Putative DNA ligase k alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA ligase k alpha, putative

Species:

Leishmania braziliensis

UniProt:

A4HEY9_LEIBR

TriTrypDb:

LbrM.26.1360 , LBRM2903_260018700

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HEY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEY9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	21
GO:0006259	DNA metabolic process	4	21
GO:0006281	DNA repair	5	21
GO:0006310	DNA recombination	5	21
GO:0006725	cellular aromatic compound metabolic process	3	21
GO:0006807	nitrogen compound metabolic process	2	21
GO:0006950	response to stress	2	21
GO:0006974	DNA damage response	4	21
GO:0008152	metabolic process	1	21
GO:0009987	cellular process	1	21
GO:0033554	cellular response to stress	3	21
GO:0034641	cellular nitrogen compound metabolic process	3	21
GO:0043170	macromolecule metabolic process	3	21
GO:0044237	cellular metabolic process	2	21
GO:0044238	primary metabolic process	2	21
GO:0044260	obsolete cellular macromolecule metabolic process	3	21
GO:0046483	heterocycle metabolic process	3	21
GO:0050896	response to stimulus	1	21
GO:0051716	cellular response to stimulus	2	21
GO:0071704	organic substance metabolic process	2	21
GO:0090304	nucleic acid metabolic process	4	21
GO:1901360	organic cyclic compound metabolic process	3	21

