Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEZ9_LEIBR

TriTrypDb:

LbrM.26.1460 , LBRM2903_260019700

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	548	552	PF00656	0.629
CLV_C14_Caspase3-7	566	570	PF00656	0.443
CLV_C14_Caspase3-7	685	689	PF00656	0.690
CLV_C14_Caspase3-7	75	79	PF00656	0.526
CLV_NRD_NRD_1	137	139	PF00675	0.596
CLV_NRD_NRD_1	276	278	PF00675	0.487
CLV_NRD_NRD_1	593	595	PF00675	0.442
CLV_NRD_NRD_1	697	699	PF00675	0.654
CLV_NRD_NRD_1	728	730	PF00675	0.355
CLV_NRD_NRD_1	759	761	PF00675	0.369
CLV_NRD_NRD_1	82	84	PF00675	0.684
CLV_PCSK_FUR_1	137	141	PF00082	0.670
CLV_PCSK_KEX2_1	136	138	PF00082	0.593
CLV_PCSK_KEX2_1	139	141	PF00082	0.609
CLV_PCSK_KEX2_1	697	699	PF00082	0.654
CLV_PCSK_KEX2_1	728	730	PF00082	0.355
CLV_PCSK_KEX2_1	759	761	PF00082	0.380
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.546
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.380
CLV_PCSK_PC7_1	132	138	PF00082	0.514
CLV_PCSK_SKI1_1	279	283	PF00082	0.440
CLV_PCSK_SKI1_1	34	38	PF00082	0.436
CLV_PCSK_SKI1_1	431	435	PF00082	0.400
CLV_PCSK_SKI1_1	454	458	PF00082	0.448
CLV_PCSK_SKI1_1	532	536	PF00082	0.541
CLV_PCSK_SKI1_1	575	579	PF00082	0.424
CLV_PCSK_SKI1_1	784	788	PF00082	0.418
DEG_APCC_DBOX_1	772	780	PF00400	0.319
DEG_MDM2_SWIB_1	235	243	PF02201	0.410
DEG_SPOP_SBC_1	348	352	PF00917	0.693
DEG_SPOP_SBC_1	361	365	PF00917	0.573
DOC_CKS1_1	335	340	PF01111	0.507
DOC_CYCLIN_RxL_1	30	38	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	175	178	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	644	650	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.574
DOC_MAPK_gen_1	194	202	PF00069	0.642
DOC_MAPK_gen_1	210	220	PF00069	0.369
DOC_MAPK_gen_1	274	283	PF00069	0.626
DOC_MAPK_MEF2A_6	277	285	PF00069	0.583
DOC_MAPK_MEF2A_6	30	39	PF00069	0.606
DOC_MAPK_MEF2A_6	48	57	PF00069	0.301
DOC_MAPK_NFAT4_5	278	286	PF00069	0.405
DOC_MAPK_RevD_3	639	653	PF00069	0.500
DOC_PP1_RVXF_1	452	459	PF00149	0.414
DOC_PP2B_LxvP_1	175	178	PF13499	0.718
DOC_PP2B_LxvP_1	457	460	PF13499	0.411
DOC_USP7_MATH_1	161	165	PF00917	0.681
DOC_USP7_MATH_1	186	190	PF00917	0.670
DOC_USP7_MATH_1	348	352	PF00917	0.674
DOC_USP7_MATH_1	375	379	PF00917	0.680
DOC_USP7_MATH_1	401	405	PF00917	0.651
DOC_USP7_MATH_1	460	464	PF00917	0.489
DOC_USP7_MATH_1	635	639	PF00917	0.555
DOC_USP7_MATH_1	640	644	PF00917	0.726
DOC_USP7_UBL2_3	139	143	PF12436	0.549
DOC_USP7_UBL2_3	274	278	PF12436	0.497
DOC_USP7_UBL2_3	30	34	PF12436	0.525
DOC_WW_Pin1_4	166	171	PF00397	0.629
DOC_WW_Pin1_4	177	182	PF00397	0.648
