Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEZ8_LEIBR

TriTrypDb:

LbrM.26.1450 , LBRM2903_260019600

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.864
CLV_NRD_NRD_1	4	6	PF00675	0.771
CLV_PCSK_KEX2_1	4	6	PF00082	0.771
CLV_PCSK_SKI1_1	261	265	PF00082	0.828
CLV_PCSK_SKI1_1	447	451	PF00082	0.549
CLV_PCSK_SKI1_1	455	459	PF00082	0.410
CLV_Separin_Metazoa	363	367	PF03568	0.750
DEG_Nend_UBRbox_3	1	3	PF02207	0.773
DEG_ODPH_VHL_1	164	176	PF01847	0.849
DEG_SCF_TRCP1_1	84	89	PF00400	0.880
DEG_SPOP_SBC_1	288	292	PF00917	0.820
DOC_CDC14_PxL_1	28	36	PF14671	0.828
DOC_PP2B_LxvP_1	295	298	PF13499	0.817
DOC_PP2B_LxvP_1	34	37	PF13499	0.808
DOC_PP4_FxxP_1	473	476	PF00568	0.549
DOC_PP4_MxPP_1	80	83	PF00568	0.846
DOC_USP7_MATH_1	196	200	PF00917	0.845
DOC_USP7_MATH_1	268	272	PF00917	0.804
DOC_USP7_MATH_1	288	292	PF00917	0.470
DOC_USP7_MATH_1	310	314	PF00917	0.818
DOC_USP7_MATH_1	346	350	PF00917	0.794
DOC_USP7_MATH_1	44	48	PF00917	0.855
DOC_USP7_MATH_1	466	470	PF00917	0.549
DOC_USP7_MATH_1	50	54	PF00917	0.739
DOC_WW_Pin1_4	145	150	PF00397	0.834
DOC_WW_Pin1_4	158	163	PF00397	0.620
DOC_WW_Pin1_4	169	174	PF00397	0.656
DOC_WW_Pin1_4	177	182	PF00397	0.518
DOC_WW_Pin1_4	247	252	PF00397	0.846
DOC_WW_Pin1_4	299	304	PF00397	0.825
DOC_WW_Pin1_4	306	311	PF00397	0.694
DOC_WW_Pin1_4	315	320	PF00397	0.538
DOC_WW_Pin1_4	40	45	PF00397	0.861
DOC_WW_Pin1_4	417	422	PF00397	0.549
DOC_WW_Pin1_4	54	59	PF00397	0.596
DOC_WW_Pin1_4	78	83	PF00397	0.854
DOC_WW_Pin1_4	86	91	PF00397	0.733
LIG_14-3-3_CanoR_1	111	118	PF00244	0.860
LIG_14-3-3_CanoR_1	150	154	PF00244	0.835
LIG_Actin_WH2_2	215	231	PF00022	0.816
LIG_BRCT_BRCA1_1	129	133	PF00533	0.835
LIG_BRCT_BRCA1_1	52	56	PF00533	0.846
LIG_BRCT_BRCA1_2	129	135	PF00533	0.831
LIG_EVH1_1	34	38	PF00568	0.812
LIG_FHA_1	112	118	PF00498	0.860
LIG_FHA_1	267	273	PF00498	0.805
LIG_FHA_1	278	284	PF00498	0.618
LIG_FHA_1	316	322	PF00498	0.810
LIG_FHA_2	170	176	PF00498	0.854
LIG_FHA_2	418	424	PF00498	0.549
LIG_LIR_Apic_2	471	476	PF02991	0.549
LIG_LIR_Gen_1	130	139	PF02991	0.830
LIG_LIR_Gen_1	422	433	PF02991	0.549
LIG_LIR_Gen_1	458	468	PF02991	0.549
LIG_LIR_Nem_3	130	136	PF02991	0.828
LIG_LIR_Nem_3	422	428	PF02991	0.549
LIG_LIR_Nem_3	436	441	PF02991	0.305
LIG_LIR_Nem_3	458	464	PF02991	0.549
LIG_LYPXL_S_1	101	105	PF13949	0.839
LIG_LYPXL_yS_3	102	105	PF13949	0.838
LIG_MYND_1	32	36	PF01753	0.809
LIG_MYND_1	99	103	PF01753	0.834
LIG_PTAP_UEV_1	250	255	PF05743	0.835
LIG_PTB_Apo_2	427	434	PF02174	0.549
LIG_PTB_Phospho_1	427	433	PF10480	0.549
LIG_SH2_STAP1	108	112	PF00017	0.840
LIG_SH2_STAP1	433	437	PF00017	0.549
LIG_SH3_1	29	35	PF00018	0.825
LIG_SH3_2	35	40	PF14604	0.826
