Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HEX0_LEIBR

TriTrypDb:

LbrM.26.1170 , LBRM2903_260016700

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.645
CLV_C14_Caspase3-7	306	310	PF00656	0.577
CLV_C14_Caspase3-7	4	8	PF00656	0.479
CLV_C14_Caspase3-7	752	756	PF00656	0.633
CLV_MEL_PAP_1	112	118	PF00089	0.528
CLV_NRD_NRD_1	114	116	PF00675	0.634
CLV_NRD_NRD_1	362	364	PF00675	0.759
CLV_NRD_NRD_1	366	368	PF00675	0.708
CLV_NRD_NRD_1	487	489	PF00675	0.611
CLV_NRD_NRD_1	496	498	PF00675	0.580
CLV_NRD_NRD_1	555	557	PF00675	0.598
CLV_NRD_NRD_1	636	638	PF00675	0.727
CLV_NRD_NRD_1	639	641	PF00675	0.660
CLV_NRD_NRD_1	68	70	PF00675	0.705
CLV_NRD_NRD_1	72	74	PF00675	0.721
CLV_NRD_NRD_1	826	828	PF00675	0.710
CLV_NRD_NRD_1	89	91	PF00675	0.536
CLV_PCSK_FUR_1	636	640	PF00082	0.704
CLV_PCSK_KEX2_1	114	116	PF00082	0.634
CLV_PCSK_KEX2_1	362	364	PF00082	0.759
CLV_PCSK_KEX2_1	366	368	PF00082	0.708
CLV_PCSK_KEX2_1	487	489	PF00082	0.611
CLV_PCSK_KEX2_1	496	498	PF00082	0.580
CLV_PCSK_KEX2_1	555	557	PF00082	0.598
CLV_PCSK_KEX2_1	636	638	PF00082	0.727
CLV_PCSK_KEX2_1	639	641	PF00082	0.660
CLV_PCSK_KEX2_1	68	70	PF00082	0.708
CLV_PCSK_KEX2_1	72	74	PF00082	0.718
CLV_PCSK_KEX2_1	826	828	PF00082	0.710
CLV_PCSK_KEX2_1	88	90	PF00082	0.536
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.790
CLV_PCSK_PC7_1	362	368	PF00082	0.564
CLV_PCSK_PC7_1	68	74	PF00082	0.508
CLV_PCSK_SKI1_1	395	399	PF00082	0.597
CLV_PCSK_SKI1_1	488	492	PF00082	0.451
CLV_PCSK_SKI1_1	509	513	PF00082	0.666
CLV_PCSK_SKI1_1	619	623	PF00082	0.594
CLV_PCSK_SKI1_1	780	784	PF00082	0.353
CLV_PCSK_SKI1_1	827	831	PF00082	0.623
CLV_Separin_Metazoa	383	387	PF03568	0.525
DEG_APCC_DBOX_1	705	713	PF00400	0.362
DEG_COP1_1	117	126	PF00400	0.529
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DEG_SCF_FBW7_1	680	687	PF00400	0.727
DEG_SPOP_SBC_1	661	665	PF00917	0.580
DEG_SPOP_SBC_1	679	683	PF00917	0.721
DOC_CYCLIN_yCln2_LP_2	500	506	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	815	821	PF00134	0.518
DOC_MAPK_gen_1	496	502	PF00069	0.427
DOC_MAPK_gen_1	68	78	PF00069	0.516
DOC_PP1_RVXF_1	785	792	PF00149	0.462
DOC_PP2B_LxvP_1	500	503	PF13499	0.431
DOC_PP2B_LxvP_1	670	673	PF13499	0.583
DOC_PP4_FxxP_1	276	279	PF00568	0.602
DOC_PP4_FxxP_1	688	691	PF00568	0.548
DOC_PP4_MxPP_1	375	378	PF00568	0.738
DOC_SPAK_OSR1_1	275	279	PF12202	0.609
DOC_USP7_MATH_1	118	122	PF00917	0.607
DOC_USP7_MATH_1	190	194	PF00917	0.450
DOC_USP7_MATH_1	285	289	PF00917	0.469