DOC_WW_Pin1_4	257	262	PF00397	0.556
DOC_WW_Pin1_4	310	315	PF00397	0.612
DOC_WW_Pin1_4	334	339	PF00397	0.715
DOC_WW_Pin1_4	405	410	PF00397	0.695
DOC_WW_Pin1_4	421	426	PF00397	0.557
DOC_WW_Pin1_4	477	482	PF00397	0.498
DOC_WW_Pin1_4	495	500	PF00397	0.438
DOC_WW_Pin1_4	501	506	PF00397	0.478
DOC_WW_Pin1_4	594	599	PF00397	0.480
DOC_WW_Pin1_4	751	756	PF00397	0.376
DOC_WW_Pin1_4	92	97	PF00397	0.714
LIG_14-3-3_CanoR_1	103	112	PF00244	0.688
LIG_14-3-3_CanoR_1	228	232	PF00244	0.386
LIG_14-3-3_CanoR_1	268	276	PF00244	0.522
LIG_14-3-3_CanoR_1	322	331	PF00244	0.527
LIG_14-3-3_CanoR_1	417	425	PF00244	0.577
LIG_14-3-3_CanoR_1	431	436	PF00244	0.361
LIG_14-3-3_CanoR_1	52	56	PF00244	0.612
LIG_14-3-3_CanoR_1	525	534	PF00244	0.626
LIG_14-3-3_CanoR_1	594	598	PF00244	0.435
LIG_APCC_ABBA_1	503	508	PF00400	0.491
LIG_APCC_ABBA_1	619	624	PF00400	0.320
LIG_BIR_III_4	540	544	PF00653	0.618
LIG_BRCT_BRCA1_1	431	435	PF00533	0.362
LIG_Clathr_ClatBox_1	299	303	PF01394	0.518
LIG_Clathr_ClatBox_1	711	715	PF01394	0.579
LIG_CSL_BTD_1	457	460	PF09270	0.411
LIG_CtBP_PxDLS_1	481	485	PF00389	0.362
LIG_deltaCOP1_diTrp_1	467	474	PF00928	0.390
LIG_FHA_1	280	286	PF00498	0.542
LIG_FHA_1	362	368	PF00498	0.550
LIG_FHA_1	432	438	PF00498	0.272
LIG_FHA_1	440	446	PF00498	0.395
LIG_FHA_1	498	504	PF00498	0.743
LIG_FHA_1	52	58	PF00498	0.487
LIG_FHA_1	529	535	PF00498	0.562
LIG_FHA_2	361	367	PF00498	0.550
LIG_FHA_2	683	689	PF00498	0.691
LIG_FHA_2	703	709	PF00498	0.452
LIG_FXI_DFP_1	47	51	PF00024	0.403
LIG_LIR_Apic_2	164	170	PF02991	0.689
LIG_LIR_Apic_2	68	72	PF02991	0.493
LIG_LIR_Gen_1	236	244	PF02991	0.423
LIG_LIR_Gen_1	432	440	PF02991	0.356
LIG_LIR_Gen_1	656	664	PF02991	0.584
LIG_LIR_Gen_1	670	681	PF02991	0.520
LIG_LIR_Nem_3	236	242	PF02991	0.440
LIG_LIR_Nem_3	656	662	PF02991	0.586
LIG_LIR_Nem_3	670	676	PF02991	0.514
LIG_LIR_Nem_3	68	73	PF02991	0.651
LIG_Pex14_1	470	474	PF04695	0.388
LIG_Pex14_2	231	235	PF04695	0.384
LIG_PTAP_UEV_1	636	641	PF05743	0.450
LIG_PTB_Apo_2	340	347	PF02174	0.550
LIG_SH2_CRK	659	663	PF00017	0.524
LIG_SH2_CRK	70	74	PF00017	0.653
LIG_SH2_NCK_1	625	629	PF00017	0.495
LIG_SH2_NCK_1	673	677	PF00017	0.563
LIG_SH2_STAP1	600	604	PF00017	0.410
LIG_SH2_STAP1	625	629	PF00017	0.495
LIG_SH2_STAT3	772	775	PF00017	0.484
LIG_SH2_STAT5	428	431	PF00017	0.382
LIG_SH2_STAT5	588	591	PF00017	0.449
LIG_SH2_STAT5	766	769	PF00017	0.412
LIG_SH3_2	174	179	PF14604	0.567
LIG_SH3_3	171	177	PF00018	0.643
LIG_SH3_3	332	338	PF00018	0.607
LIG_SH3_3	382	388	PF00018	0.526
