Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEY6_LEIBR

TriTrypDb:

LbrM.26.1330 , LBRM2903_260018400

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HEY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.500
CLV_NRD_NRD_1	111	113	PF00675	0.339
CLV_NRD_NRD_1	14	16	PF00675	0.500
CLV_NRD_NRD_1	305	307	PF00675	0.476
CLV_NRD_NRD_1	321	323	PF00675	0.240
CLV_NRD_NRD_1	55	57	PF00675	0.483
CLV_NRD_NRD_1	99	101	PF00675	0.424
CLV_PCSK_KEX2_1	110	112	PF00082	0.376
CLV_PCSK_KEX2_1	321	323	PF00082	0.270
CLV_PCSK_KEX2_1	55	57	PF00082	0.460
CLV_PCSK_SKI1_1	10	14	PF00082	0.482
CLV_PCSK_SKI1_1	170	174	PF00082	0.386
CLV_PCSK_SKI1_1	191	195	PF00082	0.386
CLV_PCSK_SKI1_1	243	247	PF00082	0.266
CLV_PCSK_SKI1_1	306	310	PF00082	0.374
DEG_APCC_DBOX_1	227	235	PF00400	0.350
DEG_Nend_Nbox_1	1	3	PF02207	0.721
DOC_CYCLIN_RxL_1	237	247	PF00134	0.334
DOC_CYCLIN_RxL_1	32	43	PF00134	0.623
DOC_CYCLIN_RxL_1	4	14	PF00134	0.708
DOC_MAPK_gen_1	146	155	PF00069	0.562
DOC_MAPK_MEF2A_6	146	155	PF00069	0.667
DOC_PP1_RVXF_1	196	203	PF00149	0.472
DOC_PP1_RVXF_1	241	247	PF00149	0.279
DOC_PP2B_LxvP_1	239	242	PF13499	0.382
DOC_PP2B_LxvP_1	67	70	PF13499	0.672
DOC_USP7_MATH_1	104	108	PF00917	0.464
DOC_USP7_MATH_1	137	141	PF00917	0.718
DOC_USP7_UBL2_3	97	101	PF12436	0.602
LIG_14-3-3_CanoR_1	181	189	PF00244	0.599
LIG_14-3-3_CanoR_1	321	325	PF00244	0.453
LIG_14-3-3_CanoR_1	4	9	PF00244	0.629
LIG_Actin_WH2_2	216	234	PF00022	0.483
LIG_BIR_III_2	298	302	PF00653	0.618
LIG_DLG_GKlike_1	4	12	PF00625	0.544
LIG_eIF4E_1	203	209	PF01652	0.273
LIG_eIF4E_1	251	257	PF01652	0.326
LIG_FHA_1	182	188	PF00498	0.636
LIG_FHA_1	3	9	PF00498	0.706
LIG_FHA_1	324	330	PF00498	0.409
LIG_FHA_2	125	131	PF00498	0.509
LIG_FHA_2	315	321	PF00498	0.580
LIG_LIR_Gen_1	323	333	PF02991	0.347
LIG_LIR_Nem_3	194	200	PF02991	0.572
LIG_LIR_Nem_3	24	30	PF02991	0.588
LIG_LIR_Nem_3	272	278	PF02991	0.554
LIG_LIR_Nem_3	31	36	PF02991	0.586
LIG_LIR_Nem_3	323	328	PF02991	0.347
LIG_PCNA_PIPBox_1	20	29	PF02747	0.601
LIG_PDZ_Class_2	333	338	PF00595	0.329
LIG_SH2_CRK	197	201	PF00017	0.491
LIG_SH2_CRK	33	37	PF00017	0.693
LIG_SH2_STAP1	183	187	PF00017	0.702
LIG_SH2_STAT3	183	186	PF00017	0.650
LIG_SH2_STAT5	183	186	PF00017	0.676
LIG_SH2_STAT5	2	5	PF00017	0.722
LIG_SH2_STAT5	201	204	PF00017	0.163
LIG_SH2_STAT5	216	219	PF00017	0.386
LIG_SH3_3	220	226	PF00018	0.445
LIG_SH3_3	260	266	PF00018	0.567
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.301
LIG_SUMO_SIM_par_1	326	332	PF11976	0.278
LIG_TYR_ITIM	195	200	PF00017	0.635
LIG_UBA3_1	172	176	PF00899	0.625
LIG_UBA3_1	8	16	PF00899	0.713
MOD_CK1_1	147	153	PF00069	0.737
MOD_CK1_1	332	338	PF00069	0.259
MOD_CK1_1	72	78	PF00069	0.727
MOD_CK1_1	80	86	PF00069	0.636
MOD_CK2_1	137	143	PF00069	0.544
MOD_CK2_1	18	24	PF00069	0.684
MOD_CK2_1	314	320	PF00069	0.638
MOD_GlcNHglycan	146	149	PF01048	0.535
MOD_GlcNHglycan	246	249	PF01048	0.312
MOD_GlcNHglycan	283	286	PF01048	0.413
MOD_GlcNHglycan	51	54	PF01048	0.420
MOD_GlcNHglycan	74	77	PF01048	0.468
MOD_GlcNHglycan	81	85	PF01048	0.409
MOD_GSK3_1	124	131	PF00069	0.559
MOD_GSK3_1	137	144	PF00069	0.597
MOD_GSK3_1	187	194	PF00069	0.550
MOD_GSK3_1	72	79	PF00069	0.686
MOD_NEK2_1	182	187	PF00069	0.576
MOD_NEK2_1	244	249	PF00069	0.279
MOD_NEK2_1	256	261	PF00069	0.370
MOD_NEK2_1	329	334	PF00069	0.167
MOD_PIKK_1	104	110	PF00454	0.461
MOD_PIKK_1	128	134	PF00454	0.656
MOD_PIKK_1	175	181	PF00454	0.625
MOD_PIKK_1	182	188	PF00454	0.622
MOD_PK_1	149	155	PF00069	0.560
MOD_PKA_2	187	193	PF00069	0.560
MOD_PKA_2	3	9	PF00069	0.629
MOD_PKA_2	320	326	PF00069	0.474
MOD_PKB_1	110	118	PF00069	0.474
MOD_Plk_1	80	86	PF00069	0.592
MOD_Plk_2-3	18	24	PF00069	0.684
MOD_Plk_4	18	24	PF00069	0.693
MOD_Plk_4	4	10	PF00069	0.546
TRG_AP2beta_CARGO_1	24	34	PF09066	0.591
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.409
TRG_ENDOCYTIC_2	197	200	PF00928	0.546
TRG_ENDOCYTIC_2	201	204	PF00928	0.295
TRG_ENDOCYTIC_2	216	219	PF00928	0.455
TRG_ENDOCYTIC_2	251	254	PF00928	0.326
TRG_ENDOCYTIC_2	33	36	PF00928	0.670
TRG_ER_diArg_1	110	112	PF00400	0.623
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V8	Leptomonas seymouri	68%	95%
A0A0S4KIA3	Bodo saltans	32%	100%
A0A1X0NS63	Trypanosomatidae	45%	92%
A0A3R7M7G1	Trypanosoma rangeli	51%	100%
A0A3S7WZZ7	Leishmania donovani	89%	99%
A4I260	Leishmania infantum	89%	99%
C9ZRU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AYB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q963	Leishmania major	89%	100%
V5B9S2	Trypanosoma cruzi	48%	98%