LIG_SH3_3	248	254	PF00018	0.843
LIG_SH3_3	280	286	PF00018	0.811
LIG_SH3_3	29	35	PF00018	0.825
LIG_SH3_3	300	306	PF00018	0.471
LIG_SH3_3	340	346	PF00018	0.794
LIG_SH3_3	390	396	PF00018	0.825
LIG_SH3_3	97	103	PF00018	0.838
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.854
LIG_SUMO_SIM_par_1	218	224	PF11976	0.820
LIG_TRAF2_1	411	414	PF00917	0.549
LIG_TRAF2_1	90	93	PF00917	0.865
LIG_TYR_ITIM	100	105	PF00017	0.841
LIG_WRC_WIRS_1	136	141	PF05994	0.833
LIG_WW_2	32	35	PF00397	0.810
MOD_CDK_SPK_2	145	150	PF00069	0.834
MOD_CDK_SPK_2	54	59	PF00069	0.841
MOD_CDK_SPxxK_3	54	61	PF00069	0.845
MOD_CK1_1	106	112	PF00069	0.838
MOD_CK1_1	138	144	PF00069	0.829
MOD_CK1_1	158	164	PF00069	0.499
MOD_CK1_1	192	198	PF00069	0.841
MOD_CK1_1	224	230	PF00069	0.804
MOD_CK1_1	267	273	PF00069	0.805
MOD_CK1_1	469	475	PF00069	0.549
MOD_CK1_1	72	78	PF00069	0.860
MOD_GlcNHglycan	125	128	PF01048	0.848
MOD_GlcNHglycan	194	197	PF01048	0.840
MOD_GlcNHglycan	212	215	PF01048	0.519
MOD_GlcNHglycan	230	233	PF01048	0.479
MOD_GlcNHglycan	240	243	PF01048	0.644
MOD_GlcNHglycan	244	247	PF01048	0.588
MOD_GlcNHglycan	255	258	PF01048	0.565
MOD_GlcNHglycan	266	269	PF01048	0.618
MOD_GlcNHglycan	291	294	PF01048	0.821
MOD_GlcNHglycan	52	55	PF01048	0.843
MOD_GlcNHglycan	84	87	PF01048	0.878
MOD_GSK3_1	103	110	PF00069	0.833
MOD_GSK3_1	123	130	PF00069	0.499
MOD_GSK3_1	131	138	PF00069	0.690
MOD_GSK3_1	145	152	PF00069	0.590
MOD_GSK3_1	160	167	PF00069	0.584
MOD_GSK3_1	191	198	PF00069	0.842
MOD_GSK3_1	224	231	PF00069	0.802
MOD_GSK3_1	238	245	PF00069	0.575
MOD_GSK3_1	249	256	PF00069	0.645
MOD_GSK3_1	263	270	PF00069	0.572
MOD_GSK3_1	271	278	PF00069	0.653
MOD_GSK3_1	289	296	PF00069	0.508
MOD_GSK3_1	297	304	PF00069	0.680
MOD_GSK3_1	306	313	PF00069	0.520
MOD_GSK3_1	36	43	PF00069	0.842
MOD_GSK3_1	395	402	PF00069	0.825
MOD_GSK3_1	50	57	PF00069	0.598
MOD_GSK3_1	72	79	PF00069	0.862
MOD_GSK3_1	82	89	PF00069	0.690
MOD_N-GLC_1	293	298	PF02516	0.819
MOD_NEK2_1	139	144	PF00069	0.829
MOD_NEK2_1	221	226	PF00069	0.814
MOD_NEK2_1	228	233	PF00069	0.675
MOD_NEK2_1	275	280	PF00069	0.798
MOD_NEK2_1	314	319	PF00069	0.818
MOD_NEK2_1	399	404	PF00069	0.825
MOD_NEK2_2	103	108	PF00069	0.834
MOD_NEK2_2	196	201	PF00069	0.844
MOD_NEK2_2	346	351	PF00069	0.795
MOD_OFUCOSY	230	237	PF10250	0.799
MOD_PK_1	113	119	PF00069	0.861
MOD_PKA_1	4	10	PF00069	0.767
MOD_PKA_2	128	134	PF00069	0.834
MOD_PKA_2	149	155	PF00069	0.832
MOD_PKA_2	228	234	PF00069	0.798
MOD_PKA_2	4	10	PF00069	0.767
MOD_PKB_1	111	119	PF00069	0.859
MOD_Plk_1	261	267	PF00069	0.824
MOD_Plk_1	382	388	PF00069	0.813
MOD_Plk_1	433	439	PF00069	0.549
MOD_Plk_1	455	461	PF00069	0.549
