J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEX5_LEIBR

TriTrypDb:

LbrM.26.1220 , LBRM2903_260017200

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 7
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HEX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	577	581	PF00656	0.423
CLV_NRD_NRD_1	105	107	PF00675	0.629
CLV_NRD_NRD_1	208	210	PF00675	0.716
CLV_NRD_NRD_1	22	24	PF00675	0.406
CLV_NRD_NRD_1	270	272	PF00675	0.674
CLV_NRD_NRD_1	355	357	PF00675	0.452
CLV_NRD_NRD_1	387	389	PF00675	0.536
CLV_NRD_NRD_1	449	451	PF00675	0.661
CLV_NRD_NRD_1	475	477	PF00675	0.525
CLV_NRD_NRD_1	621	623	PF00675	0.557
CLV_PCSK_FUR_1	102	106	PF00082	0.660
CLV_PCSK_KEX2_1	102	104	PF00082	0.641
CLV_PCSK_KEX2_1	105	107	PF00082	0.641
CLV_PCSK_KEX2_1	208	210	PF00082	0.716
CLV_PCSK_KEX2_1	22	24	PF00082	0.406
CLV_PCSK_KEX2_1	266	268	PF00082	0.646
CLV_PCSK_KEX2_1	270	272	PF00082	0.649
CLV_PCSK_KEX2_1	354	356	PF00082	0.452
CLV_PCSK_KEX2_1	373	375	PF00082	0.606
CLV_PCSK_KEX2_1	387	389	PF00082	0.586
CLV_PCSK_KEX2_1	496	498	PF00082	0.623
CLV_PCSK_KEX2_1	620	622	PF00082	0.563
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.653
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.463
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.606
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.623
CLV_PCSK_PC7_1	18	24	PF00082	0.478
CLV_PCSK_SKI1_1	113	117	PF00082	0.636
CLV_PCSK_SKI1_1	122	126	PF00082	0.602
CLV_PCSK_SKI1_1	23	27	PF00082	0.393
CLV_PCSK_SKI1_1	263	267	PF00082	0.669
CLV_PCSK_SKI1_1	312	316	PF00082	0.467
CLV_PCSK_SKI1_1	378	382	PF00082	0.577
CLV_PCSK_SKI1_1	476	480	PF00082	0.585
CLV_PCSK_SKI1_1	485	489	PF00082	0.524
CLV_PCSK_SKI1_1	576	580	PF00082	0.687
CLV_PCSK_SKI1_1	622	626	PF00082	0.556
DEG_APCC_DBOX_1	121	129	PF00400	0.494
DEG_APCC_DBOX_1	22	30	PF00400	0.604
DEG_APCC_DBOX_1	246	254	PF00400	0.447
DEG_APCC_DBOX_1	621	629	PF00400	0.336
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_SPOP_SBC_1	439	443	PF00917	0.463
DEG_SPOP_SBC_1	55	59	PF00917	0.553
DEG_SPOP_SBC_1	60	64	PF00917	0.566
DEG_SPOP_SBC_1	80	84	PF00917	0.516
DOC_CYCLIN_RxL_1	372	385	PF00134	0.406
DOC_MAPK_gen_1	387	395	PF00069	0.301
DOC_MAPK_RevD_3	7	23	PF00069	0.537
DOC_PP2B_LxvP_1	303	306	PF13499	0.330
DOC_PP4_FxxP_1	237	240	PF00568	0.508
DOC_USP7_MATH_1	109	113	PF00917	0.504
DOC_USP7_MATH_1	120	124	PF00917	0.439
DOC_USP7_MATH_1	190	194	PF00917	0.410
DOC_USP7_MATH_1	216	220	PF00917	0.535
DOC_USP7_MATH_1	440	444	PF00917	0.497
DOC_USP7_MATH_1	455	459	PF00917	0.564
DOC_USP7_MATH_1	522	526	PF00917	0.573
DOC_USP7_MATH_1	532	536	PF00917	0.339
DOC_USP7_MATH_1	572	576	PF00917	0.391
DOC_USP7_MATH_1	598	602	PF00917	0.373
DOC_USP7_MATH_1	60	64	PF00917	0.527
DOC_USP7_UBL2_3	277	281	PF12436	0.484
DOC_WW_Pin1_4	139	144	PF00397	0.309
DOC_WW_Pin1_4	329	334	PF00397	0.358
DOC_WW_Pin1_4	520	525	PF00397	0.588
LIG_14-3-3_CanoR_1	155	161	PF00244	0.590
LIG_14-3-3_CanoR_1	18	22	PF00244	0.538
LIG_14-3-3_CanoR_1	35	45	PF00244	0.192
