Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WWE domain/WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HEZ5_LEIBR

TriTrypDb:

LbrM.26.1420 , LBRM2903_260019300

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9

Expansion

Sequence features

A4HEZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEZ5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.621
CLV_C14_Caspase3-7	36	40	PF00656	0.537
CLV_C14_Caspase3-7	55	59	PF00656	0.500
CLV_NRD_NRD_1	443	445	PF00675	0.294
CLV_PCSK_KEX2_1	157	159	PF00082	0.249
CLV_PCSK_KEX2_1	192	194	PF00082	0.467
CLV_PCSK_KEX2_1	443	445	PF00082	0.495
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.249
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.461
CLV_PCSK_SKI1_1	189	193	PF00082	0.453
CLV_PCSK_SKI1_1	520	524	PF00082	0.361
CLV_PCSK_SKI1_1	74	78	PF00082	0.633
CLV_Separin_Metazoa	329	333	PF03568	0.593
DEG_APCC_DBOX_1	326	334	PF00400	0.336
DEG_APCC_DBOX_1	400	408	PF00400	0.385
DOC_ANK_TNKS_1	360	367	PF00023	0.484
DOC_CYCLIN_RxL_1	514	526	PF00134	0.395
DOC_MAPK_gen_1	156	164	PF00069	0.446
DOC_MAPK_gen_1	64	71	PF00069	0.620
DOC_MAPK_HePTP_8	61	73	PF00069	0.448
DOC_MAPK_MEF2A_6	64	73	PF00069	0.566
DOC_MAPK_RevD_3	143	158	PF00069	0.515
DOC_USP7_MATH_1	171	175	PF00917	0.511
DOC_USP7_MATH_1	335	339	PF00917	0.374
DOC_USP7_MATH_1	388	392	PF00917	0.513
DOC_USP7_MATH_1	394	398	PF00917	0.508
DOC_USP7_MATH_1	418	422	PF00917	0.536
DOC_USP7_MATH_1	425	429	PF00917	0.531
DOC_USP7_MATH_1	44	48	PF00917	0.768
DOC_USP7_MATH_1	493	497	PF00917	0.529
DOC_USP7_MATH_1	509	513	PF00917	0.484
DOC_USP7_MATH_1	547	551	PF00917	0.469
DOC_USP7_MATH_1	559	563	PF00917	0.555
DOC_USP7_MATH_1	59	63	PF00917	0.546
DOC_WW_Pin1_4	280	285	PF00397	0.439
DOC_WW_Pin1_4	331	336	PF00397	0.460
DOC_WW_Pin1_4	513	518	PF00397	0.463
LIG_14-3-3_CanoR_1	148	154	PF00244	0.531
LIG_14-3-3_CanoR_1	427	433	PF00244	0.434
LIG_14-3-3_CanoR_1	520	530	PF00244	0.411
LIG_Actin_WH2_2	64	79	PF00022	0.445
LIG_AP2alpha_2	218	220	PF02296	0.448
LIG_APCC_ABBA_1	217	222	PF00400	0.546
LIG_BRCT_BRCA1_1	420	424	PF00533	0.434
LIG_BRCT_BRCA1_1	549	553	PF00533	0.270
LIG_deltaCOP1_diTrp_1	469	479	PF00928	0.546
LIG_FHA_1	148	154	PF00498	0.473
LIG_FHA_1	17	23	PF00498	0.522
LIG_FHA_1	186	192	PF00498	0.656
LIG_FHA_1	202	208	PF00498	0.640
LIG_FHA_1	272	278	PF00498	0.483
LIG_FHA_1	281	287	PF00498	0.569
LIG_FHA_1	319	325	PF00498	0.403
LIG_FHA_1	357	363	PF00498	0.418
LIG_FHA_1	485	491	PF00498	0.513
LIG_FHA_2	107	113	PF00498	0.696
LIG_FHA_2	196	202	PF00498	0.568
LIG_FHA_2	324	330	PF00498	0.470
LIG_FHA_2	436	442	PF00498	0.407
LIG_FHA_2	459	465	PF00498	0.534
LIG_FHA_2	53	59	PF00498	0.504
LIG_LIR_Apic_2	198	202	PF02991	0.615
LIG_LIR_Apic_2	326	331	PF02991	0.537
LIG_LIR_Gen_1	528	537	PF02991	0.455
LIG_LIR_Nem_3	113	119	PF02991	0.507
LIG_LIR_Nem_3	128	132	PF02991	0.446
LIG_LIR_Nem_3	469	475	PF02991	0.385
LIG_LIR_Nem_3	577	581	PF02991	0.549
LIG_SH2_NCK_1	199	203	PF00017	0.593
LIG_SH2_SRC	363	366	PF00017	0.446
LIG_SH2_STAP1	344	348	PF00017	0.488
LIG_SH2_STAT3	181	184	PF00017	0.570
LIG_SH2_STAT3	515	518	PF00017	0.447
LIG_SH2_STAT5	132	135	PF00017	0.467
LIG_SH2_STAT5	160	163	PF00017	0.524
LIG_SH2_STAT5	199	202	PF00017	0.651
LIG_SH2_STAT5	278	281	PF00017	0.476
LIG_SH2_STAT5	422	425	PF00017	0.246
LIG_SH2_STAT5	515	518	PF00017	0.472
LIG_SH3_3	293	299	PF00018	0.530
LIG_SH3_3	35	41	PF00018	0.536
LIG_SH3_3	98	104	PF00018	0.606
LIG_SUMO_SIM_anti_2	496	502	PF11976	0.301
