NUC153 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 74, putative

Species:

Leishmania braziliensis

UniProt:

A4HEY0_LEIBR

TriTrypDb:

LbrM.26.1270 , LBRM2903_260017800

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HEY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEY0

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.448
CLV_NRD_NRD_1	105	107	PF00675	0.372
CLV_NRD_NRD_1	27	29	PF00675	0.467
CLV_NRD_NRD_1	524	526	PF00675	0.557
CLV_NRD_NRD_1	539	541	PF00675	0.377
CLV_NRD_NRD_1	546	548	PF00675	0.473
CLV_NRD_NRD_1	620	622	PF00675	0.645
CLV_NRD_NRD_1	652	654	PF00675	0.549
CLV_NRD_NRD_1	677	679	PF00675	0.535
CLV_PCSK_FUR_1	617	621	PF00082	0.700
CLV_PCSK_KEX2_1	27	29	PF00082	0.481
CLV_PCSK_KEX2_1	31	33	PF00082	0.471
CLV_PCSK_KEX2_1	458	460	PF00082	0.480
CLV_PCSK_KEX2_1	524	526	PF00082	0.566
CLV_PCSK_KEX2_1	539	541	PF00082	0.383
CLV_PCSK_KEX2_1	546	548	PF00082	0.474
CLV_PCSK_KEX2_1	619	621	PF00082	0.648
CLV_PCSK_KEX2_1	652	654	PF00082	0.549
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.501
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.480
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.703
CLV_PCSK_PC7_1	27	33	PF00082	0.523
CLV_PCSK_SKI1_1	107	111	PF00082	0.336
CLV_PCSK_SKI1_1	115	119	PF00082	0.356
CLV_PCSK_SKI1_1	265	269	PF00082	0.498
CLV_PCSK_SKI1_1	303	307	PF00082	0.363
CLV_PCSK_SKI1_1	386	390	PF00082	0.371
CLV_PCSK_SKI1_1	455	459	PF00082	0.353
CLV_PCSK_SKI1_1	539	543	PF00082	0.518
CLV_PCSK_SKI1_1	54	58	PF00082	0.323
CLV_PCSK_SKI1_1	644	648	PF00082	0.682
CLV_PCSK_SKI1_1	652	656	PF00082	0.565
DEG_APCC_DBOX_1	605	613	PF00400	0.644
DEG_Nend_UBRbox_3	1	3	PF02207	0.403
DOC_CYCLIN_RxL_1	262	271	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	263	269	PF00134	0.401
DOC_MAPK_gen_1	368	378	PF00069	0.289
DOC_MAPK_gen_1	678	688	PF00069	0.544
DOC_PP4_FxxP_1	657	660	PF00568	0.465
DOC_USP7_MATH_1	16	20	PF00917	0.462
DOC_USP7_MATH_1	205	209	PF00917	0.378
DOC_USP7_MATH_1	516	520	PF00917	0.639
DOC_USP7_MATH_1	541	545	PF00917	0.496
DOC_USP7_MATH_1	632	636	PF00917	0.679
DOC_USP7_UBL2_3	306	310	PF12436	0.364
DOC_WW_Pin1_4	150	155	PF00397	0.471
DOC_WW_Pin1_4	619	624	PF00397	0.579
DOC_WW_Pin1_4	99	104	PF00397	0.365
LIG_14-3-3_CanoR_1	158	162	PF00244	0.280
LIG_14-3-3_CanoR_1	235	245	PF00244	0.503
LIG_14-3-3_CanoR_1	371	376	PF00244	0.391
LIG_14-3-3_CanoR_1	459	467	PF00244	0.466
LIG_14-3-3_CanoR_1	540	550	PF00244	0.589
LIG_14-3-3_CanoR_1	588	596	PF00244	0.503
LIG_14-3-3_CanoR_1	652	657	PF00244	0.508
LIG_BRCT_BRCA1_1	83	87	PF00533	0.430
LIG_FHA_1	120	126	PF00498	0.509
LIG_FHA_1	246	252	PF00498	0.413
LIG_FHA_1	300	306	PF00498	0.385
LIG_FHA_1	378	384	PF00498	0.398
LIG_FHA_1	468	474	PF00498	0.449
LIG_FHA_1	641	647	PF00498	0.516
LIG_FHA_1	9	15	PF00498	0.368
LIG_FHA_2	315	321	PF00498	0.365
LIG_FHA_2	388	394	PF00498	0.487
LIG_FHA_2	533	539	PF00498	0.571
