Guanine nucleotide-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanine nucleotide-binding protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HEZ2_LEIBR

TriTrypDb:

LbrM.26.1390 , LBRM2903_260019000

Length:

901

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEZ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.697
CLV_C14_Caspase3-7	236	240	PF00656	0.726
CLV_C14_Caspase3-7	329	333	PF00656	0.804
CLV_C14_Caspase3-7	352	356	PF00656	0.468
CLV_C14_Caspase3-7	373	377	PF00656	0.622
CLV_C14_Caspase3-7	51	55	PF00656	0.408
CLV_C14_Caspase3-7	756	760	PF00656	0.549
CLV_NRD_NRD_1	150	152	PF00675	0.633
CLV_NRD_NRD_1	18	20	PF00675	0.677
CLV_NRD_NRD_1	199	201	PF00675	0.588
CLV_NRD_NRD_1	227	229	PF00675	0.707
CLV_NRD_NRD_1	366	368	PF00675	0.366
CLV_NRD_NRD_1	437	439	PF00675	0.599
CLV_NRD_NRD_1	531	533	PF00675	0.605
CLV_NRD_NRD_1	535	537	PF00675	0.597
CLV_NRD_NRD_1	57	59	PF00675	0.619
CLV_NRD_NRD_1	599	601	PF00675	0.554
CLV_NRD_NRD_1	620	622	PF00675	0.457
CLV_NRD_NRD_1	671	673	PF00675	0.705
CLV_NRD_NRD_1	70	72	PF00675	0.640
CLV_NRD_NRD_1	87	89	PF00675	0.714
CLV_PCSK_FUR_1	68	72	PF00082	0.643
CLV_PCSK_KEX2_1	16	18	PF00082	0.674
CLV_PCSK_KEX2_1	199	201	PF00082	0.841
CLV_PCSK_KEX2_1	20	22	PF00082	0.667
CLV_PCSK_KEX2_1	227	229	PF00082	0.799
CLV_PCSK_KEX2_1	366	368	PF00082	0.488
CLV_PCSK_KEX2_1	531	533	PF00082	0.652
CLV_PCSK_KEX2_1	59	61	PF00082	0.613
CLV_PCSK_KEX2_1	599	601	PF00082	0.554
CLV_PCSK_KEX2_1	620	622	PF00082	0.457
CLV_PCSK_KEX2_1	670	672	PF00082	0.690
CLV_PCSK_KEX2_1	70	72	PF00082	0.642
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.674
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.667
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.439
CLV_PCSK_PC1ET2_1	670	672	PF00082	0.690
CLV_PCSK_SKI1_1	137	141	PF00082	0.687
CLV_PCSK_SKI1_1	294	298	PF00082	0.631
CLV_PCSK_SKI1_1	505	509	PF00082	0.479
CLV_PCSK_SKI1_1	666	670	PF00082	0.562
CLV_PCSK_SKI1_1	841	845	PF00082	0.447
CLV_PCSK_SKI1_1	861	865	PF00082	0.353
DEG_SCF_FBW7_1	735	742	PF00400	0.546
DEG_SCF_TRCP1_1	687	693	PF00400	0.841
DEG_SPOP_SBC_1	81	85	PF00917	0.524
DOC_MAPK_FxFP_2	176	179	PF00069	0.676
DOC_MAPK_gen_1	435	444	PF00069	0.575
DOC_MAPK_gen_1	546	554	PF00069	0.678
DOC_MAPK_gen_1	599	607	PF00069	0.561
DOC_MAPK_gen_1	831	837	PF00069	0.462
DOC_MAPK_gen_1	838	846	PF00069	0.440
DOC_MAPK_gen_1	880	889	PF00069	0.535
DOC_MAPK_MEF2A_6	435	444	PF00069	0.473
DOC_MAPK_MEF2A_6	880	889	PF00069	0.535
DOC_MAPK_RevD_3	186	200	PF00069	0.560
DOC_PP2B_LxvP_1	763	766	PF13499	0.539
DOC_PP2B_LxvP_1	887	890	PF13499	0.455
