LeishMANIAdb
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J domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
J domain-containing protein
Gene product:
DnaJ domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HEZ6_LEIBR
TriTrypDb:
LbrM.26.1430 , LBRM2903_260019400 *
Length:
538

Annotations

LeishMANIAdb annotations

These kinetoplastid-specific proteins contain a conserved DnaJ domain at their C-termini and a completely unique structure before and after that.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HEZ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEZ6

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
GO:0061077 chaperone-mediated protein folding 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0044183 protein folding chaperone 1 1
GO:0051082 unfolded protein binding 3 1
GO:0051087 protein-folding chaperone binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 175 179 PF00656 0.380
CLV_C14_Caspase3-7 382 386 PF00656 0.605
CLV_C14_Caspase3-7 462 466 PF00656 0.530
CLV_MEL_PAP_1 474 480 PF00089 0.314
CLV_NRD_NRD_1 331 333 PF00675 0.432
CLV_NRD_NRD_1 423 425 PF00675 0.201
CLV_NRD_NRD_1 476 478 PF00675 0.382
CLV_PCSK_FUR_1 249 253 PF00082 0.400
CLV_PCSK_KEX2_1 251 253 PF00082 0.456
CLV_PCSK_KEX2_1 331 333 PF00082 0.432
CLV_PCSK_KEX2_1 344 346 PF00082 0.390
CLV_PCSK_KEX2_1 468 470 PF00082 0.242
CLV_PCSK_KEX2_1 476 478 PF00082 0.373
CLV_PCSK_PC1ET2_1 251 253 PF00082 0.456
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.469
CLV_PCSK_PC1ET2_1 468 470 PF00082 0.273
CLV_PCSK_SKI1_1 169 173 PF00082 0.571
CLV_PCSK_SKI1_1 257 261 PF00082 0.319
CLV_PCSK_SKI1_1 362 366 PF00082 0.391
CLV_PCSK_SKI1_1 430 434 PF00082 0.301
CLV_PCSK_SKI1_1 7 11 PF00082 0.253
CLV_PCSK_SKI1_1 72 76 PF00082 0.577
CLV_PCSK_SKI1_1 95 99 PF00082 0.438
DEG_APCC_DBOX_1 303 311 PF00400 0.336
DEG_APCC_DBOX_1 71 79 PF00400 0.241
DOC_CKS1_1 11 16 PF01111 0.197
DOC_CYCLIN_RxL_1 424 437 PF00134 0.496
DOC_MAPK_gen_1 92 100 PF00069 0.413
DOC_PP1_RVXF_1 117 124 PF00149 0.391
DOC_PP1_RVXF_1 5 12 PF00149 0.436
DOC_PP4_FxxP_1 11 14 PF00568 0.486
DOC_USP7_MATH_1 366 370 PF00917 0.706
DOC_USP7_MATH_1 380 384 PF00917 0.741
DOC_USP7_MATH_1 392 396 PF00917 0.634
DOC_USP7_MATH_1 497 501 PF00917 0.395
DOC_WW_Pin1_4 10 15 PF00397 0.336
DOC_WW_Pin1_4 308 313 PF00397 0.297
DOC_WW_Pin1_4 529 534 PF00397 0.348
LIG_14-3-3_CanoR_1 151 155 PF00244 0.527
LIG_14-3-3_CanoR_1 217 223 PF00244 0.302
LIG_14-3-3_CanoR_1 249 259 PF00244 0.563
LIG_14-3-3_CanoR_1 304 308 PF00244 0.352
LIG_14-3-3_CanoR_1 332 338 PF00244 0.658
LIG_14-3-3_CanoR_1 476 485 PF00244 0.632
LIG_14-3-3_CanoR_1 525 530 PF00244 0.458