DOC_USP7_MATH_1	290	294	PF00917	0.494
DOC_USP7_MATH_1	307	311	PF00917	0.670
DOC_USP7_MATH_1	405	409	PF00917	0.577
DOC_USP7_MATH_1	585	589	PF00917	0.795
DOC_USP7_MATH_1	660	664	PF00917	0.717
DOC_USP7_MATH_1	684	688	PF00917	0.664
DOC_USP7_MATH_1	80	84	PF00917	0.643
DOC_USP7_MATH_1	820	824	PF00917	0.528
DOC_WW_Pin1_4	511	516	PF00397	0.609
DOC_WW_Pin1_4	567	572	PF00397	0.559
DOC_WW_Pin1_4	675	680	PF00397	0.727
LIG_14-3-3_CanoR_1	11	15	PF00244	0.494
LIG_14-3-3_CanoR_1	114	123	PF00244	0.724
LIG_14-3-3_CanoR_1	154	161	PF00244	0.542
LIG_14-3-3_CanoR_1	488	498	PF00244	0.411
LIG_14-3-3_CanoR_1	57	62	PF00244	0.560
LIG_14-3-3_CanoR_1	637	643	PF00244	0.748
LIG_14-3-3_CanoR_1	653	659	PF00244	0.560
LIG_14-3-3_CanoR_1	699	707	PF00244	0.639
LIG_14-3-3_CanoR_1	826	830	PF00244	0.721
LIG_14-3-3_CanoR_1	88	98	PF00244	0.626
LIG_Actin_WH2_2	23	39	PF00022	0.520
LIG_Actin_WH2_2	522	540	PF00022	0.721
LIG_APCC_ABBA_1	210	215	PF00400	0.342
LIG_BIR_III_4	758	762	PF00653	0.486
LIG_deltaCOP1_diTrp_1	732	742	PF00928	0.504
LIG_EH1_1	803	811	PF00400	0.319
LIG_eIF4E_1	106	112	PF01652	0.615
LIG_FHA_1	25	31	PF00498	0.512
LIG_FHA_1	296	302	PF00498	0.783
LIG_FHA_1	342	348	PF00498	0.550
LIG_FHA_1	538	544	PF00498	0.570
LIG_FHA_1	662	668	PF00498	0.565
LIG_FHA_2	126	132	PF00498	0.532
LIG_FHA_2	158	164	PF00498	0.476
LIG_FHA_2	2	8	PF00498	0.480
LIG_FHA_2	249	255	PF00498	0.426
LIG_FHA_2	394	400	PF00498	0.435
LIG_FHA_2	681	687	PF00498	0.725
LIG_FHA_2	727	733	PF00498	0.710
LIG_GBD_Chelix_1	549	557	PF00786	0.340
LIG_Integrin_RGD_1	725	727	PF01839	0.685
LIG_LIR_Apic_2	686	691	PF02991	0.552
LIG_LIR_Apic_2	96	101	PF02991	0.519
LIG_LIR_Gen_1	131	141	PF02991	0.486
LIG_LIR_Gen_1	257	267	PF02991	0.394
LIG_LIR_Gen_1	60	67	PF02991	0.565
LIG_LIR_Gen_1	799	810	PF02991	0.466
LIG_LIR_Nem_3	131	136	PF02991	0.494
LIG_LIR_Nem_3	257	262	PF02991	0.399
LIG_LIR_Nem_3	413	418	PF02991	0.490
LIG_LIR_Nem_3	60	66	PF02991	0.566
LIG_LIR_Nem_3	794	798	PF02991	0.489
LIG_LIR_Nem_3	799	805	PF02991	0.467
LIG_NRBOX	261	267	PF00104	0.558
LIG_PALB2_WD40_1	254	262	PF16756	0.372
LIG_Pex14_1	178	182	PF04695	0.497
LIG_Pex14_2	791	795	PF04695	0.322
LIG_SH2_CRK	415	419	PF00017	0.487
LIG_SH2_SRC	802	805	PF00017	0.317
LIG_SH2_STAP1	802	806	PF00017	0.462
LIG_SH2_STAT5	447	450	PF00017	0.422
LIG_SH2_STAT5	798	801	PF00017	0.576
LIG_SH3_3	121	127	PF00018	0.531
LIG_SH3_3	374	380	PF00018	0.620
LIG_SH3_3	397	403	PF00018	0.515
LIG_SH3_3	457	463	PF00018	0.538
LIG_SH3_3	47	53	PF00018	0.507
