RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HEW9_LEIBR

TriTrypDb:

LbrM.26.1160 , LBRM2903_260016600

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HEW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HEW9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.335
CLV_NRD_NRD_1	220	222	PF00675	0.342
CLV_NRD_NRD_1	282	284	PF00675	0.430
CLV_NRD_NRD_1	293	295	PF00675	0.409
CLV_NRD_NRD_1	302	304	PF00675	0.377
CLV_NRD_NRD_1	359	361	PF00675	0.359
CLV_NRD_NRD_1	56	58	PF00675	0.646
CLV_PCSK_KEX2_1	187	189	PF00082	0.335
CLV_PCSK_KEX2_1	220	222	PF00082	0.342
CLV_PCSK_KEX2_1	282	284	PF00082	0.430
CLV_PCSK_KEX2_1	293	295	PF00082	0.367
CLV_PCSK_KEX2_1	302	304	PF00082	0.362
CLV_PCSK_KEX2_1	488	490	PF00082	0.466
CLV_PCSK_KEX2_1	56	58	PF00082	0.621
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.466
CLV_PCSK_SKI1_1	158	162	PF00082	0.526
CLV_PCSK_SKI1_1	212	216	PF00082	0.350
CLV_PCSK_SKI1_1	255	259	PF00082	0.372
CLV_PCSK_SKI1_1	277	281	PF00082	0.358
CLV_PCSK_SKI1_1	294	298	PF00082	0.289
CLV_PCSK_SKI1_1	303	307	PF00082	0.335
CLV_PCSK_SKI1_1	407	411	PF00082	0.616
CLV_PCSK_SKI1_1	491	495	PF00082	0.387
CLV_Separin_Metazoa	217	221	PF03568	0.348
DEG_APCC_DBOX_1	293	301	PF00400	0.325
DEG_APCC_DBOX_1	415	423	PF00400	0.384
DEG_SCF_FBW7_1	17	22	PF00400	0.583
DEG_SCF_FBW7_1	29	35	PF00400	0.496
DEG_SPOP_SBC_1	34	38	PF00917	0.692
DEG_SPOP_SBC_1	66	70	PF00917	0.638
DOC_CKS1_1	29	34	PF01111	0.525
DOC_MAPK_gen_1	360	367	PF00069	0.371
DOC_MAPK_HePTP_8	463	475	PF00069	0.423
DOC_MAPK_MEF2A_6	360	369	PF00069	0.351
DOC_MAPK_MEF2A_6	466	475	PF00069	0.518
DOC_PP2B_LxvP_1	104	107	PF13499	0.528
DOC_PP2B_LxvP_1	257	260	PF13499	0.294
DOC_PP4_FxxP_1	311	314	PF00568	0.340
DOC_PP4_MxPP_1	328	331	PF00568	0.433
DOC_USP7_MATH_1	19	23	PF00917	0.664
DOC_USP7_MATH_1	2	6	PF00917	0.626
DOC_USP7_MATH_1	32	36	PF00917	0.624
DOC_USP7_MATH_1	332	336	PF00917	0.476
DOC_USP7_MATH_1	456	460	PF00917	0.379
DOC_USP7_MATH_1	46	50	PF00917	0.692
DOC_USP7_MATH_1	72	76	PF00917	0.594
DOC_USP7_UBL2_3	521	525	PF12436	0.509
DOC_WW_Pin1_4	13	18	PF00397	0.703
DOC_WW_Pin1_4	171	176	PF00397	0.437
DOC_WW_Pin1_4	25	30	PF00397	0.736
DOC_WW_Pin1_4	345	350	PF00397	0.351
DOC_WW_Pin1_4	51	56	PF00397	0.703
DOC_WW_Pin1_4	91	96	PF00397	0.563
LIG_14-3-3_CanoR_1	187	191	PF00244	0.337
LIG_14-3-3_CanoR_1	212	217	PF00244	0.346
LIG_14-3-3_CanoR_1	294	304	PF00244	0.460
LIG_14-3-3_CanoR_1	3	7	PF00244	0.654
LIG_14-3-3_CanoR_1	360	365	PF00244	0.382
