PseudoU_synth_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4HEX1_LEIBR

TriTrypDb:

LbrM.26.1180 , LBRM2903_260016800

Length:

957

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEX1

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0009982	pseudouridine synthase activity	4	7
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.632
CLV_C14_Caspase3-7	166	170	PF00656	0.478
CLV_C14_Caspase3-7	219	223	PF00656	0.349
CLV_C14_Caspase3-7	343	347	PF00656	0.417
CLV_C14_Caspase3-7	756	760	PF00656	0.564
CLV_C14_Caspase3-7	817	821	PF00656	0.536
CLV_NRD_NRD_1	108	110	PF00675	0.422
CLV_NRD_NRD_1	128	130	PF00675	0.665
CLV_NRD_NRD_1	395	397	PF00675	0.296
CLV_NRD_NRD_1	5	7	PF00675	0.614
CLV_NRD_NRD_1	65	67	PF00675	0.436
CLV_NRD_NRD_1	745	747	PF00675	0.585
CLV_NRD_NRD_1	771	773	PF00675	0.716
CLV_NRD_NRD_1	86	88	PF00675	0.370
CLV_PCSK_KEX2_1	128	130	PF00082	0.665
CLV_PCSK_KEX2_1	132	134	PF00082	0.705
CLV_PCSK_KEX2_1	269	271	PF00082	0.275
CLV_PCSK_KEX2_1	388	390	PF00082	0.275
CLV_PCSK_KEX2_1	5	7	PF00082	0.614
CLV_PCSK_KEX2_1	65	67	PF00082	0.437
CLV_PCSK_KEX2_1	745	747	PF00082	0.585
CLV_PCSK_KEX2_1	793	795	PF00082	0.625
CLV_PCSK_KEX2_1	86	88	PF00082	0.422
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.541
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.329
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.226
CLV_PCSK_PC1ET2_1	793	795	PF00082	0.625
CLV_PCSK_PC7_1	128	134	PF00082	0.721
CLV_PCSK_PC7_1	82	88	PF00082	0.426
CLV_PCSK_SKI1_1	128	132	PF00082	0.629
CLV_PCSK_SKI1_1	396	400	PF00082	0.480
CLV_PCSK_SKI1_1	564	568	PF00082	0.711
CLV_PCSK_SKI1_1	746	750	PF00082	0.494
CLV_PCSK_SKI1_1	86	90	PF00082	0.370
CLV_PCSK_SKI1_1	888	892	PF00082	0.643
DEG_APCC_DBOX_1	388	396	PF00400	0.417
DEG_APCC_DBOX_1	649	657	PF00400	0.457
DEG_ODPH_VHL_1	266	277	PF01847	0.529
DEG_SCF_FBW7_2	428	433	PF00400	0.672
DEG_SCF_FBW7_2	584	590	PF00400	0.541
DEG_SPOP_SBC_1	161	165	PF00917	0.607
DEG_SPOP_SBC_1	452	456	PF00917	0.625
DEG_SPOP_SBC_1	797	801	PF00917	0.583
DEG_SPOP_SBC_1	903	907	PF00917	0.522
DOC_CKS1_1	584	589	PF01111	0.540
DOC_CKS1_1	638	643	PF01111	0.494
DOC_CYCLIN_RxL_1	123	134	PF00134	0.547
DOC_CYCLIN_RxL_1	80	93	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	519	522	PF00134	0.644
DOC_MAPK_gen_1	128	139	PF00069	0.473
DOC_MAPK_gen_1	269	277	PF00069	0.529
DOC_MAPK_gen_1	369	379	PF00069	0.475
