Protein farnesyltransferase subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

farnesyltransferase beta subunit

Species:

Leishmania braziliensis

UniProt:

A4HF02_LEIBR

TriTrypDb:

LbrM.26.1490 , LBRM2903_260020100

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005965	protein farnesyltransferase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

A4HF02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF02

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0018342	protein prenylation	4	12
GO:0018343	protein farnesylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0097354	prenylation	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004659	prenyltransferase activity	4	12
GO:0004660	protein farnesyltransferase activity	4	12
GO:0005488	binding	1	12
GO:0008318	protein prenyltransferase activity	3	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008270	zinc ion binding	6	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.466
CLV_C14_Caspase3-7	336	340	PF00656	0.323
CLV_C14_Caspase3-7	55	59	PF00656	0.645
CLV_C14_Caspase3-7	558	562	PF00656	0.545
CLV_NRD_NRD_1	13	15	PF00675	0.326
CLV_NRD_NRD_1	330	332	PF00675	0.490
CLV_NRD_NRD_1	397	399	PF00675	0.256
CLV_NRD_NRD_1	594	596	PF00675	0.233
CLV_PCSK_KEX2_1	280	282	PF00082	0.247
CLV_PCSK_KEX2_1	330	332	PF00082	0.490
CLV_PCSK_KEX2_1	397	399	PF00082	0.249
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.242
CLV_PCSK_PC7_1	276	282	PF00082	0.281
CLV_PCSK_SKI1_1	281	285	PF00082	0.242
CLV_PCSK_SKI1_1	442	446	PF00082	0.643
CLV_PCSK_SKI1_1	481	485	PF00082	0.418
CLV_PCSK_SKI1_1	579	583	PF00082	0.635
CLV_Separin_Metazoa	528	532	PF03568	0.423
DEG_Nend_UBRbox_3	1	3	PF02207	0.565
DEG_SPOP_SBC_1	178	182	PF00917	0.388
DEG_SPOP_SBC_1	50	54	PF00917	0.607
DEG_SPOP_SBC_1	75	79	PF00917	0.553
DOC_CKS1_1	448	453	PF01111	0.481
DOC_CYCLIN_RxL_1	276	285	PF00134	0.360
DOC_MAPK_gen_1	14	21	PF00069	0.313
DOC_MAPK_gen_1	280	286	PF00069	0.442
DOC_MAPK_gen_1	476	486	PF00069	0.545
DOC_MAPK_gen_1	94	103	PF00069	0.514
DOC_MAPK_MEF2A_6	338	345	PF00069	0.476
DOC_USP7_MATH_1	177	181	PF00917	0.562
DOC_USP7_MATH_1	207	211	PF00917	0.508
DOC_USP7_MATH_1	365	369	PF00917	0.547
DOC_USP7_MATH_1	50	54	PF00917	0.607
DOC_USP7_MATH_1	554	558	PF00917	0.608
DOC_USP7_MATH_1	669	673	PF00917	0.553
DOC_USP7_MATH_1	695	699	PF00917	0.484
DOC_USP7_MATH_1	73	77	PF00917	0.581
DOC_USP7_UBL2_3	179	183	PF12436	0.398
DOC_WW_Pin1_4	144	149	PF00397	0.416
DOC_WW_Pin1_4	447	452	PF00397	0.505
DOC_WW_Pin1_4	469	474	PF00397	0.570
DOC_WW_Pin1_4	53	58	PF00397	0.679
DOC_WW_Pin1_4	652	657	PF00397	0.617
LIG_14-3-3_CanoR_1	14	21	PF00244	0.498
LIG_14-3-3_CanoR_1	200	205	PF00244	0.497
LIG_14-3-3_CanoR_1	281	287	PF00244	0.490
LIG_14-3-3_CanoR_1	304	308	PF00244	0.431
LIG_14-3-3_CanoR_1	642	650	PF00244	0.552
LIG_14-3-3_CanoR_1	714	722	PF00244	0.435
LIG_14-3-3_CanoR_1	72	82	PF00244	0.496
LIG_Actin_WH2_2	516	533	PF00022	0.564
LIG_AP2alpha_2	86	88	PF02296	0.396
LIG_BRCT_BRCA1_1	214	218	PF00533	0.474
LIG_Clathr_ClatBox_1	18	22	PF01394	0.532
LIG_Clathr_ClatBox_1	315	319	PF01394	0.383
LIG_deltaCOP1_diTrp_1	574	582	PF00928	0.526
LIG_deltaCOP1_diTrp_1	91	95	PF00928	0.317