DOC_PP4_FxxP_1	176	179	PF00568	0.676
DOC_PP4_FxxP_1	473	476	PF00568	0.345
DOC_PP4_FxxP_1	768	771	PF00568	0.521
DOC_PP4_FxxP_1	865	868	PF00568	0.598
DOC_USP7_MATH_1	177	181	PF00917	0.692
DOC_USP7_MATH_1	194	198	PF00917	0.663
DOC_USP7_MATH_1	232	236	PF00917	0.574
DOC_USP7_MATH_1	279	283	PF00917	0.634
DOC_USP7_MATH_1	566	570	PF00917	0.610
DOC_USP7_MATH_1	652	656	PF00917	0.684
DOC_USP7_MATH_1	789	793	PF00917	0.576
DOC_USP7_MATH_1	82	86	PF00917	0.529
DOC_USP7_UBL2_3	16	20	PF12436	0.628
DOC_USP7_UBL2_3	435	439	PF12436	0.504
DOC_USP7_UBL2_3	534	538	PF12436	0.759
DOC_USP7_UBL2_3	666	670	PF12436	0.650
DOC_WW_Pin1_4	187	192	PF00397	0.591
DOC_WW_Pin1_4	294	299	PF00397	0.742
DOC_WW_Pin1_4	305	310	PF00397	0.768
DOC_WW_Pin1_4	642	647	PF00397	0.718
DOC_WW_Pin1_4	701	706	PF00397	0.664
DOC_WW_Pin1_4	733	738	PF00397	0.548
DOC_WW_Pin1_4	757	762	PF00397	0.549
LIG_14-3-3_CanoR_1	119	124	PF00244	0.810
LIG_14-3-3_CanoR_1	162	166	PF00244	0.686
LIG_14-3-3_CanoR_1	231	241	PF00244	0.612
LIG_14-3-3_CanoR_1	509	517	PF00244	0.529
LIG_14-3-3_CanoR_1	700	708	PF00244	0.475
LIG_APCC_ABBA_1	368	373	PF00400	0.596
LIG_APCC_ABBAyCdc20_2	367	373	PF00400	0.602
LIG_BIR_III_2	376	380	PF00653	0.540
LIG_BIR_III_4	239	243	PF00653	0.803
LIG_BRCT_BRCA1_1	245	249	PF00533	0.680
LIG_BRCT_BRCA1_1	791	795	PF00533	0.469
LIG_deltaCOP1_diTrp_1	174	178	PF00928	0.673
LIG_deltaCOP1_diTrp_1	397	403	PF00928	0.474
LIG_eIF4E_1	579	585	PF01652	0.503
LIG_FHA_1	142	148	PF00498	0.539
LIG_FHA_1	370	376	PF00498	0.606
LIG_FHA_1	403	409	PF00498	0.470
LIG_FHA_1	547	553	PF00498	0.759
LIG_FHA_1	651	657	PF00498	0.579
LIG_FHA_1	728	734	PF00498	0.546
LIG_FHA_1	740	746	PF00498	0.546
LIG_FHA_1	778	784	PF00498	0.529
LIG_FHA_2	380	386	PF00498	0.415
LIG_FHA_2	682	688	PF00498	0.586
LIG_FHA_2	754	760	PF00498	0.546
LIG_GBD_Chelix_1	608	616	PF00786	0.610
LIG_Integrin_RGD_1	44	46	PF01839	0.443
LIG_LIR_Apic_2	174	179	PF02991	0.674
LIG_LIR_Apic_2	376	381	PF02991	0.539
LIG_LIR_Gen_1	397	406	PF02991	0.468
LIG_LIR_Gen_1	704	713	PF02991	0.534
LIG_LIR_LC3C_4	409	414	PF02991	0.539
LIG_LIR_Nem_3	174	178	PF02991	0.763
LIG_LIR_Nem_3	246	252	PF02991	0.745
LIG_LIR_Nem_3	365	371	PF02991	0.358
LIG_LIR_Nem_3	397	402	PF02991	0.474
LIG_LIR_Nem_3	417	423	PF02991	0.215
LIG_LIR_Nem_3	704	710	PF02991	0.560
LIG_LYPXL_yS_3	420	423	PF13949	0.448
LIG_MAD2	731	739	PF02301	0.546
LIG_MLH1_MIPbox_1	246	250	PF16413	0.764
LIG_MYND_1	894	898	PF01753	0.500
LIG_Pex14_2	172	176	PF04695	0.668
LIG_SH2_CRK	156	160	PF00017	0.699
LIG_SH2_NCK_1	866	870	PF00017	0.498
LIG_SH2_SRC	707	710	PF00017	0.501
LIG_SH2_SRC	799	802	PF00017	0.490
