Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HF01_LEIBR

TriTrypDb:

LbrM.26.1480 , LBRM2903_260020000

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HF01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HF01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.426
CLV_NRD_NRD_1	420	422	PF00675	0.420
CLV_NRD_NRD_1	48	50	PF00675	0.706
CLV_NRD_NRD_1	92	94	PF00675	0.614
CLV_PCSK_FUR_1	46	50	PF00082	0.697
CLV_PCSK_KEX2_1	176	178	PF00082	0.426
CLV_PCSK_KEX2_1	419	421	PF00082	0.424
CLV_PCSK_KEX2_1	48	50	PF00082	0.697
CLV_PCSK_KEX2_1	505	507	PF00082	0.455
CLV_PCSK_KEX2_1	91	93	PF00082	0.616
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.455
CLV_PCSK_SKI1_1	128	132	PF00082	0.240
CLV_PCSK_SKI1_1	186	190	PF00082	0.240
CLV_PCSK_SKI1_1	20	24	PF00082	0.624
DEG_APCC_DBOX_1	19	27	PF00400	0.368
DEG_SPOP_SBC_1	200	204	PF00917	0.240
DEG_SPOP_SBC_1	327	331	PF00917	0.332
DOC_CKS1_1	426	431	PF01111	0.638
DOC_CYCLIN_RxL_1	125	132	PF00134	0.228
DOC_CYCLIN_RxL_1	91	104	PF00134	0.420
DOC_MAPK_gen_1	113	121	PF00069	0.425
DOC_MAPK_gen_1	176	184	PF00069	0.599
DOC_MAPK_gen_1	91	101	PF00069	0.418
DOC_MAPK_HePTP_8	183	195	PF00069	0.428
DOC_MAPK_MEF2A_6	186	195	PF00069	0.240
DOC_PP1_RVXF_1	126	132	PF00149	0.228
DOC_PP1_RVXF_1	95	102	PF00149	0.420
DOC_PP2B_LxvP_1	197	200	PF13499	0.240
DOC_PP2B_LxvP_1	70	73	PF13499	0.400
DOC_USP7_MATH_1	200	204	PF00917	0.240
DOC_USP7_MATH_1	222	226	PF00917	0.362
DOC_USP7_MATH_1	273	277	PF00917	0.361
DOC_USP7_MATH_1	29	33	PF00917	0.370
DOC_USP7_MATH_1	71	75	PF00917	0.400
DOC_WW_Pin1_4	103	108	PF00397	0.469
DOC_WW_Pin1_4	120	125	PF00397	0.390
DOC_WW_Pin1_4	233	238	PF00397	0.462
DOC_WW_Pin1_4	425	430	PF00397	0.714
DOC_WW_Pin1_4	457	462	PF00397	0.786
DOC_WW_Pin1_4	475	480	PF00397	0.653
LIG_14-3-3_CanoR_1	128	137	PF00244	0.314
LIG_14-3-3_CanoR_1	238	246	PF00244	0.326
LIG_14-3-3_CanoR_1	311	316	PF00244	0.367
LIG_14-3-3_CanoR_1	396	401	PF00244	0.624
LIG_14-3-3_CanoR_1	452	458	PF00244	0.643
LIG_14-3-3_CanoR_1	97	102	PF00244	0.422
LIG_BRCT_BRCA1_1	184	188	PF00533	0.534
LIG_BRCT_BRCA1_1	241	245	PF00533	0.342
LIG_BRCT_BRCA1_1	97	101	PF00533	0.422
LIG_FHA_1	222	228	PF00498	0.348
LIG_FHA_1	311	317	PF00498	0.423
LIG_FHA_1	32	38	PF00498	0.443
LIG_FHA_1	362	368	PF00498	0.334
LIG_FHA_1	57	63	PF00498	0.402
LIG_LIR_Gen_1	295	304	PF02991	0.323