LIG_14-3-3_CanoR_1	574	579	PF00244	0.440
LIG_Actin_WH2_2	537	555	PF00022	0.321
LIG_APCC_ABBA_1	251	256	PF00400	0.519
LIG_APCC_ABBA_1	323	328	PF00400	0.251
LIG_BRCT_BRCA1_1	233	237	PF00533	0.475
LIG_BRCT_BRCA1_1	574	578	PF00533	0.438
LIG_BRCT_BRCA1_1	61	65	PF00533	0.370
LIG_BRCT_BRCA1_1	86	90	PF00533	0.520
LIG_CaM_IQ_9	307	323	PF13499	0.188
LIG_FHA_1	600	606	PF00498	0.365
LIG_FHA_1	629	635	PF00498	0.388
LIG_FHA_2	407	413	PF00498	0.410
LIG_FHA_2	439	445	PF00498	0.434
LIG_FHA_2	575	581	PF00498	0.436
LIG_FHA_2	589	595	PF00498	0.354
LIG_FHA_2	92	98	PF00498	0.410
LIG_GBD_Chelix_1	471	479	PF00786	0.638
LIG_LIR_Apic_2	234	240	PF02991	0.450
LIG_LIR_Gen_1	192	203	PF02991	0.495
LIG_LIR_Gen_1	4	12	PF02991	0.568
LIG_LIR_Gen_1	62	71	PF02991	0.484
LIG_LIR_Gen_1	87	98	PF02991	0.493
LIG_LIR_Nem_3	192	198	PF02991	0.476
LIG_LIR_Nem_3	296	302	PF02991	0.263
LIG_LIR_Nem_3	343	349	PF02991	0.264
LIG_LIR_Nem_3	4	10	PF02991	0.569
LIG_LIR_Nem_3	62	68	PF02991	0.456
LIG_LIR_Nem_3	630	635	PF02991	0.338
LIG_LIR_Nem_3	87	93	PF02991	0.514
LIG_PCNA_PIPBox_1	188	197	PF02747	0.415
LIG_PCNA_yPIPBox_3	640	651	PF02747	0.318
LIG_Pex14_1	173	177	PF04695	0.294
LIG_Pex14_2	394	398	PF04695	0.449
LIG_Rb_pABgroove_1	248	256	PF01858	0.444
LIG_Rb_pABgroove_1	603	611	PF01858	0.437
LIG_SH2_CRK	183	187	PF00017	0.386
LIG_SH2_CRK	195	199	PF00017	0.401
LIG_SH2_CRK	300	304	PF00017	0.262
LIG_SH2_CRK	346	350	PF00017	0.251
LIG_SH2_CRK	635	639	PF00017	0.408
LIG_SH2_NCK_1	183	187	PF00017	0.404
LIG_SH2_NCK_1	195	199	PF00017	0.416
LIG_SH2_NCK_1	254	258	PF00017	0.516
LIG_SH2_NCK_1	436	440	PF00017	0.462
LIG_SH2_NCK_1	590	594	PF00017	0.356
LIG_SH2_SRC	254	257	PF00017	0.519
LIG_SH2_STAP1	195	199	PF00017	0.452
LIG_SH2_STAP1	436	440	PF00017	0.487
LIG_SH2_STAT3	657	660	PF00017	0.426
LIG_SH2_STAT5	204	207	PF00017	0.450
LIG_SH2_STAT5	408	411	PF00017	0.491
LIG_SH2_STAT5	432	435	PF00017	0.390
LIG_SH2_STAT5	551	554	PF00017	0.475
LIG_SH2_STAT5	590	593	PF00017	0.325
LIG_SH3_3	137	143	PF00018	0.431
LIG_SH3_3	195	201	PF00018	0.443
LIG_SH3_3	535	541	PF00018	0.477
LIG_SH3_3	608	614	PF00018	0.425
LIG_Sin3_3	42	49	PF02671	0.206
LIG_SUMO_SIM_anti_2	409	417	PF11976	0.506
LIG_SUMO_SIM_par_1	8	15	PF11976	0.545
LIG_TRAF2_1	409	412	PF00917	0.443
LIG_TRAF2_1	592	595	PF00917	0.341
MOD_CK1_1	158	164	PF00069	0.491
MOD_CK1_1	17	23	PF00069	0.516
MOD_CK1_1	193	199	PF00069	0.647
MOD_CK1_1	396	402	PF00069	0.557
MOD_CK1_1	512	518	PF00069	0.625
MOD_CK1_1	525	531	PF00069	0.502
MOD_CK1_1	63	69	PF00069	0.598
MOD_CK1_1	81	87	PF00069	0.681
MOD_CK2_1	406	412	PF00069	0.517
MOD_CK2_1	438	444	PF00069	0.588
MOD_CK2_1	508	514	PF00069	0.475
MOD_CK2_1	588	594	PF00069	0.422
MOD_CK2_1	91	97	PF00069	0.523
MOD_Cter_Amidation	448	451	PF01082	0.495
MOD_GlcNHglycan	160	163	PF01048	0.385
MOD_GlcNHglycan	216	219	PF01048	0.669
MOD_GlcNHglycan	220	223	PF01048	0.660
MOD_GlcNHglycan	282	285	PF01048	0.675
MOD_GlcNHglycan	288	291	PF01048	0.576
MOD_GlcNHglycan	395	398	PF01048	0.367
