018	0.391
LIG_SH3_3	650	656	PF00018	0.404
LIG_SH3_3	736	742	PF00018	0.449
LIG_SUMO_SIM_anti_2	496	502	PF11976	0.364
LIG_SUMO_SIM_par_1	826	833	PF11976	0.473
LIG_TRAF2_1	10	13	PF00917	0.538
LIG_TRAF2_1	317	320	PF00917	0.402
LIG_TRAF2_1	421	424	PF00917	0.499
LIG_TRAF2_1	484	487	PF00917	0.475
LIG_TRAF2_1	647	650	PF00917	0.391
LIG_TRAF2_1	920	923	PF00917	0.434
LIG_TRAF2_1	994	997	PF00917	0.522
LIG_UBA3_1	497	504	PF00899	0.287
LIG_UBA3_1	689	697	PF00899	0.528
LIG_WRC_WIRS_1	885	890	PF05994	0.441
MOD_CDC14_SPxK_1	429	432	PF00782	0.607
MOD_CDC14_SPxK_1	558	561	PF00782	0.546
MOD_CDK_SPxK_1	426	432	PF00069	0.578
MOD_CDK_SPxK_1	555	561	PF00069	0.550
MOD_CDK_SPxxK_3	266	273	PF00069	0.486
MOD_CK1_1	103	109	PF00069	0.724
MOD_CK1_1	262	268	PF00069	0.777
MOD_CK1_1	34	40	PF00069	0.658
MOD_CK1_1	425	431	PF00069	0.550
MOD_CK1_1	457	463	PF00069	0.617
MOD_CK1_1	489	495	PF00069	0.370
MOD_CK1_1	624	630	PF00069	0.514
MOD_CK1_1	639	645	PF00069	0.428
MOD_CK1_1	682	688	PF00069	0.484
MOD_CK1_1	716	722	PF00069	0.470
MOD_CK1_1	760	766	PF00069	0.336
MOD_CK1_1	789	795	PF00069	0.665
MOD_CK1_1	918	924	PF00069	0.647
MOD_CK1_1	953	959	PF00069	0.432
MOD_CK1_1	96	102	PF00069	0.627
MOD_CK2_1	142	148	PF00069	0.516
MOD_CK2_1	158	164	PF00069	0.450
MOD_CK2_1	418	424	PF00069	0.485
MOD_CK2_1	6	12	PF00069	0.512
MOD_CK2_1	606	612	PF00069	0.310
MOD_CK2_1	628	634	PF00069	0.637
MOD_CK2_1	716	722	PF00069	0.470
MOD_CK2_1	765	771	PF00069	0.335
MOD_CK2_1	927	933	PF00069	0.413
MOD_CK2_1	991	997	PF00069	0.621
MOD_DYRK1A_RPxSP_1	606	610	PF00069	0.311
MOD_GlcNHglycan	105	108	PF01048	0.716
MOD_GlcNHglycan	109	112	PF01048	0.787
MOD_GlcNHglycan	116	119	PF01048	0.665
MOD_GlcNHglycan	248	251	PF01048	0.733
MOD_GlcNHglycan	36	39	PF01048	0.593
MOD_GlcNHglycan	375	378	PF01048	0.522
MOD_GlcNHglycan	384	387	PF01048	0.432
MOD_GlcNHglycan	438	441	PF01048	0.634
MOD_GlcNHglycan	459	462	PF01048	0.610
MOD_GlcNHglycan	465	468	PF01048	0.605
MOD_GlcNHglycan	477	480	PF01048	0.587
MOD_GlcNHglycan	532	535	PF01048	0.404
MOD_GlcNHglycan	540	543	PF01048	0.381
MOD_GlcNHglycan	623	626	PF01048	0.538
MOD_GlcNHglycan	726	729	PF01048	0.495
MOD_GlcNHglycan	789	792	PF01048	0.607
MOD_GlcNHglycan	814	817	PF01048	0.457
MOD_GlcNHglycan	836	839	PF01048	0.569
MOD_GlcNHglycan	850	853	PF01048	0.520
MOD_GlcNHglycan	946	949	PF01048	0.454
MOD_GlcNHglycan	95	98	PF01048	0.584
MOD_GlcNHglycan	988	992	PF01048	0.597
MOD_GlcNHglycan	993	996	PF01048	0.573
MOD_GSK3_1	107	114	PF00069	0.629
MOD_GSK3_1	137	144	PF00069	0.498
MOD_GSK3_1	18	25	PF00069	0.701
MOD_GSK3_1	262	269	PF00069	0.600
MOD_GSK3_1	332	339	PF00069	0.396
MOD_GSK3_1	34	41	PF00069	0.668
MOD_GSK3_1	418	425	PF00069	0.400
MOD_GSK3_1	426	433	PF00069	0.630
MOD_GSK3_1	551	558	PF00069	0.620
MOD_GSK3_1	563	570	PF00069	0.555
MOD_GSK3_1	617	624	PF00069	0.471
MOD_GSK3_1	638	645	PF00069	0.524
MOD_GSK3_1	657	664	PF00069	0.431
MOD_GSK3_1	669	676	PF00069	0.495
MOD_GSK3_1	678	685	PF00069	0.478
MOD_GSK3_1	730	737	PF00069	0.400
MOD_GSK3_1	765	772	PF00069	0.458
MOD_GSK3_1	782	789	PF00069	0.646
