Putative DNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative DNA ligase

Gene product:

mitochondrial DNA ligase homolog, putative

Species:

Leishmania braziliensis

UniProt:

A4HEZ0_LEIBR

TriTrypDb:

LbrM.26.1370 , LBRM2903_260018800

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEZ0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	20
GO:0006259	DNA metabolic process	4	20
GO:0006281	DNA repair	5	20
GO:0006310	DNA recombination	5	20
GO:0006725	cellular aromatic compound metabolic process	3	20
GO:0006807	nitrogen compound metabolic process	2	20
GO:0006950	response to stress	2	20
GO:0006974	DNA damage response	4	20
GO:0008152	metabolic process	1	20
GO:0009987	cellular process	1	20
GO:0033554	cellular response to stress	3	20
GO:0034641	cellular nitrogen compound metabolic process	3	20
GO:0043170	macromolecule metabolic process	3	20
GO:0044237	cellular metabolic process	2	20
GO:0044238	primary metabolic process	2	20
GO:0044260	obsolete cellular macromolecule metabolic process	3	20
GO:0046483	heterocycle metabolic process	3	20
GO:0050896	response to stimulus	1	20
GO:0051716	cellular response to stimulus	2	20
GO:0071704	organic substance metabolic process	2	20
GO:0090304	nucleic acid metabolic process	4	20
GO:1901360	organic cyclic compound metabolic process	3	20