LIG_FHA_2	653	659	PF00498	0.606
LIG_FHA_2	685	691	PF00498	0.589
LIG_LIR_Apic_2	655	660	PF02991	0.470
LIG_LIR_Gen_1	137	148	PF02991	0.460
LIG_LIR_Gen_1	314	323	PF02991	0.374
LIG_LIR_Gen_1	374	383	PF02991	0.410
LIG_LIR_Gen_1	389	398	PF02991	0.449
LIG_LIR_Gen_1	528	536	PF02991	0.444
LIG_LIR_Gen_1	553	561	PF02991	0.584
LIG_LIR_Nem_3	102	108	PF02991	0.362
LIG_LIR_Nem_3	137	143	PF02991	0.389
LIG_LIR_Nem_3	314	319	PF02991	0.365
LIG_LIR_Nem_3	326	331	PF02991	0.390
LIG_LIR_Nem_3	374	378	PF02991	0.402
LIG_LIR_Nem_3	389	395	PF02991	0.413
LIG_LIR_Nem_3	442	447	PF02991	0.543
LIG_LIR_Nem_3	528	532	PF02991	0.443
LIG_LIR_Nem_3	553	558	PF02991	0.529
LIG_Pex14_2	505	509	PF04695	0.510
LIG_PTB_Apo_2	426	433	PF02174	0.400
LIG_PTB_Apo_2	523	530	PF02174	0.536
LIG_PTB_Phospho_1	426	432	PF10480	0.393
LIG_PTB_Phospho_1	523	529	PF10480	0.585
LIG_REV1ctd_RIR_1	281	291	PF16727	0.423
LIG_RPA_C_Fungi	535	547	PF08784	0.501
LIG_SH2_CRK	529	533	PF00017	0.459
LIG_SH2_SRC	570	573	PF00017	0.535
LIG_SH2_STAP1	259	263	PF00017	0.367
LIG_SH2_STAP1	529	533	PF00017	0.459
LIG_SH2_STAP1	550	554	PF00017	0.489
LIG_SH2_STAT5	282	285	PF00017	0.341
LIG_SH2_STAT5	447	450	PF00017	0.440
LIG_SH3_3	126	132	PF00018	0.378
LIG_SH3_3	435	441	PF00018	0.409
LIG_SUMO_SIM_anti_2	374	382	PF11976	0.411
LIG_SUMO_SIM_par_1	265	271	PF11976	0.393
LIG_TRAF2_1	238	241	PF00917	0.479
LIG_TRAF2_1	35	38	PF00917	0.632
MOD_CDK_SPxK_1	619	625	PF00069	0.520
MOD_CDK_SPxxK_3	99	106	PF00069	0.366
MOD_CK1_1	150	156	PF00069	0.244
MOD_CK1_1	160	166	PF00069	0.378
MOD_CK1_1	222	228	PF00069	0.573
MOD_CK1_1	288	294	PF00069	0.439
MOD_CK1_1	299	305	PF00069	0.329
MOD_CK1_1	314	320	PF00069	0.405
MOD_CK1_1	587	593	PF00069	0.685
MOD_CK2_1	16	22	PF00069	0.450
MOD_CK2_1	371	377	PF00069	0.377
MOD_CK2_1	396	402	PF00069	0.432
MOD_CK2_1	532	538	PF00069	0.525
MOD_CK2_1	652	658	PF00069	0.614
MOD_CK2_1	678	684	PF00069	0.588
MOD_Cter_Amidation	650	653	PF01082	0.501
MOD_GlcNHglycan	122	125	PF01048	0.410
MOD_GlcNHglycan	149	152	PF01048	0.335
MOD_GlcNHglycan	173	176	PF01048	0.507
MOD_GlcNHglycan	190	193	PF01048	0.378
MOD_GlcNHglycan	221	224	PF01048	0.455
MOD_GlcNHglycan	225	228	PF01048	0.406
MOD_GlcNHglycan	240	244	PF01048	0.299
MOD_GlcNHglycan	252	255	PF01048	0.414
MOD_GlcNHglycan	298	301	PF01048	0.330
MOD_GlcNHglycan	33	36	PF01048	0.678
MOD_GlcNHglycan	344	348	PF01048	0.340
MOD_GlcNHglycan	493	496	PF01048	0.576
MOD_GlcNHglycan	543	546	PF01048	0.593
MOD_GlcNHglycan	591	594	PF01048	0.761
MOD_GlcNHglycan	614	617	PF01048	0.641
MOD_GlcNHglycan	638	641	PF01048	0.692
MOD_GlcNHglycan	648	651	PF01048	0.548
MOD_GlcNHglycan	696	699	PF01048	0.675
MOD_GlcNHglycan	96	99	PF01048	0.453
MOD_GSK3_1	1	8	PF00069	0.441
MOD_GSK3_1	115	122	PF00069	0.363
MOD_GSK3_1	12	19	PF00069	0.360
MOD_GSK3_1	146	153	PF00069	0.330
MOD_GSK3_1	169	176	PF00069	0.475
MOD_GSK3_1	205	212	PF00069	0.283
MOD_GSK3_1	219	226	PF00069	0.496