LIG_SH2_SRC	866	869	PF00017	0.590
LIG_SH2_STAP1	371	375	PF00017	0.567
LIG_SH2_STAP1	392	396	PF00017	0.497
LIG_SH2_STAT3	593	596	PF00017	0.460
LIG_SH2_STAT3	806	809	PF00017	0.542
LIG_SH2_STAT5	359	362	PF00017	0.595
LIG_SH2_STAT5	371	374	PF00017	0.453
LIG_SH2_STAT5	432	435	PF00017	0.416
LIG_SH2_STAT5	466	469	PF00017	0.459
LIG_SH2_STAT5	707	710	PF00017	0.501
LIG_SH2_STAT5	799	802	PF00017	0.485
LIG_SH3_3	185	191	PF00018	0.545
LIG_SH3_3	245	251	PF00018	0.635
LIG_SH3_3	295	301	PF00018	0.634
LIG_SH3_3	755	761	PF00018	0.546
LIG_SH3_3	767	773	PF00018	0.623
LIG_SH3_3	888	894	PF00018	0.589
LIG_SH3_3	895	901	PF00018	0.653
LIG_Sin3_3	185	192	PF02671	0.547
LIG_Sin3_3	850	857	PF02671	0.559
LIG_SUMO_SIM_anti_2	215	222	PF11976	0.779
LIG_SUMO_SIM_anti_2	409	417	PF11976	0.436
LIG_SUMO_SIM_anti_2	604	609	PF11976	0.525
LIG_SUMO_SIM_par_1	404	410	PF11976	0.469
LIG_SUMO_SIM_par_1	411	417	PF11976	0.431
LIG_SUMO_SIM_par_1	730	736	PF11976	0.546
LIG_TRAF2_1	362	365	PF00917	0.361
LIG_TYR_ITIM	154	159	PF00017	0.683
LIG_UBA3_1	429	435	PF00899	0.469
LIG_UBA3_1	723	731	PF00899	0.546
LIG_WRC_WIRS_1	508	513	PF05994	0.501
MOD_CDC14_SPxK_1	308	311	PF00782	0.588
MOD_CDK_SPK_2	294	299	PF00069	0.596
MOD_CDK_SPxK_1	305	311	PF00069	0.592
MOD_CK1_1	101	107	PF00069	0.738
MOD_CK1_1	121	127	PF00069	0.515
MOD_CK1_1	180	186	PF00069	0.710
MOD_CK1_1	282	288	PF00069	0.669
MOD_CK1_1	290	296	PF00069	0.559
MOD_CK1_1	305	311	PF00069	0.533
MOD_CK1_1	335	341	PF00069	0.566
MOD_CK1_1	645	651	PF00069	0.650
MOD_CK2_1	107	113	PF00069	0.770
MOD_CK2_1	346	352	PF00069	0.481
MOD_CK2_1	359	365	PF00069	0.323
MOD_CK2_1	379	385	PF00069	0.541
MOD_CK2_1	387	393	PF00069	0.513
MOD_CK2_1	566	572	PF00069	0.553
MOD_CK2_1	685	691	PF00069	0.629
MOD_CK2_1	818	824	PF00069	0.512
MOD_Cter_Amidation	5	8	PF01082	0.690
MOD_Cter_Amidation	68	71	PF01082	0.643
MOD_DYRK1A_RPxSP_1	294	298	PF00069	0.592
MOD_GlcNHglycan	102	106	PF01048	0.804
MOD_GlcNHglycan	180	183	PF01048	0.781
MOD_GlcNHglycan	235	238	PF01048	0.696
MOD_GlcNHglycan	281	284	PF01048	0.701
MOD_GlcNHglycan	289	292	PF01048	0.633
MOD_GlcNHglycan	303	307	PF01048	0.843
MOD_GlcNHglycan	340	343	PF01048	0.670
MOD_GlcNHglycan	348	351	PF01048	0.429
MOD_GlcNHglycan	4	7	PF01048	0.707
MOD_GlcNHglycan	502	505	PF01048	0.597
MOD_GlcNHglycan	686	690	PF01048	0.747
MOD_GlcNHglycan	84	87	PF01048	0.626
MOD_GSK3_1	100	107	PF00069	0.817
MOD_GSK3_1	118	125	PF00069	0.513
MOD_GSK3_1	161	168	PF00069	0.688
MOD_GSK3_1	177	184	PF00069	0.679
MOD_GSK3_1	279	286	PF00069	0.759
MOD_GSK3_1	290	297	PF00069	0.663
MOD_GSK3_1	328	335	PF00069	0.814