LIG_SUMO_SIM_par_1	347	353	PF11976	0.544
LIG_SUMO_SIM_par_1	386	392	PF11976	0.493
LIG_SUMO_SIM_par_1	417	423	PF11976	0.434
LIG_SUMO_SIM_par_1	583	592	PF11976	0.523
LIG_SUMO_SIM_par_1	74	79	PF11976	0.527
LIG_TRAF2_1	380	383	PF00917	0.620
LIG_TRAF2_1	573	576	PF00917	0.679
LIG_TRAF2_1	730	733	PF00917	0.609
LIG_UBA3_1	610	617	PF00899	0.658
LIG_WRC_WIRS_1	2	7	PF05994	0.480
LIG_WW_2	377	380	PF00397	0.590
MOD_CK1_1	10	16	PF00069	0.493
MOD_CK1_1	107	113	PF00069	0.642
MOD_CK1_1	117	123	PF00069	0.745
MOD_CK1_1	18	24	PF00069	0.476
MOD_CK1_1	284	290	PF00069	0.471
MOD_CK1_1	420	426	PF00069	0.600
MOD_CK1_1	429	435	PF00069	0.471
MOD_CK1_1	446	452	PF00069	0.462
MOD_CK1_1	588	594	PF00069	0.629
MOD_CK1_1	629	635	PF00069	0.631
MOD_CK1_1	678	684	PF00069	0.658
MOD_CK2_1	125	131	PF00069	0.559
MOD_CK2_1	248	254	PF00069	0.467
MOD_CK2_1	327	333	PF00069	0.554
MOD_CK2_1	362	368	PF00069	0.564
MOD_CK2_1	420	426	PF00069	0.442
MOD_CK2_1	513	519	PF00069	0.565
MOD_CK2_1	570	576	PF00069	0.715
MOD_CK2_1	622	628	PF00069	0.761
MOD_CK2_1	726	732	PF00069	0.632
MOD_Cter_Amidation	112	115	PF01082	0.683
MOD_Cter_Amidation	485	488	PF01082	0.495
MOD_Cter_Amidation	70	73	PF01082	0.507
MOD_GlcNHglycan	116	119	PF01048	0.727
MOD_GlcNHglycan	120	123	PF01048	0.732
MOD_GlcNHglycan	128	131	PF01048	0.562
MOD_GlcNHglycan	145	148	PF01048	0.518
MOD_GlcNHglycan	179	182	PF01048	0.493
MOD_GlcNHglycan	18	21	PF01048	0.490
MOD_GlcNHglycan	283	286	PF01048	0.443
MOD_GlcNHglycan	31	34	PF01048	0.468
MOD_GlcNHglycan	344	347	PF01048	0.712
MOD_GlcNHglycan	407	410	PF01048	0.655
MOD_GlcNHglycan	453	456	PF01048	0.656
MOD_GlcNHglycan	471	475	PF01048	0.573
MOD_GlcNHglycan	491	494	PF01048	0.565
MOD_GlcNHglycan	624	627	PF01048	0.604
MOD_GlcNHglycan	716	719	PF01048	0.425
MOD_GlcNHglycan	78	81	PF01048	0.716
MOD_GlcNHglycan	822	825	PF01048	0.548
MOD_GSK3_1	1	8	PF00069	0.484
MOD_GSK3_1	100	107	PF00069	0.647
MOD_GSK3_1	114	121	PF00069	0.688
MOD_GSK3_1	143	150	PF00069	0.633
MOD_GSK3_1	153	160	PF00069	0.642
MOD_GSK3_1	25	32	PF00069	0.513
MOD_GSK3_1	277	284	PF00069	0.552
MOD_GSK3_1	362	369	PF00069	0.560
MOD_GSK3_1	422	429	PF00069	0.478
MOD_GSK3_1	507	514	PF00069	0.585
MOD_GSK3_1	53	60	PF00069	0.487
MOD_GSK3_1	557	564	PF00069	0.641
MOD_GSK3_1	585	592	PF00069	0.681
MOD_GSK3_1	622	629	PF00069	0.785
MOD_GSK3_1	661	668	PF00069	0.589
MOD_GSK3_1	675	682	PF00069	0.734
MOD_GSK3_1	698	705	PF00069	0.506
MOD_GSK3_1	76	83	PF00069	0.690
MOD_GSK3_1	89	96	PF00069	0.548
MOD_LATS_1	87	93	PF00433	0.533