DOC_MAPK_gen_1	388	394	PF00069	0.475
DOC_MAPK_gen_1	5	13	PF00069	0.525
DOC_MAPK_gen_1	772	780	PF00069	0.553
DOC_MAPK_MEF2A_6	132	141	PF00069	0.474
DOC_MAPK_MEF2A_6	209	218	PF00069	0.436
DOC_PP2B_LxvP_1	507	510	PF13499	0.609
DOC_PP2B_LxvP_1	519	522	PF13499	0.629
DOC_PP4_FxxP_1	947	950	PF00568	0.540
DOC_USP7_MATH_1	155	159	PF00917	0.714
DOC_USP7_MATH_1	309	313	PF00917	0.419
DOC_USP7_MATH_1	347	351	PF00917	0.463
DOC_USP7_MATH_1	452	456	PF00917	0.590
DOC_USP7_MATH_1	676	680	PF00917	0.624
DOC_USP7_MATH_1	715	719	PF00917	0.620
DOC_USP7_MATH_1	761	765	PF00917	0.767
DOC_USP7_MATH_1	797	801	PF00917	0.660
DOC_USP7_MATH_1	846	850	PF00917	0.578
DOC_USP7_MATH_1	903	907	PF00917	0.535
DOC_USP7_UBL2_3	399	403	PF12436	0.421
DOC_USP7_UBL2_3	789	793	PF12436	0.621
DOC_WW_Pin1_4	20	25	PF00397	0.494
DOC_WW_Pin1_4	303	308	PF00397	0.471
DOC_WW_Pin1_4	426	431	PF00397	0.717
DOC_WW_Pin1_4	45	50	PF00397	0.534
DOC_WW_Pin1_4	453	458	PF00397	0.561
DOC_WW_Pin1_4	511	516	PF00397	0.646
DOC_WW_Pin1_4	520	525	PF00397	0.513
DOC_WW_Pin1_4	583	588	PF00397	0.608
DOC_WW_Pin1_4	590	595	PF00397	0.630
DOC_WW_Pin1_4	617	622	PF00397	0.611
DOC_WW_Pin1_4	637	642	PF00397	0.496
DOC_WW_Pin1_4	765	770	PF00397	0.707
DOC_WW_Pin1_4	925	930	PF00397	0.570
DOC_WW_Pin1_4	97	102	PF00397	0.445
LIG_14-3-3_CanoR_1	123	131	PF00244	0.632
LIG_14-3-3_CanoR_1	143	148	PF00244	0.560
LIG_14-3-3_CanoR_1	181	189	PF00244	0.469
LIG_14-3-3_CanoR_1	27	36	PF00244	0.451
LIG_14-3-3_CanoR_1	328	334	PF00244	0.431
LIG_14-3-3_CanoR_1	546	554	PF00244	0.532
LIG_14-3-3_CanoR_1	650	660	PF00244	0.471
LIG_14-3-3_CanoR_1	822	832	PF00244	0.592
LIG_APCC_ABBAyCdc20_2	730	736	PF00400	0.592
LIG_BIR_II_1	1	5	PF00653	0.510
LIG_BIR_III_4	781	785	PF00653	0.628
LIG_FHA_1	213	219	PF00498	0.398
LIG_FHA_1	257	263	PF00498	0.486
LIG_FHA_1	286	292	PF00498	0.475
LIG_FHA_1	30	36	PF00498	0.509
LIG_FHA_1	311	317	PF00498	0.464
LIG_FHA_1	372	378	PF00498	0.475
LIG_FHA_1	469	475	PF00498	0.469
LIG_FHA_1	485	491	PF00498	0.585
LIG_FHA_1	549	555	PF00498	0.444
LIG_FHA_1	567	573	PF00498	0.561
LIG_FHA_1	641	647	PF00498	0.610
LIG_FHA_1	74	80	PF00498	0.324
LIG_FHA_1	873	879	PF00498	0.610
LIG_FHA_1	91	97	PF00498	0.401
LIG_FHA_2	161	167	PF00498	0.623
LIG_FHA_2	217	223	PF00498	0.373
LIG_FHA_2	341	347	PF00498	0.414
LIG_FHA_2	40	46	PF00498	0.534
LIG_FHA_2	7	13	PF00498	0.577
LIG_FHA_2	715	721	PF00498	0.505