LIG_SH3_3	615	621	PF00018	0.304
LIG_SH3_3	634	640	PF00018	0.645
LIG_SH3_3	693	699	PF00018	0.754
LIG_SH3_3	93	99	PF00018	0.645
LIG_SH3_4	84	91	PF00018	0.648
LIG_SUMO_SIM_anti_2	216	223	PF11976	0.373
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.409
LIG_SUMO_SIM_anti_2	735	740	PF11976	0.404
LIG_SUMO_SIM_par_1	216	223	PF11976	0.373
LIG_SUMO_SIM_par_1	295	305	PF11976	0.378
LIG_SUMO_SIM_par_1	710	715	PF11976	0.519
LIG_TRAF2_1	196	199	PF00917	0.517
LIG_TRAF2_1	621	624	PF00917	0.333
LIG_WW_3	176	180	PF00397	0.564
MOD_CDK_SPK_2	594	599	PF00069	0.322
MOD_CDK_SPxK_1	421	427	PF00069	0.531
MOD_CK1_1	189	195	PF00069	0.547
MOD_CK1_1	234	240	PF00069	0.475
MOD_CK1_1	3	9	PF00069	0.573
MOD_CK1_1	307	313	PF00069	0.509
MOD_CK1_1	351	357	PF00069	0.646
MOD_CK1_1	360	366	PF00069	0.615
MOD_CK1_1	378	384	PF00069	0.572
MOD_CK1_1	404	410	PF00069	0.648
MOD_CK1_1	416	422	PF00069	0.657
MOD_CK1_1	501	507	PF00069	0.618
MOD_CK1_1	62	68	PF00069	0.552
MOD_CK1_1	683	689	PF00069	0.685
MOD_CK2_1	193	199	PF00069	0.522
MOD_CK2_1	3	9	PF00069	0.651
MOD_CK2_1	360	366	PF00069	0.670
MOD_CK2_1	506	512	PF00069	0.624
MOD_CK2_1	524	530	PF00069	0.459
MOD_CMANNOS	458	461	PF00535	0.407
MOD_GlcNHglycan	146	149	PF01048	0.673
MOD_GlcNHglycan	246	249	PF01048	0.527
MOD_GlcNHglycan	271	274	PF01048	0.596
MOD_GlcNHglycan	295	298	PF01048	0.403
MOD_GlcNHglycan	306	309	PF01048	0.566
MOD_GlcNHglycan	317	320	PF01048	0.574
MOD_GlcNHglycan	325	328	PF01048	0.676
MOD_GlcNHglycan	351	354	PF01048	0.683
MOD_GlcNHglycan	359	362	PF01048	0.660
MOD_GlcNHglycan	377	380	PF01048	0.619
MOD_GlcNHglycan	403	406	PF01048	0.737
MOD_GlcNHglycan	431	434	PF01048	0.364
MOD_GlcNHglycan	6	9	PF01048	0.607
MOD_GlcNHglycan	637	640	PF01048	0.547
MOD_GlcNHglycan	659	662	PF01048	0.526
MOD_GSK3_1	161	168	PF00069	0.616
MOD_GSK3_1	189	196	PF00069	0.542
MOD_GSK3_1	227	234	PF00069	0.464
MOD_GSK3_1	257	264	PF00069	0.622
MOD_GSK3_1	347	354	PF00069	0.600
MOD_GSK3_1	357	364	PF00069	0.622
MOD_GSK3_1	375	382	PF00069	0.687
MOD_GSK3_1	401	408	PF00069	0.638
MOD_GSK3_1	416	423	PF00069	0.773
MOD_GSK3_1	491	498	PF00069	0.519
MOD_GSK3_1	524	531	PF00069	0.637
MOD_GSK3_1	547	554	PF00069	0.625
MOD_GSK3_1	58	65	PF00069	0.427
MOD_GSK3_1	589	596	PF00069	0.530
MOD_GSK3_1	635	642	PF00069	0.541
MOD_GSK3_1	679	686	PF00069	0.682
MOD_LATS_1	266	272	PF00433	0.534
MOD_N-GLC_1	103	108	PF02516	0.622
MOD_N-GLC_1	161	166	PF02516	0.543
MOD_N-GLC_1	342	347	PF02516	0.552
MOD_N-GLC_1	348	353	PF02516	0.525
MOD_N-GLC_1	361	366	PF02516	0.504
MOD_N-GLC_1	375	380	PF02516	0.499