MOD_N-GLC_1	665	670	PF02516	0.721
MOD_NEK2_1	1	6	PF00069	0.613
MOD_NEK2_1	177	182	PF00069	0.535
MOD_NEK2_1	428	433	PF00069	0.422
MOD_NEK2_1	557	562	PF00069	0.549
MOD_NEK2_1	78	83	PF00069	0.767
MOD_OFUCOSY	443	450	PF10250	0.370
MOD_OFUCOSY	97	104	PF10250	0.515
MOD_PIKK_1	630	636	PF00454	0.807
MOD_PIKK_1	82	88	PF00454	0.695
MOD_PK_1	57	63	PF00069	0.501
MOD_PKA_1	114	120	PF00069	0.671
MOD_PKA_1	362	368	PF00069	0.635
MOD_PKA_1	496	502	PF00069	0.641
MOD_PKA_1	638	644	PF00069	0.770
MOD_PKA_1	88	94	PF00069	0.533
MOD_PKA_2	114	120	PF00069	0.671
MOD_PKA_2	153	159	PF00069	0.527
MOD_PKA_2	362	368	PF00069	0.635
MOD_PKA_2	496	502	PF00069	0.641
MOD_PKA_2	5	11	PF00069	0.570
MOD_PKA_2	537	543	PF00069	0.572
MOD_PKA_2	622	628	PF00069	0.638
MOD_PKA_2	638	644	PF00069	0.742
MOD_PKA_2	652	658	PF00069	0.670
MOD_PKA_2	698	704	PF00069	0.662
MOD_PKA_2	705	711	PF00069	0.600
MOD_PKA_2	825	831	PF00069	0.719
MOD_PKA_2	88	94	PF00069	0.691
MOD_Plk_1	627	633	PF00069	0.574
MOD_Plk_1	665	671	PF00069	0.570
MOD_Plk_1	702	708	PF00069	0.534
MOD_Plk_2-3	157	163	PF00069	0.489
MOD_Plk_2-3	328	334	PF00069	0.553
MOD_Plk_4	107	113	PF00069	0.576
MOD_Plk_4	290	296	PF00069	0.698
MOD_Plk_4	417	423	PF00069	0.505
MOD_Plk_4	443	449	PF00069	0.399
MOD_Plk_4	557	563	PF00069	0.520
MOD_Plk_4	57	63	PF00069	0.657
MOD_ProDKin_1	511	517	PF00069	0.613
MOD_ProDKin_1	567	573	PF00069	0.562
MOD_ProDKin_1	675	681	PF00069	0.727
MOD_SUMO_rev_2	306	313	PF00179	0.577
TRG_DiLeu_BaEn_1	261	266	PF01217	0.456
TRG_DiLeu_BaEn_3	208	214	PF01217	0.508
TRG_DiLeu_BaEn_4	205	211	PF01217	0.548
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.598
TRG_ENDOCYTIC_2	415	418	PF00928	0.482
TRG_ENDOCYTIC_2	802	805	PF00928	0.468
TRG_ER_diArg_1	114	116	PF00400	0.637
TRG_ER_diArg_1	361	363	PF00400	0.755
TRG_ER_diArg_1	495	497	PF00400	0.617
TRG_ER_diArg_1	536	539	PF00400	0.612
TRG_ER_diArg_1	555	557	PF00400	0.496
TRG_ER_diArg_1	636	639	PF00400	0.709
TRG_ER_diArg_1	67	69	PF00400	0.691
TRG_ER_diArg_1	825	827	PF00400	0.566
TRG_ER_diArg_1	88	90	PF00400	0.536
TRG_NES_CRM1_1	219	233	PF08389	0.354
TRG_NLS_MonoCore_2	636	641	PF00514	0.795
TRG_NLS_MonoExtN_4	636	642	PF00514	0.779
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	555	559	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC42	Leptomonas seymouri	39%	100%
A0A3Q8IDS0	Leishmania donovani	68%	100%
A4I244	Leishmania infantum	67%	100%
E9AY94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q979	Leishmania major	65%	98%