J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEY2_LEIBR

TriTrypDb:

LbrM.26.1290 , LBRM2903_260018000

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HEY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.544
CLV_C14_Caspase3-7	316	320	PF00656	0.532
CLV_C14_Caspase3-7	66	70	PF00656	0.486
CLV_NRD_NRD_1	196	198	PF00675	0.538
CLV_NRD_NRD_1	343	345	PF00675	0.543
CLV_NRD_NRD_1	449	451	PF00675	0.222
CLV_NRD_NRD_1	467	469	PF00675	0.350
CLV_NRD_NRD_1	508	510	PF00675	0.637
CLV_NRD_NRD_1	583	585	PF00675	0.743
CLV_NRD_NRD_1	73	75	PF00675	0.551
CLV_NRD_NRD_1	748	750	PF00675	0.629
CLV_NRD_NRD_1	774	776	PF00675	0.573
CLV_NRD_NRD_1	815	817	PF00675	0.481
CLV_PCSK_FUR_1	329	333	PF00082	0.601
CLV_PCSK_FUR_1	343	347	PF00082	0.714
CLV_PCSK_FUR_1	815	819	PF00082	0.486
CLV_PCSK_KEX2_1	106	108	PF00082	0.537
CLV_PCSK_KEX2_1	196	198	PF00082	0.543
CLV_PCSK_KEX2_1	215	217	PF00082	0.421
CLV_PCSK_KEX2_1	331	333	PF00082	0.554
CLV_PCSK_KEX2_1	343	345	PF00082	0.480
CLV_PCSK_KEX2_1	467	469	PF00082	0.304
CLV_PCSK_KEX2_1	508	510	PF00082	0.637
CLV_PCSK_KEX2_1	582	584	PF00082	0.747
CLV_PCSK_KEX2_1	73	75	PF00082	0.522
CLV_PCSK_KEX2_1	765	767	PF00082	0.659
CLV_PCSK_KEX2_1	815	817	PF00082	0.477
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.491
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.476
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.628
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.561
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.291
CLV_PCSK_PC1ET2_1	765	767	PF00082	0.426
CLV_PCSK_PC1ET2_1	817	819	PF00082	0.588
CLV_PCSK_PC7_1	339	345	PF00082	0.541
CLV_PCSK_SKI1_1	103	107	PF00082	0.566
CLV_PCSK_SKI1_1	171	175	PF00082	0.646
CLV_PCSK_SKI1_1	246	250	PF00082	0.524
CLV_PCSK_SKI1_1	302	306	PF00082	0.577
CLV_PCSK_SKI1_1	331	335	PF00082	0.611
CLV_PCSK_SKI1_1	345	349	PF00082	0.620
CLV_PCSK_SKI1_1	368	372	PF00082	0.451
CLV_PCSK_SKI1_1	508	512	PF00082	0.611
CLV_PCSK_SKI1_1	717	721	PF00082	0.641
CLV_PCSK_SKI1_1	749	753	PF00082	0.492
CLV_PCSK_SKI1_1	766	770	PF00082	0.491
CLV_Separin_Metazoa	514	518	PF03568	0.655
DEG_Nend_UBRbox_1	1	4	PF02207	0.476
DEG_SPOP_SBC_1	590	594	PF00917	0.693
DEG_SPOP_SBC_1	677	681	PF00917	0.724
DEG_SPOP_SBC_1	857	861	PF00917	0.584
DOC_CKS1_1	561	566	PF01111	0.700
DOC_CKS1_1	767	772	PF01111	0.396
