Leucine rich repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEX7_LEIBR

TriTrypDb:

LbrM.26.1240 , LBRM2903_260017400

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HEX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEX7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0036158	outer dynein arm assembly	7	10
GO:0036159	inner dynein arm assembly	7	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0070286	axonemal dynein complex assembly	6	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0044877	protein-containing complex binding	2	10
GO:0070840	dynein complex binding	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.616
CLV_C14_Caspase3-7	206	210	PF00656	0.358
CLV_C14_Caspase3-7	239	243	PF00656	0.568
CLV_C14_Caspase3-7	555	559	PF00656	0.737
CLV_C14_Caspase3-7	566	570	PF00656	0.745
CLV_NRD_NRD_1	433	435	PF00675	0.354
CLV_NRD_NRD_1	457	459	PF00675	0.360
CLV_NRD_NRD_1	494	496	PF00675	0.461
CLV_PCSK_FUR_1	440	444	PF00082	0.431
CLV_PCSK_KEX2_1	299	301	PF00082	0.506
CLV_PCSK_KEX2_1	435	437	PF00082	0.477
CLV_PCSK_KEX2_1	442	444	PF00082	0.425
CLV_PCSK_KEX2_1	457	459	PF00082	0.275
CLV_PCSK_KEX2_1	488	490	PF00082	0.414
CLV_PCSK_KEX2_1	494	496	PF00082	0.450
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.525
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.469
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.499
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.523
CLV_PCSK_SKI1_1	176	180	PF00082	0.385
CLV_PCSK_SKI1_1	435	439	PF00082	0.439
CLV_PCSK_SKI1_1	442	446	PF00082	0.407
CLV_PCSK_SKI1_1	450	454	PF00082	0.364
CLV_PCSK_SKI1_1	458	462	PF00082	0.307
DEG_SCF_FBW7_1	614	621	PF00400	0.527
DEG_SPOP_SBC_1	245	249	PF00917	0.453
DEG_SPOP_SBC_1	291	295	PF00917	0.407
DEG_SPOP_SBC_1	618	622	PF00917	0.601
DOC_CDC14_PxL_1	410	418	PF14671	0.379
DOC_CYCLIN_RxL_1	436	449	PF00134	0.443
DOC_MAPK_gen_1	204	213	PF00069	0.478
DOC_MAPK_gen_1	412	421	PF00069	0.355
DOC_MAPK_gen_1	440	447	PF00069	0.455
DOC_MAPK_gen_1	634	641	PF00069	0.512
DOC_PP1_RVXF_1	82	88	PF00149	0.331
DOC_PP4_FxxP_1	24	27	PF00568	0.472
DOC_USP7_MATH_1	258	262	PF00917	0.677
DOC_USP7_MATH_1	361	365	PF00917	0.322
DOC_USP7_MATH_1	538	542	PF00917	0.761
DOC_USP7_MATH_1	552	556	PF00917	0.673
DOC_USP7_MATH_1	557	561	PF00917	0.658
DOC_USP7_MATH_1	593	597	PF00917	0.699
DOC_USP7_MATH_1	618	622	PF00917	0.710
DOC_USP7_MATH_1	637	641	PF00917	0.802
DOC_USP7_MATH_1	647	651	PF00917	0.624
DOC_WW_Pin1_4	149	154	PF00397	0.694
DOC_WW_Pin1_4	254	259	PF00397	0.641
DOC_WW_Pin1_4	320	325	PF00397	0.470
DOC_WW_Pin1_4	342	347	PF00397	0.705
DOC_WW_Pin1_4	614	619	PF00397	0.642
LIG_14-3-3_CanoR_1	235	244	PF00244	0.383
LIG_14-3-3_CanoR_1	342	346	PF00244	0.745
LIG_14-3-3_CanoR_1	359	368	PF00244	0.214
LIG_14-3-3_CanoR_1	415	420	PF00244	0.391
LIG_14-3-3_CanoR_1	457	465	PF00244	0.450
LIG_14-3-3_CanoR_1	551	557	PF00244	0.722
LIG_14-3-3_CanoR_1	588	592	PF00244	0.519
LIG_Actin_WH2_2	406	422	PF00022	0.348
LIG_AP2alpha_2	112	114	PF02296	0.638
LIG_APCC_ABBA_1	77	82	PF00400	0.393
LIG_APCC_ABBAyCdc20_2	442	448	PF00400	0.435