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0003824	catalytic activity	1	21
GO:0003909	DNA ligase activity	4	21
GO:0003910	DNA ligase (ATP) activity	5	21
GO:0005488	binding	1	21
GO:0005524	ATP binding	5	21
GO:0016874	ligase activity	2	21
GO:0016886	ligase activity, forming phosphoric ester bonds	3	21
GO:0017076	purine nucleotide binding	4	21
GO:0030554	adenyl nucleotide binding	5	21
GO:0032553	ribonucleotide binding	3	21
GO:0032555	purine ribonucleotide binding	4	21
GO:0032559	adenyl ribonucleotide binding	5	21
GO:0035639	purine ribonucleoside triphosphate binding	4	21
GO:0036094	small molecule binding	2	21
GO:0043167	ion binding	2	21
GO:0043168	anion binding	3	21
GO:0097159	organic cyclic compound binding	2	21
GO:0097367	carbohydrate derivative binding	2	21
GO:0140097	catalytic activity, acting on DNA	3	21
GO:0140640	catalytic activity, acting on a nucleic acid	2	21
GO:1901265	nucleoside phosphate binding	3	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	519	523	PF00656	0.516
CLV_NRD_NRD_1	138	140	PF00675	0.578
CLV_NRD_NRD_1	25	27	PF00675	0.552
CLV_NRD_NRD_1	447	449	PF00675	0.438
CLV_NRD_NRD_1	477	479	PF00675	0.324
CLV_NRD_NRD_1	587	589	PF00675	0.340
CLV_NRD_NRD_1	94	96	PF00675	0.313
CLV_PCSK_KEX2_1	111	113	PF00082	0.313
CLV_PCSK_KEX2_1	159	161	PF00082	0.489
CLV_PCSK_KEX2_1	25	27	PF00082	0.550
CLV_PCSK_KEX2_1	30	32	PF00082	0.618
CLV_PCSK_KEX2_1	447	449	PF00082	0.463
CLV_PCSK_KEX2_1	477	479	PF00082	0.324
CLV_PCSK_KEX2_1	502	504	PF00082	0.717
CLV_PCSK_KEX2_1	586	588	PF00082	0.310
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.337
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.489
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.760
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.727
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.319
CLV_PCSK_PC7_1	26	32	PF00082	0.490
CLV_PCSK_SKI1_1	213	217	PF00082	0.449
CLV_PCSK_SKI1_1	256	260	PF00082	0.446
CLV_PCSK_SKI1_1	280	284	PF00082	0.421
CLV_PCSK_SKI1_1	31	35	PF00082	0.594
CLV_PCSK_SKI1_1	47	51	PF00082	0.667
CLV_PCSK_SKI1_1	481	485	PF00082	0.532
CLV_PCSK_SKI1_1	499	503	PF00082	0.693
CLV_PCSK_SKI1_1	558	562	PF00082	0.408
CLV_PCSK_SKI1_1	600	604	PF00082	0.328
DEG_APCC_DBOX_1	212	220	PF00400	0.416
DEG_SCF_FBW7_1	382	387	PF00400	0.423
DEG_SCF_FBW7_1	577	582	PF00400	0.425
DOC_ANK_TNKS_1	623	630	PF00023	0.562
DOC_CKS1_1	381	386	PF01111	0.551
DOC_CYCLIN_RxL_1	277	286	PF00134	0.381
DOC_CYCLIN_yClb5_NLxxxL_5	213	219	PF00134	0.409
DOC_MAPK_MEF2A_6	168	175	PF00069	0.616
DOC_MAPK_MEF2A_6	3	10	PF00069	0.574
DOC_PP1_RVXF_1	254	261	PF00149	0.461
DOC_PP1_RVXF_1	93	100	PF00149	0.299
DOC_SPAK_OSR1_1	574	578	PF12202	0.425
DOC_USP7_MATH_1	166	170	PF00917	0.568
DOC_USP7_MATH_1	384	388	PF00917	0.361
DOC_USP7_MATH_1	78	82	PF00917	0.408
DOC_USP7_UBL2_3	221	225	PF12436	0.370
DOC_USP7_UBL2_3	594	598	PF12436	0.460
DOC_WW_Pin1_4	141	146	PF00397	0.711
DOC_WW_Pin1_4	236	241	PF00397	0.330
DOC_WW_Pin1_4	312	317	PF00397	0.683
DOC_WW_Pin1_4	380	385	PF00397	0.428
DOC_WW_Pin1_4	565	570	PF00397	0.363
DOC_WW_Pin1_4	575	580	PF00397	0.315
DOC_WW_Pin1_4	607	612	PF00397	0.256
DOC_WW_Pin1_4	88	93	PF00397	0.318