DOC_CYCLIN_RxL_1	714	722	PF00134	0.636
DOC_MAPK_gen_1	215	222	PF00069	0.509
DOC_MAPK_gen_1	343	349	PF00069	0.500
DOC_MAPK_gen_1	415	425	PF00069	0.406
DOC_MAPK_gen_1	542	550	PF00069	0.561
DOC_MAPK_MEF2A_6	523	532	PF00069	0.546
DOC_MAPK_MEF2A_6	542	550	PF00069	0.517
DOC_MAPK_RevD_3	735	750	PF00069	0.631
DOC_MAPK_RevD_3	803	818	PF00069	0.566
DOC_PP1_RVXF_1	158	164	PF00149	0.638
DOC_PP1_RVXF_1	265	272	PF00149	0.456
DOC_PP4_FxxP_1	740	743	PF00568	0.493
DOC_USP7_MATH_1	169	173	PF00917	0.691
DOC_USP7_MATH_1	295	299	PF00917	0.629
DOC_USP7_MATH_1	526	530	PF00917	0.550
DOC_USP7_MATH_1	578	582	PF00917	0.784
DOC_USP7_MATH_1	590	594	PF00917	0.668
DOC_USP7_MATH_1	610	614	PF00917	0.777
DOC_USP7_MATH_1	647	651	PF00917	0.631
DOC_USP7_MATH_1	670	674	PF00917	0.729
DOC_USP7_MATH_1	677	681	PF00917	0.706
DOC_USP7_MATH_1	8	12	PF00917	0.718
DOC_USP7_MATH_1	858	862	PF00917	0.554
DOC_USP7_UBL2_3	415	419	PF12436	0.290
DOC_WW_Pin1_4	121	126	PF00397	0.706
DOC_WW_Pin1_4	138	143	PF00397	0.658
DOC_WW_Pin1_4	210	215	PF00397	0.534
DOC_WW_Pin1_4	276	281	PF00397	0.398
DOC_WW_Pin1_4	438	443	PF00397	0.480
DOC_WW_Pin1_4	490	495	PF00397	0.520
DOC_WW_Pin1_4	560	565	PF00397	0.682
DOC_WW_Pin1_4	604	609	PF00397	0.510
DOC_WW_Pin1_4	660	665	PF00397	0.696
DOC_WW_Pin1_4	678	683	PF00397	0.565
DOC_WW_Pin1_4	766	771	PF00397	0.407
LIG_14-3-3_CanoR_1	155	160	PF00244	0.677
LIG_14-3-3_CanoR_1	196	202	PF00244	0.446
LIG_14-3-3_CanoR_1	314	318	PF00244	0.621
LIG_14-3-3_CanoR_1	332	338	PF00244	0.592
LIG_14-3-3_CanoR_1	615	624	PF00244	0.710
LIG_14-3-3_CanoR_1	7	13	PF00244	0.646
LIG_14-3-3_CanoR_1	835	841	PF00244	0.469
LIG_Actin_WH2_2	181	198	PF00022	0.644
LIG_Actin_WH2_2	320	337	PF00022	0.647
LIG_AP_GAE_1	40	46	PF02883	0.673
LIG_BIR_III_4	235	239	PF00653	0.452
LIG_BRCT_BRCA1_1	319	323	PF00533	0.520
LIG_BRCT_BRCA1_1	358	362	PF00533	0.527
LIG_BRCT_BRCA1_1	679	683	PF00533	0.689
LIG_BRCT_BRCA1_1	695	699	PF00533	0.403
LIG_DLG_GKlike_1	155	162	PF00625	0.612
LIG_DLG_GKlike_1	197	204	PF00625	0.420
LIG_eIF4E_1	741	747	PF01652	0.583
LIG_FHA_1	409	415	PF00498	0.434
LIG_FHA_1	56	62	PF00498	0.404
LIG_FHA_1	669	675	PF00498	0.480
LIG_FHA_1	746	752	PF00498	0.582
LIG_FHA_1	835	841	PF00498	0.643
LIG_FHA_2	314	320	PF00498	0.509
LIG_FHA_2	491	497	PF00498	0.505
LIG_FHA_2	751	757	PF00498	0.547
LIG_FHA_2	97	103	PF00498	0.714