MOD_GSK3_1	288	295	PF00069	0.432
MOD_GSK3_1	311	318	PF00069	0.383
MOD_GSK3_1	458	465	PF00069	0.494
MOD_GSK3_1	491	498	PF00069	0.588
MOD_GSK3_1	632	639	PF00069	0.725
MOD_GSK3_1	640	647	PF00069	0.692
MOD_GSK3_1	674	681	PF00069	0.493
MOD_GSK3_1	81	88	PF00069	0.366
MOD_N-GLC_1	12	17	PF02516	0.377
MOD_N-GLC_1	314	319	PF02516	0.363
MOD_N-GLC_1	60	65	PF02516	0.324
MOD_NEK2_1	1	6	PF00069	0.418
MOD_NEK2_1	134	139	PF00069	0.404
MOD_NEK2_1	147	152	PF00069	0.262
MOD_NEK2_1	245	250	PF00069	0.348
MOD_NEK2_1	674	679	PF00069	0.670
MOD_NEK2_1	694	699	PF00069	0.566
MOD_NEK2_1	85	90	PF00069	0.361
MOD_PKA_1	31	37	PF00069	0.630
MOD_PKA_1	458	464	PF00069	0.444
MOD_PKA_1	652	658	PF00069	0.593
MOD_PKA_1	678	684	PF00069	0.630
MOD_PKA_2	157	163	PF00069	0.285
MOD_PKA_2	31	37	PF00069	0.630
MOD_PKA_2	458	464	PF00069	0.481
MOD_PKA_2	587	593	PF00069	0.618
MOD_PKA_2	636	642	PF00069	0.775
MOD_PKA_2	652	658	PF00069	0.544
MOD_Plk_1	292	298	PF00069	0.391
MOD_Plk_1	314	320	PF00069	0.369
MOD_Plk_1	326	332	PF00069	0.337
MOD_Plk_1	386	392	PF00069	0.469
MOD_Plk_1	393	399	PF00069	0.402
MOD_Plk_1	81	87	PF00069	0.442
MOD_Plk_2-3	377	383	PF00069	0.395
MOD_Plk_2-3	387	393	PF00069	0.467
MOD_Plk_2-3	684	690	PF00069	0.557
MOD_Plk_4	278	284	PF00069	0.339
MOD_Plk_4	292	298	PF00069	0.393
MOD_Plk_4	371	377	PF00069	0.378
MOD_Plk_4	387	393	PF00069	0.475
MOD_Plk_4	652	658	PF00069	0.623
MOD_ProDKin_1	150	156	PF00069	0.467
MOD_ProDKin_1	619	625	PF00069	0.577
MOD_ProDKin_1	99	105	PF00069	0.366
MOD_SUMO_rev_2	381	388	PF00179	0.428
MOD_SUMO_rev_2	474	482	PF00179	0.475
TRG_DiLeu_BaEn_1	241	246	PF01217	0.528
TRG_DiLeu_BaEn_1	528	533	PF01217	0.443
TRG_DiLeu_BaEn_2	161	167	PF01217	0.411
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.402
TRG_ENDOCYTIC_2	105	108	PF00928	0.484
TRG_ENDOCYTIC_2	140	143	PF00928	0.481
TRG_ENDOCYTIC_2	392	395	PF00928	0.455
TRG_ENDOCYTIC_2	432	435	PF00928	0.415
TRG_ENDOCYTIC_2	529	532	PF00928	0.458
TRG_ER_diArg_1	128	131	PF00400	0.364
TRG_ER_diArg_1	652	654	PF00400	0.605
TRG_NES_CRM1_1	92	104	PF08389	0.339
TRG_NLS_MonoExtC_3	27	32	PF00514	0.474
TRG_NLS_MonoExtC_3	618	623	PF00514	0.733
TRG_NLS_MonoExtC_3	677	682	PF00514	0.559
TRG_NLS_MonoExtN_4	27	32	PF00514	0.474
TRG_NLS_MonoExtN_4	617	623	PF00514	0.732
TRG_NLS_MonoExtN_4	678	683	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D9	Leptomonas seymouri	79%	100%
A0A0S4JNM6	Bodo saltans	53%	100%
A0A1X0NSW1	Trypanosomatidae	63%	100%
A0A3R7KNJ7	Trypanosoma rangeli	70%	100%
A0A3S7WZS4	Leishmania donovani	88%	100%
A4I254	Leishmania infantum	89%	100%
C9ZRU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AYA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
G0S902	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	26%	100%
O74879	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q4Q969	Leishmania major	88%	99%
Q802W4	Danio rerio	32%	97%