LIG_LIR_Apic_2	156	162	PF02991	0.655
LIG_LIR_Apic_2	18	24	PF02991	0.490
LIG_LIR_Gen_1	201	212	PF02991	0.392
LIG_LIR_Gen_1	601	610	PF02991	0.460
LIG_LIR_Gen_1	72	79	PF02991	0.377
LIG_LIR_Gen_1	729	740	PF02991	0.550
LIG_LIR_Gen_1	909	917	PF02991	0.520
LIG_LIR_Gen_1	941	952	PF02991	0.469
LIG_LIR_Nem_3	201	207	PF02991	0.374
LIG_LIR_Nem_3	297	303	PF02991	0.476
LIG_LIR_Nem_3	601	606	PF02991	0.452
LIG_LIR_Nem_3	72	78	PF02991	0.403
LIG_LIR_Nem_3	729	735	PF02991	0.564
LIG_LIR_Nem_3	909	914	PF02991	0.520
LIG_LIR_Nem_3	941	947	PF02991	0.460
LIG_MYND_1	518	522	PF01753	0.527
LIG_NRBOX	257	263	PF00104	0.529
LIG_RPA_C_Fungi	140	152	PF08784	0.511
LIG_SH2_CRK	159	163	PF00017	0.661
LIG_SH2_CRK	204	208	PF00017	0.389
LIG_SH2_CRK	234	238	PF00017	0.312
LIG_SH2_CRK	255	259	PF00017	0.312
LIG_SH2_CRK	71	75	PF00017	0.319
LIG_SH2_GRB2like	254	257	PF00017	0.388
LIG_SH2_NCK_1	159	163	PF00017	0.661
LIG_SH2_NCK_1	857	861	PF00017	0.521
LIG_SH2_SRC	303	306	PF00017	0.388
LIG_SH2_STAP1	104	108	PF00017	0.380
LIG_SH2_STAP1	300	304	PF00017	0.388
LIG_SH2_STAP1	568	572	PF00017	0.492
LIG_SH2_STAP1	71	75	PF00017	0.446
LIG_SH2_STAP1	92	96	PF00017	0.400
LIG_SH2_STAT3	114	117	PF00017	0.447
LIG_SH2_STAT3	472	475	PF00017	0.495
LIG_SH2_STAT5	114	117	PF00017	0.447
LIG_SH2_STAT5	159	162	PF00017	0.661
LIG_SH2_STAT5	264	267	PF00017	0.381
LIG_SH2_STAT5	478	481	PF00017	0.474
LIG_SH2_STAT5	543	546	PF00017	0.550
LIG_SH2_STAT5	568	571	PF00017	0.487
LIG_SH2_STAT5	642	645	PF00017	0.518
LIG_SH2_STAT5	92	95	PF00017	0.335
LIG_SH3_1	33	39	PF00018	0.571
LIG_SH3_3	1	7	PF00018	0.507
LIG_SH3_3	236	242	PF00018	0.388
LIG_SH3_3	262	268	PF00018	0.312
LIG_SH3_3	313	319	PF00018	0.315
LIG_SH3_3	33	39	PF00018	0.487
LIG_SH3_3	360	366	PF00018	0.388
LIG_SH3_3	43	49	PF00018	0.526
LIG_SH3_3	455	461	PF00018	0.537
LIG_SH3_3	512	518	PF00018	0.731
LIG_SH3_3	581	587	PF00018	0.673
LIG_SUMO_SIM_anti_2	374	381	PF11976	0.312
LIG_SUMO_SIM_par_1	87	93	PF11976	0.307
LIG_TRAF2_1	42	45	PF00917	0.548
LIG_TRAF2_1	631	634	PF00917	0.528
LIG_TRAF2_1	837	840	PF00917	0.604
LIG_TRFH_1	264	268	PF08558	0.312
LIG_TYR_ITIM	202	207	PF00017	0.375
LIG_TYR_ITIM	69	74	PF00017	0.329
MOD_CDC14_SPxK_1	48	51	PF00782	0.569
MOD_CDC14_SPxK_1	932	935	PF00782	0.519
MOD_CDK_SPxK_1	45	51	PF00069	0.562
MOD_CDK_SPxK_1	929	935	PF00069	0.530
MOD_CDK_SPxxK_3	20	27	PF00069	0.494
