RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HEX2_LEIBR

TriTrypDb:

LbrM.26.1190 , LBRM2903_260016900

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.633
CLV_C14_Caspase3-7	456	460	PF00656	0.472
CLV_NRD_NRD_1	214	216	PF00675	0.631
CLV_NRD_NRD_1	218	220	PF00675	0.631
CLV_NRD_NRD_1	385	387	PF00675	0.504
CLV_NRD_NRD_1	412	414	PF00675	0.446
CLV_NRD_NRD_1	447	449	PF00675	0.463
CLV_PCSK_FUR_1	215	219	PF00082	0.524
CLV_PCSK_FUR_1	383	387	PF00082	0.467
CLV_PCSK_KEX2_1	216	218	PF00082	0.636
CLV_PCSK_KEX2_1	383	385	PF00082	0.495
CLV_PCSK_KEX2_1	412	414	PF00082	0.474
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.619
CLV_PCSK_SKI1_1	281	285	PF00082	0.575
CLV_PCSK_SKI1_1	377	381	PF00082	0.506
CLV_PCSK_SKI1_1	386	390	PF00082	0.481
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DEG_SPOP_SBC_1	133	137	PF00917	0.689
DEG_SPOP_SBC_1	49	53	PF00917	0.700
DOC_CKS1_1	36	41	PF01111	0.554
DOC_CKS1_1	99	104	PF01111	0.536
DOC_CYCLIN_RxL_1	383	394	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.550
DOC_MAPK_gen_1	281	289	PF00069	0.511
DOC_MAPK_gen_1	383	390	PF00069	0.475
DOC_MAPK_gen_1	407	416	PF00069	0.537
DOC_MAPK_MEF2A_6	29	37	PF00069	0.537
DOC_PP1_RVXF_1	77	83	PF00149	0.478
DOC_USP7_MATH_1	132	136	PF00917	0.686
DOC_USP7_MATH_1	302	306	PF00917	0.712
DOC_USP7_MATH_1	464	468	PF00917	0.614
DOC_USP7_MATH_1	49	53	PF00917	0.746
DOC_USP7_MATH_1	55	59	PF00917	0.612
DOC_USP7_MATH_2	107	113	PF00917	0.558
DOC_USP7_UBL2_3	445	449	PF12436	0.452
DOC_WW_Pin1_4	258	263	PF00397	0.539
DOC_WW_Pin1_4	29	34	PF00397	0.632
DOC_WW_Pin1_4	292	297	PF00397	0.576
DOC_WW_Pin1_4	298	303	PF00397	0.613
DOC_WW_Pin1_4	35	40	PF00397	0.666
DOC_WW_Pin1_4	391	396	PF00397	0.484
DOC_WW_Pin1_4	51	56	PF00397	0.731
DOC_WW_Pin1_4	59	64	PF00397	0.709
DOC_WW_Pin1_4	98	103	PF00397	0.762
LIG_14-3-3_CanoR_1	342	348	PF00244	0.455
LIG_14-3-3_CanoR_1	377	382	PF00244	0.570
LIG_14-3-3_CanoR_1	412	417	PF00244	0.529
LIG_14-3-3_CanoR_1	441	447	PF00244	0.522
LIG_14-3-3_CanoR_1	79	83	PF00244	0.474
LIG_AP2alpha_2	93	95	PF02296	0.567
LIG_CSL_BTD_1	94	97	PF09270	0.512
LIG_FHA_1	139	145	PF00498	0.397
LIG_FHA_1	207	213	PF00498	0.560
LIG_FHA_1	277	283	PF00498	0.534
LIG_FHA_1	376	382	PF00498	0.526
LIG_FHA_1	418	424	PF00498	0.460
LIG_FHA_2	344	350	PF00498	0.442
LIG_FHA_2	354	360	PF00498	0.400
LIG_FHA_2	69	75	PF00498	0.504
LIG_LIR_Gen_1	333	341	PF02991	0.576
LIG_LIR_Nem_3	333	339	PF02991	0.578
LIG_PDZ_Class_1	464	469	PF00595	0.529
LIG_Pex14_2	78	82	PF04695	0.563
LIG_SH2_STAP1	336	340	PF00017	0.440
LIG_SH2_STAT5	155	158	PF00017	0.497
LIG_SH3_3	101	107	PF00018	0.715
LIG_SH3_3	142	148	PF00018	0.448
LIG_SH3_3	165	171	PF00018	0.413
LIG_SH3_3	254	260	PF00018	0.589
LIG_SH3_3	27	33	PF00018	0.632
LIG_SH3_3	57	63	PF00018	0.630
LIG_SH3_3	91	97	PF00018	0.584
LIG_SUMO_SIM_anti_2	141	148	PF11976	0.341
LIG_SUMO_SIM_anti_2	318	326	PF11976	0.580
LIG_SUMO_SIM_par_1	285	291	PF11976	0.560
LIG_SUMO_SIM_par_1	32	38	PF11976	0.544
LIG_TRAF2_1	305	308	PF00917	0.540
MOD_CDK_SPK_2	292	297	PF00069	0.606
MOD_CDK_SPK_2	391	396	PF00069	0.453
MOD_CDK_SPxK_1	35	41	PF00069	0.549
MOD_CK1_1	122	128	PF00069	0.590
MOD_CK1_1	207	213	PF00069	0.624
MOD_CK1_1	249	255	PF00069	0.674
MOD_CK1_1	277	283	PF00069	0.562