LIG_LIR_Gen_1	364	373	PF02991	0.334
LIG_LIR_Gen_1	58	69	PF02991	0.427
LIG_LIR_Nem_3	295	300	PF02991	0.332
LIG_LIR_Nem_3	364	368	PF02991	0.334
LIG_LIR_Nem_3	434	439	PF02991	0.616
LIG_LIR_Nem_3	58	64	PF02991	0.479
LIG_Pex14_2	357	361	PF04695	0.380
LIG_REV1ctd_RIR_1	81	90	PF16727	0.407
LIG_SH2_CRK	190	194	PF00017	0.240
LIG_SH2_CRK	297	301	PF00017	0.338
LIG_SH2_NCK_1	253	257	PF00017	0.310
LIG_SH2_NCK_1	439	443	PF00017	0.605
LIG_SH2_PTP2	299	302	PF00017	0.299
LIG_SH2_SRC	299	302	PF00017	0.299
LIG_SH2_SRC	439	442	PF00017	0.604
LIG_SH2_STAP1	297	301	PF00017	0.306
LIG_SH2_STAT5	25	28	PF00017	0.370
LIG_SH2_STAT5	297	300	PF00017	0.485
LIG_SH2_STAT5	301	304	PF00017	0.474
LIG_SH2_STAT5	335	338	PF00017	0.363
LIG_SH2_STAT5	412	415	PF00017	0.565
LIG_SH3_3	118	124	PF00018	0.425
LIG_SH3_3	473	479	PF00018	0.670
LIG_SH3_3	488	494	PF00018	0.643
LIG_SUMO_SIM_anti_2	264	270	PF11976	0.369
LIG_SUMO_SIM_par_1	228	236	PF11976	0.299
LIG_TRFH_1	103	107	PF08558	0.422
LIG_WRC_WIRS_1	136	141	PF05994	0.240
LIG_WW_3	110	114	PF00397	0.412
MOD_CDC14_SPxK_1	110	113	PF00782	0.410
MOD_CDK_SPK_2	233	238	PF00069	0.462
MOD_CDK_SPK_2	475	480	PF00069	0.653
MOD_CDK_SPxK_1	107	113	PF00069	0.412
MOD_CK1_1	106	112	PF00069	0.444
MOD_CK1_1	122	128	PF00069	0.388
MOD_CK1_1	160	166	PF00069	0.688
MOD_CK1_1	264	270	PF00069	0.427
MOD_CK1_1	295	301	PF00069	0.348
MOD_CK1_1	31	37	PF00069	0.438
MOD_CK1_1	454	460	PF00069	0.657
MOD_CK2_1	137	143	PF00069	0.275
MOD_CK2_1	2	8	PF00069	0.402
MOD_CK2_1	304	310	PF00069	0.323
MOD_CK2_1	475	481	PF00069	0.689
MOD_CMANNOS	78	81	PF00535	0.607
MOD_Cter_Amidation	417	420	PF01082	0.410
MOD_GlcNHglycan	131	134	PF01048	0.307
MOD_GlcNHglycan	139	142	PF01048	0.237
MOD_GlcNHglycan	146	149	PF01048	0.434
MOD_GlcNHglycan	159	162	PF01048	0.438
MOD_GlcNHglycan	203	206	PF01048	0.690
MOD_GlcNHglycan	210	213	PF01048	0.648
MOD_GlcNHglycan	224	227	PF01048	0.521
MOD_GlcNHglycan	254	257	PF01048	0.518
MOD_GlcNHglycan	306	309	PF01048	0.678
MOD_GlcNHglycan	323	326	PF01048	0.568
MOD_GlcNHglycan	346	349	PF01048	0.669
MOD_GlcNHglycan	4	7	PF01048	0.629
MOD_GlcNHglycan	42	45	PF01048	0.680
MOD_GlcNHglycan	446	449	PF01048	0.502
MOD_GlcNHglycan	500	503	PF01048	0.456
MOD_GSK3_1	103	110	PF00069	0.434
MOD_GSK3_1	149	156	PF00069	0.643
MOD_GSK3_1	162	169	PF00069	0.721
MOD_GSK3_1	178	185	PF00069	0.579
MOD_GSK3_1	311	318	PF00069	0.450