MOD_GSK3_1	338	345	PF00069	0.689
MOD_GSK3_1	402	409	PF00069	0.580
MOD_GSK3_1	638	645	PF00069	0.574
MOD_GSK3_1	646	653	PF00069	0.640
MOD_GSK3_1	681	688	PF00069	0.617
MOD_GSK3_1	699	706	PF00069	0.458
MOD_GSK3_1	727	734	PF00069	0.513
MOD_GSK3_1	735	742	PF00069	0.519
MOD_GSK3_1	753	760	PF00069	0.546
MOD_GSK3_1	76	83	PF00069	0.511
MOD_GSK3_1	892	899	PF00069	0.730
MOD_N-GLC_1	107	112	PF02516	0.564
MOD_N-GLC_1	335	340	PF02516	0.565
MOD_NEK2_1	118	123	PF00069	0.707
MOD_NEK2_1	233	238	PF00069	0.720
MOD_NEK2_1	387	392	PF00069	0.524
MOD_NEK2_1	615	620	PF00069	0.587
MOD_NEK2_1	650	655	PF00069	0.531
MOD_NEK2_1	873	878	PF00069	0.507
MOD_NEK2_2	135	140	PF00069	0.692
MOD_PIKK_1	283	289	PF00454	0.835
MOD_PK_1	498	504	PF00069	0.432
MOD_PK_1	731	737	PF00069	0.546
MOD_PKA_2	118	124	PF00069	0.810
MOD_PKA_2	161	167	PF00069	0.688
MOD_PKA_2	699	705	PF00069	0.527
MOD_PKA_2	727	733	PF00069	0.546
MOD_Plk_1	273	279	PF00069	0.823
MOD_Plk_1	338	344	PF00069	0.656
MOD_Plk_1	387	393	PF00069	0.542
MOD_Plk_2-3	388	394	PF00069	0.541
MOD_Plk_2-3	46	52	PF00069	0.416
MOD_Plk_4	122	128	PF00069	0.810
MOD_Plk_4	244	250	PF00069	0.667
MOD_Plk_4	428	434	PF00069	0.471
MOD_Plk_4	646	652	PF00069	0.587
MOD_Plk_4	703	709	PF00069	0.584
MOD_Plk_4	719	725	PF00069	0.546
MOD_Plk_4	753	759	PF00069	0.546
MOD_Plk_4	874	880	PF00069	0.445
MOD_Plk_4	892	898	PF00069	0.566
MOD_ProDKin_1	187	193	PF00069	0.593
MOD_ProDKin_1	294	300	PF00069	0.740
MOD_ProDKin_1	305	311	PF00069	0.769
MOD_ProDKin_1	642	648	PF00069	0.722
MOD_ProDKin_1	701	707	PF00069	0.646
MOD_ProDKin_1	733	739	PF00069	0.548
MOD_ProDKin_1	757	763	PF00069	0.549
TRG_ENDOCYTIC_2	156	159	PF00928	0.694
TRG_ENDOCYTIC_2	420	423	PF00928	0.417
TRG_ENDOCYTIC_2	464	467	PF00928	0.441
TRG_ENDOCYTIC_2	544	547	PF00928	0.642
TRG_ENDOCYTIC_2	602	605	PF00928	0.557
TRG_ENDOCYTIC_2	707	710	PF00928	0.501
TRG_ENDOCYTIC_2	799	802	PF00928	0.490
TRG_ER_diArg_1	227	229	PF00400	0.799
TRG_ER_diArg_1	366	368	PF00400	0.366
TRG_ER_diArg_1	57	60	PF00400	0.610
TRG_ER_diArg_1	620	622	PF00400	0.459
TRG_ER_diArg_1	671	673	PF00400	0.538
TRG_ER_diArg_1	68	71	PF00400	0.630
TRG_ER_diArg_1	882	885	PF00400	0.466
TRG_NLS_MonoCore_2	668	673	PF00514	0.530
TRG_NLS_MonoExtC_3	15	20	PF00514	0.629
TRG_NLS_MonoExtC_3	665	670	PF00514	0.553
TRG_NLS_MonoExtN_4	534	540	PF00514	0.751
TRG_NLS_MonoExtN_4	666	673	PF00514	0.638
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA6	Leptomonas seymouri	58%	100%
A0A3S7WZV4	Leishmania donovani	77%	100%
A4I266	Leishmania infantum	76%	100%
E9AYB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q957	Leishmania major	76%	99%