LIG_14-3-3_CanoR_1	181	187	PF00244	0.612
LIG_14-3-3_CanoR_1	25	32	PF00244	0.535
LIG_14-3-3_CanoR_1	425	431	PF00244	0.342
LIG_14-3-3_CanoR_1	481	487	PF00244	0.656
LIG_14-3-3_CanoR_1	530	535	PF00244	0.436
LIG_14-3-3_CanoR_1	574	578	PF00244	0.372
LIG_14-3-3_CanoR_1	588	594	PF00244	0.230
LIG_Actin_WH2_2	431	449	PF00022	0.504
LIG_APCC_Cbox_2	114	120	PF00515	0.180
LIG_BRCT_BRCA1_1	402	406	PF00533	0.554
LIG_FHA_1	129	135	PF00498	0.589
LIG_FHA_1	210	216	PF00498	0.456
LIG_FHA_1	253	259	PF00498	0.518
LIG_FHA_1	286	292	PF00498	0.432
LIG_FHA_1	3	9	PF00498	0.573
LIG_FHA_1	319	325	PF00498	0.561
LIG_FHA_1	370	376	PF00498	0.482
LIG_FHA_1	381	387	PF00498	0.299
LIG_FHA_2	264	270	PF00498	0.377
LIG_FHA_2	483	489	PF00498	0.725
LIG_FHA_2	580	586	PF00498	0.319
LIG_LIR_Apic_2	378	384	PF02991	0.569
LIG_LIR_Gen_1	203	211	PF02991	0.543
LIG_LIR_Gen_1	331	342	PF02991	0.510
LIG_LIR_Gen_1	542	551	PF02991	0.385
LIG_LIR_Gen_1	563	569	PF02991	0.425
LIG_LIR_Gen_1	603	614	PF02991	0.313
LIG_LIR_Nem_3	203	209	PF02991	0.565
LIG_LIR_Nem_3	331	337	PF02991	0.495
LIG_LIR_Nem_3	417	423	PF02991	0.361
LIG_LIR_Nem_3	439	444	PF02991	0.552
LIG_LIR_Nem_3	542	548	PF02991	0.378
LIG_LIR_Nem_3	554	560	PF02991	0.304
LIG_LIR_Nem_3	563	567	PF02991	0.326
LIG_LIR_Nem_3	603	609	PF02991	0.312
LIG_MYND_1	316	320	PF01753	0.417
LIG_NRBOX	422	428	PF00104	0.480
LIG_PDZ_Class_3	628	633	PF00595	0.514
LIG_PDZ_Wminus1_1	631	633	PF00595	0.494
LIG_Pex14_1	593	597	PF04695	0.425
LIG_Pex14_2	560	564	PF04695	0.279
LIG_REV1ctd_RIR_1	258	267	PF16727	0.414
LIG_SH2_CRK	334	338	PF00017	0.519
LIG_SH2_CRK	441	445	PF00017	0.470
LIG_SH2_PTP2	545	548	PF00017	0.400
LIG_SH2_SRC	545	548	PF00017	0.337
LIG_SH2_SRC	606	609	PF00017	0.279
LIG_SH2_STAP1	402	406	PF00017	0.393
LIG_SH2_STAT5	206	209	PF00017	0.557
LIG_SH2_STAT5	452	455	PF00017	0.441
LIG_SH2_STAT5	545	548	PF00017	0.356
LIG_SH3_3	612	618	PF00018	0.298
LIG_SUMO_SIM_par_1	286	292	PF11976	0.393
LIG_TYR_ITIM	418	423	PF00017	0.466
LIG_TYR_ITIM	469	474	PF00017	0.478
LIG_TYR_ITIM	604	609	PF00017	0.317
LIG_UBA3_1	215	221	PF00899	0.467
LIG_WRC_WIRS_1	561	566	PF05994	0.425
MOD_CDK_SPK_2	141	146	PF00069	0.487
MOD_CDK_SPK_2	236	241	PF00069	0.340
MOD_CDK_SPK_2	312	317	PF00069	0.387
MOD_CDK_SPxK_1	565	571	PF00069	0.445
MOD_CDK_SPxxK_3	565	572	PF00069	0.398
MOD_CDK_SPxxK_3	88	95	PF00069	0.312
MOD_CK1_1	144	150	PF00069	0.662
MOD_CK1_1	153	159	PF00069	0.705
MOD_CK1_1	592	598	PF00069	0.461
MOD_CK2_1	263	269	PF00069	0.389
MOD_CK2_1	579	585	PF00069	0.214
MOD_CMANNOS	590	593	PF00535	0.425
MOD_GlcNHglycan	136	139	PF01048	0.668
MOD_GlcNHglycan	14	17	PF01048	0.677
MOD_GlcNHglycan	146	149	PF01048	0.627
MOD_GlcNHglycan	164	167	PF01048	0.620
MOD_GlcNHglycan	263	266	PF01048	0.464
MOD_GlcNHglycan	324	327	PF01048	0.650
MOD_GlcNHglycan	330	333	PF01048	0.477
MOD_GlcNHglycan	372	375	PF01048	0.370
MOD_GlcNHglycan	385	389	PF01048	0.445
MOD_GlcNHglycan	411	414	PF01048	0.476
MOD_GlcNHglycan	495	498	PF01048	0.655
MOD_GlcNHglycan	504	507	PF01048	0.625
MOD_GlcNHglycan	552	556	PF01048	0.365
MOD_GSK3_1	140	147	PF00069	0.635
MOD_GSK3_1	155	162	PF00069	0.582
MOD_GSK3_1	181	188	PF00069	0.599
MOD_GSK3_1	259	266	PF00069	0.375