MOD_GlcNHglycan	42	45	PF01048	0.450
MOD_GlcNHglycan	458	461	PF01048	0.737
MOD_GlcNHglycan	511	514	PF01048	0.685
MOD_GlcNHglycan	570	573	PF01048	0.442
MOD_GlcNHglycan	65	68	PF01048	0.564
MOD_GSK3_1	158	165	PF00069	0.404
MOD_GSK3_1	189	196	PF00069	0.585
MOD_GSK3_1	214	221	PF00069	0.694
MOD_GSK3_1	36	43	PF00069	0.346
MOD_GSK3_1	438	445	PF00069	0.510
MOD_GSK3_1	50	57	PF00069	0.580
MOD_GSK3_1	504	511	PF00069	0.537
MOD_GSK3_1	532	539	PF00069	0.676
MOD_GSK3_1	568	575	PF00069	0.459
MOD_GSK3_1	59	66	PF00069	0.603
MOD_GSK3_1	78	85	PF00069	0.652
MOD_NEK2_1	1	6	PF00069	0.578
MOD_NEK2_1	12	17	PF00069	0.488
MOD_NEK2_1	156	161	PF00069	0.432
MOD_NEK2_1	428	433	PF00069	0.381
MOD_NEK2_1	504	509	PF00069	0.445
MOD_NEK2_1	596	601	PF00069	0.475
MOD_NEK2_1	628	633	PF00069	0.444
MOD_NEK2_1	650	655	PF00069	0.514
MOD_PIKK_1	307	313	PF00454	0.374
MOD_PIKK_1	396	402	PF00454	0.471
MOD_PIKK_1	470	476	PF00454	0.360
MOD_PKA_1	266	272	PF00069	0.567
MOD_PKA_2	12	18	PF00069	0.643
MOD_PKA_2	266	272	PF00069	0.567
MOD_PKA_2	340	346	PF00069	0.442
MOD_PKA_2	507	513	PF00069	0.679
MOD_PKB_1	153	161	PF00069	0.595
MOD_PKB_1	506	514	PF00069	0.486
MOD_Plk_1	109	115	PF00069	0.680
MOD_Plk_1	504	510	PF00069	0.393
MOD_Plk_2-3	407	413	PF00069	0.428
MOD_Plk_4	132	138	PF00069	0.265
MOD_Plk_4	190	196	PF00069	0.648
MOD_Plk_4	255	261	PF00069	0.671
MOD_Plk_4	428	434	PF00069	0.378
MOD_Plk_4	522	528	PF00069	0.710
MOD_Plk_4	628	634	PF00069	0.422
MOD_Plk_4	66	72	PF00069	0.540
MOD_ProDKin_1	139	145	PF00069	0.309
MOD_ProDKin_1	329	335	PF00069	0.443
MOD_ProDKin_1	520	526	PF00069	0.761
TRG_DiLeu_BaEn_4	411	417	PF01217	0.619
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.595
TRG_ENDOCYTIC_2	169	172	PF00928	0.390
TRG_ENDOCYTIC_2	183	186	PF00928	0.399
TRG_ENDOCYTIC_2	195	198	PF00928	0.502
TRG_ENDOCYTIC_2	203	206	PF00928	0.394
TRG_ENDOCYTIC_2	299	302	PF00928	0.294
TRG_ENDOCYTIC_2	346	349	PF00928	0.294
TRG_ENDOCYTIC_2	501	504	PF00928	0.465
TRG_ENDOCYTIC_2	590	593	PF00928	0.398
TRG_ER_diArg_1	101	104	PF00400	0.551
TRG_ER_diArg_1	153	156	PF00400	0.560
TRG_ER_diArg_1	208	210	PF00400	0.664
TRG_ER_diArg_1	21	23	PF00400	0.515
TRG_ER_diArg_1	223	226	PF00400	0.674
TRG_ER_diArg_1	386	388	PF00400	0.397
TRG_ER_diArg_1	416	419	PF00400	0.494
TRG_ER_diArg_1	506	509	PF00400	0.599
TRG_ER_diArg_1	573	576	PF00400	0.707
TRG_ER_diArg_1	620	622	PF00400	0.469
TRG_NES_CRM1_1	623	637	PF08389	0.456
TRG_NLS_MonoCore_2	353	358	PF00514	0.386
TRG_NLS_MonoExtC_3	353	359	PF00514	0.386
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.206

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL2	Leptomonas seymouri	62%	100%
A0A0S4JWY5	Bodo saltans	35%	100%
A0A1X0NS91	Trypanosomatidae	43%	100%
A0A3Q8ICT2	Leishmania donovani	80%	100%
A0A422N6M1	Trypanosoma rangeli	43%	100%
A4I249	Leishmania infantum	79%	100%
C9ZRV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AY99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q974	Leishmania major	79%	99%
V5BUD6	Trypanosoma cruzi	43%	100%