MOD_Plk_1	72	78	PF00069	0.860
MOD_Plk_4	103	109	PF00069	0.834
MOD_Plk_4	113	119	PF00069	0.686
MOD_Plk_4	271	277	PF00069	0.792
MOD_Plk_4	382	388	PF00069	0.813
MOD_Plk_4	469	475	PF00069	0.549
MOD_ProDKin_1	145	151	PF00069	0.835
MOD_ProDKin_1	158	164	PF00069	0.621
MOD_ProDKin_1	169	175	PF00069	0.657
MOD_ProDKin_1	177	183	PF00069	0.518
MOD_ProDKin_1	247	253	PF00069	0.846
MOD_ProDKin_1	299	305	PF00069	0.826
MOD_ProDKin_1	306	312	PF00069	0.695
MOD_ProDKin_1	315	321	PF00069	0.533
MOD_ProDKin_1	40	46	PF00069	0.859
MOD_ProDKin_1	417	423	PF00069	0.549
MOD_ProDKin_1	54	60	PF00069	0.598
MOD_ProDKin_1	78	84	PF00069	0.857
MOD_ProDKin_1	86	92	PF00069	0.734
MOD_SUMO_for_1	359	362	PF00179	0.745
TRG_ENDOCYTIC_2	102	105	PF00928	0.838
TRG_ENDOCYTIC_2	461	464	PF00928	0.549
TRG_ER_diArg_1	58	61	PF00400	0.848
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.848
TRG_Pf-PMV_PEXEL_1	68	73	PF00026	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PRW9	TACFU	32%	100%
A4FV48	BOVIN	34%	100%
A4IFP3	BOVIN	37%	100%
A9SIZ6	PHYPA	35%	100%
B2KKL4	SIGCA	33%	100%
B8MKR3	TALSN	44%	98%
B8R1K0	PAPAN	33%	100%
C8VJR5	EMENI	46%	100%
D8X2C5	SIGCA	37%	100%
O04354	BOROF	42%	100%
O48845	ARATH	42%	100%
O74212	MORAP	45%	100%
O74875	SCHPO	41%	100%
O95864	HUMAN	33%	100%
O96099	DICDI	38%	100%
P00175	YEAST	44%	83%
P04166	RAT	48%	100%
P09437	WICAO	40%	85%
P11832	ARATH	33%	53%
P16081	ORYSJ	36%	53%
P17569	CUCMA	35%	53%
P27783	BETPN	32%	54%
P27967	HORVU	35%	53%
P27968	HORVU	40%	55%
P27969	HORVU	35%	54%
P32953	RHOGR	33%	86%
P36841	VOLCA	36%	56%
P39864	PHYIN	38%	54%
P39865	PHAVU	34%	55%
P39866	PHAVU	35%	55%
P39869	LOTJA	36%	54%
P39870	SOYBN	33%	55%
P40312	YEAST	43%	100%
P40934	BRAOB	38%	100%
P43101	CICIN	37%	53%
P49096	MUSDO	41%	100%
P49097	CUSRE	40%	100%
P49098	TOBAC	40%	100%
P49099	TOBAC	39%	100%
P49100	ORYSJ	38%	100%
P49102	MAIZE	36%	55%
Q10352	SCHPO	42%	100%
Q1ZXQ5	DICDI	37%	100%
Q28CZ9	XENTR	31%	93%
Q32LH7	BOVIN	38%	94%
Q3EBF7	ARATH	36%	100%
Q3TDX8	MOUSE	38%	92%
Q42342	ARATH	38%	100%
Q43469	HELAN	37%	100%
Q4R749	MACFA	33%	100%
Q502I6	DANRE	37%	93%
Q5REA7	PONAB	33%	100%
Q68EJ0	RAT	39%	94%
Q6DDK2	XENLA	34%	100%
Q7L1T6	HUMAN	38%	94%
Q874I5	CANTR	46%	100%
Q8K1P9	RAT	33%	100%
Q8S3C0	THRSP	35%	94%
Q9CQX2	MOUSE	46%	100%
Q9DEX7	DANRE	31%	100%
Q9FDW8	ARATH	38%	100%
Q9HFV1	RHIST	42%	100%
Q9JJE7	MOUSE	34%	100%
Q9LEM9	CERPU	39%	94%
Q9LEN0	CERPU	30%	100%
Q9LXD1	ARATH	34%	100%
Q9P5L0	NEUCR	40%	100%
Q9USM6	SCHPO	35%	100%
Q9V4N3	DROME	41%	100%
Q9Y1W0	DICDI	38%	100%
Q9Y5Q0	HUMAN	34%	100%
Q9Y706	MORAP	36%	100%
Q9Z0R9	MOUSE	33%	100%
Q9Z122	RAT	33%	100%
Q9ZNV4	ARATH	34%	100%
Q9ZNW2	PHYPA	42%	93%
S0DLN7	GIBF5	44%	51%