Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEZ1_LEIBR

TriTrypDb:

LbrM.26.1380 , LBRM2903_260018900

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.522
CLV_C14_Caspase3-7	535	539	PF00656	0.756
CLV_C14_Caspase3-7	548	552	PF00656	0.603
CLV_NRD_NRD_1	324	326	PF00675	0.475
CLV_NRD_NRD_1	350	352	PF00675	0.496
CLV_NRD_NRD_1	400	402	PF00675	0.460
CLV_NRD_NRD_1	417	419	PF00675	0.374
CLV_PCSK_KEX2_1	27	29	PF00082	0.600
CLV_PCSK_KEX2_1	324	326	PF00082	0.537
CLV_PCSK_KEX2_1	350	352	PF00082	0.496
CLV_PCSK_KEX2_1	400	402	PF00082	0.378
CLV_PCSK_KEX2_1	417	419	PF00082	0.402
CLV_PCSK_KEX2_1	560	562	PF00082	0.601
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.395
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.601
CLV_PCSK_SKI1_1	149	153	PF00082	0.493
CLV_PCSK_SKI1_1	350	354	PF00082	0.496
CLV_PCSK_SKI1_1	417	421	PF00082	0.494
CLV_PCSK_SKI1_1	464	468	PF00082	0.397
CLV_Separin_Metazoa	512	516	PF03568	0.282
DEG_APCC_DBOX_1	416	424	PF00400	0.487
DEG_APCC_DBOX_1	463	471	PF00400	0.510
DEG_APCC_DBOX_1	592	600	PF00400	0.454
DEG_Nend_Nbox_1	1	2	PF02207	0.602
DEG_SPOP_SBC_1	137	141	PF00917	0.780
DEG_SPOP_SBC_1	172	176	PF00917	0.535
DEG_SPOP_SBC_1	38	42	PF00917	0.639
DOC_ANK_TNKS_1	14	21	PF00023	0.540
DOC_CYCLIN_RxL_1	415	424	PF00134	0.491
DOC_MAPK_gen_1	188	197	PF00069	0.584
DOC_MAPK_gen_1	417	425	PF00069	0.369
DOC_MAPK_MEF2A_6	190	199	PF00069	0.333
DOC_MAPK_MEF2A_6	242	250	PF00069	0.562
DOC_MAPK_MEF2A_6	418	427	PF00069	0.365
DOC_PP2B_LxvP_1	134	137	PF13499	0.479
DOC_PP4_FxxP_1	362	365	PF00568	0.522
DOC_USP7_MATH_1	168	172	PF00917	0.770
DOC_USP7_MATH_1	264	268	PF00917	0.612
DOC_USP7_MATH_1	279	283	PF00917	0.755
DOC_USP7_MATH_1	37	41	PF00917	0.455
DOC_USP7_MATH_1	475	479	PF00917	0.527
DOC_USP7_MATH_1	501	505	PF00917	0.560
DOC_USP7_MATH_1	537	541	PF00917	0.725
DOC_USP7_MATH_1	542	546	PF00917	0.711
DOC_USP7_MATH_1	60	64	PF00917	0.647
DOC_USP7_MATH_1	68	72	PF00917	0.616
DOC_USP7_UBL2_3	118	122	PF12436	0.521
DOC_WW_Pin1_4	173	178	PF00397	0.764
DOC_WW_Pin1_4	275	280	PF00397	0.675
DOC_WW_Pin1_4	533	538	PF00397	0.498
DOC_WW_Pin1_4	551	556	PF00397	0.406
LIG_14-3-3_CanoR_1	206	214	PF00244	0.459
LIG_14-3-3_CanoR_1	324	328	PF00244	0.574
LIG_14-3-3_CanoR_1	350	357	PF00244	0.506
LIG_14-3-3_CanoR_1	383	389	PF00244	0.509
LIG_14-3-3_CanoR_1	49	54	PF00244	0.721
LIG_14-3-3_CanoR_1	522	528	PF00244	0.609
LIG_14-3-3_CanoR_1	595	600	PF00244	0.447
LIG_14-3-3_CanoR_1	69	79	PF00244	0.605
LIG_14-3-3_CanoR_1	80	85	PF00244	0.624
LIG_Actin_WH2_2	420	435	PF00022	0.488
LIG_Actin_WH2_2	503	521	PF00022	0.548
LIG_BIR_III_4	135	139	PF00653	0.500