MOD_CK1_1	301	307	PF00069	0.578
MOD_CK1_1	370	376	PF00069	0.532
MOD_CK1_1	415	421	PF00069	0.464
MOD_CK1_1	47	53	PF00069	0.749
MOD_CK1_1	56	62	PF00069	0.820
MOD_CK1_1	98	104	PF00069	0.712
MOD_CK2_1	103	109	PF00069	0.800
MOD_CK2_1	133	139	PF00069	0.678
MOD_CK2_1	269	275	PF00069	0.683
MOD_CK2_1	302	308	PF00069	0.534
MOD_CK2_1	313	319	PF00069	0.467
MOD_CK2_1	343	349	PF00069	0.439
MOD_CK2_1	353	359	PF00069	0.403
MOD_CK2_1	370	376	PF00069	0.483
MOD_CK2_1	68	74	PF00069	0.568
MOD_DYRK1A_RPxSP_1	29	33	PF00069	0.612
MOD_GlcNHglycan	121	124	PF01048	0.763
MOD_GlcNHglycan	126	129	PF01048	0.674
MOD_GlcNHglycan	209	212	PF01048	0.541
MOD_GlcNHglycan	243	246	PF01048	0.650
MOD_GlcNHglycan	251	254	PF01048	0.625
MOD_GlcNHglycan	271	274	PF01048	0.633
MOD_GlcNHglycan	275	279	PF01048	0.593
MOD_GlcNHglycan	403	406	PF01048	0.539
MOD_GlcNHglycan	466	469	PF01048	0.580
MOD_GlcNHglycan	55	58	PF01048	0.793
MOD_GSK3_1	115	122	PF00069	0.675
MOD_GSK3_1	134	141	PF00069	0.624
MOD_GSK3_1	202	209	PF00069	0.593
MOD_GSK3_1	25	32	PF00069	0.605
MOD_GSK3_1	298	305	PF00069	0.704
MOD_GSK3_1	341	348	PF00069	0.353
MOD_GSK3_1	40	47	PF00069	0.579
MOD_GSK3_1	417	424	PF00069	0.573
MOD_GSK3_1	459	466	PF00069	0.672
MOD_GSK3_1	49	56	PF00069	0.742
MOD_NEK2_1	119	124	PF00069	0.539
MOD_NEK2_1	126	131	PF00069	0.726
MOD_NEK2_1	190	195	PF00069	0.608
MOD_NEK2_1	206	211	PF00069	0.477
MOD_NEK2_1	340	345	PF00069	0.442
MOD_NEK2_1	361	366	PF00069	0.453
MOD_NEK2_1	375	380	PF00069	0.442
MOD_NEK2_1	388	393	PF00069	0.505
MOD_NEK2_1	422	427	PF00069	0.490
MOD_NEK2_1	78	83	PF00069	0.562
MOD_PIKK_1	227	233	PF00454	0.529
MOD_PIKK_1	251	257	PF00454	0.660
MOD_PIKK_1	313	319	PF00454	0.531
MOD_PIKK_1	330	336	PF00454	0.506
MOD_PIKK_1	361	367	PF00454	0.453
MOD_PK_1	191	197	PF00069	0.538
MOD_PKA_1	412	418	PF00069	0.362
MOD_PKA_1	448	454	PF00069	0.483
MOD_PKA_2	190	196	PF00069	0.560
MOD_PKA_2	341	347	PF00069	0.436
MOD_PKA_2	40	46	PF00069	0.550
MOD_PKA_2	412	418	PF00069	0.362
MOD_PKA_2	440	446	PF00069	0.531
MOD_PKA_2	78	84	PF00069	0.480
MOD_Plk_1	133	139	PF00069	0.510
MOD_Plk_1	320	326	PF00069	0.596
MOD_Plk_1	375	381	PF00069	0.528
MOD_Plk_2-3	134	140	PF00069	0.608
MOD_Plk_2-3	308	314	PF00069	0.537
MOD_Plk_4	191	197	PF00069	0.656
MOD_Plk_4	295	301	PF00069	0.730
MOD_ProDKin_1	258	264	PF00069	0.541
MOD_ProDKin_1	29	35	PF00069	0.634
MOD_ProDKin_1	292	298	PF00069	0.577
MOD_ProDKin_1	391	397	PF00069	0.482
MOD_ProDKin_1	51	57	PF00069	0.749
MOD_ProDKin_1	59	65	PF00069	0.633
MOD_ProDKin_1	98	104	PF00069	0.763
MOD_SUMO_for_1	395	398	PF00179	0.464
TRG_ENDOCYTIC_2	336	339	PF00928	0.447
TRG_ER_diArg_1	215	218	PF00400	0.687
TRG_ER_diArg_1	22	25	PF00400	0.592
TRG_ER_diArg_1	383	386	PF00400	0.467
TRG_ER_diArg_1	411	413	PF00400	0.450
TRG_NES_CRM1_1	406	417	PF08389	0.536
TRG_NLS_MonoCore_2	214	219	PF00514	0.523
TRG_NLS_MonoExtC_3	214	219	PF00514	0.616
TRG_NLS_MonoExtN_4	215	220	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	412	417	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J9	Leptomonas seymouri	44%	87%
A0A3S7WZT2	Leishmania donovani	68%	89%
A4I246	Leishmania infantum	68%	89%
E9AY96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	89%
Q4Q977	Leishmania major	67%	100%