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	20
GO:0003824	catalytic activity	1	20
GO:0003909	DNA ligase activity	4	20
GO:0003910	DNA ligase (ATP) activity	5	20
GO:0005488	binding	1	20
GO:0005524	ATP binding	5	20
GO:0016874	ligase activity	2	20
GO:0016886	ligase activity, forming phosphoric ester bonds	3	20
GO:0017076	purine nucleotide binding	4	20
GO:0030554	adenyl nucleotide binding	5	20
GO:0032553	ribonucleotide binding	3	20
GO:0032555	purine ribonucleotide binding	4	20
GO:0032559	adenyl ribonucleotide binding	5	20
GO:0035639	purine ribonucleoside triphosphate binding	4	20
GO:0036094	small molecule binding	2	20
GO:0043167	ion binding	2	20
GO:0043168	anion binding	3	20
GO:0097159	organic cyclic compound binding	2	20
GO:0097367	carbohydrate derivative binding	2	20
GO:0140097	catalytic activity, acting on DNA	3	20
GO:0140640	catalytic activity, acting on a nucleic acid	2	20
GO:1901265	nucleoside phosphate binding	3	20
GO:1901363	heterocyclic compound binding	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.222
CLV_C14_Caspase3-7	413	417	PF00656	0.413
CLV_NRD_NRD_1	10	12	PF00675	0.547
CLV_NRD_NRD_1	246	248	PF00675	0.262
CLV_NRD_NRD_1	430	432	PF00675	0.319
CLV_NRD_NRD_1	437	439	PF00675	0.322
CLV_PCSK_FUR_1	8	12	PF00082	0.504
CLV_PCSK_KEX2_1	10	12	PF00082	0.495
CLV_PCSK_KEX2_1	16	18	PF00082	0.473
CLV_PCSK_KEX2_1	246	248	PF00082	0.272
CLV_PCSK_KEX2_1	301	303	PF00082	0.306
CLV_PCSK_KEX2_1	375	377	PF00082	0.277
CLV_PCSK_KEX2_1	429	431	PF00082	0.303
CLV_PCSK_KEX2_1	94	96	PF00082	0.453
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.460
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.314
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.284
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.312
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.296
CLV_PCSK_SKI1_1	127	131	PF00082	0.364
CLV_PCSK_SKI1_1	170	174	PF00082	0.343
CLV_PCSK_SKI1_1	348	352	PF00082	0.369
CLV_PCSK_SKI1_1	404	408	PF00082	0.446
CLV_PCSK_SKI1_1	439	443	PF00082	0.320
CLV_PCSK_SKI1_1	444	448	PF00082	0.325
DEG_SIAH_1	337	345	PF03145	0.374
DOC_CKS1_1	420	425	PF01111	0.271
DOC_CKS1_1	47	52	PF01111	0.338
DOC_MAPK_gen_1	94	101	PF00069	0.576
DOC_MAPK_MEF2A_6	220	227	PF00069	0.254
DOC_PP1_RVXF_1	125	132	PF00149	0.512
DOC_PP1_RVXF_1	390	397	PF00149	0.379
DOC_PP2B_LxvP_1	231	234	PF13499	0.300
DOC_PP4_FxxP_1	131	134	PF00568	0.506
DOC_PP4_FxxP_1	420	423	PF00568	0.407
DOC_USP7_UBL2_3	251	255	PF12436	0.220
DOC_USP7_UBL2_3	425	429	PF12436	0.406
DOC_WW_Pin1_4	164	169	PF00397	0.350
DOC_WW_Pin1_4	173	178	PF00397	0.276
DOC_WW_Pin1_4	250	255	PF00397	0.280
DOC_WW_Pin1_4	276	281	PF00397	0.254
DOC_WW_Pin1_4	419	424	PF00397	0.331
DOC_WW_Pin1_4	46	51	PF00397	0.329
LIG_14-3-3_CanoR_1	64	72	PF00244	0.355
LIG_14-3-3_CanoR_1	8	14	PF00244	0.429
LIG_APCC_ABBA_1	216	221	PF00400	0.158
LIG_BIR_II_1	1	5	PF00653	0.294
LIG_BIR_III_2	29	33	PF00653	0.219
LIG_BRCT_BRCA1_1	1	5	PF00533	0.371
LIG_BRCT_BRCA1_1	127	131	PF00533	0.493
LIG_BRCT_BRCA1_1	280	284	PF00533	0.392
LIG_BRCT_BRCA1_1	355	359	PF00533	0.343
LIG_deltaCOP1_diTrp_1	433	441	PF00928	0.158
LIG_FHA_1	222	228	PF00498	0.355
LIG_FHA_2	164	170	PF00498	0.400
LIG_FHA_2	24	30	PF00498	0.396
LIG_LIR_Apic_2	128	134	PF02991	0.486
LIG_LIR_Gen_1	235	245	PF02991	0.343
LIG_LIR_Gen_1	285	296	PF02991	0.310
LIG_LIR_Gen_1	443	453	PF02991	0.315
LIG_LIR_Gen_1	71	80	PF02991	0.331
LIG_LIR_LC3C_4	150	153	PF02991	0.179
LIG_LIR_Nem_3	124	129	PF02991	0.388
LIG_LIR_Nem_3	235	241	PF02991	0.325
LIG_LIR_Nem_3	265	269	PF02991	0.272
LIG_LIR_Nem_3	285	291	PF02991	0.309
LIG_LIR_Nem_3	29	34	PF02991	0.284
LIG_LIR_Nem_3	356	362	PF02991	0.267
LIG_LIR_Nem_3	377	381	PF02991	0.325
LIG_LIR_Nem_3	388	394	PF02991	0.371
LIG_LIR_Nem_3	443	448	PF02991	0.327
LIG_LIR_Nem_3	71	75	PF02991	0.346
LIG_MYND_1	213	217	PF01753	0.300
LIG_PCNA_PIPBox_1	260	269	PF02747	0.300