LIG_SUMO_SIM_par_1	159	166	PF11976	0.490
LIG_SUMO_SIM_par_1	302	307	PF11976	0.285
LIG_SUMO_SIM_par_1	499	505	PF11976	0.297
LIG_SxIP_EBH_1	268	277	PF03271	0.449
LIG_TRAF2_1	110	113	PF00917	0.498
LIG_UBA3_1	68	77	PF00899	0.516
MOD_CDK_SPK_2	331	336	PF00069	0.384
MOD_CDK_SPxxK_3	513	520	PF00069	0.465
MOD_CK1_1	174	180	PF00069	0.705
MOD_CK1_1	276	282	PF00069	0.371
MOD_CK1_1	318	324	PF00069	0.521
MOD_CK1_1	338	344	PF00069	0.336
MOD_CK1_1	397	403	PF00069	0.515
MOD_CK1_1	428	434	PF00069	0.357
MOD_CK1_1	526	532	PF00069	0.468
MOD_CK1_1	7	13	PF00069	0.658
MOD_CK2_1	106	112	PF00069	0.682
MOD_CK2_1	323	329	PF00069	0.473
MOD_CK2_1	435	441	PF00069	0.484
MOD_CK2_1	458	464	PF00069	0.467
MOD_GlcNHglycan	135	138	PF01048	0.320
MOD_GlcNHglycan	173	176	PF01048	0.308
MOD_GlcNHglycan	181	184	PF01048	0.608
MOD_GlcNHglycan	306	309	PF01048	0.443
MOD_GlcNHglycan	42	45	PF01048	0.777
MOD_GlcNHglycan	46	49	PF01048	0.759
MOD_GlcNHglycan	95	98	PF01048	0.651
MOD_GSK3_1	107	114	PF00069	0.681
MOD_GSK3_1	12	19	PF00069	0.753
MOD_GSK3_1	143	150	PF00069	0.458
MOD_GSK3_1	197	204	PF00069	0.633
MOD_GSK3_1	246	253	PF00069	0.555
MOD_GSK3_1	276	283	PF00069	0.381
MOD_GSK3_1	315	322	PF00069	0.459
MOD_GSK3_1	331	338	PF00069	0.387
MOD_GSK3_1	388	395	PF00069	0.455
MOD_GSK3_1	40	47	PF00069	0.589
MOD_GSK3_1	509	516	PF00069	0.461
MOD_GSK3_1	533	540	PF00069	0.446
MOD_GSK3_1	559	566	PF00069	0.525
MOD_N-GLC_1	233	238	PF02516	0.771
MOD_N-GLC_1	342	347	PF02516	0.491
MOD_N-GLC_1	4	9	PF02516	0.517
MOD_N-GLC_1	475	480	PF02516	0.392
MOD_N-GLC_1	531	536	PF02516	0.366
MOD_N-GLC_1	537	542	PF02516	0.467
MOD_N-GLC_2	149	151	PF02516	0.185
MOD_NEK2_1	147	152	PF00069	0.528
MOD_NEK2_1	16	21	PF00069	0.636
MOD_NEK2_1	266	271	PF00069	0.408
MOD_NEK2_1	304	309	PF00069	0.377
MOD_NEK2_1	315	320	PF00069	0.373
MOD_NEK2_1	484	489	PF00069	0.496
MOD_NEK2_1	533	538	PF00069	0.452
MOD_NEK2_2	143	148	PF00069	0.385
MOD_NEK2_2	499	504	PF00069	0.294
MOD_NEK2_2	509	514	PF00069	0.445
MOD_PIKK_1	388	394	PF00454	0.385
MOD_PKA_1	156	162	PF00069	0.547
MOD_PKA_2	147	153	PF00069	0.531
MOD_PKA_2	493	499	PF00069	0.502
MOD_Plk_1	111	117	PF00069	0.554
MOD_Plk_1	250	256	PF00069	0.568
MOD_Plk_1	315	321	PF00069	0.476
MOD_Plk_1	452	458	PF00069	0.439
MOD_Plk_1	463	469	PF00069	0.502
MOD_Plk_1	475	481	PF00069	0.516
MOD_Plk_1	537	543	PF00069	0.501
MOD_Plk_4	149	155	PF00069	0.513
MOD_Plk_4	273	279	PF00069	0.377
MOD_Plk_4	320	326	PF00069	0.493
MOD_Plk_4	335	341	PF00069	0.336
MOD_Plk_4	418	424	PF00069	0.297
MOD_Plk_4	452	458	PF00069	0.502
MOD_Plk_4	526	532	PF00069	0.447
MOD_Plk_4	548	554	PF00069	0.442
MOD_Plk_4	559	565	PF00069	0.468
MOD_ProDKin_1	280	286	PF00069	0.447
MOD_ProDKin_1	331	337	PF00069	0.446
MOD_ProDKin_1	513	519	PF00069	0.461
MOD_SUMO_rev_2	201	209	PF00179	0.711
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.319
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.621
TRG_ER_diArg_1	443	445	PF00400	0.294
TRG_ER_diArg_1	553	556	PF00400	0.371
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUB1	Leptomonas seymouri	60%	100%
A0A0S4KLR3	Bodo saltans	28%	100%
A0A1X0NS60	Trypanosomatidae	34%	100%
A0A3S7WZV3	Leishmania donovani	73%	100%
A0A422NIT0	Trypanosoma rangeli	34%	100%
A4I269	Leishmania infantum	73%	100%
C9ZRS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AYB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q954	Leishmania major	74%	99%
V5BEB9	Trypanosoma cruzi	33%	100%