LIG_GBD_Chelix_1	789	797	PF00786	0.586
LIG_IBAR_NPY_1	398	400	PF08397	0.428
LIG_LIR_Gen_1	221	231	PF02991	0.449
LIG_LIR_Gen_1	23	32	PF02991	0.467
LIG_LIR_Gen_1	40	49	PF02991	0.630
LIG_LIR_Gen_1	456	465	PF02991	0.296
LIG_LIR_Gen_1	689	699	PF02991	0.546
LIG_LIR_Gen_1	756	763	PF02991	0.482
LIG_LIR_Gen_1	785	793	PF02991	0.470
LIG_LIR_Nem_3	23	29	PF02991	0.471
LIG_LIR_Nem_3	270	274	PF02991	0.398
LIG_LIR_Nem_3	291	296	PF02991	0.546
LIG_LIR_Nem_3	40	46	PF02991	0.674
LIG_LIR_Nem_3	456	462	PF02991	0.296
LIG_LIR_Nem_3	483	489	PF02991	0.642
LIG_LIR_Nem_3	505	510	PF02991	0.613
LIG_LIR_Nem_3	689	695	PF02991	0.555
LIG_LIR_Nem_3	756	762	PF02991	0.483
LIG_LIR_Nem_3	780	784	PF02991	0.462
LIG_LIR_Nem_3	785	789	PF02991	0.477
LIG_PCNA_yPIPBox_3	234	246	PF02747	0.400
LIG_PCNA_yPIPBox_3	798	809	PF02747	0.568
LIG_Pex14_1	219	223	PF04695	0.445
LIG_Pex14_2	695	699	PF04695	0.522
LIG_PTB_Apo_2	287	294	PF02174	0.453
LIG_PTB_Apo_2	780	787	PF02174	0.593
LIG_PTB_Phospho_1	287	293	PF10480	0.450
LIG_PTB_Phospho_1	780	786	PF10480	0.593
LIG_SH2_CRK	207	211	PF00017	0.636
LIG_SH2_CRK	26	30	PF00017	0.465
LIG_SH2_CRK	293	297	PF00017	0.582
LIG_SH2_CRK	418	422	PF00017	0.290
LIG_SH2_CRK	459	463	PF00017	0.290
LIG_SH2_CRK	786	790	PF00017	0.546
LIG_SH2_GRB2like	25	28	PF00017	0.595
LIG_SH2_GRB2like	781	784	PF00017	0.560
LIG_SH2_STAP1	4	8	PF00017	0.722
LIG_SH2_STAP1	759	763	PF00017	0.377
LIG_SH2_STAP1	786	790	PF00017	0.591
LIG_SH2_STAP1	799	803	PF00017	0.517
LIG_SH2_STAP1	820	824	PF00017	0.488
LIG_SH2_STAT3	25	28	PF00017	0.595
LIG_SH2_STAT3	799	802	PF00017	0.486
LIG_SH2_STAT3	849	852	PF00017	0.497
LIG_SH2_STAT5	194	197	PF00017	0.511
LIG_SH2_STAT5	598	601	PF00017	0.683
LIG_SH2_STAT5	727	730	PF00017	0.496
LIG_SH2_STAT5	77	80	PF00017	0.505
LIG_SH2_STAT5	781	784	PF00017	0.473
LIG_SH2_STAT5	824	827	PF00017	0.507
LIG_SH2_STAT5	849	852	PF00017	0.497
LIG_SH3_3	274	280	PF00018	0.435
LIG_SH3_3	421	427	PF00018	0.290
LIG_SH3_3	436	442	PF00018	0.375
LIG_SH3_3	558	564	PF00018	0.717
LIG_SH3_3	681	687	PF00018	0.647
LIG_TRAF2_1	441	444	PF00917	0.325
LIG_TRFH_1	683	687	PF08558	0.595
LIG_TYR_ITIM	272	277	PF00017	0.368
LIG_TYR_ITIM	779	784	PF00017	0.367
LIG_TYR_ITSM	289	296	PF00017	0.525
LIG_UBA3_1	366	374	PF00899	0.454
MOD_CDK_SPK_2	121	126	PF00069	0.556
MOD_CDK_SPK_2	210	215	PF00069	0.520
