Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEX3_LEIBR

TriTrypDb:

LbrM.26.1200 , LBRM2903_260017000

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HEX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.600
CLV_C14_Caspase3-7	273	277	PF00656	0.561
CLV_NRD_NRD_1	139	141	PF00675	0.696
CLV_NRD_NRD_1	171	173	PF00675	0.497
CLV_NRD_NRD_1	421	423	PF00675	0.521
CLV_NRD_NRD_1	430	432	PF00675	0.573
CLV_NRD_NRD_1	594	596	PF00675	0.618
CLV_PCSK_KEX2_1	138	140	PF00082	0.598
CLV_PCSK_KEX2_1	421	423	PF00082	0.521
CLV_PCSK_KEX2_1	430	432	PF00082	0.573
CLV_PCSK_KEX2_1	593	595	PF00082	0.647
CLV_PCSK_KEX2_1	636	638	PF00082	0.469
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.573
CLV_PCSK_PC1ET2_1	636	638	PF00082	0.451
CLV_PCSK_SKI1_1	374	378	PF00082	0.382
CLV_PCSK_SKI1_1	595	599	PF00082	0.515
DEG_SPOP_SBC_1	242	246	PF00917	0.558
DEG_SPOP_SBC_1	89	93	PF00917	0.633
DOC_ANK_TNKS_1	462	469	PF00023	0.710
DOC_MAPK_HePTP_8	520	532	PF00069	0.424
DOC_MAPK_MEF2A_6	523	532	PF00069	0.427
DOC_MAPK_MEF2A_6	76	83	PF00069	0.519
DOC_PP1_RVXF_1	70	76	PF00149	0.535
DOC_PP2B_PxIxI_1	341	347	PF00149	0.467
DOC_PP4_FxxP_1	464	467	PF00568	0.556
DOC_SPAK_OSR1_1	463	467	PF12202	0.571
DOC_USP7_MATH_1	12	16	PF00917	0.716
DOC_USP7_MATH_1	134	138	PF00917	0.559
DOC_USP7_MATH_1	180	184	PF00917	0.511
DOC_USP7_MATH_1	188	192	PF00917	0.446
DOC_USP7_MATH_1	242	246	PF00917	0.695
DOC_USP7_MATH_1	397	401	PF00917	0.533
DOC_USP7_MATH_1	406	410	PF00917	0.642
DOC_USP7_MATH_1	448	452	PF00917	0.529
DOC_USP7_MATH_1	467	471	PF00917	0.668
DOC_USP7_MATH_1	640	644	PF00917	0.490
DOC_USP7_MATH_1	88	92	PF00917	0.622
DOC_USP7_MATH_1	95	99	PF00917	0.583
DOC_WW_Pin1_4	132	137	PF00397	0.707
DOC_WW_Pin1_4	324	329	PF00397	0.514
DOC_WW_Pin1_4	91	96	PF00397	0.634
LIG_14-3-3_CanoR_1	317	325	PF00244	0.451
LIG_14-3-3_CanoR_1	343	351	PF00244	0.486
LIG_14-3-3_CanoR_1	374	380	PF00244	0.304
LIG_14-3-3_CanoR_1	422	432	PF00244	0.494
LIG_14-3-3_CanoR_1	449	455	PF00244	0.490
LIG_BRCT_BRCA1_1	205	209	PF00533	0.617
LIG_BRCT_BRCA1_1	52	56	PF00533	0.558
LIG_BRCT_BRCA1_1	605	609	PF00533	0.429
LIG_CaM_NSCaTE_8	144	151	PF13499	0.573
LIG_FHA_1	244	250	PF00498	0.608
LIG_FHA_1	319	325	PF00498	0.451
LIG_FHA_1	35	41	PF00498	0.639
LIG_FHA_1	350	356	PF00498	0.417
LIG_FHA_1	424	430	PF00498	0.550
