Prefoldin subunit 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin subunit 3

Gene product:

prefoldin-like protein

Species:

Leishmania braziliensis

UniProt:

A4HEZ3_LEIBR

TriTrypDb:

LbrM.26.1400 , LBRM2903_260019100

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005737	cytoplasm	2	1
GO:0005844	polysome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HEZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.597
CLV_MEL_PAP_1	43	49	PF00089	0.556
CLV_NRD_NRD_1	184	186	PF00675	0.538
CLV_PCSK_KEX2_1	184	186	PF00082	0.496
CLV_PCSK_KEX2_1	45	47	PF00082	0.528
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.528
CLV_PCSK_SKI1_1	22	26	PF00082	0.534
CLV_PCSK_SKI1_1	96	100	PF00082	0.403
DOC_MAPK_gen_1	76	84	PF00069	0.445
DOC_MAPK_MEF2A_6	18	25	PF00069	0.532
DOC_PP1_RVXF_1	20	26	PF00149	0.519
DOC_USP7_UBL2_3	7	11	PF12436	0.599
DOC_WW_Pin1_4	13	18	PF00397	0.587
LIG_14-3-3_CanoR_1	143	152	PF00244	0.603
LIG_14-3-3_CanoR_1	184	194	PF00244	0.421
LIG_14-3-3_CanoR_1	46	54	PF00244	0.515
LIG_14-3-3_CanoR_1	60	66	PF00244	0.451
LIG_Actin_WH2_2	72	88	PF00022	0.579
LIG_BIR_II_1	1	5	PF00653	0.426
LIG_FHA_1	103	109	PF00498	0.499
LIG_FHA_1	117	123	PF00498	0.499
LIG_FHA_1	147	153	PF00498	0.579
LIG_FHA_1	171	177	PF00498	0.548
LIG_FHA_2	131	137	PF00498	0.513
LIG_FHA_2	152	158	PF00498	0.499
LIG_FHA_2	165	171	PF00498	0.493
LIG_FHA_2	7	13	PF00498	0.607
LIG_LIR_Apic_2	12	17	PF02991	0.506
LIG_LIR_Nem_3	48	54	PF02991	0.551
LIG_SH2_NCK_1	179	183	PF00017	0.600
LIG_SH2_PTP2	14	17	PF00017	0.505
LIG_SH2_SRC	134	137	PF00017	0.422
LIG_SH2_STAP1	134	138	PF00017	0.422
LIG_SH2_STAT5	132	135	PF00017	0.510
LIG_SH2_STAT5	14	17	PF00017	0.448
LIG_SH2_STAT5	8	11	PF00017	0.516
LIG_SUMO_SIM_par_1	167	174	PF11976	0.551
LIG_TRAF2_1	133	136	PF00917	0.579
LIG_TRAF2_1	154	157	PF00917	0.551
LIG_TRAF2_1	188	191	PF00917	0.671
MOD_CDK_SPK_2	13	18	PF00069	0.587
MOD_CK1_1	2	8	PF00069	0.533
MOD_CK1_1	36	42	PF00069	0.581
MOD_CK2_1	130	136	PF00069	0.495
MOD_CK2_1	144	150	PF00069	0.538
MOD_CK2_1	151	157	PF00069	0.522
MOD_CK2_1	164	170	PF00069	0.367
MOD_CK2_1	185	191	PF00069	0.612
MOD_CK2_1	85	91	PF00069	0.503
MOD_GlcNHglycan	1	4	PF01048	0.429
MOD_GlcNHglycan	146	149	PF01048	0.352
MOD_GlcNHglycan	35	38	PF01048	0.599
MOD_GSK3_1	2	9	PF00069	0.408
MOD_GSK3_1	32	39	PF00069	0.565
MOD_GSK3_1	45	52	PF00069	0.490
MOD_N-GLC_1	171	176	PF02516	0.313
MOD_NEK2_1	104	109	PF00069	0.513
MOD_NEK2_1	32	37	PF00069	0.570
MOD_NEK2_1	61	66	PF00069	0.532
MOD_NEK2_1	85	90	PF00069	0.579
MOD_NEK2_2	116	121	PF00069	0.499
MOD_PIKK_1	152	158	PF00454	0.541
MOD_PKA_1	185	191	PF00069	0.565
MOD_PKA_1	45	51	PF00069	0.558
MOD_PKA_2	45	51	PF00069	0.543
MOD_Plk_1	130	136	PF00069	0.512
MOD_Plk_1	171	177	PF00069	0.524
MOD_Plk_2-3	164	170	PF00069	0.579
MOD_Plk_2-3	6	12	PF00069	0.645
MOD_Plk_4	104	110	PF00069	0.513
MOD_Plk_4	164	170	PF00069	0.591
MOD_Plk_4	39	45	PF00069	0.484
MOD_Plk_4	85	91	PF00069	0.558
MOD_ProDKin_1	13	19	PF00069	0.588
MOD_SUMO_rev_2	188	194	PF00179	0.567
MOD_SUMO_rev_2	69	78	PF00179	0.529
TRG_DiLeu_BaEn_1	136	141	PF01217	0.499
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.579
TRG_ENDOCYTIC_2	179	182	PF00928	0.565
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.219
TRG_PTS1	191	194	PF00515	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB38	Leptomonas seymouri	88%	100%
A0A0S4KIH2	Bodo saltans	61%	100%
A0A1X0NS72	Trypanosomatidae	50%	100%
A0A3Q8IC74	Leishmania donovani	94%	100%
A0A422NIQ5	Trypanosoma rangeli	53%	99%
A4I267	Leishmania infantum	94%	100%
B0ZT47	Elsinoe fawcettii	44%	98%
C9ZRT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9AYB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O18054	Caenorhabditis elegans	33%	100%
P48363	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	97%
P57741	Arabidopsis thaliana	37%	99%
P61758	Homo sapiens	44%	98%
P61759	Mus musculus	44%	99%
Q10143	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q2TBX2	Bos taurus	43%	98%
Q4Q956	Leishmania major	93%	100%
Q54LS2	Dictyostelium discoideum	35%	99%
Q5RCG9	Pongo abelii	44%	98%
Q9VGP6	Drosophila melanogaster	35%	100%