MOD_GSK3_1	440	447	PF00069	0.739
MOD_GSK3_1	95	102	PF00069	0.497
MOD_N-GLC_1	167	172	PF02516	0.442
MOD_N-GLC_1	208	213	PF02516	0.699
MOD_N-GLC_1	238	243	PF02516	0.534
MOD_N-GLC_1	261	266	PF02516	0.643
MOD_N-GLC_1	279	284	PF02516	0.547
MOD_N-GLC_1	286	291	PF02516	0.635
MOD_N-GLC_1	292	297	PF02516	0.566
MOD_N-GLC_1	344	349	PF02516	0.696
MOD_N-GLC_1	396	401	PF02516	0.499
MOD_N-GLC_1	444	449	PF02516	0.432
MOD_N-GLC_1	95	100	PF02516	0.620
MOD_N-GLC_2	270	272	PF02516	0.697
MOD_NEK2_1	129	134	PF00069	0.313
MOD_NEK2_1	137	142	PF00069	0.248
MOD_NEK2_1	144	149	PF00069	0.232
MOD_NEK2_1	155	160	PF00069	0.668
MOD_NEK2_1	178	183	PF00069	0.609
MOD_NEK2_1	232	237	PF00069	0.390
MOD_NEK2_1	279	284	PF00069	0.373
MOD_NEK2_1	344	349	PF00069	0.466
MOD_NEK2_1	361	366	PF00069	0.367
MOD_NEK2_1	451	456	PF00069	0.669
MOD_NEK2_1	51	56	PF00069	0.403
MOD_NEK2_1	84	89	PF00069	0.407
MOD_NEK2_1	99	104	PF00069	0.399
MOD_PIKK_1	451	457	PF00454	0.794
MOD_PK_1	396	402	PF00069	0.591
MOD_PKA_2	149	155	PF00069	0.600
MOD_PKA_2	310	316	PF00069	0.360
MOD_PKA_2	451	457	PF00069	0.647
MOD_Plk_1	261	267	PF00069	0.413
MOD_Plk_1	279	285	PF00069	0.465
MOD_Plk_1	295	301	PF00069	0.385
MOD_Plk_1	396	402	PF00069	0.696
MOD_Plk_1	440	446	PF00069	0.656
MOD_Plk_1	95	101	PF00069	0.420
MOD_Plk_4	178	184	PF00069	0.590
MOD_Plk_4	264	270	PF00069	0.394
MOD_Plk_4	295	301	PF00069	0.344
MOD_Plk_4	311	317	PF00069	0.422
MOD_Plk_4	328	334	PF00069	0.435
MOD_Plk_4	396	402	PF00069	0.716
MOD_Plk_4	51	57	PF00069	0.429
MOD_ProDKin_1	103	109	PF00069	0.469
MOD_ProDKin_1	120	126	PF00069	0.387
MOD_ProDKin_1	233	239	PF00069	0.466
MOD_ProDKin_1	425	431	PF00069	0.712
MOD_ProDKin_1	457	463	PF00069	0.786
MOD_ProDKin_1	475	481	PF00069	0.653
MOD_SUMO_rev_2	54	62	PF00179	0.392
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.379
TRG_ENDOCYTIC_2	190	193	PF00928	0.388
TRG_ENDOCYTIC_2	297	300	PF00928	0.323
TRG_ENDOCYTIC_2	301	304	PF00928	0.326
TRG_ENDOCYTIC_2	365	368	PF00928	0.388
TRG_ENDOCYTIC_2	439	442	PF00928	0.710
TRG_ER_diArg_1	176	178	PF00400	0.726
TRG_ER_diArg_1	419	421	PF00400	0.616
TRG_ER_diArg_1	46	49	PF00400	0.502
TRG_ER_diArg_1	91	93	PF00400	0.416
TRG_ER_diLys_1	503	507	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICZ0	Leishmania donovani	55%	100%
A4I280	Leishmania infantum	55%	100%
Q4Q948	Leishmania major	52%	100%