LIG_14-3-3_CanoR_1	376	383	PF00244	0.351
LIG_14-3-3_CanoR_1	491	496	PF00244	0.541
LIG_14-3-3_CanoR_1	56	66	PF00244	0.651
LIG_Actin_RPEL_3	214	233	PF02755	0.353
LIG_Clathr_ClatBox_1	364	368	PF01394	0.435
LIG_DLG_GKlike_1	360	367	PF00625	0.353
LIG_EH1_1	438	446	PF00400	0.235
LIG_FHA_1	106	112	PF00498	0.449
LIG_FHA_1	160	166	PF00498	0.401
LIG_FHA_1	213	219	PF00498	0.375
LIG_FHA_1	235	241	PF00498	0.337
LIG_FHA_1	28	34	PF00498	0.670
LIG_FHA_1	287	293	PF00498	0.398
LIG_FHA_1	299	305	PF00498	0.323
LIG_FHA_1	339	345	PF00498	0.389
LIG_FHA_1	435	441	PF00498	0.416
LIG_FHA_1	463	469	PF00498	0.484
LIG_FHA_2	138	144	PF00498	0.627
LIG_FHA_2	159	165	PF00498	0.516
LIG_FHA_2	322	328	PF00498	0.340
LIG_FHA_2	346	352	PF00498	0.361
LIG_FHA_2	377	383	PF00498	0.494
LIG_LIR_Apic_2	198	204	PF02991	0.436
LIG_LIR_Apic_2	310	314	PF02991	0.347
LIG_LIR_Gen_1	18	25	PF02991	0.610
LIG_LIR_Gen_1	397	404	PF02991	0.434
LIG_LIR_Nem_3	18	23	PF02991	0.607
LIG_LIR_Nem_3	397	402	PF02991	0.416
LIG_NRBOX	500	506	PF00104	0.351
LIG_NRBOX	515	521	PF00104	0.343
LIG_SH2_CRK	20	24	PF00017	0.623
LIG_SH2_CRK	207	211	PF00017	0.463
LIG_SH2_CRK	399	403	PF00017	0.393
LIG_SH2_NCK_1	263	267	PF00017	0.386
LIG_SH2_NCK_1	399	403	PF00017	0.412
LIG_SH2_STAP1	192	196	PF00017	0.323
LIG_SH2_STAP1	20	24	PF00017	0.623
LIG_SH2_STAP1	207	211	PF00017	0.321
LIG_SH2_STAT5	207	210	PF00017	0.391
LIG_SH2_STAT5	234	237	PF00017	0.328
LIG_SH2_STAT5	323	326	PF00017	0.335
LIG_SH2_STAT5	454	457	PF00017	0.352
LIG_SH3_3	223	229	PF00018	0.479
LIG_SH3_3	26	32	PF00018	0.509
LIG_SUMO_SIM_anti_2	161	169	PF11976	0.507
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.369
LIG_SUMO_SIM_par_1	212	217	PF11976	0.361
LIG_SUMO_SIM_par_1	390	397	PF11976	0.415
LIG_TRAF2_1	348	351	PF00917	0.507
LIG_TYR_ITSM	16	23	PF00017	0.610
LIG_TYR_ITSM	395	402	PF00017	0.442
MOD_CDK_SPK_2	51	56	PF00069	0.607
MOD_CDK_SPxK_1	51	57	PF00069	0.609
MOD_CK1_1	195	201	PF00069	0.274
MOD_CK1_1	298	304	PF00069	0.321
MOD_CK1_1	345	351	PF00069	0.518
MOD_CK1_1	35	41	PF00069	0.708
MOD_CK1_1	394	400	PF00069	0.493
MOD_CK1_1	459	465	PF00069	0.391
MOD_CK1_1	60	66	PF00069	0.666
MOD_CK1_1	94	100	PF00069	0.617
MOD_CK2_1	158	164	PF00069	0.512
MOD_CK2_1	345	351	PF00069	0.375
MOD_CK2_1	376	382	PF00069	0.500
MOD_Cter_Amidation	486	489	PF01082	0.477
MOD_GlcNHglycan	297	300	PF01048	0.445
MOD_GlcNHglycan	389	392	PF01048	0.463
MOD_GlcNHglycan	404	407	PF01048	0.634
MOD_GlcNHglycan	60	63	PF01048	0.691