MOD_N-GLC_1	421	426	PF02516	0.471
MOD_N-GLC_1	59	64	PF02516	0.430
MOD_N-GLC_2	291	293	PF02516	0.368
MOD_N-GLC_2	74	76	PF02516	0.508
MOD_NEK2_1	151	156	PF00069	0.528
MOD_NEK2_1	244	249	PF00069	0.459
MOD_NEK2_1	315	320	PF00069	0.529
MOD_NEK2_1	323	328	PF00069	0.505
MOD_NEK2_1	438	443	PF00069	0.284
MOD_NEK2_1	528	533	PF00069	0.588
MOD_NEK2_1	56	61	PF00069	0.529
MOD_NEK2_2	51	56	PF00069	0.490
MOD_NEK2_2	640	645	PF00069	0.497
MOD_NMyristoyl	1	7	PF02799	0.577
MOD_PIKK_1	103	109	PF00454	0.695
MOD_PIKK_1	189	195	PF00454	0.544
MOD_PIKK_1	439	445	PF00454	0.384
MOD_PK_1	277	283	PF00069	0.452
MOD_PK_1	545	551	PF00069	0.522
MOD_PKA_1	277	283	PF00069	0.452
MOD_PKA_1	652	658	PF00069	0.508
MOD_PKA_2	193	199	PF00069	0.543
MOD_PKA_2	227	233	PF00069	0.378
MOD_PKA_2	250	256	PF00069	0.624
MOD_PKA_2	413	419	PF00069	0.563
MOD_PKA_2	51	57	PF00069	0.605
MOD_PKA_2	524	530	PF00069	0.712
MOD_PKA_2	593	599	PF00069	0.426
MOD_PKB_1	103	111	PF00069	0.628
MOD_Plk_1	161	167	PF00069	0.538
MOD_Plk_1	198	204	PF00069	0.464
MOD_Plk_1	235	241	PF00069	0.322
MOD_Plk_1	342	348	PF00069	0.542
MOD_Plk_1	375	381	PF00069	0.546
MOD_Plk_2-3	710	716	PF00069	0.416
MOD_Plk_4	408	414	PF00069	0.624
MOD_Plk_4	498	504	PF00069	0.542
MOD_Plk_4	51	57	PF00069	0.487
MOD_Plk_4	611	617	PF00069	0.490
MOD_Plk_4	702	708	PF00069	0.463
MOD_Plk_4	746	752	PF00069	0.397
MOD_ProDKin_1	166	172	PF00069	0.630
MOD_ProDKin_1	177	183	PF00069	0.649
MOD_ProDKin_1	257	263	PF00069	0.550
MOD_ProDKin_1	310	316	PF00069	0.614
MOD_ProDKin_1	334	340	PF00069	0.720
MOD_ProDKin_1	405	411	PF00069	0.694
MOD_ProDKin_1	421	427	PF00069	0.543
MOD_ProDKin_1	477	483	PF00069	0.503
MOD_ProDKin_1	495	501	PF00069	0.444
MOD_ProDKin_1	594	600	PF00069	0.473
MOD_ProDKin_1	751	757	PF00069	0.362
MOD_ProDKin_1	92	98	PF00069	0.716
MOD_SUMO_rev_2	591	597	PF00179	0.457
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.530
TRG_DiLeu_BaLyEn_6	721	726	PF01217	0.326
TRG_ENDOCYTIC_2	659	662	PF00928	0.528
TRG_ENDOCYTIC_2	673	676	PF00928	0.517
TRG_ENDOCYTIC_2	70	73	PF00928	0.652
TRG_ER_diArg_1	102	105	PF00400	0.685
TRG_ER_diArg_1	136	138	PF00400	0.593
TRG_ER_diArg_1	696	698	PF00400	0.659
TRG_ER_diArg_1	727	729	PF00400	0.317
TRG_ER_diLys_1	784	788	PF00400	0.551
TRG_NLS_MonoExtN_4	274	281	PF00514	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P8	Leptomonas seymouri	38%	100%
A0A3Q8IFV9	Leishmania donovani	63%	100%
A4I278	Leishmania infantum	63%	100%
E9AYC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q950	Leishmania major	63%	98%