MOD_CDK_SPxxK_3	765	772	PF00069	0.705
MOD_CK1_1	157	163	PF00069	0.717
MOD_CK1_1	284	290	PF00069	0.302
MOD_CK1_1	312	318	PF00069	0.244
MOD_CK1_1	453	459	PF00069	0.529
MOD_CK1_1	493	499	PF00069	0.692
MOD_CK1_1	627	633	PF00069	0.598
MOD_CK1_1	702	708	PF00069	0.544
MOD_CK1_1	764	770	PF00069	0.560
MOD_CK1_1	901	907	PF00069	0.656
MOD_CK2_1	160	166	PF00069	0.637
MOD_CK2_1	187	193	PF00069	0.543
MOD_CK2_1	289	295	PF00069	0.312
MOD_CK2_1	39	45	PF00069	0.515
MOD_CK2_1	494	500	PF00069	0.639
MOD_CK2_1	528	534	PF00069	0.492
MOD_CK2_1	6	12	PF00069	0.586
MOD_CK2_1	627	633	PF00069	0.707
MOD_CK2_1	768	774	PF00069	0.555
MOD_CK2_1	792	798	PF00069	0.541
MOD_CMANNOS	954	957	PF00535	0.484
MOD_Cter_Amidation	84	87	PF01082	0.385
MOD_GlcNHglycan	1	4	PF01048	0.518
MOD_GlcNHglycan	133	136	PF01048	0.531
MOD_GlcNHglycan	183	186	PF01048	0.475
MOD_GlcNHglycan	374	377	PF01048	0.312
MOD_GlcNHglycan	492	495	PF01048	0.618
MOD_GlcNHglycan	530	533	PF01048	0.466
MOD_GlcNHglycan	558	561	PF01048	0.559
MOD_GlcNHglycan	569	572	PF01048	0.749
MOD_GlcNHglycan	594	597	PF01048	0.620
MOD_GlcNHglycan	606	609	PF01048	0.592
MOD_GlcNHglycan	629	632	PF01048	0.646
MOD_GlcNHglycan	671	674	PF01048	0.662
MOD_GlcNHglycan	755	758	PF01048	0.564
MOD_GlcNHglycan	789	792	PF01048	0.577
MOD_GlcNHglycan	843	846	PF01048	0.559
MOD_GlcNHglycan	875	878	PF01048	0.528
MOD_GlcNHglycan	906	909	PF01048	0.514
MOD_GSK3_1	119	126	PF00069	0.548
MOD_GSK3_1	153	160	PF00069	0.658
MOD_GSK3_1	161	168	PF00069	0.534
MOD_GSK3_1	212	219	PF00069	0.401
MOD_GSK3_1	240	247	PF00069	0.319
MOD_GSK3_1	281	288	PF00069	0.311
MOD_GSK3_1	323	330	PF00069	0.397
MOD_GSK3_1	452	459	PF00069	0.536
MOD_GSK3_1	490	497	PF00069	0.574
MOD_GSK3_1	542	549	PF00069	0.509
MOD_GSK3_1	55	62	PF00069	0.583
MOD_GSK3_1	579	586	PF00069	0.526
MOD_GSK3_1	588	595	PF00069	0.578
MOD_GSK3_1	604	611	PF00069	0.574
MOD_GSK3_1	617	624	PF00069	0.665
MOD_GSK3_1	699	706	PF00069	0.656
MOD_GSK3_1	761	768	PF00069	0.545
MOD_GSK3_1	792	799	PF00069	0.687
MOD_GSK3_1	841	848	PF00069	0.529
MOD_GSK3_1	898	905	PF00069	0.661
MOD_GSK3_1	925	932	PF00069	0.544
MOD_N-GLC_1	55	60	PF02516	0.538
MOD_N-GLC_1	824	829	PF02516	0.523
MOD_N-GLC_2	439	441	PF02516	0.534
MOD_NEK2_1	131	136	PF00069	0.539
MOD_NEK2_1	216	221	PF00069	0.447
MOD_NEK2_1	281	286	PF00069	0.302
MOD_NEK2_1	29	34	PF00069	0.536
MOD_NEK2_1	334	339	PF00069	0.243
MOD_NEK2_1	423	428	PF00069	0.525
