Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEY8_LEIBR

TriTrypDb:

LbrM.26.1350 , LBRM2903_260018600

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.524
CLV_NRD_NRD_1	273	275	PF00675	0.562
CLV_PCSK_KEX2_1	273	275	PF00082	0.562
CLV_PCSK_SKI1_1	212	216	PF00082	0.466
CLV_PCSK_SKI1_1	313	317	PF00082	0.492
CLV_PCSK_SKI1_1	380	384	PF00082	0.588
DEG_APCC_DBOX_1	211	219	PF00400	0.469
DEG_SCF_FBW7_1	231	238	PF00400	0.534
DEG_SPOP_SBC_1	426	430	PF00917	0.486
DOC_CKS1_1	140	145	PF01111	0.496
DOC_CKS1_1	188	193	PF01111	0.587
DOC_CKS1_1	319	324	PF01111	0.480
DOC_CYCLIN_RxL_1	245	253	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.482
DOC_MAPK_gen_1	245	254	PF00069	0.411
DOC_MAPK_MEF2A_6	212	219	PF00069	0.395
DOC_MAPK_MEF2A_6	245	254	PF00069	0.411
DOC_MAPK_MEF2A_6	427	435	PF00069	0.500
DOC_MAPK_NFAT4_5	212	220	PF00069	0.397
DOC_PP1_SILK_1	269	274	PF00149	0.502
DOC_PP2B_LxvP_1	204	207	PF13499	0.397
DOC_PP4_FxxP_1	188	191	PF00568	0.600
DOC_USP7_MATH_1	110	114	PF00917	0.552
DOC_USP7_MATH_1	148	152	PF00917	0.562
DOC_USP7_MATH_1	18	22	PF00917	0.565
DOC_USP7_MATH_1	267	271	PF00917	0.495
DOC_USP7_MATH_1	297	301	PF00917	0.476
DOC_USP7_MATH_1	426	430	PF00917	0.587
DOC_WW_Pin1_4	106	111	PF00397	0.611
DOC_WW_Pin1_4	113	118	PF00397	0.562
DOC_WW_Pin1_4	139	144	PF00397	0.476
DOC_WW_Pin1_4	187	192	PF00397	0.580
DOC_WW_Pin1_4	21	26	PF00397	0.493
DOC_WW_Pin1_4	231	236	PF00397	0.691
DOC_WW_Pin1_4	318	323	PF00397	0.532
DOC_WW_Pin1_4	330	335	PF00397	0.664
DOC_WW_Pin1_4	390	395	PF00397	0.602
LIG_14-3-3_CanoR_1	154	163	PF00244	0.473
LIG_14-3-3_CanoR_1	239	244	PF00244	0.471
LIG_14-3-3_CanoR_1	369	378	PF00244	0.729
LIG_14-3-3_CanoR_1	427	432	PF00244	0.492
LIG_BRCT_BRCA1_1	394	398	PF00533	0.653
LIG_CSL_BTD_1	29	32	PF09270	0.564
LIG_deltaCOP1_diTrp_1	28	37	PF00928	0.418
LIG_FHA_1	188	194	PF00498	0.592
LIG_FHA_1	206	212	PF00498	0.489
LIG_FHA_1	296	302	PF00498	0.480
LIG_FHA_1	428	434	PF00498	0.497
LIG_FHA_2	159	165	PF00498	0.415
LIG_FHA_2	223	229	PF00498	0.444
LIG_FHA_2	242	248	PF00498	0.563
LIG_FHA_2	264	270	PF00498	0.608
LIG_FHA_2	297	303	PF00498	0.619
LIG_FHA_2	319	325	PF00498	0.485
LIG_Integrin_RGD_1	277	279	PF01839	0.576
LIG_LIR_Apic_2	157	163	PF02991	0.566
LIG_LIR_Apic_2	186	191	PF02991	0.586
LIG_LIR_Gen_1	306	316	PF02991	0.410
LIG_LIR_Gen_1	33	41	PF02991	0.545
LIG_LIR_Nem_3	306	312	PF02991	0.411
LIG_LIR_Nem_3	33	37	PF02991	0.480
LIG_LIR_Nem_3	395	401	PF02991	0.622
LIG_NRBOX	123	129	PF00104	0.519
LIG_NRBOX	214	220	PF00104	0.473
LIG_PDZ_Class_2	430	435	PF00595	0.530
LIG_Pex14_1	34	38	PF04695	0.481
LIG_Pex14_2	222	226	PF04695	0.527
LIG_SH2_NCK_1	160	164	PF00017	0.469
LIG_SH2_STAT5	160	163	PF00017	0.407
LIG_SH2_STAT5	184	187	PF00017	0.472
LIG_SH3_3	114	120	PF00018	0.482
LIG_SH3_3	188	194	PF00018	0.601
LIG_SH3_3	373	379	PF00018	0.715
LIG_SH3_3	391	397	PF00018	0.561
LIG_SH3_3	60	66	PF00018	0.558
LIG_SH3_3	88	94	PF00018	0.534
LIG_SUMO_SIM_par_1	215	221	PF11976	0.406
LIG_SUMO_SIM_par_1	79	85	PF11976	0.557
LIG_TRAF2_1	244	247	PF00917	0.555
LIG_WRC_WIRS_1	185	190	PF05994	0.460
LIG_WRC_WIRS_1	219	224	PF05994	0.497
MOD_CK1_1	109	115	PF00069	0.545
MOD_CK1_1	21	27	PF00069	0.637
MOD_CK1_1	221	227	PF00069	0.460
MOD_CK1_1	241	247	PF00069	0.455
MOD_CK1_1	326	332	PF00069	0.623
MOD_CK1_1	371	377	PF00069	0.527
MOD_CK1_1	393	399	PF00069	0.533
MOD_CK2_1	222	228	PF00069	0.422
MOD_CK2_1	241	247	PF00069	0.501
MOD_CK2_1	263	269	PF00069	0.549
MOD_CK2_1	296	302	PF00069	0.637
MOD_GlcNHglycan	131	134	PF01048	0.550
MOD_GlcNHglycan	146	149	PF01048	0.575
MOD_GlcNHglycan	279	283	PF01048	0.745
MOD_GlcNHglycan	380	383	PF01048	0.584
MOD_GlcNHglycan	59	62	PF01048	0.499
MOD_GlcNHglycan	84	87	PF01048	0.618
MOD_GSK3_1	106	113	PF00069	0.530
MOD_GSK3_1	135	142	PF00069	0.416
MOD_GSK3_1	144	151	PF00069	0.578
MOD_GSK3_1	154	161	PF00069	0.455
MOD_GSK3_1	183	190	PF00069	0.498
MOD_GSK3_1	20	27	PF00069	0.625
MOD_GSK3_1	218	225	PF00069	0.429
MOD_GSK3_1	231	238	PF00069	0.627
MOD_GSK3_1	263	270	PF00069	0.607
MOD_GSK3_1	291	298	PF00069	0.724
MOD_GSK3_1	314	321	PF00069	0.499
MOD_GSK3_1	326	333	PF00069	0.809
MOD_GSK3_1	378	385	PF00069	0.580
MOD_GSK3_1	53	60	PF00069	0.607
MOD_N-GLC_1	231	236	PF02516	0.534
MOD_NEK2_1	127	132	PF00069	0.418
MOD_NEK2_1	135	140	PF00069	0.436
MOD_NEK2_1	2	7	PF00069	0.572
MOD_NEK2_1	218	223	PF00069	0.473
MOD_NEK2_1	67	72	PF00069	0.602
MOD_PKA_2	158	164	PF00069	0.475
MOD_PKA_2	238	244	PF00069	0.479
MOD_PKA_2	368	374	PF00069	0.511
MOD_PKA_2	426	432	PF00069	0.708
MOD_Plk_1	263	269	PF00069	0.584
MOD_Plk_1	76	82	PF00069	0.460
MOD_Plk_4	135	141	PF00069	0.406
MOD_Plk_4	218	224	PF00069	0.518
MOD_Plk_4	267	273	PF00069	0.563
MOD_Plk_4	76	82	PF00069	0.472
MOD_ProDKin_1	106	112	PF00069	0.615
MOD_ProDKin_1	113	119	PF00069	0.557
MOD_ProDKin_1	139	145	PF00069	0.488
MOD_ProDKin_1	187	193	PF00069	0.581
MOD_ProDKin_1	21	27	PF00069	0.490
MOD_ProDKin_1	231	237	PF00069	0.692
MOD_ProDKin_1	318	324	PF00069	0.541
MOD_ProDKin_1	330	336	PF00069	0.660
MOD_ProDKin_1	390	396	PF00069	0.601
MOD_SUMO_rev_2	371	376	PF00179	0.521
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.539
TRG_ER_diArg_1	272	274	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H2	Leptomonas seymouri	30%	100%
A0A3S7WZZ6	Leishmania donovani	64%	87%
A4I262	Leishmania infantum	64%	100%
E9AYB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4Q961	Leishmania major	64%	95%