LIG_14-3-3_CanoR_1 67 75 PF00244 0.360
LIG_Actin_WH2_2 120 136 PF00022 0.371
LIG_BRCT_BRCA1_1 215 219 PF00533 0.411
LIG_Clathr_ClatBox_1 33 37 PF01394 0.385
LIG_eIF4E_1 28 34 PF01652 0.405
LIG_eIF4E_1 427 433 PF01652 0.496
LIG_FHA_1 116 122 PF00498 0.371
LIG_FHA_1 219 225 PF00498 0.370
LIG_FHA_1 24 30 PF00498 0.427
LIG_FHA_1 304 310 PF00498 0.317
LIG_FHA_1 491 497 PF00498 0.594
LIG_FHA_1 499 505 PF00498 0.306
LIG_FHA_2 170 176 PF00498 0.361
LIG_FHA_2 334 340 PF00498 0.573
LIG_FHA_2 460 466 PF00498 0.523
LIG_LIR_Gen_1 193 202 PF02991 0.304
LIG_LIR_Gen_1 458 464 PF02991 0.536
LIG_LIR_Gen_1 521 529 PF02991 0.391
LIG_LIR_Gen_1 63 73 PF02991 0.432
LIG_LIR_Nem_3 109 115 PF02991 0.381
LIG_LIR_Nem_3 216 222 PF02991 0.225
LIG_LIR_Nem_3 253 259 PF02991 0.540
LIG_LIR_Nem_3 458 463 PF02991 0.536
LIG_LIR_Nem_3 483 488 PF02991 0.606
LIG_LIR_Nem_3 514 519 PF02991 0.460
LIG_LIR_Nem_3 63 68 PF02991 0.433
LIG_LYPXL_S_1 128 132 PF13949 0.599
LIG_NRBOX 19 25 PF00104 0.322
LIG_NRBOX 73 79 PF00104 0.283
LIG_Pex14_1 241 245 PF04695 0.514
LIG_Pex14_1 48 52 PF04695 0.365
LIG_Pex14_2 219 223 PF04695 0.359
LIG_Pex14_2 52 56 PF04695 0.425
LIG_PTB_Apo_2 454 461 PF02174 0.396
LIG_PTB_Phospho_1 454 460 PF10480 0.396
LIG_REV1ctd_RIR_1 49 57 PF16727 0.409
LIG_SH2_CRK 104 108 PF00017 0.244
LIG_SH2_CRK 184 188 PF00017 0.467
LIG_SH2_CRK 460 464 PF00017 0.536
LIG_SH2_CRK 65 69 PF00017 0.391
LIG_SH2_SRC 210 213 PF00017 0.350
LIG_SH2_STAP1 220 224 PF00017 0.336
LIG_SH2_STAP1 277 281 PF00017 0.435
LIG_SH2_STAP1 460 464 PF00017 0.536
LIG_SH2_STAP1 65 69 PF00017 0.391
LIG_SH2_STAT3 212 215 PF00017 0.321
LIG_SH2_STAT5 104 107 PF00017 0.308
LIG_SH2_STAT5 210 213 PF00017 0.321
LIG_SH2_STAT5 220 223 PF00017 0.322
LIG_SH2_STAT5 28 31 PF00017 0.313
LIG_SH2_STAT5 519 522 PF00017 0.384
LIG_SH3_1 184 190 PF00018 0.471
LIG_SH3_2 187 192 PF14604 0.471
LIG_SH3_3 184 190 PF00018 0.471
LIG_SUMO_SIM_anti_2 303 309 PF11976 0.243
LIG_SUMO_SIM_anti_2 500 506 PF11976 0.376
LIG_SUMO_SIM_par_1 265 270 PF11976 0.393
LIG_SUMO_SIM_par_1 305 311 PF11976 0.362
LIG_SUMO_SIM_par_1 508 514 PF11976 0.266
LIG_SUMO_SIM_par_1 532 538 PF11976 0.439
LIG_TYR_ITIM 406 411 PF00017 0.292
LIG_WRC_WIRS_1 129 134 PF05994 0.583
LIG_WRC_WIRS_1 61 66 PF05994 0.549
MOD_CK1_1 140 146 PF00069 0.754
MOD_CK1_1 147 153 PF00069 0.756
MOD_CK1_1 213 219 PF00069 0.371
MOD_CK1_1 490 496 PF00069 0.560
MOD_CK1_1 63 69 PF00069 0.575
MOD_GlcNHglycan 146 149 PF01048 0.703
MOD_GlcNHglycan 224 227 PF01048 0.297
MOD_GlcNHglycan 269 272 PF01048 0.280
MOD_GlcNHglycan 394 397 PF01048 0.644
MOD_GlcNHglycan 513 516 PF01048 0.569
MOD_GlcNHglycan 53 56 PF01048 0.475
