Putative aldo/keto reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldo/keto reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HEX6_LEIBR

TriTrypDb:

LbrM.26.1230 , LBRM2903_260017300

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEX6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	7	1
GO:0004033	aldo-keto reductase (NADP) activity	5	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	6	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.266
CLV_NRD_NRD_1	200	202	PF00675	0.465
CLV_NRD_NRD_1	259	261	PF00675	0.415
CLV_PCSK_KEX2_1	259	261	PF00082	0.502
CLV_PCSK_SKI1_1	165	169	PF00082	0.363
CLV_PCSK_SKI1_1	384	388	PF00082	0.520
DEG_APCC_DBOX_1	76	84	PF00400	0.474
DEG_Nend_UBRbox_3	1	3	PF02207	0.685
DEG_SPOP_SBC_1	195	199	PF00917	0.547
DEG_SPOP_SBC_1	219	223	PF00917	0.616
DEG_SPOP_SBC_1	228	232	PF00917	0.586
DOC_CYCLIN_RxL_1	381	390	PF00134	0.556
DOC_MAPK_gen_1	259	266	PF00069	0.490
DOC_MAPK_MEF2A_6	77	86	PF00069	0.460
DOC_PP2B_LxvP_1	234	237	PF13499	0.572
DOC_PP4_FxxP_1	22	25	PF00568	0.455
DOC_USP7_MATH_1	12	16	PF00917	0.487
DOC_USP7_MATH_1	219	223	PF00917	0.680
DOC_USP7_MATH_1	226	230	PF00917	0.641
DOC_USP7_MATH_1	313	317	PF00917	0.552
DOC_USP7_MATH_1	373	377	PF00917	0.480
DOC_USP7_MATH_1	378	382	PF00917	0.664
DOC_USP7_MATH_1	87	91	PF00917	0.544
DOC_USP7_UBL2_3	359	363	PF12436	0.461
DOC_USP7_UBL2_3	85	89	PF12436	0.458
DOC_WW_Pin1_4	267	272	PF00397	0.352
DOC_WW_Pin1_4	307	312	PF00397	0.716
DOC_WW_Pin1_4	5	10	PF00397	0.418
LIG_14-3-3_CanoR_1	384	394	PF00244	0.495
LIG_14-3-3_CanoR_1	44	48	PF00244	0.383
LIG_Actin_WH2_2	94	111	PF00022	0.427
LIG_BIR_III_4	130	134	PF00653	0.540
LIG_BRCT_BRCA1_1	18	22	PF00533	0.529
LIG_EH1_1	316	324	PF00400	0.244
LIG_eIF4E_1	112	118	PF01652	0.452
LIG_eIF4E_1	60	66	PF01652	0.509
LIG_FHA_1	29	35	PF00498	0.452
LIG_FHA_2	180	186	PF00498	0.449
LIG_FHA_2	228	234	PF00498	0.442
LIG_Integrin_RGD_1	35	37	PF01839	0.312
LIG_LIR_Apic_2	19	25	PF02991	0.505
LIG_LIR_Gen_1	316	325	PF02991	0.393
LIG_LIR_Gen_1	353	362	PF02991	0.496
LIG_LIR_Gen_1	79	88	PF02991	0.476
LIG_LIR_Nem_3	316	320	PF02991	0.418
LIG_LIR_Nem_3	353	358	PF02991	0.511
LIG_LIR_Nem_3	79	84	PF02991	0.476
LIG_PCNA_PIPBox_1	391	400	PF02747	0.520
LIG_SH2_CRK	156	160	PF00017	0.564
LIG_SH2_CRK	269	273	PF00017	0.376
LIG_SH2_CRK	332	336	PF00017	0.437
LIG_SH2_NCK_1	317	321	PF00017	0.251
LIG_SH2_STAP1	415	419	PF00017	0.517
LIG_SH2_STAT3	415	418	PF00017	0.536
LIG_SH2_STAT5	112	115	PF00017	0.383
LIG_SH2_STAT5	156	159	PF00017	0.563
LIG_SH2_STAT5	257	260	PF00017	0.404
LIG_SH2_STAT5	332	335	PF00017	0.416
LIG_SH2_STAT5	354	357	PF00017	0.510
LIG_SH3_3	222	228	PF00018	0.617
LIG_TYR_ITIM	154	159	PF00017	0.563
LIG_UBA3_1	144	153	PF00899	0.563
MOD_CDK_SPxxK_3	267	274	PF00069	0.426
MOD_CK1_1	212	218	PF00069	0.721
MOD_CK1_1	220	226	PF00069	0.640
MOD_CK1_1	229	235	PF00069	0.469
MOD_CK1_1	376	382	PF00069	0.613
MOD_CK2_1	179	185	PF00069	0.554
MOD_CK2_1	194	200	PF00069	0.541
MOD_CK2_1	227	233	PF00069	0.592
MOD_CK2_1	369	375	PF00069	0.660
MOD_GlcNHglycan	14	17	PF01048	0.394
MOD_GlcNHglycan	211	214	PF01048	0.737
MOD_GlcNHglycan	222	225	PF01048	0.683
MOD_GlcNHglycan	302	305	PF01048	0.714
MOD_GlcNHglycan	367	370	PF01048	0.515