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BRCT_BRCA1_1	20	24	PF00533	0.475
LIG_BRCT_BRCA1_1	213	217	PF00533	0.419
LIG_BRCT_BRCA1_1	73	77	PF00533	0.282
LIG_Clathr_ClatBox_1	407	411	PF01394	0.337
LIG_Clathr_ClatBox_1	444	448	PF01394	0.341
LIG_eIF4E_1	190	196	PF01652	0.408
LIG_FHA_1	142	148	PF00498	0.682
LIG_FHA_1	245	251	PF00498	0.459
LIG_FHA_1	33	39	PF00498	0.469
LIG_FHA_1	587	593	PF00498	0.637
LIG_FHA_1	7	13	PF00498	0.746
LIG_FHA_2	217	223	PF00498	0.385
LIG_FHA_2	291	297	PF00498	0.391
LIG_FHA_2	560	566	PF00498	0.635
LIG_FHA_2	605	611	PF00498	0.710
LIG_FHA_2	73	79	PF00498	0.495
LIG_LIR_Apic_2	21	27	PF02991	0.474
LIG_LIR_Apic_2	357	361	PF02991	0.438
LIG_LIR_Gen_1	177	186	PF02991	0.345
LIG_LIR_Gen_1	203	213	PF02991	0.405
LIG_LIR_Gen_1	314	324	PF02991	0.405
LIG_LIR_Gen_1	78	88	PF02991	0.338
LIG_LIR_Nem_3	177	182	PF02991	0.371
LIG_LIR_Nem_3	203	208	PF02991	0.416
LIG_LIR_Nem_3	314	319	PF02991	0.396
LIG_LIR_Nem_3	492	496	PF02991	0.510
LIG_LIR_Nem_3	74	80	PF02991	0.397
LIG_LYPXL_S_1	182	186	PF13949	0.335
LIG_LYPXL_yS_3	183	186	PF13949	0.334
LIG_PTB_Apo_2	190	197	PF02174	0.470
LIG_PTB_Apo_2	63	70	PF02174	0.436
LIG_PTB_Phospho_1	63	69	PF10480	0.432
LIG_SH2_CRK	102	106	PF00017	0.559
LIG_SH2_CRK	358	362	PF00017	0.353
LIG_SH2_CRK	387	391	PF00017	0.386
LIG_SH2_CRK	53	57	PF00017	0.372
LIG_SH2_CRK	69	73	PF00017	0.351
LIG_SH2_NCK_1	69	73	PF00017	0.427
LIG_SH2_SRC	513	516	PF00017	0.572
LIG_SH2_STAP1	228	232	PF00017	0.525
LIG_SH2_STAP1	69	73	PF00017	0.430
LIG_SH2_STAT5	102	105	PF00017	0.547
LIG_SH2_STAT5	190	193	PF00017	0.410
LIG_SH2_STAT5	513	516	PF00017	0.655
LIG_SH2_STAT5	63	66	PF00017	0.352
LIG_SH2_STAT5	80	83	PF00017	0.342
LIG_SH3_3	102	108	PF00018	0.538
LIG_SH3_3	147	153	PF00018	0.572
LIG_SH3_3	160	166	PF00018	0.593
LIG_SH3_3	271	277	PF00018	0.513
LIG_SH3_3	340	346	PF00018	0.693
LIG_SH3_3	350	356	PF00018	0.654
LIG_SH3_5	509	513	PF00018	0.660
LIG_SUMO_SIM_anti_2	288	297	PF11976	0.448
LIG_SUMO_SIM_anti_2	389	394	PF11976	0.435
LIG_SUMO_SIM_anti_2	404	411	PF11976	0.243
LIG_SUMO_SIM_par_1	391	396	PF11976	0.326
LIG_SUMO_SIM_par_1	404	411	PF11976	0.400
LIG_TRAF2_1	377	380	PF00917	0.247
LIG_TRAF2_1	607	610	PF00917	0.535
LIG_TYR_ITIM	385	390	PF00017	0.382
LIG_WRC_WIRS_1	375	380	PF05994	0.379
LIG_WW_3	612	616	PF00397	0.597
MOD_CDK_SPxxK_3	342	349	PF00069	0.482
MOD_CK1_1	133	139	PF00069	0.627
MOD_CK1_1	18	24	PF00069	0.653
MOD_CK1_1	32	38	PF00069	0.462
MOD_CK1_1	364	370	PF00069	0.252
MOD_CK1_1	559	565	PF00069	0.676
MOD_CK1_1	620	626	PF00069	0.699
MOD_CK1_1	71	77	PF00069	0.279
MOD_CK2_1	200	206	PF00069	0.546
MOD_CK2_1	216	222	PF00069	0.304
MOD_CK2_1	276	282	PF00069	0.552
MOD_CK2_1	374	380	PF00069	0.256
MOD_CK2_1	480	486	PF00069	0.581
MOD_CK2_1	559	565	PF00069	0.657
MOD_CK2_1	604	610	PF00069	0.796
MOD_CK2_1	72	78	PF00069	0.390
MOD_DYRK1A_RPxSP_1	342	346	PF00069	0.482
MOD_GlcNHglycan	135	138	PF01048	0.522
MOD_GlcNHglycan	19	23	PF01048	0.645
MOD_GlcNHglycan	213	216	PF01048	0.411
MOD_GlcNHglycan	251	254	PF01048	0.693
MOD_GlcNHglycan	421	424	PF01048	0.350
MOD_GlcNHglycan	481	485	PF01048	0.346