LIG_FHA_1	511	517	PF00498	0.479
LIG_FHA_2	271	277	PF00498	0.561
LIG_FHA_2	331	337	PF00498	0.640
LIG_FHA_2	5	11	PF00498	0.534
LIG_LIR_Apic_2	130	136	PF02991	0.679
LIG_LIR_Gen_1	34	42	PF02991	0.667
LIG_LIR_Gen_1	357	362	PF02991	0.312
LIG_LIR_Gen_1	540	548	PF02991	0.430
LIG_LIR_Nem_3	357	361	PF02991	0.375
LIG_LIR_Nem_3	365	370	PF02991	0.378
LIG_LIR_Nem_3	540	546	PF02991	0.425
LIG_LYPXL_S_1	222	226	PF13949	0.498
LIG_MLH1_MIPbox_1	52	56	PF16413	0.401
LIG_PALB2_WD40_1	140	148	PF16756	0.600
LIG_PDZ_Class_2	676	681	PF00595	0.499
LIG_Pex14_2	56	60	PF04695	0.556
LIG_PTB_Apo_2	624	631	PF02174	0.500
LIG_SH2_CRK	133	137	PF00017	0.665
LIG_SH2_CRK	175	179	PF00017	0.541
LIG_SH2_CRK	358	362	PF00017	0.394
LIG_SH2_CRK	370	374	PF00017	0.355
LIG_SH2_CRK	543	547	PF00017	0.425
LIG_SH2_NCK_1	133	137	PF00017	0.508
LIG_SH2_NCK_1	394	398	PF00017	0.604
LIG_SH2_NCK_1	87	91	PF00017	0.611
LIG_SH2_PTP2	662	665	PF00017	0.516
LIG_SH2_SRC	370	373	PF00017	0.435
LIG_SH2_SRC	531	534	PF00017	0.417
LIG_SH2_STAP1	114	118	PF00017	0.606
LIG_SH2_STAT3	252	255	PF00017	0.648
LIG_SH2_STAT5	147	150	PF00017	0.588
LIG_SH2_STAT5	252	255	PF00017	0.718
LIG_SH2_STAT5	358	361	PF00017	0.373
LIG_SH2_STAT5	531	534	PF00017	0.417
LIG_SH2_STAT5	55	58	PF00017	0.365
LIG_SH2_STAT5	65	68	PF00017	0.347
LIG_SH2_STAT5	662	665	PF00017	0.629
LIG_SH3_3	205	211	PF00018	0.562
LIG_SH3_3	381	387	PF00018	0.422
LIG_SH3_3	553	559	PF00018	0.431
LIG_SH3_3	569	575	PF00018	0.718
LIG_SH3_3	626	632	PF00018	0.508
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.443
LIG_SUMO_SIM_par_1	648	653	PF11976	0.508
LIG_SUMO_SIM_par_1	96	105	PF11976	0.640
LIG_TRAF2_1	15	18	PF00917	0.650
LIG_TRAF2_1	281	284	PF00917	0.705
LIG_TRAF2_1	575	578	PF00917	0.637
LIG_TRAF2_1	579	582	PF00917	0.488
LIG_TYR_ITIM	356	361	PF00017	0.278
LIG_TYR_ITIM	541	546	PF00017	0.422
MOD_CDC14_SPxK_1	135	138	PF00782	0.655
MOD_CDK_SPxK_1	132	138	PF00069	0.670
MOD_CDK_SPxxK_3	132	139	PF00069	0.667
MOD_CK1_1	117	123	PF00069	0.485
MOD_CK1_1	168	174	PF00069	0.584
MOD_CK1_1	204	210	PF00069	0.650
MOD_CK1_1	400	406	PF00069	0.559
MOD_CK1_1	521	527	PF00069	0.454
MOD_CK1_1	576	582	PF00069	0.518
MOD_CK1_1	589	595	PF00069	0.548
MOD_CK1_1	61	67	PF00069	0.368
MOD_CK1_1	91	97	PF00069	0.642
MOD_CK2_1	12	18	PF00069	0.662
MOD_CK2_1	330	336	PF00069	0.628
