JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cupin-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEY4_LEIBR

TriTrypDb:

LbrM.26.1310 , LBRM2903_260018200

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEY4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.418
CLV_NRD_NRD_1	182	184	PF00675	0.367
CLV_NRD_NRD_1	239	241	PF00675	0.455
CLV_NRD_NRD_1	262	264	PF00675	0.223
CLV_NRD_NRD_1	471	473	PF00675	0.262
CLV_NRD_NRD_1	504	506	PF00675	0.475
CLV_NRD_NRD_1	84	86	PF00675	0.722
CLV_PCSK_KEX2_1	262	264	PF00082	0.223
CLV_PCSK_KEX2_1	470	472	PF00082	0.283
CLV_PCSK_KEX2_1	84	86	PF00082	0.760
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.283
CLV_PCSK_PC7_1	466	472	PF00082	0.262
CLV_PCSK_SKI1_1	140	144	PF00082	0.351
CLV_PCSK_SKI1_1	200	204	PF00082	0.344
CLV_PCSK_SKI1_1	379	383	PF00082	0.321
DEG_APCC_DBOX_1	12	20	PF00400	0.436
DEG_APCC_DBOX_1	273	281	PF00400	0.344
DEG_APCC_DBOX_1	504	512	PF00400	0.410
DEG_SPOP_SBC_1	475	479	PF00917	0.258
DEG_SPOP_SBC_1	5	9	PF00917	0.744
DEG_SPOP_SBC_1	553	557	PF00917	0.223
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.242
DOC_CYCLIN_yCln2_LP_2	386	389	PF00134	0.344
DOC_MAPK_DCC_7	30	39	PF00069	0.538
DOC_MAPK_gen_1	198	206	PF00069	0.353
DOC_MAPK_gen_1	240	248	PF00069	0.223
DOC_MAPK_gen_1	379	387	PF00069	0.344
DOC_MAPK_MEF2A_6	198	206	PF00069	0.475
DOC_MAPK_MEF2A_6	240	248	PF00069	0.223
DOC_MAPK_MEF2A_6	30	39	PF00069	0.538
DOC_MAPK_MEF2A_6	330	339	PF00069	0.223
DOC_PP2B_LxvP_1	386	389	PF13499	0.338
DOC_PP2B_LxvP_1	521	524	PF13499	0.328
DOC_PP2B_PxIxI_1	34	40	PF00149	0.406
DOC_PP4_FxxP_1	32	35	PF00568	0.535
DOC_PP4_FxxP_1	357	360	PF00568	0.382
DOC_PP4_FxxP_1	575	578	PF00568	0.344
DOC_USP7_MATH_1	175	179	PF00917	0.395
DOC_USP7_MATH_1	188	192	PF00917	0.430
DOC_USP7_MATH_1	361	365	PF00917	0.339
DOC_USP7_MATH_1	475	479	PF00917	0.450
DOC_USP7_MATH_1	5	9	PF00917	0.768
DOC_USP7_MATH_1	552	556	PF00917	0.407
DOC_USP7_MATH_1	96	100	PF00917	0.746
DOC_WW_Pin1_4	204	209	PF00397	0.328
DOC_WW_Pin1_4	284	289	PF00397	0.449
DOC_WW_Pin1_4	306	311	PF00397	0.451
DOC_WW_Pin1_4	554	559	PF00397	0.437
DOC_WW_Pin1_4	89	94	PF00397	0.740
LIG_14-3-3_CanoR_1	13	19	PF00244	0.478
LIG_14-3-3_CanoR_1	198	203	PF00244	0.319
LIG_14-3-3_CanoR_1	217	221	PF00244	0.439
LIG_14-3-3_CanoR_1	274	284	PF00244	0.363
LIG_14-3-3_CanoR_1	84	93	PF00244	0.758
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BIR_III_4	454	458	PF00653	0.449
LIG_BRCT_BRCA1_1	424	428	PF00533	0.449
LIG_deltaCOP1_diTrp_1	422	428	PF00928	0.475