MOD_GlcNHglycan	371	374	PF01048	0.569
MOD_GlcNHglycan	378	381	PF01048	0.577
MOD_GlcNHglycan	72	75	PF01048	0.260
MOD_GSK3_1	1	8	PF00069	0.695
MOD_GSK3_1	12	19	PF00069	0.427
MOD_GSK3_1	365	372	PF00069	0.523
MOD_N-GLC_1	173	178	PF02516	0.183
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	335	340	PF00069	0.438
MOD_NEK2_1	365	370	PF00069	0.452
MOD_NEK2_1	53	58	PF00069	0.459
MOD_NEK2_2	354	359	PF00069	0.275
MOD_NEK2_2	93	98	PF00069	0.410
MOD_PIKK_1	292	298	PF00454	0.510
MOD_PIKK_1	414	420	PF00454	0.631
MOD_PK_1	315	321	PF00069	0.277
MOD_PKA_2	43	49	PF00069	0.383
MOD_Plk_1	373	379	PF00069	0.706
MOD_Plk_1	93	99	PF00069	0.410
MOD_Plk_4	315	321	PF00069	0.520
MOD_ProDKin_1	267	273	PF00069	0.355
MOD_ProDKin_1	307	313	PF00069	0.710
MOD_ProDKin_1	5	11	PF00069	0.402
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.529
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.474
TRG_ENDOCYTIC_2	156	159	PF00928	0.564
TRG_ENDOCYTIC_2	269	272	PF00928	0.370
TRG_ENDOCYTIC_2	317	320	PF00928	0.497
TRG_ENDOCYTIC_2	332	335	PF00928	0.427
TRG_ENDOCYTIC_2	51	54	PF00928	0.540
TRG_ER_diArg_1	259	261	PF00400	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R8	Leptomonas seymouri	56%	100%
A0A0N0P8F4	Leptomonas seymouri	27%	100%
A0A0S4J7K9	Bodo saltans	27%	100%
A0A1D5XGW0	Triticum aestivum	24%	100%
A0A1X0NIH1	Trypanosomatidae	38%	100%
A0A1X9QHJ0	Triticum aestivum	24%	100%
A0A3R7NJY8	Trypanosoma rangeli	26%	100%
A0A3S7WZZ0	Leishmania donovani	77%	74%
A0A3S7X124	Leishmania donovani	24%	100%
A0A422N9R4	Trypanosoma rangeli	40%	100%
A0QJ99	Mycobacterium avium (strain 104)	28%	100%
A0QL30	Mycobacterium avium (strain 104)	26%	100%
A0QV09	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	25%	100%
A1UEC5	Mycobacterium sp. (strain KMS)	26%	100%
A3PXS9	Mycobacterium sp. (strain JLS)	26%	100%
A4HG21	Leishmania braziliensis	25%	100%
A4I250	Leishmania infantum	77%	74%
A4I342	Leishmania infantum	24%	100%
B4F9A4	Zea mays	25%	100%
B8ZS00	Mycobacterium leprae (strain Br4923)	27%	100%
C9ZJL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A735	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ACW1	Leishmania major	25%	100%
E9AYA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AZF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O69462	Mycobacterium leprae (strain TN)	27%	100%
O80944	Arabidopsis thaliana	24%	100%
P14065	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P38115	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q0GYU4	Hypocrea jecorina	25%	100%
Q0PCF4	Hordeum vulgare	24%	100%
Q10PE7	Oryza sativa subsp. japonica	23%	100%
Q12458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q1BAN7	Mycobacterium sp. (strain MCS)	26%	100%
Q3ZFI7	Hypocrea jecorina	25%	100%
Q4Q973	Leishmania major	76%	100%
Q4R802	Macaca fascicularis	22%	100%
Q73SC5	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	26%	100%
Q73VK6	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	28%	100%
Q96JD6	Homo sapiens	22%	100%
Q9C1X5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9M338	Arabidopsis thaliana	23%	100%
Q9SQ64	Papaver somniferum	24%	100%
V5BR74	Trypanosoma cruzi	41%	100%
W5DYE3	Triticum aestivum	24%	100%