LIG_FHA_1	14	20	PF00498	0.490
LIG_FHA_1	191	197	PF00498	0.775
LIG_FHA_1	199	205	PF00498	0.762
LIG_FHA_1	222	228	PF00498	0.522
LIG_FHA_1	311	317	PF00498	0.362
LIG_FHA_1	413	419	PF00498	0.470
LIG_FHA_1	702	708	PF00498	0.402
LIG_FHA_2	364	370	PF00498	0.535
LIG_FHA_2	464	470	PF00498	0.653
LIG_FHA_2	512	518	PF00498	0.607
LIG_FHA_2	61	67	PF00498	0.626
LIG_FHA_2	617	623	PF00498	0.535
LIG_FHA_2	81	87	PF00498	0.492
LIG_GBD_Chelix_1	152	160	PF00786	0.388
LIG_Integrin_isoDGR_2	412	414	PF01839	0.231
LIG_LIR_Gen_1	441	451	PF02991	0.555
LIG_LIR_Gen_1	541	552	PF02991	0.622
LIG_LIR_Nem_3	121	127	PF02991	0.400
LIG_LIR_Nem_3	215	221	PF02991	0.472
LIG_LIR_Nem_3	441	447	PF02991	0.529
LIG_LIR_Nem_3	541	547	PF02991	0.617
LIG_LIR_Nem_3	680	686	PF02991	0.407
LIG_LIR_Nem_3	91	95	PF02991	0.483
LIG_NRBOX	378	384	PF00104	0.474
LIG_PCNA_yPIPBox_3	376	386	PF02747	0.456
LIG_PCNA_yPIPBox_3	393	403	PF02747	0.331
LIG_PCNA_yPIPBox_3	594	603	PF02747	0.498
LIG_PDZ_Class_1	723	728	PF00595	0.468
LIG_Pex14_2	88	92	PF04695	0.370
LIG_PTB_Apo_2	702	709	PF02174	0.286
LIG_RPA_C_Fungi	709	721	PF08784	0.476
LIG_SH2_CRK	653	657	PF00017	0.396
LIG_SH2_CRK	683	687	PF00017	0.382
LIG_SH2_GRB2like	591	594	PF00017	0.325
LIG_SH2_NCK_1	584	588	PF00017	0.611
LIG_SH2_NCK_1	653	657	PF00017	0.396
LIG_SH2_SRC	265	268	PF00017	0.428
LIG_SH2_SRC	584	587	PF00017	0.615
LIG_SH2_SRC	666	669	PF00017	0.525
LIG_SH2_STAP1	423	427	PF00017	0.270
LIG_SH2_STAP1	440	444	PF00017	0.497
LIG_SH2_STAP1	544	548	PF00017	0.628
LIG_SH2_STAT3	591	594	PF00017	0.325
LIG_SH2_STAT5	23	26	PF00017	0.510
LIG_SH2_STAT5	307	310	PF00017	0.296
LIG_SH2_STAT5	374	377	PF00017	0.266
LIG_SH2_STAT5	440	443	PF00017	0.601
LIG_SH2_STAT5	512	515	PF00017	0.494
LIG_SH2_STAT5	591	594	PF00017	0.280
LIG_SH2_STAT5	600	603	PF00017	0.249
LIG_SH2_STAT5	653	656	PF00017	0.511
LIG_SH2_STAT5	657	660	PF00017	0.471
LIG_SH2_STAT5	666	669	PF00017	0.439
LIG_SH3_3	117	123	PF00018	0.500
LIG_SH3_3	228	234	PF00018	0.653
LIG_SH3_3	445	451	PF00018	0.459
LIG_SUMO_SIM_anti_2	134	140	PF11976	0.265
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.419
LIG_SUMO_SIM_anti_2	482	487	PF11976	0.508
LIG_SUMO_SIM_par_1	134	140	PF11976	0.316
LIG_SUMO_SIM_par_1	16	22	PF11976	0.503
LIG_SUMO_SIM_par_1	341	347	PF11976	0.396
LIG_SUMO_SIM_par_1	482	487	PF11976	0.520
LIG_SUMO_SIM_par_1	685	693	PF11976	0.455
LIG_TYR_ITIM	125	130	PF00017	0.356
LIG_UBA3_1	382	386	PF00899	0.360
MOD_CDK_SPxxK_3	469	476	PF00069	0.543
MOD_CK1_1	158	164	PF00069	0.354
MOD_CK1_1	199	205	PF00069	0.737
MOD_CK1_1	421	427	PF00069	0.281
MOD_CK1_1	46	52	PF00069	0.712
MOD_CK1_1	471	477	PF00069	0.692
MOD_CK1_1	53	59	PF00069	0.720
MOD_CK1_1	631	637	PF00069	0.266
MOD_CK1_1	674	680	PF00069	0.665
MOD_CK1_1	690	696	PF00069	0.371
MOD_CK1_1	74	80	PF00069	0.708
MOD_CK2_1	134	140	PF00069	0.353
MOD_CK2_1	179	185	PF00069	0.685
MOD_CK2_1	260	266	PF00069	0.231
MOD_CK2_1	363	369	PF00069	0.411
MOD_CK2_1	449	455	PF00069	0.682
MOD_CK2_1	674	680	PF00069	0.728
MOD_Cter_Amidation	328	331	PF01082	0.470
MOD_Cter_Amidation	534	537	PF01082	0.506
MOD_GlcNHglycan	115	118	PF01048	0.443
MOD_GlcNHglycan	149	152	PF01048	0.555
MOD_GlcNHglycan	214	217	PF01048	0.580