MOD_CDK_SPK_2	660	665	PF00069	0.714
MOD_CDK_SPxK_1	210	216	PF00069	0.516
MOD_CDK_SPxxK_3	438	445	PF00069	0.393
MOD_CDK_SPxxK_3	560	567	PF00069	0.703
MOD_CK1_1	432	438	PF00069	0.407
MOD_CK1_1	588	594	PF00069	0.648
MOD_CK1_1	645	651	PF00069	0.582
MOD_CK1_1	669	675	PF00069	0.734
MOD_CK1_1	676	682	PF00069	0.713
MOD_CK2_1	389	395	PF00069	0.580
MOD_CK2_1	438	444	PF00069	0.334
MOD_CK2_1	460	466	PF00069	0.297
MOD_CK2_1	490	496	PF00069	0.514
MOD_CK2_1	528	534	PF00069	0.563
MOD_CK2_1	633	639	PF00069	0.728
MOD_DYRK1A_RPxSP_1	560	564	PF00069	0.729
MOD_GlcNHglycan	171	174	PF01048	0.634
MOD_GlcNHglycan	308	311	PF01048	0.527
MOD_GlcNHglycan	382	385	PF01048	0.681
MOD_GlcNHglycan	434	437	PF01048	0.370
MOD_GlcNHglycan	456	459	PF01048	0.432
MOD_GlcNHglycan	571	574	PF01048	0.680
MOD_GlcNHglycan	588	591	PF01048	0.729
MOD_GlcNHglycan	600	603	PF01048	0.613
MOD_GlcNHglycan	618	621	PF01048	0.613
MOD_GlcNHglycan	644	647	PF01048	0.707
MOD_GlcNHglycan	649	652	PF01048	0.734
MOD_GlcNHglycan	668	671	PF01048	0.689
MOD_GlcNHglycan	675	678	PF01048	0.703
MOD_GlcNHglycan	94	97	PF01048	0.660
MOD_GSK3_1	3	10	PF00069	0.636
MOD_GSK3_1	313	320	PF00069	0.541
MOD_GSK3_1	578	585	PF00069	0.714
MOD_GSK3_1	586	593	PF00069	0.676
MOD_GSK3_1	604	611	PF00069	0.438
MOD_GSK3_1	614	621	PF00069	0.590
MOD_GSK3_1	660	667	PF00069	0.740
MOD_GSK3_1	668	675	PF00069	0.722
MOD_GSK3_1	852	859	PF00069	0.488
MOD_GSK3_1	86	93	PF00069	0.564
MOD_N-GLC_1	126	131	PF02516	0.687
MOD_N-GLC_1	210	215	PF02516	0.520
MOD_NEK2_1	282	287	PF00069	0.540
MOD_NEK2_1	288	293	PF00069	0.462
MOD_NEK2_1	3	8	PF00069	0.683
MOD_NEK2_1	313	318	PF00069	0.550
MOD_NEK2_1	481	486	PF00069	0.500
MOD_NEK2_1	515	520	PF00069	0.639
MOD_NEK2_1	55	60	PF00069	0.426
MOD_NEK2_1	633	638	PF00069	0.502
MOD_NEK2_1	668	673	PF00069	0.604
MOD_NEK2_1	745	750	PF00069	0.599
MOD_NEK2_1	86	91	PF00069	0.721
MOD_NEK2_2	610	615	PF00069	0.503
MOD_PIKK_1	230	236	PF00454	0.507
MOD_PIKK_1	408	414	PF00454	0.328
MOD_PIKK_1	96	102	PF00454	0.628
MOD_PKA_1	582	588	PF00069	0.724
MOD_PKA_2	313	319	PF00069	0.615
MOD_PKA_2	559	565	PF00069	0.726
MOD_PKA_2	582	588	PF00069	0.724
MOD_PKA_2	614	620	PF00069	0.646
MOD_PKA_2	834	840	PF00069	0.633
MOD_PKA_2	96	102	PF00069	0.637
MOD_PKB_1	582	590	PF00069	0.590
MOD_Plk_2-3	184	190	PF00069	0.574
MOD_Plk_2-3	48	54	PF00069	0.633
MOD_Plk_4	218	224	PF00069	0.416