LIG_PCNA_yPIPBox_3	255	267	PF02747	0.312
LIG_PDZ_Class_3	472	477	PF00595	0.523
LIG_PDZ_Wminus1_1	475	477	PF00595	0.508
LIG_PTAP_UEV_1	279	284	PF05743	0.314
LIG_REV1ctd_RIR_1	195	204	PF16727	0.314
LIG_SH2_CRK	126	130	PF00017	0.382
LIG_SH2_CRK	19	23	PF00017	0.466
LIG_SH2_CRK	288	292	PF00017	0.284
LIG_SH2_CRK	335	339	PF00017	0.358
LIG_SH2_SRC	371	374	PF00017	0.259
LIG_SH2_STAP1	273	277	PF00017	0.326
LIG_SH2_STAT3	273	276	PF00017	0.413
LIG_SH2_STAT5	115	118	PF00017	0.479
LIG_SH2_STAT5	266	269	PF00017	0.300
LIG_SH2_STAT5	306	309	PF00017	0.404
LIG_SH2_STAT5	445	448	PF00017	0.310
LIG_SH3_2	424	429	PF14604	0.158
LIG_SH3_3	277	283	PF00018	0.289
LIG_SH3_3	364	370	PF00018	0.300
LIG_SH3_3	421	427	PF00018	0.158
LIG_SH3_3	456	462	PF00018	0.295
LIG_SUMO_SIM_par_1	221	228	PF11976	0.323
LIG_TYR_ITIM	448	453	PF00017	0.314
LIG_UBA3_1	215	220	PF00899	0.413
LIG_UBA3_1	363	368	PF00899	0.292
MOD_CDK_SPK_2	173	178	PF00069	0.286
MOD_CDK_SPK_2	250	255	PF00069	0.158
MOD_CDK_SPxK_1	164	170	PF00069	0.158
MOD_CDK_SPxK_1	419	425	PF00069	0.356
MOD_CK1_1	278	284	PF00069	0.331
MOD_CK1_1	322	328	PF00069	0.158
MOD_CK2_1	157	163	PF00069	0.370
MOD_Cter_Amidation	373	376	PF01082	0.284
MOD_Cter_Amidation	8	11	PF01082	0.307
MOD_GlcNHglycan	273	276	PF01048	0.347
MOD_GlcNHglycan	280	283	PF01048	0.379
MOD_GSK3_1	121	128	PF00069	0.497
MOD_GSK3_1	271	278	PF00069	0.284
MOD_GSK3_1	42	49	PF00069	0.303
MOD_GSK3_1	440	447	PF00069	0.442
MOD_N-GLC_1	163	168	PF02516	0.278
MOD_N-GLC_1	23	28	PF02516	0.271
MOD_N-GLC_1	51	56	PF02516	0.412
MOD_N-GLC_1	97	102	PF02516	0.522
MOD_NEK2_1	121	126	PF00069	0.445
MOD_NEK2_1	156	161	PF00069	0.240
MOD_NEK2_1	22	27	PF00069	0.300
MOD_PIKK_1	353	359	PF00454	0.319
MOD_PIKK_1	452	458	PF00454	0.316
MOD_PK_1	319	325	PF00069	0.158
MOD_PKA_1	301	307	PF00069	0.319
MOD_PKA_2	301	307	PF00069	0.319
MOD_PKA_2	467	473	PF00069	0.514
MOD_PKA_2	63	69	PF00069	0.331
MOD_PKA_2	9	15	PF00069	0.374
MOD_Plk_1	23	29	PF00069	0.275
MOD_Plk_1	97	103	PF00069	0.570
MOD_Plk_4	221	227	PF00069	0.339
MOD_Plk_4	42	48	PF00069	0.284
MOD_ProDKin_1	164	170	PF00069	0.350
MOD_ProDKin_1	173	179	PF00069	0.276
MOD_ProDKin_1	250	256	PF00069	0.280
MOD_ProDKin_1	276	282	PF00069	0.254
MOD_ProDKin_1	419	425	PF00069	0.331
MOD_ProDKin_1	46	52	PF00069	0.330
MOD_SUMO_rev_2	345	350	PF00179	0.158
MOD_SUMO_rev_2	388	394	PF00179	0.480
MOD_SUMO_rev_2	413	420	PF00179	0.158
TRG_DiLeu_BaEn_1	221	226	PF01217	0.158
TRG_DiLeu_BaEn_1	286	291	PF01217	0.284
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.413
TRG_ENDOCYTIC_2	126	129	PF00928	0.393
TRG_ENDOCYTIC_2	19	22	PF00928	0.322
TRG_ENDOCYTIC_2	266	269	PF00928	0.295
TRG_ENDOCYTIC_2	288	291	PF00928	0.304
TRG_ENDOCYTIC_2	383	386	PF00928	0.374
TRG_ENDOCYTIC_2	445	448	PF00928	0.306
TRG_ENDOCYTIC_2	450	453	PF00928	0.302
TRG_ER_diArg_1	245	247	PF00400	0.284
TRG_ER_diArg_1	430	432	PF00400	0.348
TRG_ER_diArg_1	8	11	PF00400	0.461
TRG_NLS_Bipartite_1	301	316	PF00514	0.359
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX3	Leptomonas seymouri	78%	96%
A0A0S4KIC5	Bodo saltans	32%	84%
A0A0S4KP75	Bodo saltans	35%	100%
A0A1X0NS61	Trypanosomatidae	31%	91%
A0A1X0NSF5	Trypanosomatidae	61%	91%
A0A3Q8IDN6	Leishmania donovani	89%	100%
A0A3Q8IDV4	Leishmania donovani	25%	100%
A0A3S5IR98	Trypanosoma rangeli	35%	98%
A0A422NIS8	Trypanosoma rangeli	59%	100%
A4HEY9	Leishmania braziliensis	27%	100%
A4I263	Leishmania infantum	25%	100%
A4I264	Leishmania infantum	89%	100%
C9ZRT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	93%
C9ZRT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9AYB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P0C991	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	25%	100%
P0C992	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	25%	100%
Q4Q959	Leishmania major	88%	100%
V5AUB9	Trypanosoma cruzi	62%	91%
V5DAB4	Trypanosoma cruzi	33%	98%