MOD_GSK3_1	830	837	PF00069	0.416
MOD_GSK3_1	854	861	PF00069	0.467
MOD_GSK3_1	914	921	PF00069	0.491
MOD_GSK3_1	96	103	PF00069	0.718
MOD_GSK3_1	982	989	PF00069	0.546
MOD_LATS_1	133	139	PF00433	0.474
MOD_N-GLC_1	246	251	PF02516	0.630
MOD_N-GLC_1	259	264	PF02516	0.669
MOD_N-GLC_1	521	526	PF02516	0.363
MOD_N-GLC_1	73	78	PF02516	0.499
MOD_NEK2_1	112	117	PF00069	0.490
MOD_NEK2_1	150	155	PF00069	0.469
MOD_NEK2_1	337	342	PF00069	0.397
MOD_NEK2_1	413	418	PF00069	0.427
MOD_NEK2_1	422	427	PF00069	0.464
MOD_NEK2_1	509	514	PF00069	0.357
MOD_NEK2_1	521	526	PF00069	0.372
MOD_NEK2_1	544	549	PF00069	0.549
MOD_NEK2_1	73	78	PF00069	0.395
MOD_NEK2_1	834	839	PF00069	0.465
MOD_NEK2_1	926	931	PF00069	0.362
MOD_NEK2_1	987	992	PF00069	0.519
MOD_NEK2_2	118	123	PF00069	0.457
MOD_PIKK_1	137	143	PF00454	0.467
MOD_PIKK_1	422	428	PF00454	0.532
MOD_PIKK_1	489	495	PF00454	0.339
MOD_PIKK_1	642	648	PF00454	0.312
MOD_PIKK_1	673	679	PF00454	0.475
MOD_PIKK_1	682	688	PF00454	0.472
MOD_PIKK_1	804	810	PF00454	0.587
MOD_PIKK_1	904	910	PF00454	0.634
MOD_PKA_1	204	210	PF00069	0.385
MOD_PKA_1	661	667	PF00069	0.319
MOD_PKA_2	118	124	PF00069	0.492
MOD_PKA_2	159	165	PF00069	0.458
MOD_PKA_2	237	243	PF00069	0.557
MOD_PKA_2	282	288	PF00069	0.395
MOD_PKA_2	332	338	PF00069	0.394
MOD_PKA_2	418	424	PF00069	0.485
MOD_PKA_2	489	495	PF00069	0.339
MOD_PKA_2	661	667	PF00069	0.396
MOD_PKA_2	918	924	PF00069	0.530
MOD_PKA_2	982	988	PF00069	0.439
MOD_PKB_1	721	729	PF00069	0.403
MOD_Plk_1	290	296	PF00069	0.514
MOD_Plk_1	636	642	PF00069	0.464
MOD_Plk_1	73	79	PF00069	0.395
MOD_Plk_1	950	956	PF00069	0.508
MOD_Plk_2-3	858	864	PF00069	0.425
MOD_Plk_4	151	157	PF00069	0.477
MOD_Plk_4	193	199	PF00069	0.439
MOD_Plk_4	337	343	PF00069	0.529
MOD_Plk_4	50	56	PF00069	0.512
MOD_Plk_4	639	645	PF00069	0.468
MOD_Plk_4	876	882	PF00069	0.369
MOD_Plk_4	884	890	PF00069	0.403
MOD_ProDKin_1	18	24	PF00069	0.644
MOD_ProDKin_1	266	272	PF00069	0.595
MOD_ProDKin_1	426	432	PF00069	0.578
MOD_ProDKin_1	455	461	PF00069	0.677
MOD_ProDKin_1	545	551	PF00069	0.522
MOD_ProDKin_1	555	561	PF00069	0.658
MOD_ProDKin_1	564	570	PF00069	0.578
MOD_ProDKin_1	606	612	PF00069	0.311
MOD_ProDKin_1	96	102	PF00069	0.582
MOD_ProDKin_1	965	971	PF00069	0.377
MOD_SUMO_rev_2	207	211	PF00179	0.450
MOD_SUMO_rev_2	287	292	PF00179	0.485
TRG_ENDOCYTIC_2	506	509	PF00928	0.430
TRG_ENDOCYTIC_2	773	776	PF00928	0.411
TRG_ER_diArg_1	418	420	PF00400	0.465
TRG_ER_diArg_1	698	701	PF00400	0.430
TRG_NES_CRM1_1	819	832	PF08389	0.348
TRG_NLS_MonoExtC_3	696	701	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	701	705	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	729	734	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	745	749	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	866	870	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B9	Leptomonas seymouri	50%	98%
A0A3Q8IP82	Leishmania donovani	75%	98%
A4I282	Leishmania infantum	75%	98%
E9AYC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
Q4Q946	Leishmania major	74%	100%