MOD_GSK3_1	303	310	PF00069	0.551
MOD_GSK3_1	312	319	PF00069	0.615
MOD_GSK3_1	370	377	PF00069	0.434
MOD_GSK3_1	380	387	PF00069	0.461
MOD_GSK3_1	448	455	PF00069	0.532
MOD_GSK3_1	57	64	PF00069	0.490
MOD_GSK3_1	575	582	PF00069	0.288
MOD_N-GLC_1	296	301	PF02516	0.441
MOD_NEK2_1	197	202	PF00069	0.664
MOD_NEK2_1	2	7	PF00069	0.686
MOD_NEK2_1	259	264	PF00069	0.369
MOD_NEK2_1	333	338	PF00069	0.324
MOD_NEK2_1	426	431	PF00069	0.380
MOD_NEK2_1	560	565	PF00069	0.458
MOD_NEK2_1	589	594	PF00069	0.279
MOD_NEK2_2	428	433	PF00069	0.509
MOD_PK_1	348	354	PF00069	0.462
MOD_PKA_1	159	165	PF00069	0.600
MOD_PKA_1	25	31	PF00069	0.647
MOD_PKA_1	47	53	PF00069	0.667
MOD_PKA_1	502	508	PF00069	0.670
MOD_PKA_2	159	165	PF00069	0.487
MOD_PKA_2	180	186	PF00069	0.499
MOD_PKA_2	19	25	PF00069	0.557
MOD_PKA_2	375	381	PF00069	0.407
MOD_PKA_2	409	415	PF00069	0.510
MOD_PKA_2	488	494	PF00069	0.600
MOD_PKA_2	502	508	PF00069	0.740
MOD_PKA_2	529	535	PF00069	0.438
MOD_PKA_2	573	579	PF00069	0.376
MOD_PKB_1	179	187	PF00069	0.547
MOD_Plk_1	296	302	PF00069	0.446
MOD_Plk_1	384	390	PF00069	0.481
MOD_Plk_4	19	25	PF00069	0.649
MOD_Plk_4	2	8	PF00069	0.639
MOD_Plk_4	263	269	PF00069	0.389
MOD_Plk_4	285	291	PF00069	0.408
MOD_Plk_4	333	339	PF00069	0.290
MOD_Plk_4	448	454	PF00069	0.374
MOD_Plk_4	458	464	PF00069	0.362
MOD_Plk_4	530	536	PF00069	0.457
MOD_Plk_4	560	566	PF00069	0.416
MOD_ProDKin_1	141	147	PF00069	0.712
MOD_ProDKin_1	236	242	PF00069	0.330
MOD_ProDKin_1	312	318	PF00069	0.682
MOD_ProDKin_1	380	386	PF00069	0.420
MOD_ProDKin_1	565	571	PF00069	0.363
MOD_ProDKin_1	575	581	PF00069	0.315
MOD_ProDKin_1	607	613	PF00069	0.256
MOD_ProDKin_1	88	94	PF00069	0.318
MOD_SUMO_rev_2	505	512	PF00179	0.475
TRG_DiLeu_BaEn_1	211	216	PF01217	0.518
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.424
TRG_ENDOCYTIC_2	206	209	PF00928	0.557
TRG_ENDOCYTIC_2	334	337	PF00928	0.525
TRG_ENDOCYTIC_2	395	398	PF00928	0.327
TRG_ENDOCYTIC_2	420	423	PF00928	0.349
TRG_ENDOCYTIC_2	441	444	PF00928	0.512
TRG_ENDOCYTIC_2	471	474	PF00928	0.313
TRG_ENDOCYTIC_2	537	540	PF00928	0.380
TRG_ENDOCYTIC_2	545	548	PF00928	0.351
TRG_ENDOCYTIC_2	606	609	PF00928	0.306
TRG_ER_diArg_1	176	179	PF00400	0.645
TRG_ER_diArg_1	24	26	PF00400	0.568
TRG_ER_diArg_1	446	448	PF00400	0.471
TRG_ER_diArg_1	476	478	PF00400	0.283
TRG_ER_diArg_1	587	589	PF00400	0.340
TRG_NLS_MonoExtC_3	498	503	PF00514	0.708
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ3	Leptomonas seymouri	60%	98%
A0A0N1PAX3	Leptomonas seymouri	25%	100%
A0A0S4KIC5	Bodo saltans	32%	100%
A0A0S4KP75	Bodo saltans	29%	100%
A0A1X0NS61	Trypanosomatidae	46%	100%
A0A1X0NSF5	Trypanosomatidae	27%	100%
A0A3Q8IDN6	Leishmania donovani	27%	100%
A0A3Q8IDV4	Leishmania donovani	81%	100%
A0A3S5IR98	Trypanosoma rangeli	44%	100%
A4HEZ0	Leishmania braziliensis	27%	100%
A4I263	Leishmania infantum	81%	100%
A4I264	Leishmania infantum	27%	100%
C9ZRT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AYB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AYB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q959	Leishmania major	26%	73%
Q4Q960	Leishmania major	81%	100%
V5AUB9	Trypanosoma cruzi	27%	100%
V5DAB4	Trypanosoma cruzi	45%	100%