LIG_FHA_1	190	196	PF00498	0.354
LIG_FHA_1	201	207	PF00498	0.313
LIG_FHA_1	220	226	PF00498	0.423
LIG_FHA_1	287	293	PF00498	0.223
LIG_FHA_1	307	313	PF00498	0.492
LIG_FHA_1	518	524	PF00498	0.430
LIG_FHA_1	562	568	PF00498	0.453
LIG_FHA_2	104	110	PF00498	0.325
LIG_FHA_2	15	21	PF00498	0.544
LIG_FHA_2	160	166	PF00498	0.410
LIG_FHA_2	174	180	PF00498	0.199
LIG_FHA_2	300	306	PF00498	0.475
LIG_FHA_2	7	13	PF00498	0.658
LIG_FXI_DFP_1	441	445	PF00024	0.449
LIG_Integrin_isoDGR_2	209	211	PF01839	0.328
LIG_LIR_Apic_2	513	517	PF02991	0.223
LIG_LIR_Apic_2	572	578	PF02991	0.343
LIG_LIR_Gen_1	107	116	PF02991	0.281
LIG_LIR_Gen_1	324	333	PF02991	0.359
LIG_LIR_Gen_1	372	381	PF02991	0.330
LIG_LIR_Gen_1	383	389	PF02991	0.335
LIG_LIR_Nem_3	278	284	PF02991	0.232
LIG_LIR_Nem_3	324	329	PF02991	0.331
LIG_LIR_Nem_3	372	378	PF02991	0.330
LIG_LIR_Nem_3	383	387	PF02991	0.335
LIG_LIR_Nem_3	425	431	PF02991	0.387
LIG_LIR_Nem_3	585	589	PF02991	0.465
LIG_NRBOX	279	285	PF00104	0.344
LIG_NRBOX	62	68	PF00104	0.590
LIG_PDZ_Class_2	585	590	PF00595	0.489
LIG_Pex14_1	390	394	PF04695	0.344
LIG_Pex14_1	424	428	PF04695	0.449
LIG_Pex14_2	110	114	PF04695	0.344
LIG_SH2_CRK	281	285	PF00017	0.332
LIG_SH2_CRK	314	318	PF00017	0.449
LIG_SH2_CRK	375	379	PF00017	0.328
LIG_SH2_NCK_1	220	224	PF00017	0.449
LIG_SH2_PTP2	514	517	PF00017	0.363
LIG_SH2_SRC	514	517	PF00017	0.363
LIG_SH2_SRC	522	525	PF00017	0.290
LIG_SH2_STAP1	220	224	PF00017	0.444
LIG_SH2_STAP1	269	273	PF00017	0.423
LIG_SH2_STAP1	571	575	PF00017	0.333
LIG_SH2_STAT3	51	54	PF00017	0.570
LIG_SH2_STAT5	141	144	PF00017	0.363
LIG_SH2_STAT5	514	517	PF00017	0.341
LIG_SH2_STAT5	522	525	PF00017	0.311
LIG_SH3_3	193	199	PF00018	0.449
LIG_SH3_3	241	247	PF00018	0.300
LIG_SH3_3	285	291	PF00018	0.288
LIG_SH3_3	382	388	PF00018	0.369
LIG_SH3_3	390	396	PF00018	0.317
LIG_SH3_3	504	510	PF00018	0.475
LIG_SH3_3	556	562	PF00018	0.361
LIG_SUMO_SIM_par_1	14	20	PF11976	0.652
LIG_SUMO_SIM_par_1	201	207	PF11976	0.330
LIG_SUMO_SIM_par_1	579	585	PF11976	0.454
LIG_TRAF2_1	106	109	PF00917	0.510
LIG_TRAF2_1	499	502	PF00917	0.475
LIG_TRFH_1	384	388	PF08558	0.344
LIG_TYR_ITIM	312	317	PF00017	0.407
LIG_UBA3_1	404	409	PF00899	0.223
LIG_WW_2	559	562	PF00397	0.385
MOD_CDK_SPxxK_3	204	211	PF00069	0.328
MOD_CK1_1	159	165	PF00069	0.326
MOD_CK1_1	362	368	PF00069	0.322
MOD_CK1_1	4	10	PF00069	0.733
MOD_CK1_1	474	480	PF00069	0.411
MOD_CK2_1	103	109	PF00069	0.277
MOD_CK2_1	14	20	PF00069	0.560
MOD_CK2_1	159	165	PF00069	0.411
MOD_CK2_1	188	194	PF00069	0.465
MOD_CK2_1	488	494	PF00069	0.370
