Prefoldin subunit 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin subunit 3

Gene product:

prefoldin-like protein

Species:

Leishmania braziliensis

UniProt:

A4HEZ3_LEIBR

TriTrypDb:

LbrM.26.1400 , LBRM2903_260019100

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005844	polysome	3	1
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

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Expansion

Sequence features

A4HEZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEZ3

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.597
CLV_MEL_PAP_1	43	49	PF00089	0.556
CLV_NRD_NRD_1	184	186	PF00675	0.538
CLV_PCSK_KEX2_1	184	186	PF00082	0.496
CLV_PCSK_KEX2_1	45	47	PF00082	0.528
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.528
CLV_PCSK_SKI1_1	22	26	PF00082	0.534
CLV_PCSK_SKI1_1	96	100	PF00082	0.403
DOC_MAPK_gen_1	76	84	PF00069	0.445
DOC_MAPK_MEF2A_6	18	25	PF00069	0.532

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB38	Leptomonas seymouri	88%	100%
A0A0S4KIH2	Bodo saltans	61%	100%
A0A1X0NS72	Trypanosomatidae	50%	100%
A0A3Q8IC74	Leishmania donovani	94%	100%
A0A422NIQ5	Trypanosoma rangeli	53%	99%
A4I267	Leishmania infantum	94%	100%
B0ZT47	Elsinoe fawcettii	44%	98%
C9ZRT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9AYB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O18054	Caenorhabditis elegans	33%	100%

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