MOD_GlcNHglycan 82 85 PF01048 0.368
MOD_GSK3_1 133 140 PF00069 0.730
MOD_GSK3_1 142 149 PF00069 0.759
MOD_GSK3_1 218 225 PF00069 0.335
MOD_GSK3_1 247 254 PF00069 0.375
MOD_GSK3_1 267 274 PF00069 0.351
MOD_GSK3_1 288 295 PF00069 0.436
MOD_GSK3_1 459 466 PF00069 0.385
MOD_GSK3_1 525 532 PF00069 0.396
MOD_GSK3_1 56 63 PF00069 0.504
MOD_NEK2_1 115 120 PF00069 0.446
MOD_NEK2_1 365 370 PF00069 0.603
MOD_NEK2_1 412 417 PF00069 0.397
MOD_NEK2_1 51 56 PF00069 0.469
MOD_NEK2_2 218 223 PF00069 0.428
MOD_NEK2_2 229 234 PF00069 0.258
MOD_PKA_1 251 257 PF00069 0.540
MOD_PKA_1 476 482 PF00069 0.477
MOD_PKA_2 133 139 PF00069 0.590
MOD_PKA_2 150 156 PF00069 0.684
MOD_PKA_2 188 194 PF00069 0.599
MOD_PKA_2 251 257 PF00069 0.481
MOD_PKA_2 288 294 PF00069 0.426
MOD_PKA_2 303 309 PF00069 0.386
MOD_PKA_2 476 482 PF00069 0.477
MOD_PKA_2 524 530 PF00069 0.606
MOD_Plk_1 229 235 PF00069 0.410
MOD_Plk_2-3 347 353 PF00069 0.375
MOD_Plk_4 102 108 PF00069 0.480
MOD_Plk_4 128 134 PF00069 0.567
MOD_Plk_4 153 159 PF00069 0.652
MOD_Plk_4 218 224 PF00069 0.432
MOD_Plk_4 229 235 PF00069 0.327
MOD_Plk_4 271 277 PF00069 0.330
MOD_Plk_4 29 35 PF00069 0.436
MOD_Plk_4 303 309 PF00069 0.360
MOD_Plk_4 315 321 PF00069 0.312
MOD_Plk_4 451 457 PF00069 0.384
MOD_Plk_4 459 465 PF00069 0.426
MOD_Plk_4 518 524 PF00069 0.502
MOD_Plk_4 57 63 PF00069 0.456
MOD_ProDKin_1 10 16 PF00069 0.336
MOD_ProDKin_1 308 314 PF00069 0.297
MOD_ProDKin_1 529 535 PF00069 0.430
MOD_SUMO_rev_2 338 346 PF00179 0.589
TRG_DiLeu_BaEn_1 19 24 PF01217 0.410
TRG_DiLeu_BaEn_1 303 308 PF01217 0.297
TRG_DiLeu_BaLyEn_6 116 121 PF01217 0.620
TRG_DiLeu_BaLyEn_6 64 69 PF01217 0.425
TRG_DiLeu_BaLyEn_6 73 78 PF01217 0.457
TRG_ENDOCYTIC_2 104 107 PF00928 0.456
TRG_ENDOCYTIC_2 112 115 PF00928 0.433
TRG_ENDOCYTIC_2 129 132 PF00928 0.560
TRG_ENDOCYTIC_2 220 223 PF00928 0.338
TRG_ENDOCYTIC_2 408 411 PF00928 0.281
TRG_ENDOCYTIC_2 460 463 PF00928 0.279
TRG_ENDOCYTIC_2 472 475 PF00928 0.425
TRG_ENDOCYTIC_2 519 522 PF00928 0.475
TRG_ENDOCYTIC_2 523 526 PF00928 0.501
TRG_ENDOCYTIC_2 65 68 PF00928 0.490
TRG_ER_diArg_1 475 477 PF00400 0.493
TRG_NES_CRM1_1 27 40 PF08389 0.502
TRG_Pf-PMV_PEXEL_1 67 71 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4K7 Leptomonas seymouri 57% 100%
A0A1X0NST5 Trypanosomatidae 32% 100%
A0A3Q8ICU0 Leishmania donovani 78% 100%
A0A3R7KCJ4 Trypanosoma rangeli 31% 100%
A4I270 Leishmania infantum 79% 100%
C9ZRS7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AYC0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
Q4Q953 Leishmania major 80% 100%
V5DAA3 Trypanosoma cruzi 33% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS