Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEY7_LEIBR

TriTrypDb:

LbrM.26.1340 , LBRM2903_260018500

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HEY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.421
CLV_NRD_NRD_1	208	210	PF00675	0.405
CLV_PCSK_FUR_1	206	210	PF00082	0.421
CLV_PCSK_KEX2_1	192	194	PF00082	0.437
CLV_PCSK_KEX2_1	203	205	PF00082	0.414
CLV_PCSK_KEX2_1	208	210	PF00082	0.417
CLV_PCSK_KEX2_1	267	269	PF00082	0.564
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.414
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.600
CLV_PCSK_PC7_1	188	194	PF00082	0.443
CLV_PCSK_PC7_1	204	210	PF00082	0.418
CLV_PCSK_SKI1_1	120	124	PF00082	0.640
CLV_PCSK_SKI1_1	200	204	PF00082	0.429
DEG_APCC_DBOX_1	119	127	PF00400	0.666
DEG_APCC_DBOX_1	208	216	PF00400	0.403
DEG_Nend_UBRbox_1	1	4	PF02207	0.586
DEG_SCF_FBW7_1	68	74	PF00400	0.468
DOC_CDC14_PxL_1	126	134	PF14671	0.461
DOC_CKS1_1	68	73	PF01111	0.694
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.637
DOC_MAPK_gen_1	56	66	PF00069	0.491
DOC_MAPK_JIP1_4	120	126	PF00069	0.665
DOC_PP2B_LxvP_1	69	72	PF13499	0.679
DOC_USP7_MATH_1	183	187	PF00917	0.444
DOC_USP7_MATH_1	254	258	PF00917	0.509
DOC_USP7_MATH_1	81	85	PF00917	0.737
DOC_USP7_UBL2_3	170	174	PF12436	0.537
DOC_USP7_UBL2_3	263	267	PF12436	0.610
DOC_WW_Pin1_4	140	145	PF00397	0.475
DOC_WW_Pin1_4	22	27	PF00397	0.680
DOC_WW_Pin1_4	64	69	PF00397	0.563
LIG_14-3-3_CanoR_1	103	108	PF00244	0.592
LIG_14-3-3_CanoR_1	20	26	PF00244	0.773
LIG_14-3-3_CanoR_1	40	46	PF00244	0.515
LIG_Actin_WH2_2	217	235	PF00022	0.426
LIG_BRCT_BRCA1_1	150	154	PF00533	0.413
LIG_FHA_1	31	37	PF00498	0.624
LIG_FHA_2	42	48	PF00498	0.507
LIG_FHA_2	60	66	PF00498	0.624
LIG_FHA_2	83	89	PF00498	0.659
LIG_Integrin_RGD_1	56	58	PF01839	0.491
LIG_LIR_Gen_1	62	71	PF02991	0.583
LIG_LIR_Nem_3	62	66	PF02991	0.596
LIG_PDZ_Class_2	272	277	PF00595	0.503
LIG_Pex14_1	167	171	PF04695	0.428
LIG_PTB_Apo_2	214	221	PF02174	0.426
LIG_SH2_CRK	172	176	PF00017	0.426
LIG_SH3_3	65	71	PF00018	0.608
LIG_SUMO_SIM_par_1	122	128	PF11976	0.676
LIG_UBA3_1	122	127	PF00899	0.453
LIG_UBA3_1	228	236	PF00899	0.441
LIG_WRC_WIRS_1	104	109	PF05994	0.571
MOD_CDK_SPxK_1	22	28	PF00069	0.642
MOD_CK1_1	234	240	PF00069	0.462
MOD_CK2_1	94	100	PF00069	0.489
MOD_Cter_Amidation	265	268	PF01082	0.579
MOD_GlcNHglycan	11	14	PF01048	0.606
MOD_GlcNHglycan	150	153	PF01048	0.593
MOD_GlcNHglycan	252	255	PF01048	0.441
MOD_GlcNHglycan	257	260	PF01048	0.524
MOD_GlcNHglycan	3	6	PF01048	0.684
MOD_GlcNHglycan	51	54	PF01048	0.720
MOD_GlcNHglycan	73	76	PF01048	0.622
MOD_GSK3_1	246	253	PF00069	0.469
MOD_GSK3_1	266	273	PF00069	0.484
MOD_GSK3_1	67	74	PF00069	0.514
MOD_GSK3_1	89	96	PF00069	0.678
MOD_N-GLC_1	20	25	PF02516	0.659
MOD_N-GLC_1	30	35	PF02516	0.678
MOD_N-GLC_1	40	45	PF02516	0.768
MOD_N-GLC_1	49	54	PF02516	0.523
MOD_N-GLC_1	81	86	PF02516	0.696
MOD_N-GLC_1	89	94	PF02516	0.470
MOD_NEK2_1	1	6	PF00069	0.630
MOD_NEK2_1	232	237	PF00069	0.460
MOD_NEK2_1	245	250	PF00069	0.450
MOD_PIKK_1	246	252	PF00454	0.539
MOD_PKA_2	161	167	PF00069	0.486
MOD_PKA_2	255	261	PF00069	0.530
MOD_PKB_1	268	276	PF00069	0.510
MOD_Plk_1	115	121	PF00069	0.605
MOD_Plk_1	40	46	PF00069	0.579
MOD_Plk_1	89	95	PF00069	0.475
MOD_Plk_4	41	47	PF00069	0.511
MOD_Plk_4	59	65	PF00069	0.716
MOD_Plk_4	82	88	PF00069	0.566
MOD_ProDKin_1	140	146	PF00069	0.470
MOD_ProDKin_1	22	28	PF00069	0.683
MOD_ProDKin_1	64	70	PF00069	0.560
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.652
TRG_ENDOCYTIC_2	156	159	PF00928	0.596
TRG_ENDOCYTIC_2	172	175	PF00928	0.308
TRG_ER_diArg_1	107	110	PF00400	0.556
TRG_ER_diArg_1	192	194	PF00400	0.437
TRG_ER_diArg_1	207	209	PF00400	0.420
TRG_ER_diArg_1	268	271	PF00400	0.524
TRG_ER_diLys_1	272	277	PF00400	0.503
TRG_NLS_Bipartite_1	192	207	PF00514	0.422
TRG_NLS_MonoExtC_3	266	271	PF00514	0.636
TRG_NLS_MonoExtN_4	200	207	PF00514	0.430
TRG_NLS_MonoExtN_4	265	271	PF00514	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC03	Leptomonas seymouri	63%	100%
A0A1X0NS69	Trypanosomatidae	62%	100%
A0A3R7ND13	Trypanosoma rangeli	64%	100%
A0A3S7WZU2	Leishmania donovani	77%	100%
A4I261	Leishmania infantum	77%	100%
C9ZRT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AYB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q962	Leishmania major	78%	100%
V5BIT0	Trypanosoma cruzi	63%	90%