MOD_NEK2_1	450	455	PF00069	0.544
MOD_NEK2_1	547	552	PF00069	0.540
MOD_NEK2_1	566	571	PF00069	0.567
MOD_NEK2_1	651	656	PF00069	0.539
MOD_NEK2_1	73	78	PF00069	0.467
MOD_NEK2_2	598	603	PF00069	0.460
MOD_PIKK_1	123	129	PF00454	0.555
MOD_PIKK_1	187	193	PF00454	0.451
MOD_PIKK_1	498	504	PF00454	0.597
MOD_PIKK_1	678	684	PF00454	0.644
MOD_PIKK_1	815	821	PF00454	0.538
MOD_PKA_2	117	123	PF00069	0.694
MOD_PKA_2	310	316	PF00069	0.231
MOD_PKA_2	327	333	PF00069	0.206
MOD_PKA_2	528	534	PF00069	0.466
MOD_PKA_2	667	673	PF00069	0.516
MOD_PKB_1	143	151	PF00069	0.514
MOD_PKB_1	481	489	PF00069	0.603
MOD_PKB_1	794	802	PF00069	0.547
MOD_Plk_1	55	61	PF00069	0.524
MOD_Plk_1	715	721	PF00069	0.521
MOD_Plk_4	281	287	PF00069	0.305
MOD_Plk_4	598	604	PF00069	0.526
MOD_Plk_4	6	12	PF00069	0.482
MOD_ProDKin_1	20	26	PF00069	0.495
MOD_ProDKin_1	303	309	PF00069	0.306
MOD_ProDKin_1	426	432	PF00069	0.717
MOD_ProDKin_1	45	51	PF00069	0.537
MOD_ProDKin_1	453	459	PF00069	0.554
MOD_ProDKin_1	511	517	PF00069	0.643
MOD_ProDKin_1	520	526	PF00069	0.509
MOD_ProDKin_1	583	589	PF00069	0.611
MOD_ProDKin_1	590	596	PF00069	0.626
MOD_ProDKin_1	617	623	PF00069	0.613
MOD_ProDKin_1	637	643	PF00069	0.498
MOD_ProDKin_1	765	771	PF00069	0.709
MOD_ProDKin_1	925	931	PF00069	0.569
MOD_ProDKin_1	97	103	PF00069	0.437
TRG_AP2beta_CARGO_1	72	82	PF09066	0.383
TRG_DiLeu_BaEn_4	633	639	PF01217	0.567
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.542
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.322
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.541
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.429
TRG_ENDOCYTIC_2	204	207	PF00928	0.381
TRG_ENDOCYTIC_2	234	237	PF00928	0.358
TRG_ENDOCYTIC_2	255	258	PF00928	0.312
TRG_ENDOCYTIC_2	71	74	PF00928	0.324
TRG_ENDOCYTIC_2	744	747	PF00928	0.481
TRG_ER_diArg_1	128	130	PF00400	0.564
TRG_ER_diArg_1	172	175	PF00400	0.513
TRG_ER_diArg_1	4	6	PF00400	0.616
TRG_ER_diArg_1	481	484	PF00400	0.555
TRG_ER_diArg_1	744	746	PF00400	0.584
TRG_ER_diArg_1	86	88	PF00400	0.422
TRG_ER_diArg_1	935	938	PF00400	0.554
TRG_NLS_MonoExtC_3	792	798	PF00514	0.541
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN9	Leptomonas seymouri	42%	100%
A0A3Q8IC63	Leishmania donovani	70%	98%
A4I245	Leishmania infantum	68%	100%
E9AY95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q4Q978	Leishmania major	69%	100%