MOD_GlcNHglycan	96	99	PF01048	0.592
MOD_GSK3_1	102	109	PF00069	0.507
MOD_GSK3_1	116	123	PF00069	0.376
MOD_GSK3_1	15	22	PF00069	0.665
MOD_GSK3_1	191	198	PF00069	0.289
MOD_GSK3_1	234	241	PF00069	0.345
MOD_GSK3_1	28	35	PF00069	0.588
MOD_GSK3_1	338	345	PF00069	0.521
MOD_GSK3_1	387	394	PF00069	0.474
MOD_GSK3_1	57	64	PF00069	0.583
MOD_GSK3_1	85	92	PF00069	0.682
MOD_NEK2_1	186	191	PF00069	0.334
MOD_NEK2_1	233	238	PF00069	0.309
MOD_NEK2_1	253	258	PF00069	0.285
MOD_NEK2_1	278	283	PF00069	0.375
MOD_NEK2_1	33	38	PF00069	0.701
MOD_NEK2_1	387	392	PF00069	0.456
MOD_NEK2_1	78	83	PF00069	0.781
MOD_NEK2_2	192	197	PF00069	0.345
MOD_NEK2_2	391	396	PF00069	0.320
MOD_PIKK_1	353	359	PF00454	0.388
MOD_PIKK_1	46	52	PF00454	0.492
MOD_PKA_1	360	366	PF00069	0.403
MOD_PKA_2	186	192	PF00069	0.334
MOD_PKA_2	2	8	PF00069	0.619
MOD_PKA_2	338	344	PF00069	0.388
MOD_PKA_2	400	406	PF00069	0.562
MOD_PKB_1	489	497	PF00069	0.397
MOD_Plk_1	253	259	PF00069	0.421
MOD_Plk_1	431	437	PF00069	0.503
MOD_Plk_4	19	25	PF00069	0.729
MOD_Plk_4	206	212	PF00069	0.452
MOD_Plk_4	253	259	PF00069	0.421
MOD_Plk_4	312	318	PF00069	0.330
MOD_Plk_4	39	45	PF00069	0.617
MOD_Plk_4	459	465	PF00069	0.398
MOD_Plk_4	72	78	PF00069	0.652
MOD_ProDKin_1	13	19	PF00069	0.702
MOD_ProDKin_1	171	177	PF00069	0.433
MOD_ProDKin_1	25	31	PF00069	0.737
MOD_ProDKin_1	345	351	PF00069	0.348
MOD_ProDKin_1	51	57	PF00069	0.705
MOD_ProDKin_1	91	97	PF00069	0.565
TRG_DiLeu_BaEn_1	164	169	PF01217	0.378
TRG_DiLeu_BaEn_1	254	259	PF01217	0.511
TRG_ENDOCYTIC_2	20	23	PF00928	0.753
TRG_ENDOCYTIC_2	207	210	PF00928	0.419
TRG_ENDOCYTIC_2	263	266	PF00928	0.388
TRG_ENDOCYTIC_2	399	402	PF00928	0.385
TRG_ER_diArg_1	186	188	PF00400	0.335
TRG_ER_diArg_1	219	221	PF00400	0.341
TRG_ER_diArg_1	292	294	PF00400	0.386
TRG_ER_diArg_1	302	304	PF00400	0.376
TRG_ER_diArg_1	489	492	PF00400	0.438
TRG_ER_diArg_1	55	57	PF00400	0.648
TRG_NES_CRM1_1	357	371	PF08389	0.406
TRG_NLS_MonoExtC_3	487	492	PF00514	0.462
TRG_Pf-PMV_PEXEL_1	212	217	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGU4	Leptomonas seymouri	76%	94%
A0A0S4JSB1	Bodo saltans	58%	100%
A0A1X0NS86	Trypanosomatidae	67%	99%
A0A3Q8IDM7	Leishmania donovani	90%	99%
A0A422N6M4	Trypanosoma rangeli	62%	100%
A4I243	Leishmania infantum	90%	99%
C9ZRW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	99%
E9AY93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q980	Leishmania major	88%	100%
V5B995	Trypanosoma cruzi	63%	100%