MOD_CK2_1	89	95	PF00069	0.702
MOD_Cter_Amidation	153	156	PF01082	0.223
MOD_GlcNHglycan	1	4	PF01048	0.703
MOD_GlcNHglycan	24	27	PF01048	0.521
MOD_GlcNHglycan	473	476	PF01048	0.420
MOD_GSK3_1	1	8	PF00069	0.797
MOD_GSK3_1	200	207	PF00069	0.368
MOD_GSK3_1	471	478	PF00069	0.490
MOD_GSK3_1	85	92	PF00069	0.543
MOD_N-GLC_2	319	321	PF02516	0.328
MOD_NEK2_1	1	6	PF00069	0.748
MOD_NEK2_1	145	150	PF00069	0.475
MOD_NEK2_1	22	27	PF00069	0.509
MOD_NEK2_1	273	278	PF00069	0.409
MOD_NEK2_1	476	481	PF00069	0.383
MOD_NEK2_1	482	487	PF00069	0.295
MOD_NEK2_1	573	578	PF00069	0.356
MOD_NEK2_1	67	72	PF00069	0.549
MOD_NEK2_2	517	522	PF00069	0.449
MOD_PIKK_1	159	165	PF00454	0.223
MOD_PIKK_1	275	281	PF00454	0.223
MOD_PIKK_1	96	102	PF00454	0.662
MOD_PK_1	198	204	PF00069	0.311
MOD_PKA_1	471	477	PF00069	0.294
MOD_PKA_2	216	222	PF00069	0.434
MOD_PKA_2	273	279	PF00069	0.363
MOD_PKA_2	471	477	PF00069	0.475
MOD_PKA_2	78	84	PF00069	0.702
MOD_Plk_1	145	151	PF00069	0.459
MOD_Plk_1	409	415	PF00069	0.371
MOD_Plk_1	571	577	PF00069	0.333
MOD_Plk_1	68	74	PF00069	0.626
MOD_Plk_2-3	299	305	PF00069	0.449
MOD_Plk_4	14	20	PF00069	0.652
MOD_Plk_4	373	379	PF00069	0.449
MOD_Plk_4	409	415	PF00069	0.449
MOD_Plk_4	434	440	PF00069	0.484
MOD_Plk_4	477	483	PF00069	0.398
MOD_Plk_4	510	516	PF00069	0.408
MOD_Plk_4	517	523	PF00069	0.422
MOD_Plk_4	62	68	PF00069	0.547
MOD_ProDKin_1	204	210	PF00069	0.328
MOD_ProDKin_1	284	290	PF00069	0.449
MOD_ProDKin_1	306	312	PF00069	0.451
MOD_ProDKin_1	554	560	PF00069	0.437
MOD_ProDKin_1	89	95	PF00069	0.740
MOD_SUMO_for_1	396	399	PF00179	0.329
TRG_DiLeu_BaEn_1	585	590	PF01217	0.489
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.223
TRG_DiLeu_BaLyEn_6	463	468	PF01217	0.475
TRG_ENDOCYTIC_2	281	284	PF00928	0.344
TRG_ENDOCYTIC_2	314	317	PF00928	0.344
TRG_ENDOCYTIC_2	326	329	PF00928	0.344
TRG_ENDOCYTIC_2	375	378	PF00928	0.331
TRG_ER_diArg_1	261	263	PF00400	0.223
TRG_ER_diArg_1	35	38	PF00400	0.414
TRG_ER_diArg_1	471	473	PF00400	0.223
TRG_ER_diArg_1	55	58	PF00400	0.605
TRG_ER_diArg_1	84	86	PF00400	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S7	Leptomonas seymouri	65%	100%
A0A0S4JXF9	Bodo saltans	31%	100%
A0A1X0NS77	Trypanosomatidae	43%	100%
A0A3Q8IP66	Leishmania donovani	80%	100%
A0A3R7K325	Trypanosoma rangeli	44%	100%
A4I258	Leishmania infantum	80%	100%
C9ZRU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AYA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q965	Leishmania major	80%	100%
V5BED3	Trypanosoma cruzi	43%	100%