LIG_BIR_III_4	167	171	PF00653	0.539
LIG_BRCT_BRCA1_1	292	296	PF00533	0.587
LIG_BRCT_MDC1_1	597	601	PF00533	0.480
LIG_FHA_1	129	135	PF00498	0.533
LIG_FHA_1	145	151	PF00498	0.769
LIG_FHA_1	220	226	PF00498	0.387
LIG_FHA_1	27	33	PF00498	0.601
LIG_FHA_1	283	289	PF00498	0.552
LIG_FHA_1	292	298	PF00498	0.391
LIG_FHA_1	9	15	PF00498	0.467
LIG_FHA_2	227	233	PF00498	0.451
LIG_FHA_2	324	330	PF00498	0.580
LIG_FHA_2	351	357	PF00498	0.496
LIG_FHA_2	385	391	PF00498	0.490
LIG_GBD_Chelix_1	506	514	PF00786	0.531
LIG_LIR_Apic_2	359	365	PF02991	0.301
LIG_LIR_Gen_1	193	202	PF02991	0.520
LIG_LIR_Gen_1	384	392	PF02991	0.425
LIG_LIR_Nem_3	193	197	PF02991	0.516
LIG_LIR_Nem_3	384	388	PF02991	0.402
LIG_LIR_Nem_3	406	410	PF02991	0.472
LIG_NRBOX	509	515	PF00104	0.537
LIG_PCNA_yPIPBox_3	242	251	PF02747	0.411
LIG_PCNA_yPIPBox_3	568	580	PF02747	0.270
LIG_PTB_Apo_2	505	512	PF02174	0.392
LIG_SH2_CRK	385	389	PF00017	0.346
LIG_SH2_GRB2like	361	364	PF00017	0.278
LIG_SH2_STAT5	107	110	PF00017	0.439
LIG_SH2_STAT5	116	119	PF00017	0.369
LIG_SH2_STAT5	223	226	PF00017	0.400
LIG_SH2_STAT5	361	364	PF00017	0.427
LIG_SH2_STAT5	380	383	PF00017	0.303
LIG_SH2_STAT5	480	483	PF00017	0.467
LIG_SH2_STAT5	61	64	PF00017	0.633
LIG_SH2_STAT5	84	87	PF00017	0.517
LIG_SUMO_SIM_par_1	418	424	PF11976	0.392
LIG_SUMO_SIM_par_1	49	56	PF11976	0.729
LIG_TRAF2_1	326	329	PF00917	0.566
LIG_UBA3_1	247	256	PF00899	0.531
LIG_UBA3_1	510	519	PF00899	0.440
MOD_CK1_1	109	115	PF00069	0.307
MOD_CK1_1	139	145	PF00069	0.731
MOD_CK1_1	171	177	PF00069	0.706
MOD_CK1_1	178	184	PF00069	0.767
MOD_CK1_1	210	216	PF00069	0.464
MOD_CK1_1	267	273	PF00069	0.697
MOD_CK1_1	282	288	PF00069	0.484
MOD_CK1_1	384	390	PF00069	0.524
MOD_CK1_1	41	47	PF00069	0.710
MOD_CK1_1	52	58	PF00069	0.697
MOD_CK1_1	63	69	PF00069	0.664
MOD_CK1_1	83	89	PF00069	0.496
MOD_CK2_1	323	329	PF00069	0.542
MOD_CK2_1	350	356	PF00069	0.513
MOD_CK2_1	538	544	PF00069	0.696
MOD_CK2_1	86	92	PF00069	0.362
MOD_GlcNHglycan	113	116	PF01048	0.482
MOD_GlcNHglycan	142	145	PF01048	0.741
MOD_GlcNHglycan	169	173	PF01048	0.763
MOD_GlcNHglycan	178	181	PF01048	0.795
MOD_GlcNHglycan	209	212	PF01048	0.461
MOD_GlcNHglycan	269	272	PF01048	0.696
MOD_GlcNHglycan	275	278	PF01048	0.705
MOD_GlcNHglycan	281	284	PF01048	0.642
MOD_GlcNHglycan	498	502	PF01048	0.573
MOD_GlcNHglycan	503	506	PF01048	0.474
MOD_GlcNHglycan	540	543	PF01048	0.696
MOD_GlcNHglycan	65	68	PF01048	0.710
MOD_GlcNHglycan	70	73	PF01048	0.657
MOD_GlcNHglycan	74	77	PF01048	0.660
MOD_GSK3_1	107	114	PF00069	0.294
MOD_GSK3_1	136	143	PF00069	0.727
MOD_GSK3_1	168	175	PF00069	0.753
MOD_GSK3_1	269	276	PF00069	0.721