MOD_GlcNHglycan	363	366	PF01048	0.373
MOD_GlcNHglycan	451	454	PF01048	0.789
MOD_GlcNHglycan	48	51	PF01048	0.637
MOD_GlcNHglycan	499	502	PF01048	0.561
MOD_GlcNHglycan	531	534	PF01048	0.604
MOD_GlcNHglycan	630	633	PF01048	0.266
MOD_GlcNHglycan	692	695	PF01048	0.459
MOD_GlcNHglycan	716	719	PF01048	0.441
MOD_GlcNHglycan	722	725	PF01048	0.511
MOD_GlcNHglycan	73	76	PF01048	0.785
MOD_GlcNHglycan	78	81	PF01048	0.706
MOD_GSK3_1	158	165	PF00069	0.430
MOD_GSK3_1	192	199	PF00069	0.704
MOD_GSK3_1	207	214	PF00069	0.595
MOD_GSK3_1	359	366	PF00069	0.391
MOD_GSK3_1	438	445	PF00069	0.505
MOD_GSK3_1	46	53	PF00069	0.699
MOD_GSK3_1	468	475	PF00069	0.497
MOD_GSK3_1	670	677	PF00069	0.719
MOD_GSK3_1	71	78	PF00069	0.735
MOD_GSK3_1	710	717	PF00069	0.436
MOD_NEK2_1	155	160	PF00069	0.414
MOD_NEK2_1	196	201	PF00069	0.632
MOD_NEK2_1	24	29	PF00069	0.470
MOD_NEK2_1	361	366	PF00069	0.302
MOD_NEK2_1	418	423	PF00069	0.291
MOD_NEK2_1	547	552	PF00069	0.705
MOD_NEK2_1	662	667	PF00069	0.542
MOD_NEK2_1	687	692	PF00069	0.483
MOD_NEK2_1	701	706	PF00069	0.426
MOD_NEK2_2	282	287	PF00069	0.300
MOD_NEK2_2	623	628	PF00069	0.325
MOD_OFUCOSY	159	166	PF10250	0.394
MOD_PIKK_1	372	378	PF00454	0.281
MOD_PIKK_1	547	553	PF00454	0.480
MOD_PK_1	200	206	PF00069	0.691
MOD_PKA_2	13	19	PF00069	0.498
MOD_PKA_2	199	205	PF00069	0.588
MOD_PKA_2	24	30	PF00069	0.524
MOD_PKA_2	303	309	PF00069	0.266
MOD_PKA_2	555	561	PF00069	0.511
MOD_PKA_2	60	66	PF00069	0.519
MOD_PKA_2	669	675	PF00069	0.622
MOD_PKA_2	71	77	PF00069	0.518
MOD_Plk_1	43	49	PF00069	0.448
MOD_Plk_1	670	676	PF00069	0.731
MOD_Plk_1	679	685	PF00069	0.564
MOD_Plk_2-3	134	140	PF00069	0.265
MOD_Plk_2-3	320	326	PF00069	0.586
MOD_Plk_2-3	463	469	PF00069	0.519
MOD_Plk_4	134	140	PF00069	0.265
MOD_Plk_4	200	206	PF00069	0.674
MOD_Plk_4	214	220	PF00069	0.571
MOD_Plk_4	260	266	PF00069	0.385
MOD_Plk_4	311	317	PF00069	0.303
MOD_Plk_4	421	427	PF00069	0.294
MOD_Plk_4	695	701	PF00069	0.568
MOD_ProDKin_1	144	150	PF00069	0.418
MOD_ProDKin_1	447	453	PF00069	0.509
MOD_ProDKin_1	469	475	PF00069	0.567
MOD_ProDKin_1	53	59	PF00069	0.679
MOD_ProDKin_1	652	658	PF00069	0.614
MOD_SUMO_rev_2	180	190	PF00179	0.506
MOD_SUMO_rev_2	487	497	PF00179	0.537
MOD_SUMO_rev_2	528	538	PF00179	0.559
TRG_DiLeu_BaEn_1	609	614	PF01217	0.300
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.530
TRG_ENDOCYTIC_2	127	130	PF00928	0.320
TRG_ENDOCYTIC_2	544	547	PF00928	0.642
TRG_ENDOCYTIC_2	584	587	PF00928	0.615
TRG_ENDOCYTIC_2	683	686	PF00928	0.383
TRG_ER_diArg_1	396	398	PF00400	0.300
TRG_ER_diArg_1	478	481	PF00400	0.562
TRG_ER_diArg_1	576	579	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	546	551	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	595	599	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA19	Leptomonas seymouri	56%	100%
A0A0S4KLG2	Bodo saltans	35%	100%
A0A1X0NSS5	Trypanosomatidae	39%	100%
A0A3S7WZW4	Leishmania donovani	81%	100%
A0A422NJ04	Trypanosoma rangeli	38%	100%
A4I281	Leishmania infantum	81%	100%
C9ZRR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AYC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q8WR00	Leishmania major	79%	99%
V5DA92	Trypanosoma cruzi	41%	100%