MOD_Plk_4	288	294	PF00069	0.455
MOD_Plk_4	497	503	PF00069	0.503
MOD_Plk_4	633	639	PF00069	0.693
MOD_Plk_4	785	791	PF00069	0.413
MOD_ProDKin_1	121	127	PF00069	0.702
MOD_ProDKin_1	138	144	PF00069	0.659
MOD_ProDKin_1	210	216	PF00069	0.530
MOD_ProDKin_1	276	282	PF00069	0.399
MOD_ProDKin_1	438	444	PF00069	0.480
MOD_ProDKin_1	490	496	PF00069	0.519
MOD_ProDKin_1	560	566	PF00069	0.684
MOD_ProDKin_1	604	610	PF00069	0.510
MOD_ProDKin_1	660	666	PF00069	0.695
MOD_ProDKin_1	678	684	PF00069	0.563
MOD_ProDKin_1	766	772	PF00069	0.400
MOD_SUMO_rev_2	441	446	PF00179	0.428
TRG_DiLeu_BaEn_4	41	47	PF01217	0.620
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.424
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.438
TRG_ENDOCYTIC_2	207	210	PF00928	0.492
TRG_ENDOCYTIC_2	223	226	PF00928	0.390
TRG_ENDOCYTIC_2	26	29	PF00928	0.466
TRG_ENDOCYTIC_2	274	277	PF00928	0.370
TRG_ENDOCYTIC_2	293	296	PF00928	0.597
TRG_ENDOCYTIC_2	400	403	PF00928	0.290
TRG_ENDOCYTIC_2	418	421	PF00928	0.368
TRG_ENDOCYTIC_2	459	462	PF00928	0.290
TRG_ENDOCYTIC_2	692	695	PF00928	0.595
TRG_ENDOCYTIC_2	759	762	PF00928	0.545
TRG_ENDOCYTIC_2	781	784	PF00928	0.469
TRG_ENDOCYTIC_2	786	789	PF00928	0.462
TRG_ER_diArg_1	195	197	PF00400	0.549
TRG_ER_diArg_1	342	344	PF00400	0.551
TRG_ER_diArg_1	507	509	PF00400	0.627
TRG_ER_diArg_1	541	544	PF00400	0.535
TRG_ER_diArg_1	582	584	PF00400	0.750
TRG_ER_diArg_1	72	74	PF00400	0.560
TRG_ER_diArg_1	814	816	PF00400	0.468
TRG_NES_CRM1_1	355	369	PF08389	0.584
TRG_NES_CRM1_1	792	807	PF08389	0.592
TRG_NLS_Bipartite_1	331	349	PF00514	0.662
TRG_NLS_MonoExtC_3	343	348	PF00514	0.630
TRG_NLS_MonoExtN_4	103	110	PF00514	0.480
TRG_NLS_MonoExtN_4	343	349	PF00514	0.674
TRG_NLS_MonoExtN_4	815	820	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	766	771	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	775	780	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P0	Leptomonas seymouri	65%	95%
A0A0S4JSE4	Bodo saltans	34%	100%
A0A1X0NTP4	Trypanosomatidae	43%	97%
A0A3Q8ICY0	Leishmania donovani	82%	89%
A0A3S5IQK9	Trypanosoma rangeli	46%	100%
A4I256	Leishmania infantum	81%	100%
C9ZRU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AYA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q967	Leishmania major	81%	100%
V5DAC5	Trypanosoma cruzi	45%	100%