MOD_GSK3_1	323	330	PF00069	0.331
MOD_GSK3_1	37	44	PF00069	0.539
MOD_GSK3_1	49	56	PF00069	0.667
MOD_GSK3_1	493	500	PF00069	0.578
MOD_GSK3_1	533	540	PF00069	0.722
MOD_GSK3_1	551	558	PF00069	0.521
MOD_GSK3_1	571	578	PF00069	0.470
MOD_GSK3_1	582	589	PF00069	0.472
MOD_GSK3_1	591	598	PF00069	0.250
MOD_GSK3_1	68	75	PF00069	0.455
MOD_GSK3_1	86	93	PF00069	0.375
MOD_N-GLC_1	289	294	PF02516	0.353
MOD_N-GLC_1	86	91	PF02516	0.447
MOD_NEK2_1	123	128	PF00069	0.533
MOD_NEK2_1	226	231	PF00069	0.443
MOD_NEK2_1	289	294	PF00069	0.530
MOD_NEK2_1	323	328	PF00069	0.500
MOD_NEK2_1	381	386	PF00069	0.480
MOD_NEK2_1	497	502	PF00069	0.624
MOD_NEK2_1	51	56	PF00069	0.619
MOD_NEK2_1	518	523	PF00069	0.517
MOD_NEK2_1	575	580	PF00069	0.543
MOD_NEK2_1	9	14	PF00069	0.621
MOD_NEK2_2	542	547	PF00069	0.599
MOD_PIKK_1	183	189	PF00454	0.776
MOD_PIKK_1	475	481	PF00454	0.510
MOD_PIKK_1	523	529	PF00454	0.629
MOD_PIKK_1	586	592	PF00454	0.482
MOD_PIKK_1	95	101	PF00454	0.427
MOD_PK_1	445	451	PF00069	0.565
MOD_PK_1	49	55	PF00069	0.648
MOD_PKA_1	350	356	PF00069	0.489
MOD_PKA_2	264	270	PF00069	0.624
MOD_PKA_2	323	329	PF00069	0.479
MOD_PKA_2	350	356	PF00069	0.489
MOD_PKA_2	523	529	PF00069	0.643
MOD_PKA_2	68	74	PF00069	0.621
MOD_PKB_1	593	601	PF00069	0.447
MOD_Plk_2-3	493	499	PF00069	0.598
MOD_Plk_4	226	232	PF00069	0.486
MOD_Plk_4	292	298	PF00069	0.361
MOD_Plk_4	356	362	PF00069	0.500
MOD_Plk_4	445	451	PF00069	0.607
MOD_Plk_4	469	475	PF00069	0.438
MOD_Plk_4	571	577	PF00069	0.504
MOD_Plk_4	595	601	PF00069	0.335
MOD_Plk_4	80	86	PF00069	0.614
MOD_ProDKin_1	173	179	PF00069	0.764
MOD_ProDKin_1	275	281	PF00069	0.670
MOD_ProDKin_1	533	539	PF00069	0.494
MOD_ProDKin_1	551	557	PF00069	0.393
MOD_SUMO_rev_2	545	555	PF00179	0.667
TRG_DiLeu_BaEn_1	469	474	PF01217	0.582
TRG_DiLeu_BaEn_4	315	321	PF01217	0.501
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.697
TRG_ENDOCYTIC_2	223	226	PF00928	0.400
TRG_ENDOCYTIC_2	385	388	PF00928	0.336
TRG_ER_diArg_1	323	325	PF00400	0.517
TRG_ER_diArg_1	349	351	PF00400	0.532
TRG_ER_diArg_1	416	418	PF00400	0.408
TRG_ER_diArg_1	522	525	PF00400	0.578
TRG_ER_diArg_1	561	564	PF00400	0.349
TRG_ER_diArg_1	593	596	PF00400	0.431
TRG_NES_CRM1_1	337	348	PF08389	0.477
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P9	Leptomonas seymouri	65%	100%
A0A0S4KJS0	Bodo saltans	37%	100%
A0A1X0NTU8	Trypanosomatidae	43%	100%
A0A3Q8IDS9	Leishmania donovani	79%	100%
A4I265	Leishmania infantum	79%	99%
C9ZRT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AYB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q958	Leishmania major	79%	100%
V5B9R8	Trypanosoma cruzi	44%	100%