MOD_GlcNHglycan	523	526	PF01048	0.578
MOD_GlcNHglycan	536	539	PF01048	0.691
MOD_GlcNHglycan	582	586	PF01048	0.753
MOD_GlcNHglycan	649	652	PF01048	0.749
MOD_GlcNHglycan	653	659	PF01048	0.690
MOD_GSK3_1	1	8	PF00069	0.707
MOD_GSK3_1	11	18	PF00069	0.650
MOD_GSK3_1	141	148	PF00069	0.702
MOD_GSK3_1	178	185	PF00069	0.375
MOD_GSK3_1	245	252	PF00069	0.670
MOD_GSK3_1	254	261	PF00069	0.696
MOD_GSK3_1	276	283	PF00069	0.668
MOD_GSK3_1	32	39	PF00069	0.432
MOD_GSK3_1	360	367	PF00069	0.254
MOD_GSK3_1	415	422	PF00069	0.367
MOD_GSK3_1	534	541	PF00069	0.748
MOD_GSK3_1	552	559	PF00069	0.651
MOD_GSK3_1	563	570	PF00069	0.640
MOD_GSK3_1	614	621	PF00069	0.580
MOD_GSK3_1	68	75	PF00069	0.513
MOD_N-GLC_1	211	216	PF02516	0.332
MOD_N-GLC_1	280	285	PF02516	0.761
MOD_N-GLC_1	32	37	PF02516	0.535
MOD_NEK2_1	1	6	PF00069	0.626
MOD_NEK2_1	348	353	PF00069	0.594
MOD_NEK2_1	393	398	PF00069	0.315
MOD_NEK2_1	419	424	PF00069	0.344
MOD_NEK2_1	426	431	PF00069	0.377
MOD_NEK2_1	604	609	PF00069	0.694
MOD_NEK2_2	361	366	PF00069	0.322
MOD_OFUCOSY	264	270	PF10250	0.506
MOD_PIKK_1	100	106	PF00454	0.500
MOD_PIKK_1	151	157	PF00454	0.731
MOD_PIKK_1	256	262	PF00454	0.686
MOD_PIKK_1	604	610	PF00454	0.693
MOD_PIKK_1	620	626	PF00454	0.529
MOD_PKA_2	341	347	PF00069	0.682
MOD_PKA_2	539	545	PF00069	0.757
MOD_PKA_2	550	556	PF00069	0.668
MOD_PKA_2	587	593	PF00069	0.635
MOD_PKB_1	233	241	PF00069	0.351
MOD_PKB_1	434	442	PF00069	0.474
MOD_Plk_1	200	206	PF00069	0.427
MOD_Plk_1	557	563	PF00069	0.526
MOD_Plk_2-3	567	573	PF00069	0.555
MOD_Plk_4	178	184	PF00069	0.347
MOD_Plk_4	246	252	PF00069	0.503
MOD_Plk_4	587	593	PF00069	0.516
MOD_ProDKin_1	149	155	PF00069	0.693
MOD_ProDKin_1	254	260	PF00069	0.642
MOD_ProDKin_1	320	326	PF00069	0.478
MOD_ProDKin_1	342	348	PF00069	0.705
MOD_ProDKin_1	614	620	PF00069	0.644
MOD_SUMO_rev_2	327	334	PF00179	0.558
MOD_SUMO_rev_2	481	490	PF00179	0.503
MOD_SUMO_rev_2	78	86	PF00179	0.343
TRG_DiLeu_BaEn_1	380	385	PF01217	0.220
TRG_DiLeu_BaEn_1	404	409	PF01217	0.332
TRG_DiLeu_BaEn_1	455	460	PF01217	0.363
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.482
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.515
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.564
TRG_ENDOCYTIC_2	102	105	PF00928	0.547
TRG_ENDOCYTIC_2	183	186	PF00928	0.334
TRG_ENDOCYTIC_2	387	390	PF00928	0.385
TRG_ENDOCYTIC_2	69	72	PF00928	0.420
TRG_ENDOCYTIC_2	80	83	PF00928	0.286
TRG_ER_diArg_1	232	235	PF00400	0.307
TRG_ER_diArg_1	433	436	PF00400	0.472
TRG_ER_diArg_1	457	459	PF00400	0.360
TRG_ER_diArg_1	493	495	PF00400	0.461
TRG_ER_diArg_1	545	548	PF00400	0.740
TRG_NLS_MonoExtN_4	431	438	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	443	448	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C5	Leptomonas seymouri	55%	100%
A0A0S4JQS0	Bodo saltans	38%	100%
A0A3Q8IFU8	Leishmania donovani	71%	100%
A0A422N6Q2	Trypanosoma rangeli	36%	100%
A4I251	Leishmania infantum	71%	100%
C9ZRV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AYA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q972	Leishmania major	74%	99%
V5DQX0	Trypanosoma cruzi	38%	90%