MOD_CK2_1	40	46	PF00069	0.518
MOD_CK2_1	406	412	PF00069	0.543
MOD_CK2_1	576	582	PF00069	0.540
MOD_GlcNHglycan	162	165	PF01048	0.647
MOD_GlcNHglycan	203	206	PF01048	0.632
MOD_GlcNHglycan	408	411	PF01048	0.684
MOD_GlcNHglycan	412	416	PF01048	0.711
MOD_GlcNHglycan	450	453	PF01048	0.628
MOD_GlcNHglycan	469	472	PF01048	0.652
MOD_GlcNHglycan	559	562	PF01048	0.469
MOD_GlcNHglycan	588	591	PF01048	0.541
MOD_GlcNHglycan	620	623	PF01048	0.615
MOD_GlcNHglycan	642	645	PF01048	0.532
MOD_GlcNHglycan	97	100	PF01048	0.543
MOD_GSK3_1	146	153	PF00069	0.502
MOD_GSK3_1	195	202	PF00069	0.689
MOD_GSK3_1	311	318	PF00069	0.397
MOD_GSK3_1	393	400	PF00069	0.609
MOD_GSK3_1	89	96	PF00069	0.635
MOD_N-GLC_1	200	205	PF02516	0.524
MOD_NEK2_1	200	205	PF00069	0.753
MOD_NEK2_1	228	233	PF00069	0.318
MOD_NEK2_1	311	316	PF00069	0.384
MOD_NEK2_1	650	655	PF00069	0.531
MOD_NEK2_2	165	170	PF00069	0.498
MOD_NEK2_2	375	380	PF00069	0.298
MOD_OFUCOSY	375	382	PF10250	0.429
MOD_PIKK_1	188	194	PF00454	0.490
MOD_PIKK_1	282	288	PF00454	0.553
MOD_PIKK_1	423	429	PF00454	0.632
MOD_PK_1	518	524	PF00069	0.430
MOD_PKA_2	448	454	PF00069	0.491
MOD_PKA_2	573	579	PF00069	0.714
MOD_Plk_2-3	4	10	PF00069	0.710
MOD_Plk_4	204	210	PF00069	0.615
MOD_Plk_4	397	403	PF00069	0.622
MOD_Plk_4	51	57	PF00069	0.391
MOD_Plk_4	512	518	PF00069	0.448
MOD_Plk_4	61	67	PF00069	0.362
MOD_Plk_4	645	651	PF00069	0.566
MOD_ProDKin_1	132	138	PF00069	0.705
MOD_ProDKin_1	324	330	PF00069	0.523
MOD_ProDKin_1	91	97	PF00069	0.634
MOD_SUMO_rev_2	102	108	PF00179	0.459
TRG_DiLeu_BaEn_1	551	556	PF01217	0.273
TRG_DiLeu_BaEn_1	77	82	PF01217	0.549
TRG_DiLeu_BaEn_3	34	40	PF01217	0.527
TRG_ENDOCYTIC_2	175	178	PF00928	0.542
TRG_ENDOCYTIC_2	223	226	PF00928	0.486
TRG_ENDOCYTIC_2	358	361	PF00928	0.286
TRG_ENDOCYTIC_2	543	546	PF00928	0.424
TRG_ENDOCYTIC_2	662	665	PF00928	0.618
TRG_ER_diArg_1	139	141	PF00400	0.632
TRG_ER_diArg_1	429	431	PF00400	0.577
TRG_ER_diArg_1	593	595	PF00400	0.737
TRG_NLS_MonoExtN_4	136	142	PF00514	0.647
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I055	Leptomonas seymouri	51%	98%
A0A3Q8IH11	Leishmania donovani	76%	100%
A4I247	Leishmania infantum	76%	100%
C9ZRV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AY97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q976	Leishmania major	75%	100%